scholarly journals Anti-Inflammatory Liver X Receptors and Related Molecules in Multiple Sclerosis Patients from Sardinia and Sweden

2008 ◽  
Vol 59 (6) ◽  
pp. 611-611
Author(s):  
Y.-M. Huang ◽  
X. Liu ◽  
K. Steffensen ◽  
A. Sanna ◽  
G. Arru ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Liver X Receptors ◽  
Anti Inflammatory ◽  
X Receptors ◽  
Multiple Sclerosis Patients

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamad Reza Nikouei Moghaddam ◽  
Monireh Movahedi ◽  
Maryam Bananej ◽  
Soheil Najafi ◽  
Nahid Beladi Moghadam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Uric Acid ◽  
Vitamin D3 ◽  
Chronic Inflammatory Disease ◽  
Toxic Effects ◽  
Control Group ◽  
Therapeutic Effects ◽  
Mannuronic Acid ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

Pro- and anti-inflammatory cytokine gene polymorphism profiles in Bulgarian multiple sclerosis patients

2005 ◽  
Vol 168 (1-2) ◽  
pp. 138-143 ◽  
Author(s):  
Snejina Mihailova ◽  
Milena Ivanova ◽  
Anastassia Mihaylova ◽  
Ludmila Quin ◽  
Olia Mikova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphism ◽  
Inflammatory Cytokine ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphism ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients ◽  
Anti Inflammatory Cytokine

scholarly journals Glucocorticoid Therapy of Multiple Sclerosis Patients Induces Anti-inflammatory Polarization and Increased Chemotaxis of Monocytes

2019 ◽  
Vol 10 ◽  
Author(s):  
Henrike J. Fischer ◽  
Tobias L. K. Finck ◽  
Hannah L. Pellkofer ◽  
Holger M. Reichardt ◽  
Fred Lühder
Keyword(s):  
Multiple Sclerosis ◽  
Glucocorticoid Therapy ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden

2005 ◽  
Vol 20 (3) ◽  
pp. 961-968 ◽  
Author(s):  
Xuan Liu ◽  
Knut R. Steffensen ◽  
Alessandra Sanna ◽  
Giannina Arru ◽  
Maria Laura Fois ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nuclear Receptor ◽  
Nuclear Receptor Superfamily ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

scholarly journals Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

2021 ◽  
Vol 12 ◽  
Author(s):  
Inés Pineda-Torra ◽  
Sherrice Siddique ◽  
Kirsty E. Waddington ◽  
Rachel Farrell ◽  
Elizabeth C. Jury
Keyword(s):  
Multiple Sclerosis ◽  
Lipid Metabolism ◽  
Metabolic Pathways ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Future Research ◽  
Liver X Receptors ◽  
Pharmacological Agents ◽  
Relapsing Remitting ◽  
X Receptors

Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration. Systemic lipid metabolism is disturbed in people with MS, and lipid metabolic pathways are crucial to the protective process of remyelination. The lipid-activated transcription factors liver X receptors (LXRs) are important integrators of lipid metabolism and immunity. Consequently, there is a strong interest in targeting these receptors in a number of metabolic and inflammatory diseases, including MS. We have reviewed the evidence for involvement of LXR-driven lipid metabolism in the dysfunction of peripheral and brain-resident immune cells in MS, focusing on human studies, both the relapsing remitting and progressive phases of the disease are discussed. Finally, we discuss the therapeutic potential of modulating the activity of these receptors with existing pharmacological agents and highlight important areas of future research.

scholarly journals Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Claudia Sestito ◽  
John J. P. Brevé ◽  
Marja C. J. A. van Eggermond ◽  
Joep Killestein ◽  
Charlotte E. Teunissen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Tissue Transglutaminase ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients ◽  
And Function

Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis

2001 ◽  
Vol 7 (3) ◽  
pp. 151-156 ◽  
Author(s):  
I Durán ◽  
E M Martínez-Cáceres ◽  
L Brieva ◽  
M Tintoré ◽  
X Montalban
Keyword(s):  
Multiple Sclerosis ◽  
Mononuclear Cells ◽  
Demyelinating Disease ◽  
Primary Progressive Multiple Sclerosis ◽  
Relative Role ◽  
Healthy Controls ◽  
Primary Progressive ◽  
Clinical Forms ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Cytokines play an important role in the initiation and maintenance of the inflammatory reaction in multiple sclerosis, a chronic inflammatory demyelinating disease of the central nervous system. Magnetic resonance imaging evidence supports clinical divergence between forms of multiple sclerosis with relapses and the primary progressive form without relapses, which shows fewer and smaller inflammatory lesions. With the aim of understanding better the relative role of pro-inflammatory and/or anti-inflammatory cytokines in primary progressive multiple sclerosis in comparison to relapsing forms, we analysed in 65 patients (24 primary progressive, 20 relapsing-remitting and 21 secondary progressive) and 29 healthy controls, the production of cytokines (IFN-g, TNF-a, IL-6, IL-10 and IL-12) by peripheral blood mononuclear cells after in vitro stimulation. We found a similar percentage of cytokines producing cells between healthy controls and the different clinical forms of multiple sclerosis patients. Multiple Sclerosis (2001) 7, 151-156

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