Venous invasion in oesophageal adenocarcinoma: enhanced detection using elastic stain and association with adverse histological features and clinical outcomes

2013 ◽  
Vol 64 (5) ◽  
pp. 693-700 ◽  
Author(s):  
Mathieu C Castonguay ◽  
Hector H Li-Chang ◽  
David K Driman
Keyword(s):  
Clinical Outcomes ◽  
Venous Invasion ◽  
Oesophageal Adenocarcinoma ◽  
Histological Features ◽  
Elastic Stain

scholarly journals PTU-2 Correlation between endoscopic and histological features in children and association with clinical outcomes

2021 ◽  
Author(s):  
Mara Popescu ◽  
Badra Farah ◽  
Ifrah Hasan ◽  
Zaynah Qamar ◽  
Junaid Naveed ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Histological Features

Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study

2020 ◽  
pp. 1098612X2094239
Author(s):  
Melanie J Dobromylskyj ◽  
Victoria Richards ◽  
Ken C Smith
Keyword(s):  
Soft Tissue ◽  
Survival Time ◽  
Clinical Outcomes ◽  
Histological Grade ◽  
Soft Tissue Sarcomas ◽  
Prognostic Indicators ◽  
Grading System ◽  
Anatomical Location ◽  
Diagnostic Laboratory ◽  
Histological Features

Objectives The objectives of this study included utilising a large database from a diagnostic laboratory to identify any breed, sex or age predilections for cutaneous and subcutaneous soft tissue sarcomas (STSs), and the most common anatomical locations. The second aim was to obtain clinical outcomes and to assess histological features of those tumours to identify any potentially useful prognostic indicators and propose a grading system. Methods Records from the laboratory were searched for feline submissions received from January 2012 to December 2013 diagnosed with STSs; the breed, age, sex and neuter status of the cat and anatomical location of the tumour were recorded. Clinical outcomes were acquired using a questionnaire to submitting practices, and histological features of tumours from patients with known outcomes were assessed. Results No sex, neuter status or breed predispositions were found. Most STSs arise in middle-aged and older cats, and the most common anatomical location was the trunk. Forty-seven cases had a known clinical outcome and archived tissues allowing for histological assessment of the tumour. Significant differences in median survival time (MST), mitotic index and histological score were detected between those cats that died of tumour-related disease and those that did not. A novel grading system applied to these tumours produced significant differences in MST between cats with low (MST = 900.5 days), intermediate (MST = 514 days) and high grade tumours (MST = 283 days). Conclusions and relevance This is the first study applying a histological grading system to these common tumours. Local recurrence is often the cause of a poor outcome, with metastatic disease apparently rare. The proposed grading system incorporates features that can be assessed on routine haematoxylin and eosin-stained sections; in this small study, the histological grade of the tumour appears to be associated with survival time.

Radiological Characteristics, Histological Features and Clinical Outcomes of Lung Cancer Patients with Coexistent Idiopathic Pulmonary Fibrosis

Lung ◽  
2014 ◽  
Vol 193 (1) ◽  
pp. 71-77 ◽  
Author(s):  
K. A. Khan ◽  
M. P. Kennedy ◽  
E. Moore ◽  
L. Crush ◽  
S. Prendeville ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Histological Features ◽  
Lung Cancer Patients

OC-037 Clinical outcomes and risk of lymph node metastases in patients with t1b oesophageal adenocarcinoma

2017 ◽  
Author(s):  
N Sever ◽  
L Lovat ◽  
RR Atherton ◽  
M Mitchison ◽  
M rodriguez-Justo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Clinical Outcomes ◽  
Lymph Node Metastases ◽  
Oesophageal Adenocarcinoma ◽  
Node Metastases

scholarly journals Endoscopic resection of Barrett’s adenocarcinoma: Intramucosal and low-risk tumours are not associated with lymph node metastases

2020 ◽  
pp. 205064062095890
Author(s):  
Nicolas Benech ◽  
Marc O’Brien ◽  
Maximilien Barret ◽  
Jérémie Jacques ◽  
Gabriel Rahmi ◽  
...  
Keyword(s):  
Lymph Node ◽  
High Risk ◽  
Lymph Node Metastasis ◽  
Endoscopic Resection ◽  
Low Risk ◽  
Oesophageal Adenocarcinoma ◽  
Depth Of Invasion ◽  
Histological Features ◽  
Node Metastasis

