scholarly journals Correlation Analysis of Helicobacter pylori Infection and Diges-tive Tract Symptoms in Children and Related Factors of Infec-tion

2020 ◽  
Author(s):  
Xiaohong YU ◽  
Dongjin FENG ◽  
Guangmeng WANG ◽  
Zhongmao DONG ◽  
Qi ZHOU ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Digestive Tract ◽  
Clinical Symptoms ◽  
Helicobacter Pylori Infection ◽  
Related Factors ◽  
Expression Levels ◽  
Independent Risk Factors ◽  
Ifn Γ ◽  
H Pylori

Background: To analyze the correlation between Helicobacter pylori infection and digestive tract symptoms in children and other related factors, and to explore the risk factors of H. pylori infection in children and the expression of inflammatory factors in H. pylori-positive and H. pylori-negative children. Methods: Overall, 234 children with H. pylori test in Xuzhou Children's Hospital, Xuzhou Medical University (Xuzhou, China) were enrolled. Among them, 73 children were H. pylori-positive and 161 were H. pylori-negative. The expression levels of cytokines interleukin-8 (IL-8), interleukin-18 (IL-18) and interferon-γ (IFN-γ) in H. pylori-positive and H. pylori-negative children were determined by ELISA. The correlation between H. pylori-positive and general data, digestive tract symptoms, other clinical symptoms, living habits, eating habits, family history and other related factors was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the independent risk factors of H. pylori infection in children. Results: Family monthly income, inattentive eating, sharing toothbrushes and cups, gnawing fingers, eating fried food, drinking raw water, eating smoked and pickled food, father suffering from gastropathy and mother suffering from gastropathy were independent risk factors for H. pylori infection in children. The most common digestive tract symptoms of children with H. pylori infection were abdominal pain, accompanied by one or more clinical symptoms. The expression levels of IL-8, IL-18 and IFN-γ in H. pylori-positive children were significantly higher than those in H. pylori-negative children. Conclusion: Prevention of H. pylori infection in children is helpful for healthy growth of children, and cytokines IL-8, IL-18, IFN-γ have the potential to be used as biomarkers for diagnosis of H. pylori-positive children.

scholarly journals Helicobacter pylori Recurrence after Eradication Therapy in Jiangjin District, Chongqing, China

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Gang Zhou
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Recurrence Rate ◽  
Standard Therapy ◽  
Family Members ◽  
Significant Difference ◽  
Independent Risk Factors ◽  
Eating Out ◽  
H Pylori ◽  
Infection Recurrence

Purpose. To investigate the recurrence rate of Helicobacter pylori infection after eradication in Jiangjin District, Chongqing, China, and to analyze the related causes. Methods. Outpatients who were eradicated of H. pylori infection with standard therapy between August 2014 and August 2017 were included in this study. The recurrence rate was investigated 1 year later. Data regarding gender, smoking, alcohol intake, frequency of eating out, and treatment strategy were recorded, and their relationships with the recurrence rate were analyzed. Multivariate logistic regression analysis was performed to determine the independent risk factors for H. pylori infection recurrence. Results. In total, 400 patients (225 males and 175 females) were included in this study. Of them, the recurrence rate of H. pylori infection was 4.75% (19/400), with 5.33% (12/225) in males and 4.57% (7/175) in females, showing no gender difference. The recurrence rate was 7.03% (9/128) in smokers and 3.68% (10/272) in nonsmokers, while it was 6.45% (12/186) in those who drink alcohol and 3.27% (7/214) in those who do not drink alcohol, showing no significant differences. The higher the frequency of eating out, the higher the recurrence rate of H. pylori infection (P=0.001). There was a statistically significant difference in the recurrence rate between patients receiving treatment alone and patients whose family members also received treatment (6.08% vs. 0.96%, P=0.035). Drinking and dining out were independent risk factors for H. pylori infection recurrence (P=0.014 for drinkers and P=0.015 and P=0.003 for those who sometimes and often dine out, respectively). Conclusions. The overall recurrence rate after H. pylori eradication by standard therapy in Jiangjin District is 4.75%. Reducing the frequency of eating out and family members receiving treatment may reduce the recurrence of H. pylori infection.

scholarly journals The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection

