Blood levels of vitamin D and health-functional status in asymptomatic individuals: a cross sectional study

2016 ◽  
Vol 22 (6) ◽  
pp. 950-955 ◽  
Author(s):  
Avivit Golan-Cohen ◽  
Eugene Merzon ◽  
Ouda Alhin ◽  
Eliezer Kitai ◽  
Yacov Fogelman
Keyword(s):  
Vitamin D ◽  
Functional Status ◽  
Cross Sectional Study ◽  
Blood Levels ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asymptomatic Individuals

scholarly journals Body Composition, Dietary Intake and Biochemical Profile in Thalassemia Major Patients, Southwest of Iran

2021 ◽  
Author(s):  
Behrooz Ebrahimzadeh Koor ◽  
Mojtaba Yousefi ◽  
Zahra Mohammadian ◽  
Peyman Etemadfar
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Blood Transfusion ◽  
Vitamin K ◽  
Biochemical Parameters ◽  
Cross Sectional Study ◽  
Blood Levels ◽  
Sectional Study ◽  
Cross Sectional ◽  
Standard Values

Abstract Background: Thalassemia, as an autosomal recessive disorder, leads to life-threatening anemia, in which patient's life depends on long term blood transfusion and regular medical care. In this study, body composition, nutritional intake and biochemical parameters of blood transfusing dependent major thalassemia patients were evaluated.Methods: In this cross-sectional study, 74 major thalassemia volunteers referred to educational hospital in Yasuj city were recruited. Body composition, demographic and biochemical parameters were measured. Data were statistically analyzed using parametric and non-parametric statistical tests. P-values less than 0.05 were defined as statistically significant.Results: Data analysis showed that mean of age of participants in this cross-sectional study was 21.09± 7.7 years old. 21.6% of our patients were underweight, 68.9% of them were normal weight, 9.5% were overweight and none of them were obese. 8.1% of < 20 years old patients were short stature. About 80% of patients had low blood HDL concentration. About 30% of participants were at borderline levels ​and 42% of patients were at high and toxic levels of Ferritin. Approximately, all patients had hemoglobin lower than standard of healthy individuals. The mean body fat percent of patients was 24 ± 6.6%, which was higher than the normal value ​​(P <0.001), with exception of copper, phosphorus and vitamin K and percent of protein and carbohydrates from total energy were significantly lower than standard values. The Binary logistic regression analysis also showed that the interval between sessions of blood transfusion (P=0.03), daily intake of vitamin D (P=0.01) and vitamin K (P=0.028) and fatness (0.006) were significant predictors of the Ferritin equation as iron overload in thalassemia patients.Discussion and Conclusion: Malnutrition, especially underweight was evident among our patients. Intake of the energy and most nutrients were lower than standard values. Biochemical parameters such as Ferritin and hemoglobin were also abnormal. Blood levels of vitamin D in thalassemia patients should be routinely monitored. Clinical trials on the effect of supplementation with nutrients such as vitamin D and calcium and zinc are recommended. Blood levels of vitamin D in thalassemia patients should be routinely monitored every six months.

Fibroblast growth factor 23 and its role in phosphate homeostasis in growing children compared to adults

2020 ◽  
Vol 33 (8) ◽  
pp. 1065-1071
Author(s):  
Marjan Jeddi ◽  
Maryam Heidari ◽  
Neda Hatami ◽  
Gholam Hossein Ranjbar Omrani
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Fibroblast Growth Factor 23 ◽  
Fractional Excretion ◽  
Cross Sectional Study ◽  
Fibroblast Growth ◽  
Sectional Study ◽  
Phosphate Homeostasis ◽  
Cross Sectional ◽  
Fractional Excretion Of Phosphate

AbstractObjectivesPhosphate is essential for skeletal mineralization, which is regulated by parathyroid hormone, calcitriol and fibroblast growth factor 23 (FGF23). Serum phosphate is physiologically higher in younger children, but factors that contribute to this physiological state are poorly understood. This study aimed to evaluate phosphate and its regulators in children compared with adults.Materials and methodsThe participants were children aged 3–11 years and adults older than 20 years of age. Biochemical parameters including calcium, phosphorus, alkaline phosphatase, FGF23, and vitamin D were measured. Fractional excretion of phosphate was calculated, using serum and urine phosphate and creatinine.ResultsThis cross-sectional study was conducted on 45 children (mean age: 9.0 ± 2.1) and 44 adults (mean age: 38.9 ± 11.1). The children had higher serum calcium, phosphate, alkaline phosphatase, and FGF23 (p < 0.001), but fractional excretion of phosphate was greater in adults (14.1 ± 5.7, 11.4 ± 4.4, p = 0.019, 95% confidence interval [CI]: −0.7 to −0.2). Of all individuals, 61.8% had vitamin D deficiency. By multiple regression analysis, entering age, calcium, phosphate, and vitamin D level, the only independent predictor of FGF23 was 1, 25 dihydroxy-vitamin D3 (β: 0.78, p < 0.001, 95% CI: 0.5–1.1, R2: 0.59 for children, and β: 0.59, p < 0.001, 95% CI: 0.5–1.4, R2: 0.45 for adults).ConclusionAs far as we know, there is little information regarding the role of FGF23 in physiologic state. In this cross-sectional study no association was found between FGF23 and urinary phosphate excretion in growing children. Further studies with more detail are essential to evaluate phosphate homeostasis during childhood.

scholarly journals Functional status and oral health in patients with amyotrophic lateral sclerosis: A cross-sectional study

2020 ◽  
pp. 1-9
Author(s):  
Alessandro de Sire ◽  
Marco Invernizzi ◽  
Martina Ferrillo ◽  
Francesca Gimigliano ◽  
Alessio Baricich ◽  
...  
Keyword(s):  
Health Care ◽  
Health Status ◽  
Oral Health ◽  
Functional Status ◽  
Cross Sectional Study ◽  
Oral Health Status ◽  
Multidisciplinary Management ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lateral Sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting upper and lower motor neurons. The current practice of caring for patients affected by ALS involves a multidisciplinary team without any indication about oral health care. OBJECTIVE: We sought to investigate the functional status and oral health in patients with ALS to define a specific multidisciplinary management. METHODS: In this cross-sectional study, we included patients affected by ALS, evaluating their functional status, using the Revised ALS Functional Rating Scale (ALSFRS-R) and their oral health status through specific parameters, including Brief Oral Health Status Examination (BOHSE), Winkel Tongue Coating Index (WTCI), and Oral Food Debris Index (OFDI). RESULTS: All 37 patients (mean age: 61.19±11.56 years) showed a poor oral status, independent from the functional status and strictly correlated to the severity of sialorrhea (p = 0.01). OFDI index was negatively correlated with the ALSFRS-R upper limb (p = 0.03). Patients with bulbar onset had significantly lower ability to perform adequate tongue movements in terms of protrusion (p = 0.006) and lateralization (p <  0.001). Significant negative correlations between survival rate and BOHSE (p = 0.03) was found. CONCLUSIONS: Taken together, our findings showed that a poor oral health status might be correlated to a worse functional status and survival time. Thus, an adequate oral health care and rehabilitation should be considered as crucial in the multidisciplinary management of patients with ALS.

scholarly journals Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 360
Author(s):  
Ola Hysaj ◽  
Patricia Marqués-Gallego ◽  
Aline Richard ◽  
Magdeldin Elgizouli ◽  
Alexandra Nieters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflection Point ◽  
Demographic Data ◽  
Late Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
Maximal Suppression

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

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