COMPARISON OF ADHERENCE AND EFFICACY BETWEEN INHALED SALMETEROL AND TRANSDERMAL TULOBUTEROL PATCH IN ELDERLY PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISORDER

2009 ◽  
Vol 57 (5) ◽  
pp. 919-920 ◽  
Author(s):  
Tomonori Sugawara ◽  
Yuta Nanjo ◽  
Mariko Yamazaki ◽  
Kazuya Higashihara ◽  
Yasunari Tsuda ◽  
...  
Author(s):  
Lieke Bosch ◽  
Patricia Assmann ◽  
Wim J. C. de Grauw ◽  
Bianca W. M. Schalk ◽  
Marion C. J. Biermans

Abstract Background Diagnosing heart failure (HF) in primary care can be challenging, especially in elderly patients with comorbidities. Insight in the prevalence, age, comorbidity and routine practice of diagnosing HF in general practice may improve the process of diagnosing HF. Aim To examine the prevalence of HF in relation to ageing and comorbidities, and routine practice of diagnosing HF in general practice. Methods A retrospective cohort study was performed using data from electronic health records of 56 320 adult patients of 11 general practices. HF patients were compared with patients without HF using descriptive analyses and χ2 tests. The following comorbidities were considered: chronic obstructive pulmonary disorder (COPD), diabetes mellitus (DM), hypertension, anaemia and renal function disorder (RFD). Separate analyses were performed for men and women. Findings The point prevalence of HF was 1.2% (95% confidence interval 1.13–1.33) and increased with each age category from 0.04% (18–44 years) to 20.9% (⩾85 years). All studied comorbidities were significantly (P<0.001) more common in HF patients than in patients without HF: COPD (24.1% versus 3.1%), DM (34.7% versus 6.5%), hypertension (52.7% versus 16.0%), anaemia (10.9% versus 2.3%) and RFD (61.8% versus 7.5%). N-terminal pro-BNP (NT-proBNP) was recorded in 38.1% of HF patients. Conclusions HF is highly associated with ageing and comorbidities. Diagnostic use of NT-proBNP in routine primary care seems underutilized. Instruction of GPs to determine NT-proBNP in patients suspected of HF is recommended, especially In elderly patients with comorbidities.


1999 ◽  
Author(s):  
Stephanie H. Swindle ◽  
Beth A. Todd ◽  
James F. Cuttino

Abstract Human bodies depend on a steady flow of oxygen for the heart and lungs. When a person has Chronic Obstructive Pulmonary Disorder (COPD), a device called an oxygen concentrator can be used to improve quality of life. An oxygen concentrator is an electrically powered device that takes in room air and converts it to an oxygen rich gas mixture suitable for breathing. Although a few models are battery powered, oxygen concentrators are not easily portable because they are bulky and weigh between 25–50 lbs. In this study, components were identified for re design to reduce the overall weight of the device. For instance, the concentrator casing was identified as its heaviest component. Using finite element analysis, changes in wall thickness and dimensions can be investigated to reduce weight while maintaining structural integrity. By reducing the weight of the casing, the oxygen concentrator will be easier to transport.


Author(s):  
OJS Admin

Chronic obstructive pulmonary disorder (COPD) is an aggravating and major health concern throughout the world. It is estimated that in upcoming years chronic obstructive pulmonary disease will be rankedas third common reason of mortality and fifth common cause of disablement worldwide.


2020 ◽  
Vol 33 (4) ◽  
pp. 228-232
Author(s):  
Gabriela Widelska ◽  
Kamila Kasprzak-Drozd ◽  
Karolina Wojtunik-Kulesza ◽  
Anna Krajewska ◽  
Anna Oniszczuk

Abstract Globally, diseases of the lung are one of the main causes of death, and conventional therapies are often ineffective in dealing with this serious medical and sociological problem. Since ancient times, medicinal plants have been used in the treatment of respiratory tract diseases. Such plants show antitussive, muscle relaxing, bronchi dilation or cillary movement effects. Their usefulness has been confirmed by modern and current research. A medicinal plant that is also a functional food can open new areas in the prevention and treatment of respiratory tract diseases. In this review, information about the influence of functional food on preventing and treating asthma, chronic obstructive pulmonary disorder (COPD) and high-altitude sickness are presented.


2021 ◽  
Author(s):  
Daniel Yoo ◽  
Mengqi Gong ◽  
Lei Meng ◽  
Cheuk Wai Wong ◽  
Guangping Li ◽  
...  