2020 ◽  
Vol 8 (4) ◽  
pp. 479
Author(s):  
Valeria Garcia-Castillo ◽  
Guillermo Marcial ◽  
Leonardo Albarracín ◽  
Mikado Tomokiyo ◽  
Patricia Clua ◽  
...  
Keyword(s):  
Immune Response ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Helicobacter Pylori Infection ◽  
Beneficial Effects ◽  
Ifn Γ ◽  
H Pylori

Lactobacillus fermentum UCO-979C (Lf979C) beneficially modulates the cytokine response of gastric epithelial cells and macrophages after Helicobacter pylori infection in vitro. Nevertheless, no in vivo studies were performed with this strain to confirm its beneficial immunomodulatory effects. This work evaluated whether Lf979C improves protection against H. pylori infection in mice by modulating the innate immune response. In addition, we evaluated whether its exopolysaccharide (EPS) was involved in its beneficial effects. Lf979C significantly reduced TNF-α, IL-8, and MCP-1 and augmented IFN-γ and IL-10 in the gastric mucosa of H. pylori-infected mice. The differential cytokine profile induced by Lf979C in H. pylori-infected mice correlated with an improved reduction in the pathogen gastric colonization and protection against inflammatory damage. The purified EPS of Lf979C reduced IL-8 and enhanced IL-10 levels in the gastric mucosa of infected mice, while no effect was observed for IFN-γ. This work demonstrates for the first time the in vivo ability of Lf979C to increase resistance against H. pylori infection by modulating the gastric innate immune response. In addition, we advanced knowledge of the mechanisms involved in the beneficial effects of Lf979C by demonstrating that its EPS is partially responsible for its immunomodulatory effect.

scholarly journals The cause of abdominal purpura in children and the advances in pathogenesis

2017 ◽  
Vol 1 ◽  
pp. 18
Author(s):  
Xiaolei Yang ◽  
Hai Wang
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Recurrence Rate ◽  
Clinical Experience ◽  
Parasitic Infection ◽  
Food Intolerance ◽  
Helicobacter Pylori Infection ◽  
Gastrointestinal Function ◽  
Related Factors ◽  
New Ideas

This paper analyzes the imaging and gastrointestinal function of patients with abdominal purpura by searching domestic (China) and foreign literature, combined with clinical experience, and explores the possible characteristics of the disease of the children's abdominal from the three perspectives of Helicobacter pylori infection, parasitic infection and food-intolerance type of purpura, as well as the development of closely related factors and new ideas for the clinical treatment of abdominal purpura children and for avoiding exposure to risk factors in order to reduce the recurrence rate.

scholarly journals Sero-Prevalence and Risk Factors for Helicobacter pylori Infection Among Individuals with and those Without Dyspepsia in Zaria, Northwestern Nigeria

2020 ◽  
Vol 1 (1) ◽  
pp. 73-76
Author(s):  
Okonkwo Lilian Okwubenata ◽  
Musa Bolanle Olufunke Priscilla ◽  
Hali Bello ◽  
Mustapha Shettima Kagu
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Low Socioeconomic Status ◽  
Immunoglobulin G ◽  
Rural Areas ◽  
Urban Areas ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
H Pylori ◽  
Study Participants

Background Helicobacter pylori infection is prevalent in African region especially in areas with low socioeconomic status. This study aimed to determine the prevalence and risk factors for Helicobacter pylori Infection among individuals with and those without dyspepsia Materials and Methods The study was cross sectional in which individuals with and those without dyspepsia were enrolled. The prevalence for Helicobacter pylori infection was determined by the screening of Helicobacter pylori immunoglobulin G and this was compared across variables of interest. IBM SPSS was used for the data analysis. Results Overall prevalence of Helicobacter pylori immunoglobulin G was 44 (37.9 %). There was no association between H pylori infection and dyspepsia (0.894). There was statistically significant association between residing in rural areas and acquiring of Helicobacter pylori infection (P= 0.011). Study participants from rural areas had significantly higher and lower pit latrines and water closet toilets respectively than the study participants who reside in urban areas (P= 0.0001). Conclusion Modest prevalence of Helicobacter pylori infection was observed and no association between H pylori infection and dyspepsia was observed. There is a need to take strategic measures towards improving level of socio-economic status of the rural areas so as to reduce the risk of contracting Helicobacter pylori infection in people living in rural areas

scholarly journals The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Liang Wang ◽  
Jinfeng Wang ◽  
Sha Li ◽  
Fei Bai ◽  
Hailong Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Overall Survival ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Positive Node ◽  
Node Metastasis ◽  
Undifferentiated Type ◽  
Independent Risk Factors ◽  
H Pylori

