scholarly journals Association of B2 Receptor Polymorphisms and ACE Activity With ACE Inhibitor-Induced Angioedema in Black and Mixed-Race South Africans

2013 ◽  
Vol 15 (6) ◽  
pp. 413-419 ◽  
Author(s):  
Retsilisitsoe R. Moholisa ◽  
Brian R. Rayner ◽  
E. Patricia Owen ◽  
Sylva L. U. Schwager ◽  
Joalice S. Stark ◽  
...  
Keyword(s):  
Ace Inhibitor ◽  
Mixed Race ◽  
South Africans ◽  
Ace Activity

Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery

2002 ◽  
Vol 282 (4) ◽  
pp. H1478-H1484 ◽  
Author(s):  
Mayuko Kubo-Inoue ◽  
Kensuke Egashira ◽  
Makoto Usui ◽  
Masao Takemoto ◽  
Kisho Ohtani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carotid Artery ◽  
Tissue Factor ◽  
Ace Inhibitor ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Coronary Syndrome ◽  
Ace Activity ◽  
Reliable Marker

Reduced activity of endothelial nitric oxide (NO) may be involved in thrombus formation on atherosclerotic plaques, a major cause of acute coronary syndrome. However, mechanisms of such increase in arterial thrombogenecity have not been fully understood. We previously reported that long-term inhibition of NO synthesis by administration of N G-nitro-l-arginine methyl ester (l-NAME) causes hypertension and activates vascular tissue angiotensin-converting enzyme (ACE) activity. We used this model to investigate the mechanism by which long-term impairment of NO activity increases arterial thrombogenecity. We observed cyclic flow variations (CFVs), a reliable marker of platelet thrombi, after the production of stenosis of the carotid artery in rats treated with l-NAME for 4 wk. The thrombin antagonist argatroban suppressed the CFVs. The CFVs were detected in rats receiving l-NAME plus hydralazine but not in rats receiving l-NAME plus an ACE inhibitor (imidapril). Treatment with the ACE inhibitor imidapril, but not with hydralazine, prevented l-NAME-induced increases in carotid arterial ACE activity and attenuated tissue factor expression. These results suggest that long-term inhibition of endothelial NO synthesis may increase arterial thrombogenecity at least in part through angiotensin II-induced induction of tissue factor and the resultant thrombin generation. These data provide a new insight as to how endothelial NO exhibits antithrombogenic properties of the endothelium.

ACE inhibitors in HF restore canine pulmonary endothelial function and ANG II vasoconstriction

1999 ◽  
Vol 277 (5) ◽  
pp. H1924-H1930
Author(s):  
Ingrid M. Straeter-Knowlen ◽  
Louis J. Dell'italia ◽  
Jun Dai ◽  
Gerald H. Hankes ◽  
A. Raymond Dillon ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Ace Inhibitor ◽  
Systolic Pressure ◽  
Chronic Congestive Heart Failure ◽  
Ang Ii ◽  
Pulmonary Congestion ◽  
Converting Enzyme ◽  
Ace Activity ◽  
Endothelium Dependent Relaxation

Chronic mitral regurgitation (MR) in dogs results in pulmonary congestion and increased cardiac angiotensin-converting enzyme (ACE) activity and angiotensin (ANG) II levels. ACE could contribute to altered pulmonary vasomotion in heart failure, and ACE inhibitor (ACEI) therapy may normalize pulmonary vasomotion. We evaluated pulmonary artery (PA) responses to ANG II and bradykinin (BK) in control dogs, in dogs with 4 mo of MR, in MR dogs treated with the ACEI ramipril (MR + R), and in control dogs treated with ramipril (C + R). Mean PA systolic pressure increased in MR dogs (21 ± 4 mmHg) but was normal in MR + R dogs (13 ± 1 mmHg). Constriction of PA rings to ANG II was depressed in MR dogs. ACEI treatment (MR + R) restored ANG II responsiveness, but peak ANG II response (3.6 ± 0.2 g) in MR + R dogs remained lower than in C + R dogs (4.7 ± 0.2 g). Endothelium-dependent relaxation to BK was decreased (−87 ± 4% C, −65 ± 4% MR; P < 0.05). Ramipril (MR + R) restored relaxation to BK. This demonstrates that pulmonary congestion results in impaired pulmonary vasomotion to ANG II and BK, which ACEIs could normalize, supporting the use of ACEIs in clinical management of chronic congestive heart failure.

scholarly journals Multiculturalism in the workplace: Model and test

2018 ◽  
Vol 16 ◽  
Author(s):  
Leon T.B. Jackson ◽  
Fons J.R. Van de Vijver
Keyword(s):  
Positive Impact ◽  
Mixed Race ◽  
Employee Attitudes ◽  
National Unity ◽  
South Africans ◽  
Attitudes And Practices ◽  
Multicultural Environment ◽  
Antecedent Conditions ◽  
Managerial Implications ◽  
Value Add

