Decreased Serum Levels of C-Terminal Agrin in Postmenopausal Women Following Resistance Training

2020 ◽  
Vol 28 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Darryn S. Willoughby ◽  
Kaitlan N. Beretich ◽  
Marcus Chen ◽  
LesLee K. Funderburk

Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia. This study sought to determine if resistance training (RT) impacted the serum levels of CAF in perimenopausal (PERI-M) and postmenopausal (POST-M) women. A total of 35 women, either PERI-M or POST-M, participated in 10 weeks of RT. Body composition, muscle strength, and serum estradiol and CAF were determined before and after the RT. The data were analyzed with two-way analysis of variance (p ≤ .05). Upper body and lower body strength was significantly increased, by 81% and 73% and 86% and 79% for the PERI-M and POST-M participants, respectively; however, there were no significant changes in body composition. Estradiol was significantly less for the POST-M participants at pretraining compared with the PERI-M participants. CAF moderately increased by 22% for the PERI-M participants in response to RT, whereas it significantly decreased by 49% for the POST-M participants. Ten weeks of RT reduced the circulating CAF in the POST-M women and might play a role in attenuating degenerative neuromuscular junction changes.

Author(s):  
Raja Nurul Jannat Raja Hussain ◽  
Maisarah Shari

Strength and conditioning coaches frequently use traditional resistance training (TRT) to build strength. However, in recent years, whole-body electromyostimulation (WB-EMS) was used in elite athletes to increase muscle strength. This study aimed to assess the effect of two different types of training on muscular strength. Sixty female collegiate players (Age = 23.52±1.89 years, Height = 156.20±1.71cm; Mass = 53.21±3.17kg) participated in this study and were randomly assigned to three training groups. All groups trained as usual for eight weeks, except for the first group, which received additional TRT. The second group received additional electrical stimulation training, and the third group did not receive any additional training following the regular softball bat swing training. Muscular strength (upper and lower body) was assessed by a 3RM bench press and a 3RM squat test before and after the eight-week programme. The primary findings indicate that after eight weeks of training, upper body and lower body strength increased significantly in both the TRT and WB-EMS groups (p = 0.000 and p = 0.000, respectively) in comparison to the control group. However, the t value indicated that the TRT group improved both upper body strength (20.18) and lower body strength (29.18) more than the WB-EMS group (upper body = 6.18; lower body = 6.47). The findings demonstrate the efficacy of both training modalities for increasing muscular strength and suggest that TRT be prioritised over whole-body electrical stimulation training for increasing muscular strength in collegiate softball players.


Kinesiology ◽  
2019 ◽  
Vol 51 (2) ◽  
pp. 238-245
Author(s):  
Hamid Arazi ◽  
Ehsan Eghbali

2D:4D ratio is determined by balance between androgens and estrogens. Low level estrogen reduces bone mineral density (BMD) and incurs negative changes to bone microarchitecture, increasing the risk of osteoporosis and, as a consequence, fracture risk in women. The purpose of this study was to investigate the relationship between 2D:4D, muscle strength and body composition to BMD in young women. One hundred twenty-seven young women (age range 24-36 years) voluntarily participated in this study. Lengths of the second (index) and fourth (ring) fingers, upper and lower body strength and body composition (body mass index, BMI; waist to hip ratio, WHR) and body fat percentage were estimated. Also, blood levels of calcium and 25-hydroxyvitamin D (25OHD) were evaluated and dual-energy X-ray absorptiometry device was used to measure BMD in the lumbar spine (LS) and femoral neck (FN). The results showed that digit ratios, upper body and lower body muscle strength, BMI and fat percentage had a positive relationship with LS and FN BMD (LS BMD: r=.47, r=.56, r=.46, r=.34, r=.28, p≤.001, respectively; FN BMD: r=.34, r=.49, r=.51, r=.45, r=.27, p≤.001, respectively). In addition, there was no significant relationship between WHR and BMD of LS and FN (p˃.05). Multiple linear regression analysis showed the upper body strength was a stronger determinant of LS BMD and the lower body strength was a stronger determinant of FN BMD. Based on the results, the researchers concluded that upper and lower body strength, 2D:4D ratios and BMI were important determinants of young women’s BMD. Also, it seemed that some of these factors may be able to help predicting the osteoporosis potential in young women


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3757
Author(s):  
Ellem Eduarda Pinheiro dos Santos ◽  
Rodrigo Cappato de de Araújo ◽  
Darren G. Candow ◽  
Scott C. Forbes ◽  
Jaddy Antunes Guijo ◽  
...  

