Efficacy of eight commercial formulations of lime sulphur on in vitro growth inhibition of Microsporum canis

2010 ◽  
Vol 22 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Alison Diesel ◽  
Maria Verbrugge ◽  
Karen A. Moriello
Keyword(s):  
Growth Inhibition ◽  
Microsporum Canis ◽  
In Vitro Growth ◽  
Lime Sulphur

scholarly journals ACTIVIDAD ANTAGÓNICA ENTRE BACTERIAS EPIBIÓTICAS AISLADAS DE ESPONJAS MARINAS DEL CARIBE COLOMBIANO Y SU RELACIÓN CON LA MACROEPIBIOSIS

2016 ◽  
Vol 38 (1) ◽  
Author(s):  
Jennyfer Mora Cristancho ◽  
Sven Zea ◽  
Diego L. Gil Agudelo
Keyword(s):  
Population Growth ◽  
Growth Inhibition ◽  
Bacterial Communities ◽  
Growth Regulation ◽  
In Vitro Growth ◽  
Bacterial Strains ◽  
Total Percentage ◽  
Potential Interactions ◽  
Antagonistic Interactions

Surfaces submerged in the sea are densely colonized by bacteria, and inter-specic interactions such as growth inhibition are important determinants of the development of bacterial communities, as well as of later phases of macrofouling. To determine the potential interactions among biolm bacteria from sponges we carried out in vitro growth inhibition tests between bacterial strains isolated from surfaces with various degrees of macrofouling, from the sponges Aplysina insularis (clean), Aplysina lacunosa (fouled), and from the calcareous surface of the bivalve mollusk Donax sp. The total percentage of antagonistic interactions among these strains was 64 %; strains isolated from clean surfaces inhibited the growth of strains from well-colonized surfaces in a 1:1 ratio. Strains from clean surfaces had a higher frequency of antagonistic interactions. We propose bacterial antagonistic interaction as a possible mechanism of population growth regulation and, consequently, of the development of subsequent phases of macrofouling.

In silico evaluation and in vitro growth inhibition of Plasmodium falciparum by natural amides and synthetic analogs

2020 ◽  
Vol 119 (6) ◽  
pp. 1879-1887
Author(s):  
Minelly Azevedo da Silva ◽  
Márcia Paranho Veloso ◽  
Kassius de Souza Reis ◽  
Guilherme de Matos Passarini ◽  
Ana Paula de Azevedo dos Santos ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Growth Inhibition ◽  
In Silico ◽  
In Vitro Growth ◽  
Synthetic Analogs

scholarly journals Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 894
Author(s):  
Vanessa Raquel Greatti ◽  
Fernando Oda ◽  
Rodrigo Sorrechia ◽  
Bárbara Regina Kapp ◽  
Carolina Manzato Seraphim ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Growth Inhibition ◽  
Fungal Infections ◽  
Polymeric Nanoparticles ◽  
Weight Ratio ◽  
Microsporum Canis ◽  
Nanostructured Systems ◽  
The Stability

Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound’s stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC.

Effects of granulocyte-macrophage colony-stimulating factor on in vitro growth of human solid tumors.

1989 ◽  
Vol 7 (9) ◽  
pp. 1346-1350 ◽  
Author(s):  
S E Salmon ◽  
R Liu
Keyword(s):  
Growth Inhibition ◽  
Solid Tumors ◽  
Primary Role ◽  
In Vitro Growth ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Solid tumor biopsies from 33 patients were tested in vitro to evaluate the growth modulatory effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). In 29 of 33 studies (88%), addition of GM-CSF either had no effect on in vitro growth, or induced growth inhibition. While significant growth inhibition was observed in 10 studies, marked inhibition was only observed in three studies. However, all dose-response curves were usually flat, suggesting indirect effects. Moderate growth stimulation was observed in four instances, which may have been due to residual granulocyte-macrophage progenitors within the biopsies. We conclude that GM-CSF has little or no growth-modulatory effect on most nonhematopoietic neoplasms. The primary role of GM-CSF in patients with solid tumors appears to be in prevention or reversal of myelosuppression associated with therapy. Thus, while GM-CSF seems unlikely to have a role in monotherapy of cancer, it is also unlikely to have its utility compromised by enhancement of tumor growth.

Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines

1993 ◽  
Vol 36 (23) ◽  
pp. 3511-3516 ◽  
Author(s):  
Jerome P. Horwitz ◽  
Irina Massova ◽  
Thomas E. Wiese ◽  
Antoinette J. Wozniak ◽  
Thomas H. Corbett ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Field Analysis ◽  
Molecular Field ◽  
In Vitro Growth ◽  
Comparative Molecular Field Analysis ◽  
Molecular Field Analysis

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines

2011 ◽  
Vol 89 (5) ◽  
pp. 1423-1433 ◽  
Author(s):  
Xiao-Yun Lu ◽  
Elisa Ciraolo ◽  
Rachele Stefenia ◽  
Guo-Qiang Chen ◽  
Yali Zhang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Pi3k Inhibitor ◽  
In Vitro Growth

scholarly journals Human-human hybridomas secreting monoclonal antibodies to the Mr 195,000 Plasmodium falciparum blood stage antigen.

1986 ◽  
Vol 163 (1) ◽  
pp. 179-188 ◽  
Author(s):  
R Schmidt-Ullrich ◽  
J Brown ◽  
H Whittle ◽  
P S Lin
Keyword(s):  
Plasmodium Falciparum ◽  
Growth Inhibition ◽  
Protective Immunity ◽  
Lymphoblastoid Cell Line ◽  
In Vitro Growth ◽  
Human Lymphoblastoid Cell ◽  
Immune Precipitation ◽  
Human Lymphoblastoid Cell Line ◽  
Donor Lymphocytes

Using the human lymphoblastoid cell line, GM 4672, and PBL of Gambian adults immune to Plasmodium falciparum (Pf) malaria, we have produced human-human hybridomas and selected those that produce mAb against Pf antigens. The fusion frequency, using PWM-stimulated donor lymphocytes was between 6.8 X 10(-5) and 1.5 X 10(-6). Using immune fluorescence, immune precipitation, and Pf in vitro growth inhibition, we cloned four hybridomas that reacted with the Pf Mr 195,000 schizont/merozoite protein. The differences in proteins immune precipitated and in growth inhibition indicate that, during development of protective immunity against Pf malaria, a spectrum of antibodies is produced reacting with different epitopes on the same antigen. Only a portion of these antibodies exhibits biological activity, suggesting that the recognition of certain epitopes is required for the development of a protective immune response.

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