Association of leptin with disease severity and inflammation indicators in Chinese obese children with allergic rhinitis

2018 ◽  
Vol 29 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Wenlong Liu ◽  
Qingxiang Zeng ◽  
Lifeng Zhou ◽  
Renzhong Luo ◽  
Haipeng Dong
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
Obese Children

Association of Leptin With Disease Severity and Inflammation Indicators in Chinese Obese Children With Allergic Rhinitis

PEDIATRICS ◽  
2018 ◽  
Vol 142 (Supplement 4) ◽  
pp. S226.1-S226
Author(s):  
Daniel Har ◽  
Christopher Parrish
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
Obese Children

scholarly journals Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

2018 ◽  
Vol 52 (3) ◽  
pp. 1800504 ◽  
Author(s):  
Zuelma A. Contreras ◽  
Zhanghua Chen ◽  
Theano Roumeliotaki ◽  
Isabella Annesi-Maesano ◽  
Nour Baïz ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Childhood Asthma ◽  
Early Onset ◽  
Pooled Analysis ◽  
Obesity Risk ◽  
Obese Children ◽  
The Past ◽  
Increased Risk ◽  
The Uk

The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.

Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?

2016 ◽  
Vol 274 (1) ◽  
pp. 209-213 ◽  
Author(s):  
Mahmut Dogru ◽  
Muhammed Fatih Evcimik ◽  
Omer Faruk Calim
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
Adenoid Hypertrophy ◽  
Affect Disease Severity

Autonomic function in adults with allergic rhinitis and its association with disease severity and duration

2017 ◽  
Vol 118 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Min Hee Kim ◽  
Eun Ji Choi ◽  
Bo-Hyoung Jang ◽  
Kyu Seok Kim ◽  
Seoung-Gyu Ko ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
Autonomic Function

scholarly journals Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Shaobing Xie ◽  
Hua Zhang ◽  
Zhihai Xie ◽  
Yongzhen Liu ◽  
Kelei Gao ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
House Dust ◽  
House Dust Mite ◽  
Partial Least Square ◽  
Least Square ◽  
Sphingolipid Metabolism ◽  
Dust Mite ◽  
Novel Biomarkers ◽  
Serum Metabolomics

The aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR patients and controls and for subgroups based on disease severity. These analysis results successfully revealed distinct metabolite signatures which distinguished MAR patients and MSAR patients from controls. MSAR patients also could be discriminated from MAR patients based on their metabolic fingerprints. Most observed metabolite changes were related to glycine, serine, and threonine metabolism, pyrimidine metabolism, sphingolipid metabolism, arginine and proline metabolism, and fatty acid metabolism. Levels of sarcosine, sphingosine-1-phosphate, cytidine, and linoleic acid significantly correlated with the total nasal symptom score and visual analogue scale in AR patients. These results suggest that metabolomics profiling may provide novel insights into the pathophysiological mechanisms of HDM-induced AR and contribute to its evaluation of disease severity.

Bisphenol A as a risk factor for allergic rhinitis in children

2020 ◽  
pp. 096032712095810
Author(s):  
A Nalbantoğlu ◽  
A Çelikkol ◽  
N Samancı ◽  
NC Günaydın ◽  
B Nalbantoğlu
Keyword(s):  
Allergic Rhinitis ◽  
Bisphenol A ◽  
Disease Severity ◽  
Allergic Diseases ◽  
Nasal Symptom ◽  
Interleukin 4 ◽  
Control Group ◽  
Healthy Children ◽  
Endocrine Disrupting Compound ◽  
Total Nasal Symptom Score

Aim: Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR. Methods: This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity. Results: Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis. Conclusions: The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity.

scholarly journals Comparison of six disease severity scores for allergic rhinitis against pollen counts a prospective analysis at population and individual level

2016 ◽  
Vol 27 (4) ◽  
pp. 382-390 ◽  
Author(s):  
Jakob Florack ◽  
Maria Antonia Brighetti ◽  
Serena Perna ◽  
Antonio Pizzulli ◽  
Antje Pizzulli ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Disease Severity ◽  
Prospective Analysis ◽  
Pollen Counts ◽  
Individual Level ◽  
Severity Scores ◽  
Disease Severity Scores
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