Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices

2019 ◽  
Author(s):  
Jessica Doan ◽  
Peter Phommahaxay ◽  
Sarah Olson ◽  
Matthew A. Petersen
Keyword(s):  
Drug Release ◽  
Medical Devices ◽  
Thermoplastic Polyurethane ◽  
Release Behavior ◽  
Implantable Medical Devices ◽  
Industry Standard ◽  
Rapid Characterization ◽  
The Impact ◽  
Standard Components

We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.

Drug release behavior of electrospun twisted yarns as implantable medical devices

2016 ◽  
Vol 8 (3) ◽  
pp. 035019 ◽  
Author(s):  
H Maleki ◽  
A A Gharehaghaji ◽  
T Toliyat ◽  
P J Dijkstra
Keyword(s):  
Drug Release ◽  
Medical Devices ◽  
Release Behavior ◽  
Implantable Medical Devices ◽  
Drug Release Behavior

In Vitro Release Characterization of Tetracycline Hydrochloride from PLGA/Tetracycline Hydrochloride Electrospun Nanofiber Mats

2013 ◽  
Vol 785-786 ◽  
pp. 339-345 ◽  
Author(s):  
Jian Fei Xie ◽  
Chun Yan Li ◽  
Shu Han Hong ◽  
Yu Rong Yan
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
Tetracycline Hydrochloride ◽  
Release Behavior ◽  
In Vitro Drug Release ◽  
Hydrophilic Drugs ◽  
Release Ratio ◽  
Nanofiber Mats

In order to study in vitro release behavior of hydrophilic drugs in polymer nanofibers and establish a fast characterization method, tetracycline hydrochloride-loaded poly (lacticacid-co-glycolic acid) nanofiber mats with varied tetracycline hydrochloride contents and different lacticacid to glycolic ratios in PLGA were preparied by electrospinning. Accroding to Chinese Pharmacopoeia, a basic and an improved test devices and processes were compared and their validity were commented by using an UV-visible spectrophotometer method. Results showed that the improved method can be used to estimate in vitro drug release behavior of drug-loaded mats and the results was better than the basic method. When temperature affected cumulative release ratio under controlled error, flotation method can replace the centrifugation method during the first stage of drug release testing process. Parallel experiments were carried out and results indicated that nanofibres on different part of mats had a relative stable result and repeat experimental error was kept below 4%.

Mechanical reliability of ceramic packages for active implantable medical devices - The IEC hammer test

2014 ◽  
Vol 2014 (1) ◽  
pp. 000319-000324 ◽  
Author(s):  
F. Kohler ◽  
T. Stieglitz ◽  
M. Schuettler
Keyword(s):  
Medical Devices ◽  
High Stress ◽  
Axially Symmetric ◽  
Protective Material ◽  
Implantable Medical Devices ◽  
Mechanical Impact ◽  
Event Simulation ◽  
Laboratory Setup ◽  
Computer Interfaces ◽  
The Impact

Implantable neural prostheses have to fulfill manifold requirements, from the technological side as well as legally. One particular normative demand for active implantable medical devices (AIMDs) which are intended to be implanted in the skull, is withstanding a mechanical impact of 2.5 J, defined by BS EN 45502-2-3:2010 and IEC 60068-2-75:1997. This article shows two computational approaches based on finite element modeling to evaluate the influence of geometrical variations on a brain-computer interfaces' mechanical package stability and the likelihood of withstanding mechanical impact. The presence of a fillet at inner edges (>0.5 mm) as well as a minimum wall thickness of 1 mm could be identified as a mandatory design requirements for axially symmetric packages to avoid extensively high stress levels. Mechanical event simulation (MES) predicted a passing of the hammer test if additional protective material (silicone rubber) is used. This however is postulated by the EN 45502-2-3 standard. The computational findings could be confirmed in a laboratory setup of the impact test.

scholarly journals Microneedle Patterning of 3D Nonplanar Surfaces on Implantable Medical Devices Using Soft Lithography

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 705 ◽  
Author(s):  
Jang ◽  
Doshi ◽  
Nerayo ◽  
Caprio ◽  
Alaie ◽  
...  
Keyword(s):  
Thin Film ◽  
Medical Devices ◽  
Soft Lithography ◽  
Bulk Material ◽  
Thermoplastic Polyurethane ◽  
Implantable Medical Devices ◽  
Lithographic Patterning ◽  
3D Objects ◽  
Microneedle Arrays ◽  
Planar Substrates

