Changes in biochemical indices of bone metabolism in post-menopausal women following a dietary intervention with fortified dairy products

Study objectives were to determine if erythrocyte omega-3 polyunsaturated fatty acids (n-3 PUFAs) increased in women participating in a dietary intervention that reduced inflammation and body weight and examine PUFA associations with markers of inflammation and quality of life (QOL). An experimental pre-post test, single group design was used. Fifteen post-menopausal women with obesity were enrolled in a 12-week pilot intervention focusing on lowering added sugars and increasing fiber and fish rich in n-3 PUFAs. Measurements included fasting blood samples, anthropometric, lifestyle and dietary data collected at baseline, end of intervention (Week 12) and follow-up (Week 24). Primary outcomes were change in erythrocyte PUFAs and associations between erythrocyte PUFAs, QOL (Short Form 12), and inflammatory markers (interleukin-6, tumor necrosis factor-α-receptor 2, and high sensitivity C-reactive protein (CRP)). Fourteen women completed all intervention visits. Mean erythrocyte docosahexaenoic acid and arachidonic acid (AA) increased at Week 12 and Week 24 (p < 0.001 for both), while eicosapentaenoic acid increased at Week 24 (p < 0.01). After adjustment for percent weight change, week 12 QOL related to physical function was significantly associated with erythrocyte linoleic acid (p < 0.05) and trended toward significant association with EPA (p = 0.051); week 24 CRP was directly associated with erythrocyte AA (p < 0.05). Erythrocyte n-3 PUFAs were not associated with inflammation.

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The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2009.06.003 ◽

2009 ◽

Vol 42 (13-14) ◽

pp. 1375-1380 ◽

Cited By ~ 20

Author(s):

R. Sodi ◽

M.J. Hazell ◽

B.H. Durham ◽

C. Rees ◽

L.R. Ranganath ◽

...

Keyword(s):

Body Mass Index ◽

Molecular Weight ◽

Bone Metabolism ◽

High Molecular Weight ◽

Body Mass ◽

Biochemical Markers ◽

High Molecular Weight Adiponectin ◽

Menopausal Women ◽

Post Menopausal

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Continuous oestrogen-progestogen treatment and bone metabolism in post-menopausal women

Maturitas ◽

10.1016/0378-5122(88)90131-4 ◽

1988 ◽

Vol 10 (1) ◽

pp. 51-58 ◽

Cited By ~ 44

Author(s):

B.J. Riis ◽

J. Johansen ◽

C. Christiansen

Keyword(s):

Bone Metabolism ◽

Menopausal Women ◽

Post Menopausal

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Expression of circulating Mir-139-5p is associated with Postmenopausal Osteoporosis in Indian women

Women s Health ◽

10.15406/mojwh.2021.10.00297 ◽

2021 ◽

Vol 10 (4) ◽

pp. 102-105

Author(s):

Rupakala BM ◽

K Anbazhaganb ◽

S Prabhakarac ◽

MPA Sailakshmia

Keyword(s):

Bone Metabolism ◽

Therapeutic Strategies ◽

Circulating Mirnas ◽

Biochemical Tests ◽

Indian Women ◽

Post Menopausal Osteoporosis ◽

Menopausal Women ◽

Control Bone ◽

Post Menopausal ◽

Menopausal Osteoporosis

Background: Osteoporosis in post-menopausal women is known to progress periodically and is highly associated with inflammation. MicroRNAs regulate inflammatory process, which may therefore control bone metabolism. Deregulation of miRNAs associated with inflammation may lead to development and progression of osteoporosis. We selected four miRNAs known to be involved in inflammation to test their association with post-menopausal osteoporosis. Methods: We quantified four circulating miRNAs, hsa-miR-139-5p, hsa-miR-342-3p, hsa-miR-146a and hsa-miR-24-3p in plasma samples of 25 post-menopausal osteoporosis and 25 post-menopausal healthy subjects. Related biochemical tests were done using Cobas e411 and ELISA. Results: Upon quantification of circulating miRNAs, we observed that hsa-miR-139-5p was expressed higher in post-menopausal osteoporotic samples (p=0.01). The expression of hsa-miR-24-3p was seen lower in osteoporotic samples though not highly significant (p=0.2). Conclusion: Differential expression of hsa-miR-139-5p and hsa-miR-24-3p was seen in osteoporosis subjects. These miRNA could be significantly involved in development and progression of osteoporosis. Further studies are required to highlight miRNAs’ involvement in regulating bone metabolism, which could be manipulated to use them as marker or therapeutic strategies to alleviate osteoporosis.