Background Superficial oesophageal adenocarcinoma can be resected endoscopically, but data to define a curative endoscopic resection are scarce. Objective Our study aimed to assess the risk of lymph node metastasis depending on the depth of invasion and histological features of oesophageal adenocarcinoma. Methods We retrospectively included all patients undergoing an endoscopic resection for T1 oesophageal adenocarcinoma among seven expert centres in France in 2004–2016. Mural invasion was defined as either intramucosal or submucosal tumours; the latter were further divided into superficial submucosal (≤1000 µm) and deep submucosal (>1000 µm). Absence or presence of lymphovascular invasion and/or poorly differentiated cancer (G3) defined a low-risk or a high-risk tumour, respectively. For submucosal tumours, invasion depth and histological features were systematically confirmed after a second dedicated histological assessment (new 2-mm thick slices) performed by a second pathologist. Occurrence of lymph node metastasis was recorded during the follow-up from histological or PET CT reports when an invasive procedure was not possible. Results In total, 188 superficial oesophageal adenocarcinomas were included with a median follow-up of 34 months. No lymph node metastases occurred for intramucosal oesophageal adenocarcinomas ( n = 135) even with high-risk histological features. Among submucosal oesophageal adenocarcinomas, only tumours with lymphovascular invasion or poorly differentiated cancer or with a depth of invasion >1000 µm developed lymph node metastasis tumours ( n = 10/53; 18.9%; hazard ratio 12.04). No metastatic evolution occurred under a 1000-µm threshold for all low-risk tumours (0/25), nor under 1200 µm (0/1) and three over this threshold (3/13, 23.1%). Conclusion Intramucosal and low-risk tumours with shallow submucosal invasion up to 1200 µm were not associated with lymph node metastasis during follow-up. In case of high-risk features and/or deep submucosal invasion, endoscopic resections are not sufficient to eliminate the risk of lymph node metastasis, and surgical oesophagectomy should be carried out. These results must be confirmed by larger prospective series.

scholarly journals P-OGC34 Pandemic paradigms: Early outcomes of radical chemoradiotherapy for patients with operable oesophageal and oesophago-gastric junctional adenocarcinoma

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Sukitha Namal Rupasinghe ◽  
George Ninkovic-Hall ◽  
Rachel Mckinney ◽  
Nathan Howes ◽  
Rohith Rao ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Standardized Uptake Value ◽  
Disease Free Survival ◽  
Response To Treatment ◽  
Oesophageal Adenocarcinoma ◽  
Sign Test ◽  
Entire Cohort ◽  
Pre Treatment ◽  
Neo Adjuvant Chemotherapy

Abstract Background The peak waves of the COVID pandemic necessitated a paradigm shift in surgical management of patients with oesophageal adenocarcinoma due to both pressure on services and high mortality rates for those with COVID undergoing surgery. The Association of Upper GI Surgeons (AUGIS) guidance on treating Upper gastrointestinal cancers in the COVID era made suggestions to treat operable adenocarcinomas using definitive/consolidation chemoradiation (DCRT) over standard neo-adjuvant chemotherapy (NAC) and our unit altered practice accordingly for a cohort of patients. For affected patients we monitored and audited clinical outcomes and the initial results from this are presented here. Methods Patients with oesophageal or oesophago-gastric junctional (O/OGJ) adenocarcinoma with potentially curative disease where initial management was altered from a treatment path which would have included surgery (with or without neoadjuvant therapy) to DCRT discussed at our regional multidisciplinary team (MDT) meeting between 1st February-1st June 2020 were included. Patient demographics, investigations, treatment given and clinical outcomes were prospectively recorded.   Results 31 Patients with operable adenocarcinoma of O/OGJ had treatment altered to DCRT (mean age 65.4, [range 43 – 79]), 28 (90%) Male. 1 patient deteriorated prior to starting, leaving 30 who completed DCRT.  Of these 4 patients had already had NAC prior to DCRT.  Follow up was for a median of 8 (range 4-8) months following start of treatment. Post- vs pre-treatment FDG-PET imaging demonstrated a significant reduction in the mean maximum standardized uptake value (SUVmax) (p = 0.003, Sign test), in all but 3 patients.  11 patients had DCRT alone, (all alive at the time of data collection), of whom 3 patients had no sign of tumour. 19 (56%) patients proceeded to salvage oesophagectomy at a median of 15(range 10-25) weeks after completion of DCRT. 42% of these patients had a complete pathological response to treatment. There was a 5% perioperative mortality rate for this group and 1 patient was found to be unresectable on the day of surgery. At the time the data was reviewed overall survival of the entire cohort was 91%, 56% of whom had no sign of residual or recurrent disease. Conclusions A disease free survival of 56% compares poorly with the literature at the 3-month interval. The long-term follow-up of these patients will only be apparent in the coming months and years. This data does not support the use of this modality in the future and alternate treatment plans should be devised for future pandemics.

