Dose Effects of Propranolol on Cancellous and Cortical Bone in Ovariectomized Adult Rats

2006 ◽  
Vol 318 (3) ◽  
pp. 1118-1127 ◽  
Author(s):  
N. Bonnet ◽  
N. Laroche ◽  
L. Vico ◽  
E. Dolleans ◽  
C. L. Benhamou ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Adult Rats ◽  
Dose Effects ◽  
Ovariectomized Adult Rats

IGF-I and pamidronate increase bone mineral density in ovariectomized adult rats

1993 ◽  
Vol 265 (5) ◽  
pp. E770-E776 ◽  
Author(s):  
P. Ammann ◽  
R. Rizzoli ◽  
K. Muller ◽  
D. Slosman ◽  
J. P. Bonjour
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Mineral Density ◽  
Adult Rats ◽  
Igf I ◽  
Midshaft Tibia ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Ovariectomized Adult Rats

Effects induced by insulin-like growth factor I (IGF-I) and/or the bisphosphonate pamidronate (APD) on bone mineral density (BMD) of the lumbar spine and proximal and midshaft tibia were studied in adult rats made osteopenic by ovariectomy, using dual-energy X-ray absorptiometry. IGF-I, which was administered by osmotic minipumps implanted subcutaneously for 6 wk, caused a dose-dependent increase of BMD at the three investigated sites. A 4-wk course of IGF-I, followed by intermittent cyclical APD administration, induced significant increases of BMD at the levels of spine and proximal tibia. At midshaft tibia, where cortical bone predominates, BMD was increased by IGF-I only. In conclusion, IGF-I increased BMD at sites with trabecular and/or cortical bone, whereas the APD influence was mainly detectable in the former site only.

METABOLISM OF 20β-HYDROXY-4-PREGNEN-3-ONE IN UTERINE TISSUE OF NON-PREGNANT RATS IN VITRO

1976 ◽  
Vol 83 (3) ◽  
pp. 604-620 ◽  
Author(s):  
B. P. Lisboa ◽  
M. Holtermann
Keyword(s):  
Biological Activity ◽  
Adult Female ◽  
Female Rats ◽  
Uterine Tissue ◽  
Rat Uterus ◽  
Adult Rats ◽  
Pregnant Rats ◽  
Progesterone Metabolites ◽  
Ovariectomized Adult Rats

ABSTRACT In vitro experiments carried out with uterus preparations of ovariectomized adult rats indicate the presence in this tissue of a 20β-hydroxysteroid-oxidoreductase which catalyzes the conversion of 20β-hydroxy-4-pregnen-3-one to progesterone. Since a hepatic 20β-hydroxysteroid-oxidoreductase is absent in adult female rats, the myometrial enzyme can be responsible for the biological activity of 20β-hydroxy-4-pregnen-3-one in these animals. Besides progesterone five metabolites were isolated and identified after incubation of [4-14C]20β-hydroxy-4-pregnen-3-one with uterine tissue: 20β-hydroxy-5α-pregnan-3-one, 20β-hydroxy-5β-pregnan-3-one, 5α-pregnane-3α,20β-diol, 4-pregnene-3α,20β-diol and 4-pregnene-3β,20β-diol. The conversion of 20β-hydroxy-4-pregnen-3-one to progesterone permits us to regard all five steroids isolated as progesterone metabolites in the rat uterus. 20β-hydroxy-5β-pregnan-3-one is the first C21-metabolite with a 5β(H)-configuration isolated in the rat uterus, which indicates the presence of 5β-reductase in this tissue.

scholarly journals Effects of treadmill with different intensities on bone quality and muscle properties in adult rats

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Zhehao Liu ◽  
Jiazi Gao ◽  
He Gong
Keyword(s):  
Cortical Bone ◽  
Soleus Muscle ◽  
Adult Male ◽  
Biomechanical Properties ◽  
Treadmill Running ◽  
Male Rats ◽  
Bending Test ◽  
Long Bone ◽  
Nanoindentation Test ◽  
Adult Rats