Sarcopenia refers to the age-related loss of muscle strength and muscle mass, which is associated with a reduced quality of life, particularly in older females. Resistance training (RT) is well established to be an effective intervention to counter indices of sarcopenia. Accumulating research indicates that the addition of creatine supplementation (Cr) to RT augments gains in muscle strength and muscle mass, compared to RT alone. However, some evidence indicates that sex differences may alter the effectiveness of Cr. Therefore, we systematically reviewed randomized controlled trials (RCTs) investigating the efficacy of Cr + RT on measures of upper- and lower-body strength and muscle mass in older females. A systematic literature search was performed in nine electronic databases. Ten RCTs (N = 211 participants) were included the review. Overall, Cr significantly increased measures of upper-body strength (7 studies, n = 142, p = 0.04), with no effect on lower-body strength or measures of muscle mass. Sub-analyses revealed that both upper-body (4 studies, n = 97, p = 0.05) and lower-body strength (4 studies, n = 100, p = 0.03) were increased by Cr, compared to placebo in studies ≥ 24 weeks in duration. In conclusion, older females supplementing with Cr experience significant gains in muscle strength, especially when RT lasts for at least 24 weeks in duration. However, given the level of evidence, future high-quality studies are needed to confirm these findings.


2010 ◽  
Vol 35 (5) ◽  
pp. 607-616 ◽  
Author(s):  
Abbie E. Smith ◽  
Christopher M. Lockwood ◽  
Jordan R. Moon ◽  
Kristina L. Kendall ◽  
David H. Fukuda ◽  
...  

The aim of this study was to evaluate the combined effects of a 10-week exercise program with ingestion of caffeine and epigallocatechin-3-gallate (EGCG) on body composition, cardiovascular fitness, and strength in overweight and obese women. In a double-blind, placebo-controlled approach, overweight and obese women (n = 27) were randomly assigned to treatment groups with exercise (an active-supplementing group with exercise (EX-Act) and a placebo group with exercise (EX-PL)) or without exercise (an active-supplementing group without exercise (NEX-Act) and a placebo group without exercise (NEX-PL)). All participants consumed 1 drink per day for 10 weeks; EX-Act and EX-PL participated in a concurrent endurance and resistance training program. Changes in body composition were assessed using a 4-compartment model. Changes in muscle mass (MM) were evaluated using a DXA-derived appendicular lean–soft tissue equation. There was a significant time × treatment interaction for MM (p = 0.026) and total cholesterol (TC) (p = 0.047), and a significant time × training interaction for peak oxygen consumption (p = 0.046) and upper-body and lower-body strength (p < 0.05). Significant differences between the EX groups and NEX groups for percentage change in MM and peak oxygen consumption, and upper-body and lower-body strength, were revealed. Clinical markers for hepatic and renal function revealed no adverse effects. TC significantly decreased for the active-supplementing groups (EX-Act, NEX-Act). The current study suggests that implementing a caffeine–EGCG-containing drink prior to exercise may improve MM, fitness, and lipid profiles in overweight women.


2021 ◽  
Vol 51 (5) ◽  
pp. 991-1010
Author(s):  
Henrik Petré ◽  
Erik Hemmingsson ◽  
Hans Rosdahl ◽  
Niklas Psilander

Abstract Background The effect of concurrent training on the development of maximal strength is unclear, especially in individuals with different training statuses. Objective The aim of this systematic review and meta-analysis study was to compare the effect of concurrent resistance and endurance training with that of resistance training only on the development of maximal dynamic strength in untrained, moderately trained, and trained individuals. Methods On the basis of the predetermined criteria, 27 studies that compared effects between concurrent and resistance training only on lower-body 1-repetition maximum (1RM) strength were included. The effect size (ES), calculated as the standardised difference in mean, was extracted from each study, pooled, and analysed with a random-effects model. Results The 1RM for leg press and squat exercises was negatively affected by concurrent training in trained individuals (ES =  – 0.35, p < 0.01), but not in moderately trained ( – 0.20, p = 0.08) or untrained individuals (ES = 0.03, p = 0.87) as compared to resistance training only. A subgroup analysis revealed that the negative effect observed in trained individuals occurred only when resistance and endurance training were conducted within the same training session (ES same session =  – 0.66, p < 0.01 vs. ES different sessions =  – 0.10, p = 0.55). Conclusion This study demonstrated the novel and quantifiable effects of training status on lower-body strength development and shows that the addition of endurance training to a resistance training programme may have a negative impact on lower-body strength development in trained, but not in moderately trained or untrained individuals. This impairment seems to be more pronounced when training is performed within the same session than in different sessions. Trained individuals should therefore consider separating endurance from resistance training during periods where the development of dynamic maximal strength is prioritised.


PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1627 ◽  
Author(s):  
Paulo Gentil ◽  
James Steele ◽  
Maria C. Pereira ◽  
Rafael P.M. Castanheira ◽  
Antonio Paoli ◽  
...  

