Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C→G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population

Cephalalgia ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 311-320 ◽  
Author(s):  
G Joshi ◽  
S Pradhan ◽  
B Mittal
Keyword(s):  
Progesterone Receptor ◽  
Genetic Susceptibility ◽  
Oestrogen Receptor ◽  
Indian Population ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Protective Role ◽  
Recessive Model ◽  
P Value ◽  
North Indian Population

We aimed to explore the single-locus, haplotype and epistasis patterns and the contribution of oestrogen receptor [ESR1 PvuII (rs2234693), ESR1 325 C→G (rs1801132)] and progesterone receptor [PROGINS (rs1042838)] polymorphisms in genetic susceptibility to migraine by analysing 613 subjects consisting of 217 migraine patients, 217 healthy controls (HC) and 179 patients with tension-type headache (TTH). Entire data were analysed by taking the Bonferroni corrected P-value into account. We found significant association of TT genotype [odds ratio (OR) 3.458, confidence interval (CI) 1.757, 6.806; P = 0.0003] and T allele (OR 1.729, CI 1.309, 2.284; P = 0.0001) of ESR1 PvuII single nucleotide polymorphism with migraine when compared with HC. Significant association was seen only in female migraine patients at both genotype ( P = 0.002; OR 3.834, CI 1.625, 9.043) and allele level ( P = 0.002; OR 1.721, CI 1.228, 2.413). Moreover, higher risk was limited to migraine with aura (MA) (in case of TT genotype, P = 0.002; OR 4.377, CI 1.703, 1.246; in case of T allele, P = 0.001; OR 1.888, CI 1.305, 2.735) rather than migraine without aura (MoA) ( P-value of TT genotype = 0.003; OR 3.082, CI 1.465, 6.483; P-value T allele = 0.002; OR 1.630, CI 1.188, 2.236). In case of a recessive model, risk was seen with migraine patients ( P = 0.0003; OR 2.514, CI 1.635, 3.867), MA ( P = 0.0001; OR 3.583, CI 1.858, 6.909) and MoA patients ( P = 0.002; OR 2.125, CI 1.304, 3.464) when compared with HC. No risk was observed when TTH patients were compared with HC. No significance of ESR 325 G→C polymorphism was seen in any of the models under study. Significant differences in genotypic ( P = 0.0001) and allelic frequency ( P = 0.0002) were seen in case of PROGINS polymorphism when migraine patients were compared with HC, showing a protective effect (for A1A2 genotype, OR 0.292, CI 0.155, 0.549; for A2 allele, OR 0.320, CI 0.174, 0.589). Moreover, significance was seen only in case of female migraine patients at genotype ( P = 0.002; OR 0.344, CI 0.176, 0.684) as well as allele levels ( P = 0.004; OR 0.379, CI 0.198, 0.727) in case of PROGINS polymorphism. ESR1 PvuII TT*ESR1 325 C→G CG genotype, PROGINS A1A2*ESR1 325 C→G CG genotype and ESR1 PvuII CT*PROGINS A1A2 interacted significantly, but significance was lost after Bonferroni correction. In conclusion, ESR1 PvuII polymorphism is a significant risk factor for migraine particularly in women and MA patients, but ESR 325 C→G polymorphism is not associated with migraine susceptibility. PROGINS polymorphism seems to play a protective role in genetic susceptibility to migraine in the North Indian population.

scholarly journals Risk factors for hypertensive crisis in children with acute glomerulonephritis

2016 ◽  
Vol 56 (2) ◽  
pp. 101
Author(s):  
Sherly Yuniarchan ◽  
Risky Vitria Prasetyo ◽  
Ninik Asmaningsih Soemyarso ◽  
Mohammad Sjaifullah Noer
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Risk Factor ◽  
Pediatric Population ◽  
Hypertensive Crisis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Acute Glomerulonephritis ◽  
Female Ratio

