Stiffness Comparisons Between Adventitia, Media and Full Thickness Specimens From Human Atherosclerotic Carotid Arteries

Author(s):  
Allen H. Hoffman ◽  
Zhongzhao Teng ◽  
Calvin Mui ◽  
Jie Zheng ◽  
Pamela K. Woodard ◽  
...  

Arteries display highly nonlinear, anisotropic material behavior and can be considered to be a layered composite of fiber oriented materials composed of three layers: intima, media and adventitia. The intima does not affect the material properties of the artery. Thus, the mechanical properties of an artery result from the combined interaction of the media and adventitia with each layer displaying different material properties. It has been widely accepted that atherosclerosis changes the material properties of the arterial wall. However, little experimental data exists relating the properties of the media and adventitia of atherosclerotic vessels to the overall properties of the artery. Knowledge of the properties of human atherosclerotic tissues is essential for an improved understanding the effects of atherosclerosis and also for creating more accurate computational models for predicting the effects of the disease [1]. A prior study of bovine carotid arteries determined the properties of the adventitia and media using a deductive method [2]. This paper focuses on directly measuring and comparing the stiffness of paired samples of adventitia, media and full thickness specimens from human atherosclerotic carotid arteries.

2017 ◽  
Vol 139 (12) ◽  
Author(s):  
Allen H. Hoffman ◽  
Zhongzhao Teng ◽  
Jie Zheng ◽  
Zheyang Wu ◽  
Pamela K. Woodard ◽  
...  

Arteries can be considered as layered composite material. Experimental data on the stiffness of human atherosclerotic carotid arteries and their media and adventitia layers are very limited. This study used uniaxial tests to determine the stiffness (tangent modulus) of human carotid artery sections containing American Heart Association type II and III lesions. Axial and circumferential oriented adventitia, media, and full thickness specimens were prepared from six human carotid arteries (total tissue strips: 71). Each artery yielded 12 specimens with two specimens in each of the following six categories; axial full thickness, axial adventitia (AA), axial media (AM), circumferential full thickness, circumferential adventitia (CA), and circumferential media (CM). Uniaxial testing was performed using Inspec 2200 controlled by software developed using labview. The mean stiffness of the adventitia was 3570 ± 667 and 2960 ± 331 kPa in the axial and circumferential directions, respectively, while the corresponding values for the media were 1070 ± 186 and 1800 ± 384 kPa. The adventitia was significantly stiffer than the media in both the axial (p = 0.003) and circumferential (p = 0.010) directions. The stiffness of the full thickness specimens was nearly identical in the axial (1540 ± 186) and circumferential (1530 ± 389 kPa) directions. The differences in axial and circumferential stiffness of media and adventitia were not statistically significant.


Author(s):  
Ines Gilch ◽  
Tobias Neuwirth ◽  
Benedikt Schauerte ◽  
Nora Leuning ◽  
Simon Sebold ◽  
...  

AbstractTargeted magnetic flux guidance in the rotor cross section of rotational electrical machines is crucial for the machine’s efficiency. Cutouts in the electrical steel sheets are integrated in the rotor sheets for magnetic flux guidance. These cutouts create thin structures in the rotor sheets which limit the maximum achievable rotational speed under centrifugal forces and the maximum energy density of the rotating electrical machine. In this paper, embossing-induced residual stress, employing the magneto-mechanical Villari effect, is studied as an innovative and alternative flux barrier design with negligible mechanical material deterioration. The overall objective is to replace cutouts by embossings, increasing the mechanical strength of the rotor. The identification of suitable embossing geometries, distributions and methodologies for the local introduction of residual stress is a major challenge. This paper examines finely distributed pyramidal embossings and their effect on the magnetic material behavior. The study is based on simulation and measurements of specimen with a single line of twenty embossing points performed with different punch forces. The magnetic material behavior is analyzed using neutron grating interferometry and a single sheet tester. Numerical examinations using finite element analysis and microhardness measurements provide a more detailed understanding of the interaction of residual stress distribution and magnetic material properties. The results reveal that residual stress induced by embossing affects magnetic material properties. Process parameters can be applied to adjust the magnetic material deterioration and the effect of magnetic flux guidance.


2021 ◽  
Author(s):  
Silvia J. Sarmiento Nova ◽  
Jaime Gonzalez-Libreros ◽  
Gabriel Sas ◽  
Rafael A. Sanabria Díaz ◽  
Maria C. A. Texeira da Silva ◽  
...  

<p>The Response Surface Method (RSM) has become an essential tool to solve structural reliability problems due to its accuracy, efficacy, and facility for coupling with Nonlinear Finite Element Analysis (NLFEA). In this paper, some strategies to improve the RSM efficacy without compromising its accuracy are tested. Initially, each strategy is implemented to assess the safety level of a highly nonlinear explicit limit state function. The strategy with the best results is then identified and used to carry out a reliability analysis of a prestressed concrete bridge, considering the nonlinear material behavior through NLFEA simulation. The calculated value of &#120573; is compared with the target value established in Eurocode for ULS. The results showed how RSM can be a practical methodology and how the improvements presented can reduce the computational cost of a traditional RSM giving a good alternative to simulation methods such as Monte Carlo.</p>


Author(s):  
Jami M. Saffioti ◽  
Brittany Coats

Current finite element (FE) models of the pediatric eye are based on adult material properties [2,3]. To date, there are no data characterizing the age dependent material properties of ocular tissues. The sclera is a major load bearing tissue and an essential component to most computational models of the eye. In preparation for the development of a pediatric FE model, age-dependent and anisotropic properties of sclera were evaluated in newborn (3–5 days) and toddler (4 weeks) pigs. Data from this study will guide future testing protocols for human pediatric specimens.