Resistance training (RT) offers benefits to both men and women. However, the studies about the differences between men and women in response to an RT program are not conclusive and few data are available about upper body strength response. The aim of this study was to compare elbow flexor strength gains in men and women after 10 weeks of RT. Forty-four college-aged men (22.63 ± 2.34 years) and forty-seven college-aged women (21.62 ± 2.96 years) participated in the study. The RT program was performed two days a week for 10 weeks. Before and after the training period, peak torque (PT) of the elbow flexors was measured with an isokinetic dynamometer. PT values were higher in men in comparison to women in pre- and post-tests (p< 0.01). Both males and females significantly increased elbow flexor strength (p< 0.05); however, strength changes did not differ between genders after 10 weeks of RT program (11.61 and 11.76% for men and women, respectively;p> 0.05). Effect sizes were 0.57 and 0.56 for men and women, respectively. In conclusion, the present study suggests that men and women have a similar upper body strength response to RT.


2020 ◽  
Vol 32 (3) ◽  
pp. 165-171
Author(s):  
Konstantinos D. Tambalis ◽  
Stamatis Mourtakos ◽  
Labros S. Sidossis

Purpose: To investigate the potential associations of maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) with physical fitness in children. Methods: A random sample of 5125 children and their mothers was evaluated. The mothers provided data contained in their medical booklets and pregnancy ultrasound records. The data from 5 physical fitness tests (eg, 20-m shuttle run, 30-m sprint, vertical jump, standing long jump, and small ball throw) were used to assess children’s cardiorespiratory fitness, speed, explosive power, and lower and upper body strength, respectively. Results: MppBMI was inversely associated with cardiorespiratory fitness (b = −0.02), lower body strength (b = −1.01), upper body strength (b = −0.07), and speed (b = 0.04). Also, GWG was unfavorably associated with cardiorespiratory fitness (b = −0.02), lower body strength (b = −1.12), upper body strength (b = −0.03), and speed (b = 0.03), after adjusting for sex, birth weight, and children’s BMI (all P values < .05). Children of mothers with an mppBMI ≥ 25 kg/m2 and excess GWG had almost 30% and 20% increased odds for low performances in physical fitness tests than those of mothers with an mppBMI < 25 kg/m2 and adequate GWG, respectively. Conclusions: Antenatal factors such as increased mppBMI and excess GWG could play an unfavorable role in the future health of the offspring.


2004 ◽  
Vol 14 (4) ◽  
pp. 461-472 ◽  
Author(s):  
Darryn S. Willoughby

This study examined 12 wk of resistance training and cystoseim canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85% to 90% 1 repetition maximum. MYO ingested 1200 mg/d of cystoseim canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseim canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.


Author(s):  
J R Hunter ◽  
A J Macquarrie ◽  
S C Sheridan

AbstractBackgroundParamedics are among the most frequently injured health professionals in Australia. A lack of physical capacity may contribute to injury risk in this occupational population.AimsThis study sought to describe and compare the physical fitness of male and female paramedics across age groups to ascertain differences in physical capacity.MethodsA group of regional Australian paramedics (n = 140; 78 males; mean ± SD 37.4 ± 9.9 years; body mass index 28.1 ± 4.9 kg/m2) underwent a fitness assessment. Measures included upper, lower and core-body muscular strength and flexibility. Outcomes were compared between genders and across age groups using two-way between-groups analysis of variance.ResultsMale paramedics had greater upper body strength (P < 0.05; push-ups) mean (95% CI): 22.6 (19.4–25.9) versus 18.7 (15.2–22.3); similar lower body strength (single-leg wall squat): 39.0 (32.6–45.3) s versus 36.7 (27.1–46.3) s; greater core strength (P < 0.05; prone plank hold): 87.9 (77.6–98.3) s versus 73.8 (63.7–83.8) s; similar upper body flexibility (back scratch): −4.0 (−6.7 to −1.3) cm versus −0.3 (−2.2 to 1.7) cm; and similar lower body flexibility (sit and reach): 20.4 (18.2–22.6) cm versus 26.1 (23.5–28.7) cm to female paramedics. Core, upper and lower body strength all decreased with age (P < 0.05).ConclusionsCore, upper and lower body strength and upper body flexibility were poorer for older compared to younger regional paramedics in New South Wales, Australia. Future research should investigate whether these outcomes are associated with occupational injury risk. This information would assist in the design of injury prevention interventions for paramedics such as tailored workplace exercise programs.


2016 ◽  
Vol 48 ◽  
pp. 933-934
Author(s):  
Sandro Bartolomei ◽  
Jay R. Hoffman ◽  
Jeffrey R. Stout ◽  
Franco Merni

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