Hormone therapy as risk factor of breast cancer modulated by diagnostic and lifestyle risk factors in Taiwan-A National Cohort study

Aims: It is important to identify characteristics of people who may be most at risk of COVID19 to inform policy and intervention. Little is known about the impact of unhealthy lifestyles including smoking, physical inactivity, obesity, and excessive alcohol intake. We conducted the first large scale general population study on lifestyle risk factors for COVID19. Methods: Prospective cohort study with national registry linkage to hospitalisation for COVID19. Participants were 387,109 men and women (56.4, SD 8.8 yr; 55.1% women) residing in England from UK Biobank study. Physical activity, smoking, and alcohol intake, were assessed by questionnaire at baseline (2006 to 2010). Body mass index, from measured height and weight, was used as an indicator of overall obesity. Outcome was cases of COVID19 serious enough to warrant a hospital admission from 16 March 2020 to 26 April 2020. Results: There were 760 COVID19 cases. After adjustment for age, sex and mutually for each lifestyle factor, physical inactivity (Relative risk, 1.32, 95% confidence interval, 1.10, 1.58), smoking (1.42;1.12, 1.79) and obesity (2.05 ;1.68, 2.49) but not heavy alcohol consumption (1.12; 0.93, 1.35) were all related to COVID19. We also found a dose dependent increase in risk of COVID19 with less favourable lifestyle scores, such that participants in the most adverse category had four fold higher risk (4.41; 2.52, 7.71) compared to people with the most optimal lifestyle. This gradient was little affected after adjustment for a wide range of covariates. Based on UK risk factor prevalence estimates, unhealthy behaviours in combination accounted for up to 51% of the population attributable fraction of severe COVID19. Conclusions and Relevance: Our findings suggest that an unhealthy lifestyle synonymous with an elevated risk of non-communicable disease is also a risk factor for COVID19 hospital admission, accounting for up to half of severe cases. Adopting simple lifestyle changes could lower the risk of severe infection.

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Metabolic and lifestyle risk factors for acute pancreatitis in Chinese adults: A prospective cohort study of 0.5 million people

PLoS Medicine ◽

10.1371/journal.pmed.1002618 ◽

2018 ◽

Vol 15 (8) ◽

pp. e1002618 ◽

Cited By ~ 4

Author(s):

Yuanjie Pang ◽

Christiana Kartsonaki ◽

Iain Turnbull ◽

Yu Guo ◽

Ling Yang ◽

...

Keyword(s):

Risk Factors ◽

Acute Pancreatitis ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Chinese Adults ◽

Lifestyle Risk Factors ◽

Lifestyle Risk

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Influence of Occupational Type and Lifestyle Risk Factors on Prevalence of Metabolic Syndrome among Male Workers: A Retrospective Cohort Study

Korean Journal of Adult Nursing ◽

10.7475/kjan.2016.28.2.180 ◽

2016 ◽

Vol 28 (2) ◽

pp. 180 ◽

Cited By ~ 3

Author(s):

So Hui Kang ◽

Seon Young Hwang

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Lifestyle Risk Factors ◽

Lifestyle Risk ◽

Male Workers

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Sleep Duration Interacts With Lifestyle Risk Factors and Health Status to Alter Risk of All-Cause Mortality: The Rural Chinese Cohort Study

Journal of Clinical Sleep Medicine ◽

10.5664/jcsm.7124 ◽

2018 ◽

Vol 14 (05) ◽

pp. 857-865 ◽

Cited By ~ 4

Author(s):

Feiyan Liu ◽

Hongyan Zhang ◽

Yu Liu ◽

Xizhuo Sun ◽

Zhaoxia Yin ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Health Status ◽

Sleep Duration ◽

Lifestyle Risk Factors ◽

All Cause Mortality ◽

Chinese Cohort ◽

Lifestyle Risk

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Lifestyle Risk Factors and All-Cause and Cardiovascular Disease Mortality: Data from the Korean Longitudinal Study of Aging

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16173040 ◽

2019 ◽

Vol 16 (17) ◽

pp. 3040 ◽

Cited By ~ 3

Author(s):

Inhwan Lee ◽

Shinuk Kim ◽

Hyunsik Kang

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Risk Factor ◽

Physical Inactivity ◽

Mortality Data ◽

Lifestyle Risk Factors ◽

Disease Mortality ◽

Increased Risk ◽

Lifestyle Risk ◽

Cvd Mortality

This study examined the association between lifestyle risk factors and all-cause and cardiovascular disease (CVD) mortality in 9945 Korea adults (56% women) aged 45 years and older. Smoking, heavy alcohol intake, underweight or obesity, physical inactivity, and unintentional weight loss (UWL) were included as risk factors. During 9.6 ± 2.0 years of follow-up, there were a total of 1530 cases of death from all causes, of which 365 cases were from CVD. Compared to a zero risk factor (hazard ratio, HR = 1), the crude HR of all-cause mortality was 1.864 (95% CI, 1.509–2.303) for one risk factor, 2.487 (95% confidence interval, CI, 2.013–3.072) for two risk factors, and 3.524 (95% CI, 2.803–4.432) for three or more risk factors. Compared to a zero risk factor (HR = 1), the crude HR of CVD mortality was 2.566 (95% CI, 1.550–4.250) for one risk factor, 3.655 (95% CI, 2.211–6.043) for two risk factor, and 5.416 (95% CI, 3.185–9.208) for three or more risk factors. The HRs for all-cause and CVD mortality remained significant even after adjustments for measured covariates. The current findings showed that five lifestyle risk factors, including smoking, at-risk alcohol consumption, underweight/obesity, physical inactivity, and UWL, were significantly associated with an increased risk of all-cause and CVD mortality in Korean adults.

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