Alleviating aluminum toxicity in plants: implications of reactive oxygen species signalling and crosstalk with other signaling pathways

2021 ◽  
Author(s):  
Alok Ranjan ◽  
Ragini Sinha ◽  
Tilak Raj Sharma ◽  
Arunava Pattanayak ◽  
Anil Kumar Singh
Keyword(s):  
Reactive Oxygen Species ◽  
Signaling Pathways ◽  
Aluminum Toxicity ◽  
Reactive Oxygen ◽  
Oxygen Species

Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene

2021 ◽  
Author(s):  
Zi-Yu Chen ◽  
Yu-Chen Su ◽  
Fong-Yu Cheng ◽  
Shian-Jang Yan ◽  
Ying-Jan Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Adverse Effects ◽  
Signaling Pathways ◽  
Reactive Oxygen ◽  
Engineered Nanoparticles ◽  
Stress Signaling ◽  
Oxygen Species ◽  
Safety Concerns

Engineered nanoparticles raise safety concerns. Silver nanoparticles (AgNPs) exert acute and chronic adverse effects by inducing reactive oxygen species (ROS)-mediated stress signaling pathways. We investigated the mechanisms by which AgNPs...

scholarly journals Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity

2016 ◽  
Vol 8 (2) ◽  
pp. 143-155 ◽  
Author(s):  
Sanjeev Choudhary ◽  
Istvan Boldogh ◽  
Allan R. Brasier
Keyword(s):  
Reactive Oxygen Species ◽  
Innate Immunity ◽  
Signaling Pathways ◽  
Nuclear Export ◽  
Reactive Oxygen ◽  
Small Gtpase ◽  
Early Gene ◽  
Type I ◽  
Oxygen Species ◽  
Ros Signaling

The airway mucosa is responsible for mounting a robust innate immune response (IIR) upon encountering pathogen-associated molecular patterns. The IIR produces protective gene networks that stimulate neighboring epithelia and components of the immune system to trigger adaptive immunity. Little is currently known about how cellular reactive oxygen species (ROS) signaling is produced and cooperates in the IIR. We discuss recent discoveries about 2 nuclear ROS signaling pathways controlling innate immunity. Nuclear ROS oxidize guanine bases to produce mutagenic 8-oxoguanine, a lesion excised by 8-oxoguanine DNA glycosylase1/AP-lyase (OGG1). OGG1 forms a complex with the excised base, inducing its nuclear export. The cytoplasmic OGG1:8-oxoG complex functions as a guanine nucleotide exchange factor, triggering small GTPase signaling and activating phosphorylation of the nuclear factor (NF)κB/RelA transcription factor to induce immediate early gene expression. In parallel, nuclear ROS are detected by ataxia telangiectasia mutated (ATM), a PI3 kinase activated by ROS, triggering its nuclear export. ATM forms a scaffold with ribosomal S6 kinases, inducing RelA phosphorylation and resulting in transcription-coupled synthesis of type I and type III interferons and CC and CXC chemokines. We propose that ATM and OGG1 are endogenous nuclear ROS sensors that transmit nuclear signals that coordinate with outside-in pattern recognition receptor signaling, regulating the IIR.

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