Background Hypertensive crisis occurs in 1-4% of the hypertensive pediatric population, mostly due to acute glomerulonephritis (AGN). Some factors have been suggested to affect blood pressure (BP) in children, such as age, sex, race/ethnicity, obesity, and socioeconomic status, but little is known for risk factors for hypertensive crisis in AGN.Objective To analyze the risk factors for hypertensive crisis in children with AGN.Methods Retrospectively, we studied possible risk factors for hypertensive crisis in children with AGN at Dr. Soetomo Hospital from 2007 to 2011. Hypertensive crisis was defined as systolic BP ≥180 mmHg or diastolic BP ≥120 mmHg (for children ≥ 6 years of age); and systolic and/or diastolic BP >50% above the 95th percentile (for children aged <6 years). We evaluated the demographic and clinical characteristics as potential risk factors. Statistical analysis was done with Chi-square, Fisher’s exact, and logistic regression tests. Variables with P <0.25 in the univariable analysis were further analyzed by the multivariable logistic regression model. A P value of < 0.05 was considered statistically significant.Results There were 101 children included (mean age 9.7 (SD 2.17) years), with a male-to-female ratio of 2.7:1. Hypertensive crisis occurred in 42 (41.6%) children, of whom 8 had hypertensive urgency and 34 had hypertensive emergency. Proteinuria was seen in 53 children with AGN (52.5%) and was the significant risk factor for hypertensive crisis in our subjects (OR=2.75; 95%CI 1.16 to 6.52; P=0.021). Gender, clinical profiles, ethnicity, nutritional status, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) were not significant risk factors for hypertensive crisis.Conclusion Proteinuria is the significant risk factor for hypertensive crisis in children with AGN.

scholarly journals P1708EFFECT OF PREGNANCY ON KIDNEY TRANSPLANT RECIPIENTS: A PROPENSITY SCORE-MATCHED STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Toyofumi Abe ◽  
Taniguchi Ayumu ◽  
Kawamura Masataka ◽  
Kato Taigo ◽  
Tomoko Namba-Hamano ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Risk Factor ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Pregnancy And Delivery

Abstract Background and Aims This study aimed to evaluate whether the experience of pregnancy and delivery would be associated with poor maternal outcome among kidney transplant recipients. Method A total of 401 female transplant recipients from the Osaka University Transplantation Group Database were included in this study. 73 women who underwent renal transplantation between 1970 and 2017 and became pregnant and delivered at Osaka University Kidney Transplant Group Hospitals. Multivariable logistic regression analysis was used to assess the impact of pregnancy and delivery on renal transplant recipient outcome after one-to-one propensity score (PS) matching for 12 variables including serum creatinine at one year post-transplant between the parous group and the nulliparous group. The outcomes were kidney graft survival and patient survival. Results In all patients before PS matching, 75 (18.7%) of the 401 patients died and 137 (34.2%) of the 401 patients lost their kidney grafts during the follow-up period. In the multivariate analysis, pregnancy and delivery was not a significant risk factor for death (adjusted HR 0.662 [95%CI, 0.265-1.656], p-value 0.378) and for death-censored graft survival (adjusted HR 1.224 [95%CI, 0.683-2.196], p-value 0.497). In the PS matched population, 14 (17.5%) of the 80 patients died and 31 (38.8%) of the 80 patients lost their grafts. In the multivariate analysis, pregnancy and delivery was not a significant risk factor for death (adjusted HR 0.611 [95%CI, 0.180-2.072], p-value 0.430) and for death-censored graft survival (adjusted HR 1.308 [95%CI, 0.501-3.416], p-value 0.584). Conclusion Pregnancy and delivery after kidney transplantation was not associated with poor kidney transplant outcome in recipients with adequate and stable graft function.

