Analysis of Ablation Volume Produced During Microwave Ablation of Breast Cancerous Lesion Using Fourier and Non-Fourier Models

Author(s):  
Vellavalapalli Satish ◽  
Jatin Kumar ◽  
Ramjee Repaka

Abstract The present article aims to compare the change in the temperature and ablation volume during Microwave ablation procedure. The microwave ablation process is carried out using Fourier and non-Fourier bioheat transfer models in the computational domain of breast tumor. The above models have been considered with the relaxation time known as thermal delay during ablation procedure at constant power and frequency. The above objective has been carried out on a heterogeneous three compartment Breast model using COMSOL-Multiphysics software, with inbuilt bioheat transfer and electromagnetic waves Physics interfaces. The simulation results show that the ablation volume is slightly greater while using Fourier bioheat transfer model as compared to the non-Fourier bioheat transfer model. Further, the temperature distribution also shows that there is a slight variation initially at the start of the ablation, i.e., Fourier heat transfer model shows nearly 2°C more temperature as compared to the non Fourier model and becomes equal as the time increases. The present study helps in establishing the better clinical procedure of Microwave Ablation technique.

2013 ◽  
Vol 2 (3) ◽  
Author(s):  
Guangxia Hu ◽  
Zhiyu Qian ◽  
Shangwen Ding ◽  
Ye Zhang ◽  
Jieru Xie

Abstract:This paper reports on an effective ablation volume model for microwave ablation of porcine liver. Firstly, in order to obtain the temperature field distribution, a theoretical simulation model of the microwave ablation of porcine liver was developed by solving Pennes bioheat transfer equation using the COMSOL Multiphysics software. Then the effective ablation volume and the effective ablation volume model were obtained using the 1stOpt fitting software by 7D-Soft High Technology Inc. (China). Finally, microwave ablation experiments were carried out using porcine liver to verify the accuracy and effectiveness of the model. The results show that according to the ablation volume model, one can determine the scope of the effective ablation under varying conditions of microwave power and duration. This provides an important basis for the preoperative planning system of microwave ablation.


Author(s):  
Stewart Xu Cheng ◽  
James S. Wallace

Glow plugs are a possible ignition source for direct injected natural gas engines. This ignition assistance application is much different than the cold start assist function for which most glow plugs have been designed. In the cold start application, the glow plug is simply heating the air in the cylinder. In the cycle-by-cycle ignition assist application, the glow plug needs to achieve high surface temperatures at specific times in the engine cycle to provide a localized source of ignition. Whereas a simple lumped heat capacitance model is a satisfactory representation of the glow plug for the air heating situation, a much more complex situation exists for hot surface ignition. Simple measurements and theoretical analysis show that the thickness of the heat penetration layer is small within the time scale of the ignition preparation period (1–2 ms). The experiments and analysis were used to develop a discretized representation of the glow plug domain. A simplified heat transfer model, incorporating both convection and radiation losses, was developed for the discretized representation to compute heat transfer to and from the surrounding gas. A scheme for coupling the glow plug model to the surrounding gas computational domain in the KIVA-3V engine simulation code was also developed. The glow plug model successfully simulates the natural gas ignition process for a direct-injection natural gas engine. As well, it can provide detailed information on the local glow plug surface temperature distribution, which can aid in the design of more reliable glow plugs.


Author(s):  
Виктор Михайлович Белолипецкий ◽  
Светлана Николаевна Генова

Практический интерес в районах вечной мерзлоты представляет глубина сезонного оттаивания. Построена одномерная (в вертикальном направлении) упрощенная полуэмпирическая модель динамики вечной мерзлоты в “приближении медленных движений границ фазового перехода”, основанная на задаче Стефана и эмпирических соотношениях. Калибровочные параметры модели выбираются для исследуемого района с использованием натурных измерений глубины оттаивания и температуры воздуха. Проверка работоспособности численной модели проведена для района оз. Тулик (Аляска). Получено согласие рассчитанных значений глубины талого слоя и температуры поверхности почвы с результатами измерений Due to the change in global air temperature, the assessment of permafrost reactions to climate change is of interest. As the climate warms, both the thickness of the thawed soil layer and the period for existence of the talik are increased. The present paper proposes a small-size numerical model of vertical temperature distributions in the thawed and frozen layers when a frozen layer on the soil surface is absent. In the vertical direction, thawed and frozen soils are separated. The theoretical description of the temperature field in soils when they freeze or melt is carried out using the solution of the Stefan problem. The mathematical model is based on thermal conductivity equations for the frozen and melted zones. At the interfacial boundary, the Dirichlet condition for temperature and the Stefan condition are set. The numerical methods for solving of Stefan problems are divided into two classes, namely, methods with explicit division of fronts and methods of end-to-end counting. In the present work, the method with the selection of fronts is implemented. In the one-dimensional Stefan problem, when transformed to new variables, the computational domain in the spatial variable is mapped onto the interval [0 , 1]. In the presented equations, the convective terms characterize the rate of temperature transfer (model 1). A simplified version of the Stefan problem solution is considered without taking into account this rate (“approximation of slow movements of the boundaries of the phase transition”, model 2). The model is tuned to a specific object of research. Model parameter values can vary significantly in different geographic regions. This paper simulates the dynamics of permafrost in the area of Lake Tulik (Alaska) in summer. Test calculations based on the proposed simplified model show its adequacy and consistency with field measurements. The developed model can be used for qualitative studies of the long-term dynamics of permafrost using data of the air temperature, relative air humidity and precipitation


