scholarly journals Muscarinic receptor activation in the lumbosacral spinal cord ameliorates bladder irritation in rat cystitis models

2009 ◽  
Vol 104 (10) ◽  
pp. 1531-1537 ◽  
Author(s):  
Hitoshi Masuda ◽  
Nobutaka Ichiyanagi ◽  
Minato Yokoyama ◽  
Yasuyuki Sakai ◽  
Kazunori Kihara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Muscarinic Receptor ◽  
Receptor Activation ◽  
Lumbosacral Spinal Cord

scholarly journals Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats

2008 ◽  
Vol 295 (1) ◽  
pp. R336-R342 ◽  
Author(s):  
Minoru Miyazato ◽  
Kurumi Sasatomi ◽  
Shiro Hiragata ◽  
Kimio Sugaya ◽  
Michael B. Chancellor ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Receptor Activation ◽  
Urethral Pressure ◽  
Sprague Dawley ◽  
Lumbosacral Spinal Cord ◽  
Detrusor Sphincter Dyssynergia ◽  
Sprague Dawley Rats ◽  
Spinal Cord Injured ◽  
Awake Condition ◽  
Intact Rats

We investigated the effects of intrathecal application of GABAA- or GABAB-receptor agonists on detrusor-sphincter dyssynergia (DSD) in spinal cord transection (SCT) rats. Adult female Sprague-Dawley rats were used. At 4 wk after Th9-10 SCT, simultaneous recordings of intravesical pressure and urethral pressure were performed under an awake condition to examine the effect of intrathecal application of GABAA and GABAB agonists (muscimol and baclofen, respectively) or GABAA and GABAB antagonists (bicuculline and saclofen, respectively) at the level of L6-S1 spinal cord. In spinal-intact rats, the effects of bicuculline and saclofen on bladder and urethral activity were also examined. During urethral pressure measurements, DSD characterized by urethral pressure increases during isovolumetric bladder contractions were observed in 95% of SCT rats. However, after intrathecal application of muscimol or baclofen, urethral pressure showed urethral relaxation during isovolumetric bladder contractions. The effective dose to induce inhibition of urethral activity was lower compared with the dose that inhibited bladder contractions. The effect of muscimol and baclofen was antagonized by intrathecal bicuculline and saclofen, respectively. In spinal-intact rats, intrathecal application of bicuculline induced DSD-like changes. These results indicate that GABAA- and GABAB-receptor activation in the spinal cord exerts the inhibitory effects on DSD after SCT. Decreased activation of GABAA receptors due to hypofunction of GABAergic mechanisms in the spinal cord might be responsible, at least in part, for the development of DSD after SCT.

scholarly journals GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

2008 ◽  
Vol 179 (3) ◽  
pp. 1178-1183 ◽  
Author(s):  
Minoru Miyazato ◽  
Kurumi Sasatomi ◽  
Shiro Hiragata ◽  
Kimio Sugaya ◽  
Michael B. Chancellor ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Detrusor Overactivity ◽  
Gaba Receptor ◽  
Receptor Activation ◽  
Lumbosacral Spinal Cord ◽  
Spinal Cord Injured

scholarly journals Rostrocaudal Distribution of the C-Fos-Immunopositive Spinal Network Defined by Muscle Activity during Locomotion

2021 ◽  
Vol 11 (1) ◽  
pp. 69
Author(s):  
Natalia Merkulyeva ◽  
Vsevolod Lyakhovetskii ◽  
Aleksandr Veshchitskii ◽  
Oleg Gorskii ◽  
Pavel Musienko
Keyword(s):  
Spinal Cord ◽  
Locomotor Activity ◽  
Control Systems ◽  
Muscle Activity ◽  
Knee Extensors ◽  
Emg Activity ◽  
Lumbosacral Spinal Cord ◽  
Adductor Muscles ◽  
Spinal Network ◽  
Hip Flexor

The optimization of multisystem neurorehabilitation protocols including electrical spinal cord stimulation and multi-directional tasks training require understanding of underlying circuits mechanisms and distribution of the neuronal network over the spinal cord. In this study we compared the locomotor activity during forward and backward stepping in eighteen adult decerebrated cats. Interneuronal spinal networks responsible for forward and backward stepping were visualized using the C-Fos technique. A bi-modal rostrocaudal distribution of C-Fos-immunopositive neurons over the lumbosacral spinal cord (peaks in the L4/L5 and L6/S1 segments) was revealed. These patterns were compared with motoneuronal pools using Vanderhorst and Holstege scheme; the location of the first peak was correspondent to the motoneurons of the hip flexors and knee extensors, an inter-peak drop was presumably attributed to the motoneurons controlling the adductor muscles. Both were better expressed in cats stepping forward and in parallel, electromyographic (EMG) activity of the hip flexor and knee extensors was higher, while EMG activity of the adductor was lower, during this locomotor mode. On the basis of the present data, which showed greater activity of the adductor muscles and the attributed interneuronal spinal network during backward stepping and according with data about greater demands on postural control systems during backward locomotion, we suppose that the locomotor networks for movements in opposite directions are at least partially different.

scholarly journals Bedside to Bench: Role of Muscarinic Receptor Activation in Ultrarapid Growth of Colorectal Cancer in a Patient With Pheochromocytoma

2013 ◽  
Vol 88 (11) ◽  
pp. 1340-1346 ◽  
Author(s):  
Erik C. von Rosenvinge ◽  
Kunrong Cheng ◽  
Cinthia B. Drachenberg ◽  
Carol B. Fowler ◽  
David L. Evers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Muscarinic Receptor ◽  
Receptor Activation

Acute Transverse Myelitis Associated with COVID-19 vaccine: A Case Report

2021 ◽  
Vol 12 (3) ◽  
pp. 2083-2087
Author(s):  
Ali Alshararni
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Acute Inflammation ◽  
Transverse Myelitis ◽  
Preventive Measure ◽  
Mri Findings ◽  
Dorsal Spinal Cord ◽  
Lumbosacral Spinal Cord ◽  
Acute Transverse Myelitis ◽  
Magnetic Resonance Imaging Mri

The case report demonstrates the issue of Khalid Ali, who is a citizen of Yamen, explicitly living in Saudi Arabia. He is 38 years, weighs 82kgs, and of 162 cm in height. He is a sales professional and married with two kids. Khalid Ali has been living healthy until two years ago when he started experiencing pains in his lower extremities accompanied by numbness. He was treated, and everything went back to normal until soon when the case came back after the administration of the Pfizer vaccine as a preventive measure for COVID-19 disease. The consequence of the administration of the Pfizer vaccine resulted in severe pain and weaknesses in his legs and severe headache on the second day, which resulted in him being put on an ICU after 48 hours since he was almost paralyzed. A series of tests were conducted on him, including magnetic resonance imaging (MRI), hematology, and biochemistry which involved Cerebrospinal Fluid (CSF) protein test. MRI findings were significant since they indicated acute inflammation on the spine observed on the dorsal spinal cord with contrast and lumbosacral spinal cord. All the hematology tests turned out to be expected. Biochemistry conducted tests were similarly standard except for CSF protein which was highly abnormal. The combination of the high abnormal CSF protein test and acute inflammation of the spine observed from the MRI findings were confirmed evidence of acute transverse myelitis as a result of the administration of the Pfizer vaccine.

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