scholarly journals Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries

2020 ◽  
Author(s):  
Muhammad Luthfi ◽  
Priyawan Rachmadi ◽  
Aqsa Sjuhada Oki ◽  
Retno Indrawati ◽  
Agung Sosiawan ◽  
...  
Keyword(s):  
T Cells ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cell Receptor ◽  
P Value ◽  
Cd4 Cells ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (Streptococcus mutans, S. mutans). Lymphocyte T (CD4+) cells known as helper T cells, are effector cells for mediated host immunity. Naive T cells (CD4+) must be activated to initiate effector function. This activation occurs through interaction with professional antigen- presenting cells (pro-APC), especially dendritic cells that lead to intracellular pathways that regulate T cell receptor (TCR) more specifically against antigen in T cells. Lymphocyte cells from samples were collected from severe early childhood caries (S-ECC) and Free caries aged 5 to 6 years. The subjects were instructed to gargle 10 mL of sterile NaCl 1.5% solution for 30 seconds, and expectorate it into a sterile glass then analyzing T lymphocyte cell (CD4+) expression using flow cytometry. Lymphocyte T (CD4+) cell expression at SECC (6.2525±64482) while in free caries (8.4138±1.10397) with P-value (P=0. 000). Conclusion of lymphocyte T (CD4+) cells expression at S-ECC is lower than that occurring in free caries.

scholarly journals Evaluation of the factors related to dental anxiety in North Indian population: a questionnaire study

2020 ◽  
Vol 7 (6) ◽  
pp. 2230
Author(s):  
Iqbal Singh ◽  
Nitish Bhat ◽  
Robindera Kaur ◽  
Kalpna Thakur ◽  
Hemwati Nandan ◽  
...  
Keyword(s):  
Indian Population ◽  
Dental Anxiety ◽  
North India ◽  
P Value ◽  
North Indian Population ◽  
Factors Affecting ◽  
The North ◽  
High Prevalence ◽  
Anxiety Levels ◽  
Elder People

Background: To evaluate the factors affecting dental anxiety level on the basis of a questionnaire in the North Indian Population.Methods: A questionnaire based on the various factors related to dental anxiety was formulated and distributed among the various regions of the north India. We got response from 250 people, the data was then analysed and results were formulated.Results: Out of 450 questionnaires which were distributed, a total of 400 questionnaires were received. Overall high prevalence of dental anxiety i.e. 85% was noted. More increased values for anxiety were seen for people younger than 30 years (70%), compare to that of elder people (30%). Females seem to have greater anxiety levels as compared to males (p value >0.000). Among 450 people 176 had visited clinics previously with 98 having bad experience (55.6%) and 78 people having a relatively good past dental experience (44.2%).Conclusions: Anxious patients are often more difficult to treat, therefore the questionnaire proved beneficial in estimating factors related to dental anxiety. Young people, women and those having negative dental experience had the highest anxiety levels. 

scholarly journals Overweight in Domestic Cats Living in Urban Areas of Italy: Risk Factors for an Emerging Welfare Issue

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2246
Author(s):  
Laura Arena ◽  
Laura Menchetti ◽  
Silvana Diverio ◽  
Giovanna Guardini ◽  
Angelo Gazzano ◽  
...  
Keyword(s):  
Body Condition ◽  
Urban Areas ◽  
Dietary Habits ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Welfare Issue ◽  
Mixed Breed ◽  
Welfare Implications ◽  
And Behavior

Overweight is common in cats and has health and welfare implications. This study aimed to assess potential predictive/protective factors for feline overweight associated with owner management and their relationship with cat behavior and welfare. A questionnaire was administered to 197 owners to collect information about cat demographics, management, environment, dietary habits and behavior. The feline Body Mass Index was recorded for each cat. Univariate logistic regression was used to evaluate the association of parameters with overweight cats. Variables with a p-value < 0.10 at univariable analyses were selected for the multivariable model. Most cats were mixed- breed, 1–7 years old and neutered; 51.3% were overweight. Age higher than 7 years, neutering, being alone all day and being stressed were predictive for overweight (p < 0.05). Conversely, the presence of other animals had a protective effect (p < 0.05). A general disagreement between owners’ perception and clinical evaluation of cats’ body condition was a common and significant risk factor for overweight (OR = 8.532, 95% CI = 4.073–17.875; p < 0.001). According to the owners, many veterinarians did not inform them about their cat being overweight nor about the risks (p < 0.001). This study provides helpful information on the influence of management and environment on cats’ body condition and its relationship with cat welfare.