1989 ◽  
Vol 111 (4) ◽  
pp. 263-270 ◽  
Author(s):  
C. K. Charny ◽  
R. L. Levin

A bioheat transfer model which computes the spatial variations in the arteriole, venule, and muscle temperatures in a human extremity under both resting and hyperthermic conditions is presented. This model uses the two-parameter model first proposed by Baish et al. [2] to account for the heat exchange between tissue and the paired arterioles and venules that comprise the microcirculation. Thermoregulation of the muscle blood flow during hyperthermia is also incorporated into the model. Results show that even when the paired arteriole and venule are assumed to have equal radii, the mean temperature under both steady and transient conditions is not equal to the mean of the arteriole and venule blood temperatures. Tissue temperature profiles during hyperthermia computed with the three-equation model presented in this study are similar in shape and magnitude to those predicted by the traditional one-equation Pennes bioheat transfer model [1]. This is due primarily to the influence of thermoregulatory mechanism in the heated muscle. The unexpected agreement is significant given the inherent relative simplicity of the traditional Pennes model. An “experimental” thermal conductivity is presented to relate the theoretical results to experimental procedures that are widely used to estimate the enhancement of conductivity by perfusion.


Author(s):  
Jatin Kumar ◽  
Ramjee Repaka

Abstract Microwave ablation (MWA) is a newly developed minimally invasive tumor therapy which possesses several advantages over the existing thermal therapies. Despite the several advantages, MWA also suffers same disadvantages similar to other thermal therapies like poor control over ablation volume. Sensitivity of different tissue parameters is the key factor to design a MWA protocol. In this work, sensitivity analysis has been conducted to quantify the effect of three cancerous breast parameters, viz., breast composition, tumor location, and tumor size, on the efficacy of MWA of breast cancer. Ablation volume has been taken as the indicator of the ablation efficacy during MWA procedure. A Taguchi's design of experimental approach has been utilized to optimize the number of simulations required for the analysis and then analysis of variance (ANOVA) has been performed to predict the most sensitive parameter along with their individual contribution. Finite element approach-based simulations have been performed in a multiphysics software. First, a grid-independent study has been established to optimize the number of mesh elements and to reduce the computational cost. Then, after finding the most optimum grid size, all the simulations have been performed in accordance with the protocol obtained from Taguchi's design of experiment approach and finally statistical analysis software has been used for analyzing Taguchi's design. It has been found that, the breast composition to be the most significant factor, with maximum contribution in ablation volume, among three considered factors followed by tumor location and tumor size, respectively.


Author(s):  
Daniel Chinn ◽  
Elvis Nditafon ◽  
Alvin Yew ◽  
Chandrasekhar Thamire

Thermal therapy for treatment of benign prostatic hyperplasia (BPH) is becoming increasingly popular due to the minimally invasive nature of the treatment. Successful management of such therapy requires accurate estimation of thermal dosage. The purpose of this study is to provide correlations for the thermal damage caused by ultrasound, microwave, and infrared devices under a range of operating conditions. A boundary-fitting finite difference method is used to examine the heat transfer in the prostate gland and surrounding tissue. The Pennes bioheat transfer model and a porous media model were utilized to calculate temperature histories. Necrosis zones were determined using published necrosis data for prostatic tissue and cells. Thermal damage correlations for the three different hyperthermia sources along with sample temperature contours and necrosis zones are presented. Results indicate that the applicator power level and heating time are the most important parameters in achieving the desired necrosis zones, while coolant parameters strongly affect the temperatures of the sensitive urethra and serve as constraints for protocol parameters. Out of the three sources evaluated, ultrasound modality appears to be the most capable of causing necrosis in the target zones, with least damage to the surrounding healthy tissues.


2016 ◽  
Vol 13 (10) ◽  
pp. 6728-6732
Author(s):  
P Revathy ◽  
V Sadasivam ◽  
T. Ajith Bosco Raj

In this research paper a new temperature prediction method is proposed to predict the temperature in liver during thermal ablation which also takes in to account the blood flow cooling. The proposed method suggest a modification of Pennes bioheat transfer equation (PBHTE) inorder to more accurately predict the treatment temperature. The temperature elevation by the proposed heat transfer model is compared with the PBHTE model and the other two heat continuum models by Wulff and Klinger. Appropriate temperature prediction is useful in treatment planning. This may reduce the recurrence level of cancer. Further the reduction in treatment time increases patient safety.


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