Modeling Precheck Parallel Screening Process in the Face of Strategic Applicants with Incomplete Information and Screening Errors

Ad hoc collaborations often necessitate impromptu sharing of sensitive information or resources between member organizations. Each member of resulting collaboration needs to carefully assess and tradeoff the requirements of protecting its own sensitive information against the requirements of sharing some or all of them. The challenge is that no policies have been previously arrived at for such secure sharing (since the collaboration has been formed in an ad hoc manner). Thus, it needs to be done based on an evaluation of the trustworthiness of the recipient of the information or resources. In this chapter, the authors discuss some previously proposed trust models to determine if they can be effectively used to compute trustworthiness for such sharing purposes in ad hoc collaborations. Unfortunately, none of these models appear to be completely satisfactory. Almost all of them fail to satisfy one or more of the following requirements: (i) well defined techniques and procedures to evaluate and/or measure trust relationships, (ii) techniques to compare and compose trust values which are needed in the formation of collaborations, and (iii) techniques to evaluate trust in the face of incomplete information. This prompts the authors to propose a new vector (we use the term “vector” loosely; vector in this work means a tuple) model of trust that is suitable for reasoning about the trustworthiness of systems built from the integration of multiple subsystems, such as ad hoc collaborations. They identify three parameters on which trust depends and formulate how to evaluate trust relationships. The trust relationship between a truster and a trustee is associated with a context and depends on the experience, knowledge, and recommendation that the truster has with respect to the trustee in the given context. The authors show how their model can measure trust in a given context. Sometimes enough information is not available about a given context to calculate the trust value. Towards this end the authors show how the relationships between different contexts can be captured using a context graph. Formalizing the relationships between contexts allows us to extrapolate values from related contexts to approximate a trust value of an entity even when all the information needed to calculate the trust value is not available. Finally, the authors develop formalisms to compare two trust relationships and to compose two or more of the same – features that are invaluable in ad hoc collaborations.

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Rapid Development of Neutralizing and Diagnostic SARS-COV-2 Mouse Monoclonal Antibodies

10.1101/2020.10.13.338095 ◽

2020 ◽

Author(s):

Asheley P. Chapman ◽

Xiaoling Tang ◽

Joo R. Lee ◽

Asiya Chida ◽

Kristina Mercer ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Rapid Development ◽

Functional Characterization ◽

Cell Types ◽

Lung Epithelial Cells ◽

Screening Process ◽

Viral Neutralization ◽

Gene Usage ◽

The Face ◽

Diagnostic Research

AbstractThe need for high-affinity, SARS-CoV-2-specific monoclonal antibodies (mAbs) is critical in the face of the global COVID-19 pandemic, as such reagents can have important diagnostic, research, and therapeutic applications. Of greatest interest is the ~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. We report here the development and functional characterization of 29 nanomolar-affinity mouse SARS-CoV-2 mAbs created by an accelerated immunization and hybridoma screening process. Differing functions, including binding of diverse protein epitopes, viral neutralization, impact on RBD-hACE2 binding, and immunohistochemical staining of infected lung tissue, were correlated with variable gene usage and sequence.

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Causal generative models are just a start

Behavioral and Brain Sciences ◽

10.1017/s0140525x17000115 ◽

2017 ◽

Vol 40 ◽

Cited By ~ 1

Author(s):

Ernest Davis ◽

Gary Marcus

Keyword(s):

Incomplete Information ◽

Causal Theory ◽

Generative Models ◽

Human Reasoning ◽

World Knowledge ◽

Physical Reasoning ◽

Physics Engine ◽

The World ◽

The Face

AbstractHuman reasoning is richer than Lake et al. acknowledge, and the emphasis on theories of how images and scenes are synthesized is misleading. For example, the world knowledge used in vision presumably involves a combination of geometric, physical, and other knowledge, rather than just a causal theory of how the image was produced. In physical reasoning, a model can be a set of constraints rather than a physics engine. In intuitive psychology, many inferences proceed without detailed causal generative models. How humans reliably perform such inferences, often in the face of radically incomplete information, remains a mystery.

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Why do people believe in a zero-sum economy?