Background: Different comprehensive care programmes (CCPs) have been developed for patients with chronic obstructive pulmonary disorder (COPD), but data regarding their effectiveness have been controversial. PubMed and Embase were searched to 1st June 2017 for articles that investigated the effects of the different types of CCPs on hospitalization or mortality rates in COPD. Results: A total of 67 studies including 3472633 patients (mean age: 76.1+/-12.7 years old; 41% male) were analyzed. CCPs reduced all-cause hospitalizations (hazard ratio [HR]: 0.70, 95% confidence interval [CI]: 0.63-0.79; P<0.001; I2:96%) and mortality (HR: 0.69, 95% CI: 0.573-0.83; P<0.001; I2:75%). Subgroup analyses for different CCP types were performed. Hospitalizations were reduced by pharmacist-led medication reviews (HR: 0.54; 95% CI: 0.37-0.78; P=0.001; I2:49%), structured care programmes (HR: 0.76; 95% CI: 0.66-0.87; P<0.0001; I2:88%) and self-management programmes (HR: 0.79; 95% CI: 0.64-0.99; P<0.05; I2:78%), but not continuity of care programmes (HR: 0.70; 95% CI: 0.36-1.36; P=0.29; I2:100%), early support discharge or home care packages (HR: 0.97; 95% CI: 0.91-1.04; P=0.37; I2:0%) or telemonitoring (HR: 0.61; 95% CI: 0.32-1.18; P=0.14; I2:94%). Mortality was reduced by early support discharge or home care packages (HR: 0.49; 95% CI: 0.30-0.80; P<0.01; I2:72%), structured care programmes (HR: 0.69; 95% CI: 0.53-0.90; P<0.01; I2:61%) and telemonitoring (HR: 0.52; 95% CI: 0.31-0.89; P<0.05; I2:0%), but not self-management programmes (HR: 0.79; 95% CI: 0.64-0.99; P<0.05; I2:78%). Conclusions: Comprehensive care programmes reduce hospitalization and mortality in COPD patients.


2016 ◽  
Vol 34 (7_suppl) ◽  
pp. 304-304
Author(s):  
Laura Hester ◽  
Steven I. Park ◽  
Jennifer Leigh Lund

304 Background: Evidence suggests that the number and type ofcomorbidities at cancer diagnosis influences cancer treatment and mortality, especially among older patients.We sought to describe comorbidity patterns and identify how patterns predict all-cause mortality among older non-Hodgkin lymphoma (NHL) patients. Methods: Using the linked Surveillance, Epidemiologic, and End Results (SEER)-Medicare databases, we identified patients aged > 66 with a first diagnosis of stage I-IV NHL from 2007-2009. Codes for individual comorbidities in the Charlson Comorbidity Index (CCI) were identified in the 12 months before NHL diagnosis, during which patients were required to have continuous Medicare Parts A, B, and D enrollment and no managed care. The prevalence of single and concurrent comorbidities was calculated. Medicare enrollment files contained vital status. We used multivariable Cox proportional hazard models to estimate adjusted hazard ratios (aHR) for all-cause mortality in each comorbidity group versus no comorbidity controlling for age, sex, race/ethnicity, stage, tumor growth category, and other comorbidities. Results: Among 4901 older NHL patients, 52% had ≥ 1 comorbidity and 26% had a CCI > 2. The most prevalent comorbidities were diabetes (25%), chronic obstructive pulmonary disorder (COPD) (16%), and congestive heart failure (CHF) (12%). All-cause mortality was greater among patients with CHF (aHR = 1.44; 95%CI = 1.26, 1.65), diabetes (aHR = 1.16; 95%CI = 1.03,1.29), or dementia (aHR = 1.20; 95%CI = 1.03, 1.41) compared to those without each comorbidity. More than half of diabetes patients, two-thirds of COPD patients, and three-quarters of CHF patients had > 1 additional non-cancer comorbidity. All-cause mortality was higher among NHL patients with CHF who had co-occurring COPD (aHR = 1.56; 95%CI = 1.19, 2.05), diabetes (aHR = 1.66; 95%CI = 1.29, 2.14), or both COPD and diabetes (aHR = 2.61; 95%CI = 1.97, 3.46). Conclusions: Comorbidity is common among older, newly-diagnosed NHL patients and should be carefully considered when making treatment decisions. Given the known cardiotoxicity of the main NHL chemoimmunotherapy, providers should discuss comorbidity management, particularly for CHF, before initiating therapy.


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