Desmoplastic Melanoma: A review of its pathology and clinical behaviour, and of management recommendations in published guidelines

2021 ◽  
Author(s):  
T.M. Hughes ◽  
G.J. Williams ◽  
D.E. Gyorki ◽  
J.W. Kelly ◽  
J.R. Stretch ◽  
...  
Keyword(s):  
Clinical Behaviour ◽  
Desmoplastic Melanoma ◽  
Management Recommendations

Land Use Change and Commodity Frontiers

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Daniel M. Cáceres ◽  
Esteban Tapella ◽  
Diego A. Cabrol ◽  
Lucrecia Estigarribia
Keyword(s):  
Large Scale ◽  
Field Work ◽  
Dry Forest ◽  
Social Actors ◽  
Goods And Services ◽  
Fast Pace ◽  
Forest Use ◽  
The Government ◽  
Social Environmental ◽  
Management Recommendations

Argentina is experiencing an expansion of soya and maize cultivation that is pushing the agricultural frontier over areas formerly occupied by native Chaco forest. Subsistance farmers use this dry forest to raise goats and cattle and to obtain a broad range of goods and services. Thus, two very different and non-compatible land uses are in dispute. On the one hand subsistance farmers fostering an extensive and diversified forest use, on the other hand, large-scale producers who need to clear out the forest to sow annual crops in order to appropriate soil fertility. First, the paper looks at how these social actors perceive Chaco forest, what their interests are, and what kind of values they attach to it. Second, we analyze the social-environmental conflicts that arise among actors in order to appropriate forest’s benefits. Special attention is paid to the role played by the government in relation to: (a) how does it respond to the demands of the different sectors; and (b) how it deals with the management recommendations produced by scientists carrying out social and ecological research. To put these ideas at test we focus on a case study located in Western Córdoba (Argentina), where industrial agriculture is expanding at a fast pace, and where social actors’ interests are generating a series of disputes and conflicts. Drawing upon field work, the paper shows how power alliances between economic and political powers, use the institutional framework of the State in their own benefit, disregarding wider environmental and social costs. 

Gestión de riesgos empresariales: los necesarios cambios

Oikos ◽  
2016 ◽  
Vol 19 (39) ◽  
pp. 93 ◽  
Author(s):  
Ricardo Vega Bois
Keyword(s):  
Risk Management ◽  
Quality Management ◽  
Management System ◽  
Quality Management System ◽  
Iso 9000 ◽  
Management Control ◽  
System Requirements ◽  
Requirements Quality ◽  
Management Recommendations ◽  
Environmental Audits

RESUMENLa normas de la serie ISO 9000 – 2000, Sistema de Gestión de Calidad, Requisitos de un Sistema de Gestión de Calidad, Recomendaciones para la mejora de desempeño en base a un Sistema de Gestión de calidad y Directrices para la realización de auditorías medioambientales y de calidad, han sido base para la evaluación, implementación, aplicación y seguimiento de sistemas de Control de Gestión Empresarial, estando en la actualidad (2015) en un procesos de revisión y propuesta, lo que implicará algunos cambios de forma y otros de fondo interesantes de considerar.Palabras clave: gestión, riesgos, control de gestión, calidad, normas internacionales.Enterprise risk management: the necessary changesABSTRACTThe standards ISO 9000 - 2000 Quality Management System, System Requirements Quality Management Recommendations for improving performance based on a Quality Management System and Guidelines for conducting environmental audits and quality have been the basis for evaluation, implementation, enforcement and monitoring systems Control Management, being at present (2015) in a review and proposal processes, which involve some changes in form and other interesting background consider.Keywords: management, risk, management control, quality international standards.Gestão de riscos empresariais: as mudanças necessárias RESUMO As normas da série ISO 9000-2000, Sistema de Gestão da Qualidade, Requisitos de um Sistema de Gestão de Qualidade, Recomendações para a melhora do desempenho com base a um Sistema de Gestão da Qualidade e Diretrizes para a realização de auditorias meio ambientais e de qualidade, têm sido a base para a avaliação, implementação, aplicação e fiscalização de Sistemas de Controle de Gestão Empresarial, sendo na atualidade (2015) num processo de revisão e proposta, que implicará algumas mudanças na forma e outros de fundo interessante de considerar.Palavras-chave: gestão, risco, controle de gestão, qualidade, normas internacionais.