Micropatterning is often used to engineer the surface properties of objects because it allows the enhancement or modification of specific functionalities without modification of the bulk material properties. Microneedle arrays have been explored in the past for drug delivery and enhancement of tissue anchoring; however, conventional methods are primarily limited to thick, planar substrates. Here, we demonstrate a method for the fabrication of microneedle arrays on thin flexible polyurethane substrates. These thin-film microneedle arrays can be used to fabricate balloons and other inflatable objects. In addition, these thin-filmed microneedles can be transferred, using thermal forming processes, to more complex 3D objects on which it would otherwise be difficult to directly pattern microneedles. This function is especially useful for medical devices, which require effective tissue anchorage but are a challenging target for micropatterning due to their 3D nonplanar shape, large size, and the complexity of the required micropatterns. Ultrathin flexible thermoplastic polyurethane microneedle arrays were fabricated from a polydimethylsiloxane (PDMS) mold. The technique was applied onto the nonplanar surface of rapidly prototyped soft robotic implantable polyurethane devices. We found that a microneedle-patterned surface can increase the anchorage of the device to a tissue by more than twofold. In summary, our soft lithographic patterning method can rapidly and inexpensively generate thin-film microneedle surfaces that can be used to produce balloons or enhance the properties of other 3D objects and devices.

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

2020 ◽  
Vol 35 (1) ◽  
pp. 39-48
Author(s):  
Fan Zhao ◽  
Haiyan Xu ◽  
Wen Xue ◽  
Yan Li ◽  
Jing Sun ◽  
...  
Keyword(s):  
Medical Devices ◽  
Melt Spinning ◽  
Imaging Techniques ◽  
Fibrous Materials ◽  
Hybrid Fibers ◽  
Implantable Medical Devices ◽  
X Ray ◽  
The Impact

Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then a set of iodinated poly( p-dioxanone) (PPDO) fibers was fabricated via melt-spinning hybrid blends of PPDO with TIBA (PPDO/TIBA). The impact of TIBA content on the rheological behavior of blends was evaluated firstly. The physical, chemical, and thermal properties of PPDO/TIBA fibers were investigated accordingly by SEM, FTIR, DSC, and TGA. Moreover, the radiopaque property of PPDO/TIBA hybrid fibers as a potential radio-opacifying platform for medical devices was verified in vitro and in vivo. Finally, the accumulated release results of the hybrid fibers during in vitro degradation indicate the continual X-ray visibility of the hybrid fibers maintains for 22 days. This intriguing iodinated platform may pave the way for constructing fibrous materials with in-situ X-ray tracking property.

Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate

2021 ◽  
pp. 096739112199027
Author(s):  
M Sohail Sarwar ◽  
Abdul Ghaffar ◽  
Qingrong Huang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Composite Film ◽  
Sodium Alginate ◽  
Composite Films ◽  
Simulated Gastric Fluid ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Model Drug

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

Analyzing the impact of different excipients on drug release behavior in hot-melt extrusion formulations using FTIR spectroscopic imaging

2015 ◽  
Vol 67 ◽  
pp. 21-31 ◽  
Author(s):  
Marieke Pudlas ◽  
Samuel O. Kyeremateng ◽  
Leonardo A.M. Williams ◽  
James A. Kimber ◽  
Holger van Lishaut ◽  
...  
Keyword(s):  
Drug Release ◽  
Spectroscopic Imaging ◽  
Hot Melt Extrusion ◽  
Release Behavior ◽  
Melt Extrusion ◽  
Drug Release Behavior ◽  
The Impact ◽  
Hot Melt

scholarly journals On the review of electronic technologies applied to implantable medical devices

2021 ◽  
Author(s):  
Ronny García-Ramírez ◽  
Gabriel Madrigal-Boza ◽  
Edgar Solera-Bolaños ◽  
Muhammad Ali Siddiqi ◽  
Christos Strydis ◽  
...  
Keyword(s):  
Medical Devices ◽  
Scientific Community ◽  
Heterogeneous Systems ◽  
Point Of View ◽  
Proof Of Concept ◽  
Implantable Medical Devices ◽  
Heart Arrhythmia ◽  
Sql Database ◽  
The Impact ◽  
Electronic Technologies

The development of electronic implantable medical devices (IMD) has been increasing over the years, targeting very diverse applications and implementing different technologies. The impact of IMDs in the treatment of different ailments like Parkinson’s disease, hearing impairment, heart arrhythmia, and chronic pain, among many others, has been notorious and inspired their exploration to treat other health problems. Even when there is great interest in the scientific community for the exploration and development of IMDs, no standards are ruling its development. This lack of standardization is the reason why the analysis of the tendencies of this area from the technical point of view becomes complex. The analysis of the tendencies in the development of IMD devices required the exploration of diverse sources, which describe heterogeneous systems using very different approaches and methodologies for similar problems. In this paper an open SQL database intended for collecting information from IMD publications is presented; at this point, more than 200 published works are feed in the database covering a period from 1974 to 2018. This database is extensible and enables researchers to find trends and explore the development of IMDs from a broader perspective. We also used this database as a proof of concept to explore some general trends in the design of  IMDs based on the included works.

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