Abstract Objective To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC). Methods This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group. Result Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84–5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51–4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08–2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient’s age ≥60 years old (HR, 3.32; 95% CI, 2.00–5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25–6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79–5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11–3.02; P = 0.018) were statistically significantly independent risk factors of overall survival. Conclusion H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC.

scholarly journals Secretor status and Helicobacter pylori infection are independent risk factors for gastroduodenal disease.

Gut ◽  
1993 ◽  
Vol 34 (3) ◽  
pp. 351-353 ◽  
Author(s):  
W Dickey ◽  
J S Collins ◽  
R G Watson ◽  
J M Sloan ◽  
K G Porter
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Secretor Status ◽  
Gastroduodenal Disease ◽  
Independent Risk Factors

scholarly journals Prevalence of Helicobacter pylori infection and its Associated Risk Factors among symptomatic Residents of Sulaimani city, Kurdistan region, Iraq, 2020

2021 ◽  
pp. 1-12
Author(s):  
Seerwan Hama rashid Ali ◽  
Sabiha Sharif Salih ◽  
Taib Ahmed Hama Sour ◽  
Goran Mohammad Raouf ◽  
Araz Latif Rahim
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Breath Test ◽  
Human Life ◽  
Urea Breath Test ◽  
Giemsa Stain ◽  
Helicobacter Pylori Infection ◽  
Noninvasive Test ◽  
H Pylori ◽  
Gastric Sample

Helicobacter pylori (H. pylori) bacteria are a microaerobic Gram negative that colonizes in the gastric and duodenum of human. It can cause prolong infection in the human life if not treated. Many of the studies showed that infection by H. pylori can cause some important gastrointestinal illness, such as peptic ulcer, chronic gastritis, gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. Recurrence is generally considered as H. pylori recrudescence infection after one year of eradicated treatment. There are many factors involved in the H pylori reinfection, such as the epidemiology of H. pylori infection, condition of the live, development of economical state, and health conditions. The Objectives of this study were to estimate the incidence and determine the risk factors of infection by H. pylori bacteria in dyspeptic patients in Sulaimani city. And the Aims are to estimate prevalence of the Helicobacter pylori and patients’ characteristics in Sulaimani city. This is a cross-sectional study, using a Urea breath test or stained the gastric sample with Giemsa stain, which is including adult participants aged (12-87) years during the period starting from 1 January until 31 December 2020 on Iraqi male and female patients were visiting –Center for Gastroenterology and Hepatology in Sulaimani, city, Iraq. Three hundred and four patients were included, all of them underwent Urea breath test only but eighty-one of the participants underwent endoscopy and stained the gastric sample with Giemsa stain. Urea breath test for Helicobacter pylori was positive in54.9% which have significant correlation with risk factor findings. Results: the incidence rate of H. pylori infection in our study is 54.9%, and mean age of the study participants was (40.49 ±16.39) one hundred and ninety-one cases 62.8% were female and 113 cases 37.2%were male. Infection by H. pylori bacteria is rife in dyspeptic patients; and is more common in the age group of 31-40 years. One of noninvasive test to diagnosis H. pylori is Urea breath test.  In conclusions the rate of helicobacter pylori infection in our study is 54.9% among the symptomatic patients, and the overall incidence of H. pylori UBT and Giemsa stain detection rate were 73.4 and 26.6% respectively.  

scholarly journals SEROPOSITIVITY OF HELICOBACTER PYLORI AND ASSOCIATED RISK FACTORS AMONG DYSPEPETIC PATIENTS

2020 ◽  
Author(s):  
Huda Mohammed Barajash ◽  
Eidha Ali Bin-Hameed ◽  
Ahmed Mohammed Al-Haddad
Keyword(s):  
Helicobacter Pylori ◽  
Peer Review ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Age Groups ◽  
Clinical Signs ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
H Pylori ◽  
E Mail