Hazelnut Pollination

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 555d-555
Author(s):  
J.L. Olsen ◽  
S.A. Mehlenbacher ◽  
A.N. Azarenko
Keyword(s):  
Single Gene ◽  
Pistillate Flower ◽  
Temperature Dependent ◽  
Multiple Alleles ◽  
Anisogramma Anomala ◽  
Molecular Aspects ◽  
Management Recommendations ◽  
Pollen Shed ◽  
Resistant Genotypes ◽  
Pollination And Fertilization

Hazelnuts are wind-pollinated, monoecious, mostly dichogamous, and self-incompatible of the sporophytic type. About 90% of the cultivars studied are protandrous. Anthesis of the pistillate flower is temperature-dependent and occurs from December through February, with its peak in January. Stigmatic surfaces may remain receptive for up to 3 months. Four to 5 months separate pollination and fertilization of the ovule, which usually occurs between mid-May and the end of June in Oregon. A 10% pollinizer density has been the standard, with a recommended distance of <20 m between the main cultivar and the nearest pollinizer. Two or three different pollinizer varieties with different times of pollen shed are recommended. The Oregon hazelnut industry is presently combating the fungal disease, Eastern Filbert Blight, Anisogramma anomala. Part of the current management recommendations are to reduce the susceptible pollinizer varieties to a density of around 5%, and then gradually replace those left with immune or more-resistant genotypes. Recent research by S.A. Mehlenbacher refined methods of using fluorescense microscopy to quickly determine genotype compatibility. The self-incompatiblity is controlled by a single gene with multiple alleles. The biochemical, physiological, and molecular aspects of sporophytic self-incompatiblity are being research by A.N. Azarenko.

Ponatinib: A Review of Efficacy and Safety

2018 ◽  
Vol 18 (9) ◽  
pp. 847-856 ◽  
Author(s):  
Fulvio Massaro ◽  
Matteo Molica ◽  
Massimo Breccia
Keyword(s):  
Kinase Inhibitor ◽  
Tolerability Profile ◽  
Third Generation ◽  
Efficacy And Safety ◽  
Future Perspectives ◽  
General Management ◽  
T315i Mutation ◽  
Baseline Characteristics ◽  
Management Recommendations ◽  
Cardiovascular Profile

Ponatinib is a third generation kinase inhibitor designed to overcome the gatekeeper T315I mutation. In different trials this drug showed inhibitory activity against native BCR-ABL1 kinase and several ABL1 mutations. For this reason, ponatinib is currently indicated for the treatment of chronic myeloid leukaemia (CML) in every phase of disease resistant and/or intolerant to dasatinib and nilotinib and for whom imatinib is not indicated anymore or for patients with T315I mutation. The drug is also indicated for Ph+ acute lymphoblastic leukaemia (ALL). Ponatinib was temporarily suspended in 2013 for the occurrence of cardiovascular thrombotic events. Since then, different investigators analyzed baseline characteristics of patient candidates for ponatinib, especially cardiovascular profile, in order to describe general management recommendations in this setting. In this review, clinical trials data about the use of ponatinib in CML and Ph+ ALL patients will be discussed. It will be focused also about the safety and tolerability profile of the drug and future perspectives of employment.

Forest health and climate change: A British Columbia perspective

2010 ◽  
Vol 86 (4) ◽  
pp. 412-422 ◽  
Author(s):  
Alex J. Woods ◽  
Don Heppner ◽  
Harry H. Kope ◽  
Jennifer Burleigh ◽  
Lorraine Maclauchlan
Keyword(s):  
Climate Change ◽  
British Columbia ◽  
Mountain Pine Beetle ◽  
Forest Health ◽  
Forest Insects ◽  
Pine Beetle ◽  
The World ◽  
Dothistroma Needle Blight ◽  
Management Recommendations ◽  
Needle Blight

BC’s forests have already faced two simultaneous, globally significant, epidemics linked to climate change; the Dothistroma needle blight epidemic in NW BC and the massive mountain pine beetle epidemic throughout the BC Interior. Building on these experiences, we have compiled our best estimates of how we believe other forest health agents may behave as climate change continues to influence our forests. We have drawn on literature from around the world but have focused on the situation in BC. We have made management recommendations based on what we have seen so far and what we expect to come.Key words: climate change, forest health, forest insects, forest pathogens, forest management, British Columbia

scholarly journals Is there a standardized practice for the development of international ulcerative colitis and Crohn’s disease treatment guidelines?