Orientation: This article addresses the role of multiculturalism in employee attitudes.Research purpose: It proposes a model of positive features of multiculturalism in organisations and tests it in South Africa. The model postulates three levels in multiculturalism: antecedent conditions, such as multiculturalism practices and norms that define the diversity climate; mediators, such as diversity-enhancing employee attitudes; and positive work outcomes.Motivation for the study: South Africans from diverse backgrounds hardly meet in their private spaces. Given this forced contact in the workplace and the calls for national unity and social cohesion, we propose that a workplace that is characterised by mutual respect, accommodation and tolerance for difference could have a positive impact on employee work attitudes.Research approach/design and method: A quantitative approach was adopted using survey questionnaires that were distributed to employees selected on the basis of convenience sampling (N = 299) in various workplaces.Main findings: A multi-group path analysis confirmed the validity of the model for the white, black and mixed race ethnic groups. Although the differences were negligible to medium, white groups seemed to experience a slightly more favourable multicultural environment compared to black and mixed race groups.Practical/managerial implications: All dimension scores were well above the mid-point of the scale, which suggests that psychometrically speaking, the multicultural climate, ethnic integration orientations and employee attitudes are experienced by these employees as favourable.Contribution/value-add: From a conceptual perspective, the model implies that the more distal variable of a multicultural climate influences employee attitudes through a set of more proximal integration attitudes and practices. From a practical perspective, an inclusive climate has more distal characteristics such as the general multiculturalism climate and more proximal characteristics such as ethnic vitality.

scholarly journals Allelic Diversity of the Helicobacter pylori Vacuolating Cytotoxin Gene in South Africa: Rarity of thevacA s1a Genotype and Natural Occurrence of an s2/m1 Allele

1999 ◽  
Vol 37 (4) ◽  
pp. 1203-1205 ◽  
Author(s):  
D. P. Letley ◽  
A. Lastovica ◽  
J. A. Louw ◽  
C. J. Hawkey ◽  
J. C. Atherton
Keyword(s):  
South Africa ◽  
Helicobacter Pylori ◽  
Allelic Diversity ◽  
Mixed Race ◽  
The United States ◽  
Natural Occurrence ◽  
Vacuolating Cytotoxin ◽  
South Africans ◽  
Naturally Occurring ◽  
Cytotoxin Gene

We describe the rarity of Helicobacter pylori strains of vacuolating cytotoxin type s1a (the type most commonly associated with peptic ulceration in the United States) among black and mixed-race South Africans. We also provide the first description of a naturally occurring strain with the vacA allelic structure s2/m1.

Time Profile of ACE-Activity in Plasma Following I.V.-Bolus Dose or I.V.-Infusion of the ACE-Inhibitor Quinaprilat

1996 ◽  
Vol 59 (2) ◽  
pp. 140-140
Author(s):  
D. Trenk ◽  
K. Dilger ◽  
E. Stengele ◽  
C. Logemann ◽  
E. Jâhnchen
Keyword(s):  
Bolus Dose ◽  
Ace Inhibitor ◽  
Time Profile ◽  
Ace Activity

scholarly journals The pathogenetic substantiation of the use of angiotensin-converting enzyme for the treatment of diabetic retinopathy

2012 ◽  
Vol 58 (5) ◽  
pp. 37-40
Author(s):  
M V Riabina ◽  
N B Chesnokova ◽  
T D Okhotsimskaia ◽  
T P Kuznetsova
Keyword(s):  
Diabetic Retinopathy ◽  
Ace Inhibitor ◽  
Retinal Thickness ◽  
Glycosylated Hemoglobin ◽  
Diabetic Macular Oedema ◽  
Renin Angiotensin System ◽  
Retinal Ischemia ◽  
Angiotensin System ◽  
Before And After ◽  
Ace Activity

The objective of the present work was to study visual functions, as well as changes in the systemic and local renin-angiotensin system before and after intake of the ACE inhibitor perindopril in 65 patients (130 eyes) presenting with diabetic retinopathy. The treatment caused the most pronounced changes in the patients with preproliferative diabetic retinopathy including the two-fold (p<0.05) decrease of ACE activity in the blood and its 7.5-fold (p<0.05) increase in the tears. These effects appear to be attributable to the action of perindopril on the levels of the proangiogenic factors known to be elevated in the patients with severe retinal ischemia. The treatment of patients with diabetic macular oedema with perindopril resulted in the decrease of the retinal thickness from 392.5±46.7 to 347.2±39.6 mcm in the absence of significant improvement in the acuteness of vision. All the patients experienced a significant reduction in the level of glycosylated hemoglobin.

Sign in / Sign up

Export Citation Format

Share Document