The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

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Evolution of Hashimoto thyroiditis in children with type 1 diabetes mellitus (TIDM)

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0222 ◽

2020 ◽

Vol 33 (12) ◽

pp. 1525-1531

Author(s):

Feneli Karachaliou ◽

Nikitas Skarakis ◽

Evangelia Bountouvi ◽

Theodora Spyropoulou ◽

Eleni Tsintzou ◽

...

Keyword(s):

Diabetes Mellitus ◽

Randomized Trials ◽

Elevated Serum ◽

Hashimoto Thyroiditis ◽

Diabetes Mellitus Type 1 ◽

Overt Hypothyroidism ◽

Normal Ranges ◽

Serum Tsh

AbstractObjectivesTreatment of children with Hashimoto thyroiditis (HT) and particularly of those with coexistent diabetes mellitus type 1 (TIDM) and normal/mildly elevated serum TSH is controversial. The aim of the study was to evaluate the natural course of HT in children with TIDM compared with children with no other coexistent autoimmunity and investigate for possible predictive factors of thyroid function deterioration.MethodsData from 96 children with HT, 32 with T1DM (23 girls, nine boys) mean (sd) age: 10.6 (2.3) years, and 64 age and sex-matched without T1DΜ (46 girls, 18 boys), mean (sd) age: 10.2 (2.9) years were evaluated retrospectively. They all had fT4 and TSH values within normal ranges and available data for at least three years’ follow-up.ResultsDuring the follow-up period, 11 children (34.4%) with TIDM exhibited subclinical hypothyroidism and two children (6.2%) progressed to overt hypothyroidism compared to 12 (18.8%) and two (3.1%) among children without TIDM, respectively. Among children with HT, a higher percentage (40.6%) of children with T1DM progressed to subclinical or overt hypothyroidism, compared with children (21.9%) with similar characteristics but without TIDM or other coexistent autoimmunity.ConclusionsThe annual conversion rate from euthyroidism to hypothyroidism in children with T1DM was significantly higher compared to sex and age-matched children without TIDM. Prospective randomized trials are needed to support the view of an earlier intervention therapy even in milder degrees of thyroid failure in these children.

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Higher number of steps and breaks during sedentary behaviour are associated with better lipid profiles

BMC Public Health ◽

10.1186/s12889-021-10656-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Sonja Aho ◽

Meri-Sisko Vuoristo ◽

Jani Raitanen ◽

Kirsi Mansikkamäki ◽

Johanna Alanko ◽

...

Keyword(s):

Sedentary Behaviour ◽

Serum Lipids ◽

Lipid Profiles ◽

University Hospital ◽

Favourable Effect ◽

Middle Aged ◽

Female Population ◽

Wake Time ◽

Objectively Measured ◽

Mean Concentration

Abstract Background Physical activity (PA) is known to be associated with lipid profiles and the risk of both cardiovascular diseases and cancer. The aim of this study was to evaluate the association of objectively measured PA, sedentary behaviour (SB), amount of breaks during SB and number of daily steps with serum lipids in a healthy, Finnish, middle-aged, female population. Methods The participants (571) were recruited at mammography screening, target group was women aged 50–60 years. A measurement of PA was done with accelerometer, blood lipid profile was assessed, and questionnaires of participants characteristics were sent to participants. Results The participants with the highest number of daily breaks during SB (≥ 41) had the highest mean concentration of HDL-cholesterol (high density lipoprotein cholesterol, HDL-c) (1.9 mmol/l, standard deviation (SD) 0.4) and the lowest mean concentration of triglycerides (1.0 mmol/l, SD 0.5). HDL-c level was 0.16 mmol/l higher (p < 0.001) in the group with 28–40.9 breaks/day and 0.25 mmol/l higher (p < 0.001) among participants with ≥41 breaks/day than in the group with the fewest breaks during SB (< 28). Those with the most daily steps (≥ 9100) had the highest mean HDL-c level (1.9 mmol/l). HDL-c level was 0.16 mmol/l higher (p < 0.001) among the participants with 5600–9099 steps/day and 0.26 mmol/l higher (p < 0.001) among participants with ≥9100 steps/day than those with the fewest steps (< 5600). The number of daily steps was inversely associated with the triglyceride concentration. From wake-time, participants spent 60% in SB, 18% standing, 14% in light PA, and 9% in moderate-to-vigorous PA (MVPA). PA was associated with serum total cholesterol (TC), HDL-c and triglyceride levels. The mean HDL-c level was the highest in the lowest quartile of SB and in the highest quartile of MVPA. Conclusions To our knowledge, this is the first study showing a high number of objectively measured breaks during SB is associated with a favourable effect on the level of serum lipids, which may later translate into cardiovascular health among middle-aged women. Trial registration This study was registered and approved by the Regional Ethics Committee of Tampere University Hospital in Finland (approval code R15137).