2021 ◽  
Author(s):  
Alexander Goldowsky ◽  
Rohan Sen ◽  
Gila Hoffman ◽  
Joseph D Feuerstein
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Treatment Guidelines ◽  
Conflicts Of Interest ◽  
Level Of Evidence ◽  
Evidence Quality ◽  
Chi Squared ◽  
Linear Regression Modeling ◽  
Management Recommendations

Abstract Background Guidelines are published by international gastroenterology societies regarding the management of ulcerative colitis (UC) and Crohn’s disease (CD) to help clinicians to provide high-quality patient care. We examined the guidelines for the quality and strength of evidence used to develop the recommendations, methods for grading evidence, differences in disease-specific recommendations, conflicts of interest, and plans for guideline updates. Methods A systematic search was performed on PubMed using “ulcerative colitis,” “Crohn’s disease,” and “guidelines” in April 2019. International gastroenterology society websites were searched for UC- and CD-specific guidelines. Guidelines from 12 societies were examined by two authors. Chi-squared tests were used for comparing evidence-level grades, strength of recommendations, and reported conflicts of interest. Linear-regression modeling was used to evaluate the relationship between the number of authors and the number of recommendations in a given guideline. Results Of 28 guidelines reviewed, 25 (89%) used a total of three different systems to grade the level of evidence and 2 (7%) used an unknown system. Three (11%) reviewed guidelines did not provide a conflict-of-interest statement, while three (11%) provided a timeline for guideline updates. Of 1,265 total statements examined, 246 (19%) reported no grade of evidence quality or explicitly stated that the recommendation was based on “expert opinion.” One hundred and thirty-five (22%) UC recommendations were noted to be “weak/conditional” and 95 (16%) did not have a recommendation strength. Two hundred and forty-two (37%) CD recommendations were noted to be “weak/conditional” and 151 (23%) did not have a recommendation strength. Conclusion The majority of UC and CD guidelines are based on a low/very low quality of evidence and are further weakened due to the lack of homogeneity in specific aspects of management recommendations as well as conflicts of interest.

scholarly journals A Case Study of the Effects of Management Interventions on the Phosphorus Dynamics at a Coastal, Eutrophic, Caribbean lagoon (Laguna Cartagena, Puerto Rico)

Water ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 449
Author(s):  
Yashira Marie Sánchez Colón ◽  
Fred Charles Schaffner
Keyword(s):  
Puerto Rico ◽  
Water Column ◽  
Water Levels ◽  
Wildlife Habitat ◽  
Freshwater Wetland ◽  
Water Level Fluctuations ◽  
Phosphorus Loading ◽  
Estuarine Wetlands ◽  
Management Interventions ◽  
Management Recommendations

Laguna Cartagena is a coastal, eutrophic, shallow lake and freshwater wetland in southwestern Puerto Rico, managed by the US Fish and Wildlife Service. This ecosystem has been impacted by phosphorus loading from adjacent agricultural areas since the 1950s, causing eutrophication and deteriorating wildlife habitats. Herein, we describe phosphorus input and export during September 2010–September 2011 (Phase One) and October 2013–November 2014 (Phase Two). These two phases bracket a period of intensified management interventions including excavation and removal of sediment and vegetation, draining, and burning during the summers of 2012 and 2013. Results indicate that Laguna Cartagena retains a phosphorus (sink) in its sediments, and exhibits nutrient-releasing events (source, mainly total phosphorus) to the lagoon water column, which are associated with rainfall and rising water levels. External factors including water level fluctuations and rainfall influenced phosphorus export during Phase One, but after management interventions (Phase Two), internal processes influenced sink/source dynamics, releasing elevated phosphorus concentrations to the water column. When exposed sediments were re-flooded, phosphorus concentrations to the water column increased, releasing elevated P concentrations downstream to an estuarine wetlands area and the Caribbean Sea. Herein we offer management recommendations to optimize wildlife habitat without elevating phosphorus concentrations.

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