Protective role of IL-18 −137G/C polymorphism in a North Indian population with asthma: A pilot study

Cytokine ◽  
2013 ◽  
Vol 61 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal
Keyword(s):  
Pilot Study ◽  
Indian Population ◽  
Protective Role ◽  
North Indian Population

scholarly journals ANESTHETIC CONCERNS IN PAEDS CARDIAC CATHETERIZATION AT ARMED FORCES INSTITUTE OF CARDIOLOGY / NATIONAL INSTITUTE OF HEART DISEASES

2021 ◽  
Vol 70 (Suppl-4) ◽  
pp. S752-56
Author(s):  
Dr Amna ◽  
Naila Niaz ◽  
Zainab Farid ◽  
Umair Younas ◽  
Rehana Javaid
Keyword(s):  
Cardiac Catheterization ◽  
Heart Diseases ◽  
Significant Risk ◽  
Armed Forces ◽  
Structural Heart Disease ◽  
Significant Risk Factor ◽  
P Value ◽  
Therapeutic Procedures ◽  
Pediatric Cardiac Catheterization ◽  
Medical Advances

Objective: To examine the types of procedures and analyze the frequency of anesthesia-related complications during pediatric cardiac catheterization. Study Design: A prospective observational study. Place and Duration of Study: Pediatric Cardiac Catheterization Lab at AFIC/NIHD Rawalpindi, from July 2019 to Nov 2019. Methodology: Total 180 consecutive patients undergoing cardiac catheterization fulfilling inclusion criteria were studied. Demographic variables, diseases, type of procedure, variables and anesthesia-related complications were noted. All the data was analyzed using SPSS-23. Results: The study included180 patients where 96 (53.3%) were male and 84 (46.7%) were female. Most of the patients in our study were between ages 1 to 3 years (85). 99 (55.0%) patients had diagnostic cardiac catheterizetion (CC), while 81 (45%) patients underwent interventional procedures. The overall complication rate noted as 18.9%, including arrhythmia in 11.1% followed by hypotension 4.4%, laryngospasm 3.9% and inotropic support requirement 3.3%, Mortality was 0.6%. Most of the patients presenting to the pediatric cardiac catheterization lab were for PDA device closure (16.6%). Age of child was found to be significant risk factor for cardiac catheterizetion associated complications with a p-value of 0.022. Conclusion: Congenital and structural heart disease catheterization procedures are progressively increasing, especially due to the medical advances and complex interventional therapeutic procedures. A thorough preanesthesia assessment should be carried out to optimize before cardiac catheterization.

scholarly journals A STUDY OF CORRELATION BETWEEN STATURE AND ARM SPAN OF NORTH INDIAN POPULATION

2018 ◽  
Vol 26 (2) ◽  
Author(s):  
Roberton Gautam ◽  
Vasundhara Kulshreshtha ◽  
Pradeep Singh ◽  
Anshu Gupta
Keyword(s):  
Correlation Coefficient ◽  
Indian Population ◽  
North India ◽  
P Value ◽  
North Indian Population ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Arm Span ◽  
Pearson's Correlation ◽  
Pearson's Correlation Coefficient

Introduction: Age, sex and stature are primary characteristics for identification of an individual. Stature has a definite and proportional biological relationship with each and every part of human body i.e. head, neck, trunk and extremities. Material & Methods: The present study comprised of 300 medical students belonging to North India of age group between 18 yrs. to 25 yrs. of S.N. Medical College, Agra. The two anthropometric parameters, arm span and stature were used to calculate mean, standard deviation and Pearson’s correlation coefficient. Results: The Pearson’s correlation coefficient was found to be 0.9171 and p value was calculated to be <0.00001 thus, showing a significant positive correlation between the stature and arm span for the North Indian population. Conclusion: The correlation between arm span and the stature in adult males and females, was found to be an accurate predictor of stature. Thus it becomes an important anthropologic tool for the scientists in limb reconstruction surgeries. In mass disasters like train accidents, earthquakes, etc. and where the subject is in highly decomposed, fragmentary and mutilated form, it can be helpful in determining the identity of an individual.

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