Background and Objectives: The prevalence of Helicobacter pylori infection is most common worldwide, and the seroprevalence of H. pylori infection varies greatly among societies and geographical locations. This study aimed to determine the seroprevalence of H. pylori infection among dyspepsia patients in Al-Mukalla city– Hadhramout/Yemen. Methods: A cross-sectional study was conducted among 100 suspected patients with dyspeptic disorders where the anti- H. pylori antibodies was detected using the H. pylori antibody test cassette rapid immune chromatographic assay. Also, a structured questionnaire was completed for each patient to collect socio-demographic data, personal hygienic status and some clinical signs. Results: The prevalence of serological positivity for H. pylori infection was 37% with a statistically significant value (P=0.000). A high prevalence of H. pylori infection was detected among male more than females. The age group 5–18 years followed by age groups 33–46 years and 47–60 years showed the highest prevalence of H. pylori infection. There was no significant association between H. pylori infection with social, demographic, behavioral, and health variables (P>0.05). Clinical signs of heartburn and regurgitation were found to be significant associated with H. pylori infection (P=0.014). Conclusions: Helicobacter pylori infection was found to be associated with dyspepsia. Heartburn and regurgitation have been found as clinical symptoms associated with H. pylori infection. Peer Review History: Received 18 July 2020; Revised 15 August; Accepted 29 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Prof. Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Tanveer Ahmed Khan Affiliation: Hajvery University, Lahore, Pakistan E-mail: [email protected]   Comments of reviewer(s): Similar Articles: PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

scholarly journals Stomach diseases unrelated to Helicobacter pylori infection: current state of the problem

2017 ◽  
Vol 95 (7) ◽  
pp. 594-598
Author(s):  
A. A. Svistunov ◽  
Michael A. Osadchuk
Keyword(s):  
Helicobacter Pylori ◽  
Digestive Tract ◽  
Clinical Picture ◽  
Helicobacter Pylori Infection ◽  
Pathogenetic Mechanisms ◽  
Current State ◽  
Stomach Diseases ◽  
H Pylori

The review deals with basic etiological and pathogenetic mechanisms of stomach diseases unrelated to H. pylori infection. Special attention is given to the clinical picture and prognosis of this pathology, its fundamental differences from H. pylori-associated stomach diseases. The authors emphasize the importance and relevance of studying the problem of stomach diseases unrelated to H. pylori infection and its increasing role in the structure of digestive tract diseases.

scholarly journals Seroprevalence and risk factors associated with Helicobacter pylori infection among children aged less than 18 years old in Duhok Province, Iraq

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Infection Rate ◽  
Side Population ◽  
Helicobacter Pylori Infection ◽  
Kurdistan Region ◽  
Serological Tests ◽  
Factors Associated ◽  
History Of ◽  
H Pylori

Objectives: Helicobacter pylori infection is predominantly acquired in early childhood and persists for decades before causing disease. This study aimed to detect the prevalence of H. pylori infection and identify potential factors associated with infection in Duhok province, Iraq. Methods: This cross-sectional study was conducted in Duhok Province, Kurdistan Region, Iraq. Over a four-year period from 2016 to 2020, a total of 381 children aged four to 18 years who attended the hospitals and were evaluated for specific IgG antibodies against H. pylori using serological tests were included. A questionnaire was completed at the start of the study. H. pylori serology data were analyzed using the chi-square test. Results: The seroprevalence of H. pylori IgG-specific antibodies among the study participants was 31%. The infection rate significantly increased with increasing age of the participants (p<0.001), from 19.8% among four to five-year-olds to 42.9% among 16 and 18-year-olds. The infection rate was significantly higher in girls (35.9%) than that in boys (26.5%) (p<0.047). Infections were also higher among university students (41%; p<0.001), children from the country-side population (41%; p<0.001), children from crowded households (67.3%; p<0.001), and children with a history of gastrointestinal pain (44.4%; p>0.001). Conclusion. The prevalence rate of H. pylori infection among children in Duhok province is quite similar to that reported in previous studies in the Kurdistan region, Iraq, and increases with age. University attendance, history of gastrointestinal pain, countryside population, and overcrowding were risk factors associated with H. pylori infection. Valuable approaches to improve sanitary purposes and educational and socioeconomic status should be emphasized and promoted to reduce the risk of H. pylori infection among children.

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