Deleterious effects of light exposure on immunity and sexual coloration in birds

SummaryThe alteration of rheological blood properties as well as deterioration of vascular perfusion conditions and cell-cell interactions are major determinants of thrombus formation. Herein, we present an experimental model which allows for quantitative in vivo microscopic analysis of these determinants during both thrombus formation and vascular recanalisation. The model does not require surgical preparation procedures, and enables for repeated analysis of identical microvessels over time periods of days or months, respectively. After i.v. administration of FITC-dextran thrombus formation was induced photochemically by light exposure to individual arterioles and venules of the ear of ten anaesthetised hairless mice. In venules, epiillumination induced rapid thrombus formation with first platelet deposition after 0.59 ± 0.04 min and complete vessel occlusion within 7.48 ±1.31 min. After a 24-h time period, 75% of the thrombosed venules were found recanalised. Marked leukocyte-endothelial cell interaction in those venules indicated persistent endothelial cell activation and/or injury, even after an observation period of 7 days. In arterioles, epi-illumination provoked vasomotion, while thrombus formation was significantly (p <0.05) delayed with first platelet deposition after 2.32 ± 0.22 min and complete vessel occlusion within 20.07 ±3.84 min. Strikingly, only one of the investigated arterioles was found recanalised after 24 h, which, however, did not show leukocyte-endothelial cell interaction. Heparin (300 U/kg, i.v.) effectively counteracted the process of thrombus formation in this model, including both first platelet deposition and vessel occlusion. We conclude that the model of the ear of the hairless mouse allows for distinct in vivo analysis of arteriolar and venular thrombus formation/ recanalisation, and, thus, represents an interesting tool for the study of novel antithrombotic and thrombolytic strategies, respectively.

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Nighttime Blue Light Exposure and Breast Cancer

Osteopathic Family Physician ◽

10.33181/13013 ◽

2021 ◽

pp. 30-33

Author(s):

David Jaynes ◽

Paul Switzer

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Blue Light ◽

Shift Work ◽

Light Exposure ◽

Night Shift ◽

Background Information ◽

Common Disease ◽

Essential Information ◽

Night Shift Work

The purpose of this article is to provide background information and the current understanding of a less familiar cause of female breast cancer; exposure to ultraviolet light at night. Breast cancer is a common disease that causes significant morbidity and mortality in women. There are several risk factors for breast cancer, most of which are genetic and environmental in nature. An often-overlooked risk factor is exposure to blue light during night shift work, which decreases melatonin production. One of the many cancer-preventing properties of melatonin is to limit estrogen production. Increased lifetime exposure to estrogen is a well-known cause of breast cancer. Awareness of nighttime blue light exposure as a breast cancer risk factor by women doing night shift work and those exposed to nighttime light via smartphones and laptops, is essential information to know so that protective measures can be taken.

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Predicting cold-water bleaching in corals: role of temperature, and potential integration of light exposure

Marine Ecology Progress Series ◽

10.3354/meps13336 ◽

2020 ◽

Vol 642 ◽

pp. 133-146

Author(s):

PC González-Espinosa ◽

SD Donner

Keyword(s):

Coral Bleaching ◽

Cold Water ◽

Light Exposure ◽

Light Attenuation ◽

Florida Keys ◽

Cold Temperature ◽

Warm Water ◽

Coral Tissue ◽

Effect Of Temperature ◽

Type I

Warm-water growth and survival of corals are constrained by a set of environmental conditions such as temperature, light, nutrient levels and salinity. Water temperatures of 1 to 2°C above the usual summer maximum can trigger a phenomenon known as coral bleaching, whereby disruption of the symbiosis between coral and dinoflagellate micro-algae, living within the coral tissue, reveals the white skeleton of coral. Anomalously cold water can also lead to coral bleaching but has been the subject of limited research. Although cold-water bleaching events are less common, they can produce similar impacts on coral reefs as warm-water events. In this study, we explored the effect of temperature and light on the likelihood of cold-water coral bleaching from 1998-2017 using available bleaching observations from the Eastern Tropical Pacific and the Florida Keys. Using satellite-derived sea surface temperature, photosynthetically available radiation and light attenuation data, cold temperature and light exposure metrics were developed and then tested against the bleaching observations using logistic regression. The results show that cold-water bleaching can be best predicted with an accumulated cold-temperature metric, i.e. ‘degree cooling weeks’, analogous to the heat stress metric ‘degree heating weeks’, with high accuracy (90%) and fewer Type I and Type II errors in comparison with other models. Although light, when also considered, improved prediction accuracy, we found that the most reliable framework for cold-water bleaching prediction may be based solely on cold-temperature exposure.

