scholarly journals Early Changes in Oxidative Stress Markers in a Rat Model of Acute Stress: Effect of l-carnitine on the Striatum

2011 ◽  
Vol 109 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Luis A. Méndez-Cuesta ◽  
Berenice Márquez-Valadez ◽  
Verónica Pérez-De la Cruz ◽  
Perla D. Maldonado ◽  
Ricardo A. Santana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Acute Stress ◽  
Stress Effect ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Saad Mohamed Asseri ◽  
Nehal M. Elsherbiny ◽  
Mohamed El-Sherbiny ◽  
Iman O. Sherif ◽  
Alsamman M. Alsamman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Glycyrrhizic Acid ◽  
Type I Diabetes ◽  
Vascular Dysfunction ◽  
Type I ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Ameliorative Effect ◽  
Related Proteins

AbstractThe burden of diabetes mellitus (DM) and associated complications is increasing worldwide, affecting many organ functionalities including submandibular glands (SMG). The present study aims to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced SMG damage. Experimental evaluation of GA treatment was conducted on a rat model of type I diabetes. Animals were assigned to three groups; control, diabetic and GA treated diabetic groups. After 8 weeks, the SMG was processed for assessment of oxidative stress markers, autophagy related proteins; LC3, Beclin-1 and P62, vascular regulator ET-1, aquaporins (AQPs 1.4 and 5), SIRT1 protein expressions in addition to LC3 and AQP5 mRNA expressions. Also, parenchymal structures of the SMG were examined. GA alleviated the diabetes-induced SMG damage via restoring the SMG levels of oxidative stress markers and ET-1 almost near to the normal levels most probably via regulation of SIRT1, AQPs and accordingly LC-3, P62 and Beclin-1levels. GA could be a promising candidate for the treatment of diabetes-induced SMG damage via regulating oxidative stress, autophagy and angiogenesis.

The relationship of oxidative stress markers and parameters of myocardial function in a rat model of cardiotoxicity

2014 ◽  
Vol 75 ◽  
pp. S42 ◽  
Author(s):  
Premysl Mladenka ◽  
Tomáš Filipský ◽  
Michal Ríha ◽  
Jaroslava Vávrová ◽  
Magdalena Holecková ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Myocardial Function ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Relationship Of ◽  
The Relationship

scholarly journals Neuroprotective effects of the Chrysophyllum perpulchrum extract against an Alzheimer-like rat model of β amyloid1-40 intrahippocampal injection

2021 ◽  
Vol 12 (1) ◽  
pp. 545-560
Author(s):  
Pacôme Kouadio N’Go ◽  
Omar Touhami Ahmed Ahami ◽  
Aboubaker El Hessni ◽  
Fatima-Zahra Azzaoui ◽  
Youssef Aboussaleh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Cognitive Abilities ◽  
Oxidative Stress Markers ◽  
Object Recognition Test ◽  
Cognitive Changes ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Post Surgery

Abstract Objective Alzheimer’s disease (AD) is a threatening disease for African populations in the upcoming years because of the increase in their expectancy of life. Here, we investigated whether natural products from Chrysophyllum perpulchrum as catechin and two dimeric procyanidins (catechin + hexose) could prevent progression of oxidative stress and cognitive changes using an AD-like rat model induced by Aβ1-40 injection into the hippocampal CA1 subfield. Methodology Adult male Wistar rats were either microinjected with 1% ammonia as a vehicle (10 µL) or aggregated Aβ1-40 at 10 µg bilateral hippocampus. On the 14th day of post-surgery, some Aβ rats were treated with melatonin (10 mg/kg i.p.) or with the Chrysophyllum perpulchrum extract (300 mg/kg p.o.), and some sham-operated rats received the extract alone. Cognitive abilities were tested with Y-maze, object recognition test and Morris Water Maze. Oxidative stress markers as well as the level of activated microglial cells were assayed in the brain. Results Aβ rats exhibited significant deficits of recognition memory and spatial learning. This was associated with an increase of microglia Iba 1 immunoreactivity as well as nitric oxide (NO), malondialdehyde and superoxide dismutase levels but not to the thiol content in the hippocampus, prefrontal cortex and septum of AD-like rats. The Chrysophyllum perpulchrum extract treatment mitigated Aβ-induced cognitive impairments and reversed microglia overactivation and subsequent generation of oxidative stress markers. Interestingly, the neuroprotective actions of the Chrysophyllum perpulchrum extract seem to be comparable to the control drug melatonin used albeit with some more beneficial effects. Conclusion These findings are preliminary and should be strengthened by more pharmacological studies of bioactive compounds of Chrysophyllum perpulchrum before being proposed as a promising drug against AD.

scholarly journals The effects of cocoa supplementation, caloric restriction, and regular exercise, on oxidative stress markers of brain and memory in the rat model

2013 ◽  
Vol 61 ◽  
pp. 36-41 ◽  
Author(s):  
Zsolt Radák ◽  
Gabriella Silye ◽  
Csaba Bartha ◽  
Judit Jakus ◽  
Éva Stefanovits-Bányai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caloric Restriction ◽  
Rat Model ◽  
Regular Exercise ◽  
Oxidative Stress Markers ◽  
Stress Markers

Temporal changes of oxidative stress markers in Escherichia coli K1-induced experimental meningitis in a neonatal rat model

2017 ◽  
Vol 653 ◽  
pp. 288-295 ◽  
Author(s):  
Vijayasree V. Giridharan ◽  
Lutiana R. Simões ◽  
Valdemira S. Dagostin ◽  
Jaqueline S. Generoso ◽  
Gislaine T. Rezin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Rat Model ◽  
Temporal Changes ◽  
Neonatal Rat ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Escherichia Coli K1 ◽  
Neonatal Rat Model

scholarly journals Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 466 ◽  
Author(s):  
Cristina Pop ◽  
Cristian Berce ◽  
Steliana Ghibu ◽  
Iuliu Scurtu ◽  
Olga Sorițău ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Body Weight ◽  
Rat Model ◽  
Pressure Overload ◽  
Oxidative Stress Markers ◽  
Lycium Barbarum ◽  
Stress Markers ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Despite recent advances in disease management and prevention, heart failure (HF) prevalence is still high. Hypertension, inflammation and oxidative stress are being investigated as important causative processes in HF. L. barbarum L. polysaccharides (LBPs) are widely used for their anti-inflammatory and antioxidant properties. Thus, the aim of the present study was to evaluate the effects of LBPs on inflammation and oxidative stress markers in a pressure overload-induced HF rat model, surgically induced by abdominal aorta banding in Wistar rats (AAB) (n = 28). Also, control rats (n = 10) were subjected to a sham operation. After echocardiographic confirmation of HF (week 24), AAB rats were divided into three groups: rats treated with LBPs for 12 weeks: 100 mg/kg body weight /day (AAB_100, n = 9), 200 mg/kg body weight /day (AAB_200, n = 7) and no-treatment group (control AAB, n = 12). After 12 weeks of treatment with LBPs, the decline of cardiac function was prevented compared to the control AAB rats. Treatment with 200 mg/kg body weight /day LBPs significantly reduced the inflammation as seen by cytokine levels (IL-6 and TNF-α) and the plasma lipid peroxidation, as seen by malondialdehyde levels. These results suggest that LBPs present anti-inflammatory and antioxidant effects with utility in a HF animal model and encourage further investigation of the cardioprotective effects of these polysaccharides.

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