2018 ◽  
Vol 3 (1) ◽  
pp. 13-20
Author(s):  
Dávid Huri

Automotive rubber products are subjected to large deformations during working conditions, they often contact with other parts and they show highly nonlinear material behavior. Using finite element software for complex analysis of rubber parts can be a good way, although it has to contain special modules. Different types of rubber materials require the curve fitting possibility and the wide range choice of the material models. It is also important to be able to describe the viscoelastic property and the hysteresis. The remeshing possibility can be a useful tool for large deformation and the working circumstances require the contact and self contact ability as well. This article compares some types of the finite element software available on the market based on the above mentioned features.


Author(s):  
Wing L. Cheng

Abstract This paper shares some of our experiences in the use of a supercomputer to facilitate the analysis of impact process in thick composites, and also in the benefits of color animation of the results on a Macintosh computer. An explicit nonlinear finite element program has been ported to the CRAY-2 Supercomputer at the National Center for Supercomputing Applications (NCSA) of the University of Illinois at Urbana-Champaign (UIUC). The calculations were carried out using an impact model developed for high velocity impact of fiber-reinforced layered composites. The model is built on a continuum approach and includes a basic orthotopic constitutive material behavior. It has been validated to some degree with ballistic tests and therefore can provide a reasonable estimate of the effectiveness of a fiber-reinforced layered composite construction as a protective system. A computer program was developed to convert the results of the analysis for hundreds of time steps to 8-bit raster images. The images stored in NCSA’s Hierarchical Data Format (HDF) were then transferred to a color Macintosh workstation and animated using graphics tools developed at NCSA. The same set of images were also directly recorded on a video tape and displayed on any standard VCR. This animation capability allowed us to see important detailed information about various quantities like deformation, pressure, stress, etc., which cannot be easily observed by any other means.


2021 ◽  
pp. 1-33
Author(s):  
Conner Sharpe ◽  
Carolyn Seepersad

Abstract Advances in additive manufacturing techniques have enabled the production of parts with complex internal geometries. However, the layer-based nature of additive processes often results in mechanical properties that vary based on the orientation of the feature relative to the build plane. Lattice structures have been a popular design application for additive manufacturing due to their potential uses in lightweight structural applications. Many recent works have explored the modeling, design, and fabrication challenges that arise in the multiscale setting of lattice structures. However, there remains a significant challenge in bridging the simplified computational models used in the design process and the more complex properties actually realized in fabrication. This work develops a design approach that captures orientation-dependent material properties that have been observed in metal AM processes while remaining suitable for use in an iterative design process. Exemplar problems are utilized to investigate the potential design changes and performance improvements that can be attained by taking the directional dependence of the manufacturing process into account in the design of lattice structures.


2019 ◽  
pp. 027836491989345
Author(s):  
Giovanna A Naselli ◽  
Barbara Mazzolai

Modeling soft robots is not an easy task owing to their highly nonlinear mechanical behavior. So far, several researchers have tackled the problem using different approaches, each having advantages and drawbacks in terms of accuracy, ease of implementation, and computational burden. The soft robotics community is currently working to develop a unified framework for modeling. Our contribution in this direction consists of a novel dimensionless quantity that we call the softness distribution index (SDI). The SDI for a given soft body is computed based on the distribution of its structural properties. We show that the index can serve as a tool in the choice of a modeling technique among multiple approaches suggested in literature. At the moment, the investigation is limited to bodies performing planar bending. The aim of this work is twofold: (i) to highlight the importance of the distribution of the geometrical and material properties of a soft robotic link/body throughout its structure; and (ii) to demonstrate that a classification based on this distribution provides guidelines for the modeling.


1998 ◽  
Vol 1624 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Chuntao Zhang ◽  
Ian D. Moore

Thermoplastic pipes are being used increasingly for water supply lines, storm sewers, and leachate collection systems in landfills. To facilitate limit states design for buried polymer pipes, nonlinear constitutive models have recently been developed to characterize the highly nonlinear and time-dependent material behavior of high-density polyethylene (HDPE). These models have been implemented in a finite element program to permit structural analysis for buried HDPE pipes and to provide information regarding performance limits of the structures. Predictions of HDPE pipe response under parallel plate loading and hoop compression in a soil cell are reported and compared with pipe response measured in laboratory tests. Effects on the structural performance of pipe material nonlinearity, geometrical nonlinearity, and backfill soil properties were investigated. Good correlations were found between the finite element predictions and the experimental measurements. The models can be used to predict pipe response under many different load histories (not just relaxation or creep). Work is ongoing to develop nonlinear constitutive models for polyvinylchloride and polypropylene to extend the predictive capability of the finite element model to these materials.


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