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Cycled Light Exposure Reduces Fussing and Crying in Very Preterm Infants

PEDIATRICS ◽

10.1542/peds.2011-2671d ◽

2012 ◽

Vol 130 (1) ◽

pp. X33-X33

Keyword(s):

Preterm Infants ◽

Light Exposure ◽

Very Preterm Infants ◽

Very Preterm

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Degradation in a Methyl-phenyl Co-Polymeric Polysilane for LED Applications

MRS Proceedings ◽

10.1557/proc-769-h4.3 ◽

2003 ◽

Vol 769 ◽

Cited By ~ 2

Author(s):

Asha Sharma ◽

Deepak ◽

Monica Katiyar ◽

Satyendra Kumar ◽

V. Chandrasekhar ◽

...

Keyword(s):

Thin Films ◽

Molecular Weight ◽

Light Source ◽

Room Temperature ◽

Light Exposure ◽

Room Temperature Photoluminescence ◽

Pl Spectrum ◽

Pl Intensity ◽

Methyl Phenyl

AbstractThe optical degradation of polysilane copolymer has been studied in spin cast thin films and solutions using light source of 325 nm wavelength. The room temperature photoluminescence (PL) spectrum of these films show a sharp emission at 368 nm when excited with a source of 325 nm. However, the PL intensity deteriorates with time upon light exposure. Further the causes of this degradation have been examined by characterizing the material for its transmission behaviour and changes occurring in molecular weight as analysed by GPC data.

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Photoelectric Response of Self Assembled Films of Bacterio-Rhodopsin Purple Membrane Integrated on Silicon

MRS Proceedings ◽

10.1557/proc-774-o5.4 ◽

2003 ◽

Vol 774 ◽

Author(s):

D. Ricceri ◽

G. Scicolone ◽

O. Di Marco ◽

S. Conoci ◽

B. Pignataro ◽

...

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Light Exposure ◽

Scanning Force Microscopy ◽

Purple Membrane ◽

Morphological Properties ◽

Force Microscopy ◽

Scanning Force ◽

Scanning Electron ◽

Tungsten Lamp

AbstractBacterio-rhodopsin purple membrane (PM) thin films have been prepared by selfassembling (SA) technique. Morphological properties of the layers were inspected by Scanning Electron Microscopy (SEM) and Scanning Force Microscopy (SFM) highlighting the presence of densely packed PM films. Reflectance Uv-vis spectra on these films revealed the typical bR absorption at 570 nm. By using a tungsten lamp illuminations (250-350 mW) chopped at 0.5Hz, photoelectric responses were detected. Differential (light-on and light-off) photocurrent signals of up to 1 μA/cm2 were obtained upon light exposure.

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A Photoactivatable α5β1-Specific Integrin Ligand

10.26434/chemrxiv.6097688 ◽

2018 ◽

Author(s):

Roshna Vakkeel ◽

Aleeza Farrukh ◽

Aranzazu del Campo

Keyword(s):

Cellular Response ◽

Light Exposure ◽

Matrix Composition ◽

Cellular Behavior ◽

Dynamic Variations ◽

In Situ Activation ◽

Controlled Exposure ◽

Cellular Behaviour ◽

Integrin Ligand

In order to study how dynamic changes of α5β1 integrin engagement affect cellular behaviour, photoactivatable derivatives of α5β1 specific ligands are presented in this article. The presence of the photoremovable protecting group (PRPG) introduced at a relevant position for integrin recognition, temporally inhibits ligand bioactivity. Light exposure at cell-compatible dose efficiently cleaves the PRPG and restores functionality. Selective cell response (attachment, spreading, migration) to the activated ligand on the surface is achieved upon controlled exposure. Spatial and temporal control of the cellular response is demonstrated, including the possibility to in situ activation. Photoactivatable integrin-selective ligands in model microenvironments will allow the study of cellular behavior in response to changes in the activation of individual integrins as consequence of dynamic variations of matrix composition.

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