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Effect of a mixture of calcium, vitamin D, inulin and soy isoflavones on bone metabolism in post-menopausal women: a retrospective analysis

Aging Clinical and Experimental Research ◽

10.1007/s40520-013-0093-y ◽

2013 ◽

Vol 25 (6) ◽

pp. 611-617 ◽

Cited By ~ 3

Author(s):

Maurizio Bevilacqua ◽

Velella Righini ◽

Diana Certan ◽

Giorgio Gandolini ◽

Matteo Alemanni

Keyword(s):

Vitamin D ◽

Bone Metabolism ◽

Retrospective Analysis ◽

Soy Isoflavones ◽

Menopausal Women ◽

Post Menopausal

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103 APOE ISOFORMS SHOW DIFFERENT EFFECTS ON BONE METABOLISM OF BRAZILIAN POST MENOPAUSAL WOMEN

Maturitas ◽

10.1016/s0378-5122(12)70214-1 ◽

2012 ◽

Vol 71 ◽

pp. S52

Author(s):

L.S. de Souza ◽

L.B.A. Rangel ◽

B.O. Tommasi ◽

I.D.C.F. Fin ◽

B.-H. Albergaria ◽

...

Keyword(s):

Bone Metabolism ◽

Apoe Isoforms ◽

Menopausal Women ◽

Post Menopausal

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Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2005.195 ◽

2005 ◽

Vol 43 (10) ◽

Cited By ~ 34

Author(s):

Markus Herrmann ◽

Marius Kraenzlin ◽

Gerhard Pape ◽

Marga Sand-Hill ◽

Wolfgang Herrmann

Keyword(s):

Bone Mineral Density ◽

Bone Resorption ◽

Bone Metabolism ◽

Bone Mineral ◽

Venous Blood ◽

Osteoporotic Fractures ◽

Mineral Density ◽

Menopausal Women ◽

Hip Bmd ◽

Post Menopausal

AbstractBackground: Recently, increased plasma homocysteine (Hcy) has been suggested as an independent risk factor for osteoporotic fractures. Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD). Materials and methods: We investigated 143 peri- and post-menopausal women [median age (25th–75th percentile), 67 (57–75) years]. All subjects underwent a detailed medical examination, measurement of bone mineral density at lumbar spine (BMD-LS) and total hip (BMD-HIP), and fasting venous blood and urine sampling. Osteocalcin (OC), serum calcium (Ca), urinary desoxypyridinoline cross-links (DPD), osteoprotegerin (OPG) and soluble receptor activator of NF-κB ligand (sRANKL) were studied. Results: According to BMD subjects were classified as normal (n=24), osteopenic (n=51) or osteoporotic (n=68). Median Hcy did not differ between normal, osteopenic and osteoporotic subjects (p=0.647). Partial correlation analysis, controlling for the major confounders, age, creatinine, menopause and previous fractures, revealed significant correlations between Hcy and DPD (r=0.193, p=0.022), as well as between Hcy and Ca (r=0.170, p=0.045). After adjustment for the same confounders, subsequent regression analysis confirmed significant associations of Hcy with DPD and Ca. No significant relations could be observed between Hcy and BMD-LS, BMD-HIP, OC, OPG or sRANKL. Conclusion: Our results demonstrate weak, but significant, relations between Hcy and markers of organic and inorganic bone resorption, suggesting a mechanistic role of Hcy in bone metabolism. The relation between Hcy and bone resorption was not dependent on OPG or sRANKL.

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