scholarly journals Risk factors associated with unsuccessful tuberculosis treatment outcomes in Hunan Province, China

2022 ◽  
Author(s):  
Beth Gilmour ◽  
Zuhui Xu ◽  
Liqiong Bai ◽  
Kefyalew Addis Alene ◽  
Archie C A Clements
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Tuberculosis Treatment ◽  
Hunan Province ◽  
Factors Associated

Incidence and Risk Factors Associated With Tuberculosis Treatment Outcomes Among Prisoners

2019 ◽  
Vol 27 (3) ◽  
pp. 148-154
Author(s):  
Amer Hayat Khan ◽  
Syed Azhar Syed Sulaiman ◽  
Abdul Razak Abdul Muttalif ◽  
Mohamed Azmi Ahmad Hassali ◽  
Raja Ahsan Aftab ◽  
...  
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Tuberculosis Treatment ◽  
Factors Associated

scholarly journals Factors associated with treatment failure, dropout, and death in a cohort of tuberculosis patients in Recife, Pernambuco State, Brazil

2007 ◽  
Vol 23 (7) ◽  
pp. 1573-1582 ◽  
Author(s):  
Maria de Fátima Pessoa Militão de Albuquerque ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Norma Lucena-Silva ◽  
Wayner Vieira de Souza ◽  
Andréa Tavares Dantas ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Treatment Outcomes ◽  
Group Treatment ◽  
Healthcare Access ◽  
Treatment Delay ◽  
Tuberculosis Treatment ◽  
Directly Observed Therapy ◽  
Factors Associated ◽  
Family Health Program ◽  
Tb Treatment

A cohort of cases initiating tuberculosis treatment from May 2001 to July 2003 was followed in Recife, Pernambuco State, Brazil, to investigate biological, clinical, social, lifestyle, and healthcare access factors associated with three negative tuberculosis treatment outcomes (treatment failure, dropout, and death) separately and as a group. Treatment failure was associated with treatment delay, illiteracy, and alcohol consumption. Factors associated with dropout were age, prior TB treatment, and illiteracy. Death was associated with age, treatment delay, HIV co-infection, and head of family's income. Main factors associated with negative treatment outcomes as a whole were age, HIV co-infection, illiteracy, alcoholism, and prior TB treatment. We suggest the following strategies to increase cure rates: further training of the Family Health Program personnel in TB control, awareness-raising on the need to tailor their activities to special care for cases (e.g., literacy training); targeting use of directly observed therapy for higher risk groups; establishment of a flexible referral scheme to handle technical and psychosocial problems, including alcoholism; and increased collaboration with the HIV/AIDS program.

Risk factors associated with outcomes following neoadjuvant chemoradiotherapy prior to esophagectomy in patients with adenocarcinoma of the esophagus.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 186-186
Author(s):  
Khalil Boussi ◽  
Tarita Thomas ◽  
Sam G. Pappas ◽  
Brendan Martin
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Lymph Nodes ◽  
Treatment Outcomes ◽  
Neoadjuvant Therapy ◽  
Metastatic Cancer ◽  
Neoadjuvant Chemoradiotherapy ◽  
Factors Associated ◽  
Post Surgery ◽  
Positive Lymph Nodes

186 Background: The study was conducted to evaluate risk factors associated with treatment outcomes following concurrent chemoradiotherapy (CRT) and esophagectomy in patients diagnosed with resectable esophageal cancer. Methods: IRB approval was obtained to evaluate patients with esophageal cancer treated at our center from 2002 to 2017 with neoadjuvant CRT followed by esophagectomy. Patient characteristics pre and post-surgery including age, number of positive lymph nodes, length of time between neoadjuvant therapy and surgery were evaluated. Univariable and multivariable frailty survival analysis were used to evaluate the association between risk factors and treatment outcomes. Results: 74 patients met inclusion criteria of CRT and esophagectomy. Controlling for the number of days between the end of radiotherapy and surgery, the hazard of death for patients who developed metastatic cancer following completion of therapy was 2.08 (95 CI: 1.04 – 4.13) times higher compared to patients who did not develop metastasis (p = .04). Adjusting for metastatic cancer, for every five additional days between the end of radiotherapy and surgery, patients’ hazard of death increased 5% (HR = 1.05, 95 CI: 1.02 – 1.07, p < .001). Controlling for metastatic cancer and the number of positive nodes, for every one-year increase in age, patients’ hazard of recurrence decreased 5% (HR = 0.95, 95 CI: 0.91 – 0.99, p = .04). Adjusting for age and the number of positive nodes, the hazard of recurrence for patients who developed metastatic cancer was 28.57 (95 CI: 6.58-123.97) times higher compared to patients without metastasis (p < .0001). Conclusions: Longer duration between completion of CRT and surgery as well as developing metastatic disease are associated with a significantly higher hazard of death. Additionally, developing metastatic cancer, increase in age, and additional positive lymph nodes are all associated with a significantly higher hazard of recurrence. Optimal timing between neoadjuvant therapy and surgery needs to be evaluated further, as increasing hazard of death following therapy suggests that there may be a role for adjuvant chemotherapy in these patients.

scholarly journals Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke

2020 ◽  
Vol 17 (2) ◽  
pp. 618 ◽  
Author(s):  
Yi-Ju Tseng ◽  
Ru-Fang Hu ◽  
Shin-Tyng Lee ◽  
Yu-Li Lin ◽  
Chien-Lung Hsu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Treatment Outcomes ◽  
Plasminogen Activator ◽  
Tissue Type ◽  
Hospital Death ◽  
Factors Associated ◽  
Laboratory Test Results ◽  
Poor Outcomes

