No association between nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow: a cross-sectional general population study

AbstractBACKGROUNDThe acute-phase reactant C-reactive protein (CRP) increases rapidly during an infection. We tested the hypothesis that chronic low-level increases in CRP are associated with an increased risk of infectious disease.METHODSWe studied 9660 individuals from a prospective general population cohort, including 3592 in whom infectious disease developed, and another 60 896 individuals from a cross-sectional general population study, of whom 13 332 developed infectious disease; 55% were women, and the mean age was 57 years. Hospital diagnoses of infections in 1977–2010 were based on International Classification of Diseases–coded discharge records from the national Danish Patient Registry. We measured CRP concentrations and conducted genotyping for 4 CRP polymorphisms that increase CRP. Individuals with CRP >10 mg/L were excluded because of possible ongoing infection at the time of testing.RESULTSIndividuals with CRP >3 mg/L had 1.2 and 1.7 times increased risk of infectious disease, in the prospective general population cohort and the cross-sectional general population study, respectively, compared with individuals with CRP <1 mg/L. In the combined populations, individuals in the highest CRP tertile (compared with the lowest) had an increased risk of bacterial diseases (hazard ratio 1.7, 95% CI 1.6–1.8), but not viral, mycosis, and parasitic diseases. The increased risk was mainly carried by pneumonia, sepsis, and particularly gram-negative infections. None of the genotype combinations examined conferred an increased risk of infectious disease.CONCLUSIONSChronic low-level CRP increases were associated with increased risk of bacterial infections, gram-negative infections in particular. Genotypes associated with increases in CRP were not associated with increased risk of infection.

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The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries

The American Journal of Gastroenterology ◽

10.1038/ajg.2017.421 ◽

2018 ◽

Vol 113 (1) ◽

pp. 86-96 ◽

Cited By ~ 47

Author(s):

Imran Aziz ◽

Olafur S Palsson ◽

Hans Törnblom ◽

Ami D Sperber ◽

William E Whitehead ◽

...

Keyword(s):

Quality Of Life ◽

General Population ◽

Healthcare Utilization ◽

Population Study ◽

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Cross Sectional ◽

General Population Study ◽

Rome Iv

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Occupational lifting and risk of hypertension, stratified by use of anti-hypertensives, physical activity and age - a prospective cohort study

10.21203/rs.3.rs-61037/v1 ◽

2020 ◽

Author(s):

Mette Korshøj ◽

Harald Hannerz ◽

Ruth Frikke-Schmidt ◽

Jacob Louis Marott ◽

Peter Schnohr ◽

...

Keyword(s):

Physical Activity ◽

General Population ◽

Population Study ◽

Cardiovascular Health ◽

Leisure Time Physical Activity ◽

Cross Sectional ◽

General Population Study ◽

Logistic Regression Models ◽

Prospective Association

Abstract Background Prevalence of hypertension varies across occupations, maybe due to differences in exposure to occupational lifting. This study investigated associations between occupational lifting and hypertension, stratified by use of anti-hypertensives, leisure time physical activity (LTPA), occupational physical activity (OPA) and age.Methods Data from the Copenhagen General Population Study were included. The Copenhagen General Population Study was approved by the local ethical committee (H-KF-01-144/01), and all participation were conducted in accordance with the declaration of Helsinki. Multivariable logistic regression models, adjusted for sex, age, BMI, smoking, school education, mental stress and baseline blood pressure (BP), were applied to estimate: the (i) cross-sectional association (n=67,363) between occupational lifting and hypertension (using anti-hypertensives or BP ≥140/≥90 mmHg), (ii) prospective association (n=7,020) between occupational lifting and risk of an above median change in systolic BP (baseline to follow-up) and/or a shift from no use to use of anti-hypertensives, among the included population and stratified by use of anti-hypertensives, LTPA, OPA and age.Results Cross-sectionally, heavy occupational lifting lowered hypertension risk. Mean baseline BP, showed that the higher the level of LTPA the lower mean BP across all levels of OPA were, but only among those not using anti-hypertensives. The prospective analysis showed occupational lifting to increase the risk of hypertension, among workers aged ≥ 50 years, or reporting light to moderate LTPA. Conclusions This study finds positive associations between occupational lifting and risk for hypertension among workers aged ≥ 50 years. Further research on the association between occupational lifting and precursors of cardiovascular disease are needed before recommendations for occupational lifting and cardiovascular health can be established.

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