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Elevated serum pentosidine is independently associated with the high prevalence of sarcopenia in Chinese middle‐aged and elderly men with type 2 diabetes mellitus

Journal of Diabetes Investigation ◽

10.1111/jdi.13581 ◽

2021 ◽

Author(s):

Xiaofan Zhang ◽

Juan Liu ◽

Qing Zhang ◽

Aijiao Lu ◽

Yunfeng Du ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Elevated Serum ◽

Middle Aged ◽

Elderly Men ◽

High Prevalence

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Reference intervals for serum lipids and prevalence of dyslipidaemia in 6–12-year-old children: The Health Oriented Pedagogical Project (HOPP)

Scandinavian Journal of Public Health ◽

10.1177/1403494818767824 ◽

2018 ◽

Vol 46 (21_suppl) ◽

pp. 21-27 ◽

Cited By ~ 4

Author(s):

Martin Frank Strand ◽

Per Morten Fredriksen ◽

Ole Petter Hjelle ◽

Morten Lindberg

Keyword(s):

Total Cholesterol ◽

Serum Lipids ◽

Venous Blood ◽

Elevated Serum ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Reference Intervals ◽

Age And Gender ◽

Norwegian Population ◽

And Gender

Aims: Elevated serum lipid concentrations in childhood are thought to be risk factors for the development of cardiovascular disease later in life. The present study aims to provide age- and gender-related reference intervals for total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol in healthy school children. We also investigated the prevalence of dyslipidaemia using the published criteria for these biomarkers. Methods: Venous blood and anthropometric data were collected from 1340 children in the HOPP study, aged between 6 and 12 years. Age- and gender-related reference intervals (2.5th and 97.5th percentiles) were established according to the IFCC recommendations, using the software RefVal 4.10. Results: Gender differences were observed for total cholesterol and non-HDL cholesterol, but not for HDL cholesterol. Age differences were observed for total cholesterol. The reference intervals were in the range of 3.1–5.9 mmol/L for total cholesterol, 1.0–2.4 mmol/L for HDL cholesterol and 1.4–4.2 mmol/L for non-HDL cholesterol. Dyslipidaemia prevalence was as follows: increased TC 9.6%, decreased HDL 1.6%, and increased non-HDL 5.6%. Conclusions: Age- and gender-related reference intervals in a Norwegian population are similar to those reported in other countries. The prevalence of dyslipidaemia among Norwegian children is significant, emphasising the importance of appropriate reference intervals in clinical practice.

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Elevated Serum TSH in Human Thyroid Cancer

Oncology ◽

10.1159/000224517 ◽

1970 ◽

Vol 24 (3) ◽

pp. 172-180 ◽

Cited By ~ 12

Author(s):

J.R. Hargadine ◽

J.M. Lowenstein ◽

F.S. Greenspan

Keyword(s):

Thyroid Cancer ◽

Elevated Serum ◽

Human Thyroid ◽

Serum Tsh

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Liposuction and Serum Lipids

The American Journal of Cosmetic Surgery ◽

10.1177/074880689701400317 ◽

1997 ◽

Vol 14 (3) ◽

pp. 345-346 ◽

Cited By ~ 8

Author(s):

Bruce Hildreth

Keyword(s):

Serum Lipids ◽

Elevated Serum ◽

Lipid Levels

The effect of liposuction on serum lipids is unknown. This study evaluated the reduction in lipid levels following suction-assisted lipectomy (SAL) in 23 patients with preoperative elevated serum lipids. Sixty-five percent (15 patients) had reduction in lipids following SAL. The mechanism of this change is unknown and further, better controlled, studies are necessary.

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Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽

10.7717/peerj.4637 ◽

2018 ◽

Vol 6 ◽

pp. e4637 ◽

Cited By ~ 2

Author(s):

Xingchen Zhou ◽

Wu Zhu ◽

Minxue Shen ◽

Yijing He ◽

Cong Peng ◽

...

Keyword(s):

Serum Level ◽

Serum Lipid ◽

Serum Lipids ◽

Elevated Serum ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

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