Behavioral and Brain Sciences ◽

10.1017/s0140525x18000389 ◽

2018 ◽

Vol 41 ◽

Cited By ~ 1

Author(s):

Samuel G. B. Johnson

Keyword(s):

Perspective Taking ◽

Evolutionary Model ◽

Everyday Experience ◽

Coalitional Psychology ◽

The Face ◽

Zero Sum

AbstractZero-sum thinking and aversion to trade pervade our society, yet fly in the face of everyday experience and the consensus of economists. Boyer & Petersen's (B&P's) evolutionary model invokes coalitional psychology to explain these puzzling intuitions. I raise several empirical challenges to this explanation, proposing two alternative mechanisms – intuitive mercantilism (assigning value to money rather than goods) and errors in perspective-taking.

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Mars: was There an Ancient Eden?

International Astronomical Union Colloquium ◽

10.1017/s025292110001472x ◽

1997 ◽

Vol 161 ◽

pp. 203-218 ◽

Cited By ~ 3

Author(s):

Tobias C. Owen

Keyword(s):

Positive Answer ◽

Biogenic Elements ◽

Habitable Zones ◽

The Face ◽

The Origin Of Life ◽

Early Mars ◽

Favorable Conditions ◽

Open Question ◽

Rocky Planets ◽

Impact Erosion

AbstractThe clear evidence of water erosion on the surface of Mars suggests an early climate much more clement than the present one. Using a model for the origin of inner planet atmospheres by icy planetesimal impact, it is possible to reconstruct the original volatile inventory on Mars, starting from the thin atmosphere we observe today. Evidence for cometary impact can be found in the present abundances and isotope ratios of gases in the atmosphere and in SNC meteorites. If we invoke impact erosion to account for the present excess of129Xe, we predict an early inventory equivalent to at least 7.5 bars of CO2. This reservoir of volatiles is adequate to produce a substantial greenhouse effect, provided there is some small addition of SO2(volcanoes) or reduced gases (cometary impact). Thus it seems likely that conditions on early Mars were suitable for the origin of life – biogenic elements and liquid water were present at favorable conditions of pressure and temperature. Whether life began on Mars remains an open question, receiving hints of a positive answer from recent work on one of the Martian meteorites. The implications for habitable zones around other stars include the need to have rocky planets with sufficient mass to preserve atmospheres in the face of intensive early bombardment.

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Evidence for a shear mechanism for the precipitation of γ-zirconium hydride in zirconium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010011043x ◽

1978 ◽

Vol 36 (1) ◽

pp. 658-659

Author(s):

G.J.C. Carpenter

Keyword(s):

Elevated Temperature ◽

Strain Field ◽

Zirconium Hydride ◽

Zirconium Atom ◽

Atom Diffusion ◽

Solvus Temperature ◽

Hexagonal Close Packed ◽

Partial Dislocations ◽

The Face

In zirconium-hydrogen alloys, rapid cooling from an elevated temperature causes precipitation of the face-centred tetragonal (fct) phase, γZrH, in the form of needles, parallel to the close-packed <1120>zr directions (1). With low hydrogen concentrations, the hydride solvus is sufficiently low that zirconium atom diffusion cannot occur. For example, with 6 μg/g hydrogen, the solvus temperature is approximately 370 K (2), at which only the hydrogen diffuses readily. Shears are therefore necessary to produce the crystallographic transformation from hexagonal close-packed (hep) zirconium to fct hydride.The simplest mechanism for the transformation is the passage of Shockley partial dislocations having Burgers vectors (b) of the type 1/3<0110> on every second (0001)Zr plane. If the partial dislocations are in the form of loops with the same b, the crosssection of a hydride precipitate will be as shown in fig.1. A consequence of this type of transformation is that a cumulative shear, S, is produced that leads to a strain field in the surrounding zirconium matrix, as illustrated in fig.2a.