Evaluation of Myogenin and MyoD1 as Immunohistochemical Markers of Canine Rhabdomyosarcoma

2021 ◽  
Vol 58 (3) ◽  
pp. 516-526
Author(s):  
Joanne L. Tuohy ◽  
Brittney J. Byer ◽  
Suzanne Royer ◽  
Charles Keller ◽  
Margaret A. Nagai-Singer ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Soft Tissue ◽  
Clinical Outcomes ◽  
Soft Tissue Sarcomas ◽  
Biological Behavior ◽  
Diagnostic Challenge ◽  
Histological Features ◽  
Immunohistochemical Markers ◽  
Ihc Markers

Canine rhabdomyosarcoma (RMS) presents a diagnostic challenge due to its overlapping histologic features with other soft tissue sarcomas. The diagnosis of RMS currently relies on positive immunohistochemical (IHC) labeling for desmin; however, desmin expression is also observed in non-RMS tumors. Myogenin and MyoD1 are transcription factors reported to be sensitive and specific IHC markers for human RMS, but they are not widely used in veterinary oncology. The goals of this study were to develop an IHC protocol for myogenin and MyoD1, evaluate myogenin and MyoD1 labeling in canine RMS, and report clinical outcomes. Sixteen cases of possible RMS were retrospectively evaluated. A diagnosis of RMS was confirmed in 13 cases based on histological features and immunolabeling for myogenin and MyoD1, with the aid of electron microscopy in 2 cases. Desmin was negative in 3 cases of RMS. Two cases were of the sclerosing variant. The median age of dogs with RMS was 7.2 years. Anatomic tumor locations included previously reported sites such as bladder, larynx, heart, and orbit, as well as other locations typical of soft tissue sarcomas. Survival ranged from 47 to 1480 days for 5 dogs with available data. This study demonstrated that MyoD1 and myogenin should be included with desmin as part of a diagnostic IHC panel for canine RMS. Utilization of these antibodies to improve the accuracy of canine RMS diagnosis will ultimately allow for better characterization of the biological behavior and clinical outcomes of this disease, providing the groundwork for future comparative investigations in canine RMS.

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

2017 ◽  
Vol 71 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Christopher William Bleaney ◽  
Mickhaiel Barrow ◽  
Stephen Hayes ◽  
Yeng Ang
Keyword(s):  
Clinical Outcomes ◽  
Cell Biology ◽  
Signet Ring Cell ◽  
Current Understanding ◽  
Oesophageal Adenocarcinoma ◽  
Signet Ring Cells ◽  
Signet Ring Cell Adenocarcinoma ◽  
Signet Ring ◽  
Ring Cell ◽  
The Impact

AimTo review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis.MethodsWe conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised.ResultsSignet-ring cell carcinoma was represented in 7.61% of the 18 989 cases of oesophageal carcinoma reviewed in multiple studies. The presence of signet-ring cells conferred a worse prognosis and these tumours responded differently to conventional treatments as compared with typical adenocarcinoma. Little is known about the biological features of signet-ring cell adenocarcinoma of the oesophagus. Work in gastric lesions has identified potential targets for future treatments such as CDH1 and RHOA genes. Categorisation of signet-ring cell carcinomas by the proportion of signet-ring cells within tumours differs among clinicians despite WHO criteria for classification. The current UK guidelines for histopathological reporting of oesophageal tumours do not emphasise the importance of identifying signet-ring cells.ConclusionThe presence of signet-ring cells in oesophageal adenocarcinomas leads to poorer clinical outcomes. Current understanding of signet-ring cell biology in oesophageal cancer is limited.

scholarly journals Clinicopathologic Characteristics and Clinical Outcomes of Esophageal Basaloid Squamous Carcinoma: Experience at a Single Institution

10.9738/cc195 ◽  
2013 ◽  
Vol 98 (4) ◽  
pp. 450-454 ◽  
Author(s):  
Youichi Kumagai ◽  
Koji Nagata ◽  
Toru Ishiguro ◽  
Norihiro Haga ◽  
Kohki Kuwabara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
Venous Invasion ◽  
Clinicopathologic Characteristics ◽  
Pathologic Stage ◽  
Basaloid Squamous Carcinoma ◽  
Basaloid Squamous

Abstract This retrospective study investigated the clinicopathologic characteristics and clinical outcomes of esophageal basaloid squamous carcinoma (BSC). Among 190 patients with esophageal carcinoma treated surgically between 1998 and 2011, we identified 9 (4.7%) with BSC. All of the patients were male, with a median age of 65 years. The frequencies of venous invasion, lymphatic invasion, and lymph node metastasis were 56%, 89%, and 67%, respectively. A total of 2 patients were pathologic stage 1, 5 were stage 2, and 2 were stage 3. Tumor recurrence was observed in 56% of the patients. The 5-year survival rate for patients with esophageal BSC was 40%, which was compatible with the figure of 53.8% for control patients (n = 18) with typical squamous cell carcinoma matched for sex, age, tumor location, and pathologic stage (P = 0.45). Although esophageal BSC shows aggressive lymph-vascular invasion and has a high likelihood of recurrence, its prognosis seems identical to that of typical squamous cell carcinoma.

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