Ischemic stroke is the most common type of stroke, and early interventional treatment is associated with favorable outcomes. In the guidelines, thrombolytic therapy using recombinant tissue-type plasminogen activator (rt-PA) is recommended for eligible patients with acute ischemic stroke. However, the risk of hemorrhagic complications limits the use of rt-PA, and the risk factors for poor treatment outcomes need to be identified. To identify the risk factors associated with in-hospital poor outcomes in patients treated with rt-PA, we analyzed the electronic medical records of patients who were diagnosed with acute ischemic stroke and treated for rt-PA at Chang Gung Memorial Hospitals from 2006 to 2016. In-hospital death, intensive care unit (ICU) stay, or prolonged hospitalization were defined as unfavorable treatment outcomes. Medical history variables and laboratory test results were considered variables of interest to determine risk factors. Among 643 eligible patients, 537 (83.5%) and 106 (16.5%) patients had favorable and poor outcomes, respectively. In the multivariable analysis, risk factors associated with poor outcomes were female gender, higher stroke severity index (SSI), higher serum glucose levels, lower mean corpuscular hemoglobin concentration (MCHC), lower platelet counts, and anemia. The risk factors found in this research could help us study the treatment strategy for ischemic stroke.

scholarly journals Risk factors for poor multidrug-resistant tuberculosis treatment outcomes in Kyiv Oblast, Ukraine

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Omowunmi Aibana ◽  
Mariya Bachmaha ◽  
Viatcheslav Krasiuk ◽  
Natasha Rybak ◽  
Timothy P. Flanigan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Multidrug Resistant ◽  
Tuberculosis Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals The Effect of Incarceration on Tuberculosis Treatment Outcomes in Brazil: a Retrospective Cohort Study

2021 ◽  
Author(s):  
Jamieson M. O'Marr ◽  
Crhistinne Goncalves ◽  
Denise Arakaki-Sanchez ◽  
Daniele Maria Pelissari ◽  
Fernanda Dockhorn Costa ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Latin American ◽  
Treatment Success ◽  
Tuberculosis Treatment ◽  
Directly Observed Therapy ◽  
Multivariate Logistic Regression ◽  
Factors Associated ◽  
The Past ◽  
Incarcerated Population ◽  
Poor Outcomes

Background: Tuberculosis notifications in Latin American prisons have more than doubled over the past two decades; however, treatment outcomes and their determinants among incarcerated individuals in this region are not well understood. Methods: Newly diagnosed drug-susceptible tuberculosis cases reported to Brazils Sistema de Informação de Agravos de Notificação (SINAN) between January 2015 and December 2017 were included. Multivariate logistic regression was used to assess socioeconomic and clinical factors associated with treatment success among incarcerated individuals. Results: Incarcerated individuals (n=17,776) had greater treatment success than non-incarcerated individuals (n=160,728; 82.2% vs 75.1%, p<0.0001), including after adjusting for demographic and clinical risk factors (adjusted Odds Ratio [aOR]: 1.27; 95% CI: 1.19-1.34). These differences were partially mediated by increased use of directly observed therapy among incarcerated individuals (DOT) (61% vs 47%, p<0.001), which was associated with greater efficacy in the incarcerated population (aOR 2.56 vs aOR 2.17; p<0.001). DOT was associated with improved treatment success among incarcerated subpopulations at elevated risk of poor outcomes. Conclusion: Tuberculosis treatment success among incarcerated individuals in Brazil is higher than non-incarcerated individuals, but both fall below WHO targets. Expanding the use of DOT and services for socially and medically vulnerable individuals may improve outcomes in carceral settings.

Factors Associated with Unsuccessful Outcomes of Tuberculosis Treatment in 125 Municipalities in Colombia 2014 to 2016

2021 ◽  
Author(s):  
Lizeth Andrea Paniagua-Saldarriaga ◽  
Daniele Maria Pelissari ◽  
Zulma Vanessa Rueda
Keyword(s):  
Risk Factors ◽  
Health Insurance ◽  
Treatment Success ◽  
Tuberculosis Treatment ◽  
People Living With Hiv ◽  
Surveillance Systems ◽  
Factors Associated ◽  
Tb Treatment ◽  
Lost To Follow Up

Our aim was to identify the risk factors associated with unsuccessful outcomes of tuberculosis (TB) treatment in patients diagnosed between 2014 and 2016 in the 125 municipalities of Antioquia, Colombia. We studied a retrospective cohort of patients with TB diagnosed between 2014 and 2016, from national routine surveillance systems, in 125 municipalities of Antioquia. Factors associated with unsuccessful tuberculosis treatment outcomes (treatment failed, lost to follow up, or death) were identified utilizing a Poisson regression with robust variance. Over 3 years, of the 6,739 drug-susceptible tuberculosis patients, 73.4% had successful treatment and 26.6% unsuccessful outcomes (17% lost to follow up, 8.9% deaths, and 0.7% treatment failures). Patients with subsidized health insurance (Relative risk [RR]: 2.4; 95% CI: 2.1–2.8) and without health insurance (RR: 2.5; 95% CI: 2.1–3.0) had a higher risk for unsuccessful tuberculosis treatment compared to those with contributive health insurance. Other risk factors included age over 15 years, male sex, homelessness, people living with HIV, previous treatment, and primary diagnosis during hospitalization. Protective factors were living in a rural area and extrapulmonary disease. It is important to generate strategies that improves tuberculosis diagnosis in primary healthcare institutions. In addition, it is imperative to initiate new research about the barriers and obstacles related to patients, healthcare workers and services, and the health system, including the analysis of urban violence, to understand why the goal of TB treatment success has not been reached.

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