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A study of interface sliding at F.C.C.-B.C.C. boundaries in a Cu-Zn alloy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100109252 ◽

1978 ◽

Vol 36 (1) ◽

pp. 422-423

Author(s):

F. Monchoux ◽

A. Rocher ◽

J.L. Martin

Keyword(s):

Face Centered Cubic ◽

Creep Tests ◽

High Voltage Electron Microscopy ◽

Diffusion Treatment ◽

Voltage Electron ◽

The Face ◽

Face Centered ◽

Interface Sliding ◽

Zn Alloy ◽

Made In

Interphase sliding is an important phenomenon of high temperature plasticity. In order to study the microstructural changes associated with it, as well as its influence on the strain rate dependence on stress and temperature, plane boundaries were obtained by welding together two polycrystals of Cu-Zn alloys having the face centered cubic and body centered cubic structures respectively following the procedure described in (1). These specimens were then deformed in shear along the interface on a creep machine (2) at the same temperature as that of the diffusion treatment so as to avoid any precipitation. The present paper reports observations by conventional and high voltage electron microscopy of the microstructure of both phases, in the vicinity of the phase boundary, after different creep tests corresponding to various deformation conditions.Foils were cut by spark machining out of the bulk samples, 0.2 mm thick. They were then electropolished down to 0.1 mm, after which a hole with thin edges was made in an area including the boundary

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The glycomes of Caenorhabditis elegans and other model organisms

Biochemical Society Symposium ◽

10.1042/bss0690117 ◽

2002 ◽

Vol 69 ◽

pp. 117-134 ◽

Cited By ~ 47

Author(s):

Stuart M. Haslam ◽

David Gems ◽

Howard R. Morris ◽

Anne Dell

Keyword(s):

Caenorhabditis Elegans ◽

Current Knowledge ◽

Structural Data ◽

Model Organisms ◽

Entire Genome ◽

C Elegans ◽

The Face ◽

Area Of Concern ◽

Nematode Worm

There is no doubt that the immense amount of information that is being generated by the initial sequencing and secondary interrogation of various genomes will change the face of glycobiological research. However, a major area of concern is that detailed structural knowledge of the ultimate products of genes that are identified as being involved in glycoconjugate biosynthesis is still limited. This is illustrated clearly by the nematode worm Caenorhabditis elegans, which was the first multicellular organism to have its entire genome sequenced. To date, only limited structural data on the glycosylated molecules of this organism have been reported. Our laboratory is addressing this problem by performing detailed MS structural characterization of the N-linked glycans of C. elegans; high-mannose structures dominate, with only minor amounts of complex-type structures. Novel, highly fucosylated truncated structures are also present which are difucosylated on the proximal N-acetylglucosamine of the chitobiose core as well as containing unusual Fucα1–2Gal1–2Man as peripheral structures. The implications of these results in terms of the identification of ligands for genomically predicted lectins and potential glycosyltransferases are discussed in this chapter. Current knowledge on the glycomes of other model organisms such as Dictyostelium discoideum, Saccharomyces cerevisiae and Drosophila melanogaster is also discussed briefly.

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Supporting the Use of Rudimentary Vocalizations

Perspectives on Augmentative and Alternative Communication ◽

10.1044/aac23.3.132 ◽

2014 ◽

Vol 23 (3) ◽

pp. 132-139 ◽

Cited By ~ 1

Author(s):

Lauren Zubow ◽

Richard Hurtig

Keyword(s):

Rett Syndrome ◽

Visual Cues ◽

Acoustic Analysis ◽

Eye Gaze ◽

Research Question ◽

Primary Research ◽

Multiple Modalities ◽

Face To Face ◽

Perceptual Judgments ◽

The Face

Children with Rett Syndrome (RS) are reported to use multiple modalities to communicate although their intentionality is often questioned (Bartolotta, Zipp, Simpkins, & Glazewski, 2011; Hetzroni & Rubin, 2006; Sigafoos et al., 2000; Sigafoos, Woodyatt, Tuckeer, Roberts-Pennell, & Pittendreigh, 2000). This paper will present results of a study analyzing the unconventional vocalizations of a child with RS. The primary research question addresses the ability of familiar and unfamiliar listeners to interpret unconventional vocalizations as “yes” or “no” responses. This paper will also address the acoustic analysis and perceptual judgments of these vocalizations. Pre-recorded isolated vocalizations of “yes” and “no” were presented to 5 listeners (mother, father, 1 unfamiliar, and 2 familiar clinicians) and the listeners were asked to rate the vocalizations as either “yes” or “no.” The ratings were compared to the original identification made by the child's mother during the face-to-face interaction from which the samples were drawn. Findings of this study suggest, in this case, the child's vocalizations were intentional and could be interpreted by familiar and unfamiliar listeners as either “yes” or “no” without contextual or visual cues. The results suggest that communication partners should be trained to attend to eye-gaze and vocalizations to ensure the child's intended choice is accurately understood.

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