Abstract Background Bone is a dynamically hierarchical material that can be divided into length scales of several orders of magnitude. Exercise can cause bone deformation, which in turn affects bone mass and structure. This study aimed to study the effects of treadmill running with different intensities on the long bone integrity and muscle biomechanical properties of adult male rats. Methods Forty-eight 5-month-old male SD rats were randomly divided into 4 groups: i.e., sedentary group (SED), exercise with speed of 12 m/min group (EX12), 16 m/min group (EX16), and 20 m/min group (EX20). The exercise was carried out for 30 min every day, 5 days a week for 4 weeks. The femurs were examined using three-point bending test, microcomputer tomography scanning and nanoindentation test; the soleus muscle was dissected for tensile test; ALP and TRACP concentrations were measured by serum analysis. Results The failure load was significantly increased by the EX12 group, whereas the elastic modulus was not significantly changed. The microstructure and mineral densities of the trabecular and cortical bone were significantly improved by the EX12 group. The mechanical properties of the soleus muscle were significantly increased by treadmill exercise. Bone formation showed significant increase by the EX12 group. Statistically higher nanomechanical properties of cortical bone were detected in the EX12 group. Conclusion The speed of 12 m/min resulted in significant changes in the microstructure and biomechanical properties of bone; besides, it significantly increased the ultimate load of the soleus muscle. The different intensities of treadmill running in this study provide an experimental basis for the selection of exercise intensity for adult male rats.

Effect of Median Eminence Lesions and Hormonal Replacement on the Prolactin Receptors in the Adrenal Gland and Langerhans Islets from Ovariectomized Adult Rats

1985 ◽  
Vol 5 (1) ◽  
pp. 105-119 ◽  
Author(s):  
Isabel A. Lüthy ◽  
Marta Tesone ◽  
Ricardo M. Oliveira-filho ◽  
Gustavo M. Somoza ◽  
Eduardo H. Charreau ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Median Eminence ◽  
Prolactin Receptors ◽  
Adult Rats ◽  
Hormonal Replacement ◽  
Langerhans Islets ◽  
Ovariectomized Adult Rats

Cortical bone is more sensitive to alcohol dose effects than trabecular bone in the rat

2012 ◽  
Vol 79 (5) ◽  
pp. 492-499 ◽  
Author(s):  
Delphine B. Maurel ◽  
Nathalie Boisseau ◽  
Claude-Laurent Benhamou ◽  
Christelle Jaffré
Keyword(s):  
Trabecular Bone ◽  
Cortical Bone ◽  
Dose Effects ◽  
Alcohol Dose

scholarly journals Age-related osteogenesis on lateral force application to rat incisor – Part II: Bony recession and cortical remodeling

2021 ◽  
Vol 11 ◽  
pp. 174-182
Author(s):  
Jin-Wook Kim ◽  
Hyoung-Seon Baik ◽  
Sung-Seo Mo ◽  
Hai-Van Giap ◽  
Kee-Joon Lee
Keyword(s):  
Cortical Bone ◽  
Tooth Movement ◽  
Lateral Displacement ◽  
Young Group ◽  
Bone Volume ◽  
Limiting Factor ◽  
Adult Rats ◽  
Skeletal Malocclusion ◽  
Age Related ◽  
Significant Difference

Objective: The aim of this study is to analyze the age-related changes in the bony recession and cortical bone remodeling induced by lateral orthodontic tooth movement, using a three-dimensional micro-computed tomography (CT) analysis. Material and Methods: A total of 40 male Sprague-Dawley rats were divided into two distinct age groups (young, 10 weeks and adult, 52 weeks). Double-helical springs exerting 40 g of force were applied to central incisors to analysis of changes in lateral cortical bone and tooth movement with age and time. The young and adult rats were divided into four subgroups, T0 (0 week), T1 (1 week), T2 (2 weeks), and T3 (3 weeks), depending on the period of wearing the appliance. Micro-CT image was taken on each dissected pre-maxilla specimen. In each subgroup, distance between the center of teeth, suture width, tooth displacement, bony recession, and bone volume was evaluated. Results: The changes in the distance between the center of teeth and the suture width were significantly greater in the young group. However, the change in the tooth displacement showed no significant difference between groups. In the young group, bony recession of outer cortical layer was observed at T1 (P < 0.05), but the amount of recession gradually decreased at T2 and T3. In contrast, in the adult group, bony recession increased gradually over observation period (P < 0.05). The bone volume decreased at T1 (P < 0.05), but recovered at T2 and T3 in both groups. Conclusion: The compensatory bone formation occurs in the pressure side of cortical bone more significantly in the young group than in the adult according to the lateral displacement of incisor in rats. The reduced bone reaction in the adult is considered a limiting factor of the excessive tooth movement in the compromised treatment of skeletal malocclusion.

THE EFFECT OF GONADOTROPHIC HORMONES ON THE HYPOPHYSIS OF THE RAT

1962 ◽  
Vol 41 (1) ◽  
pp. 31-34 ◽  
Author(s):  
F. E. Szontágh ◽  
S. Uhlarik ◽  
A. Jakobovits
Keyword(s):  
Anterior Lobe ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Moderate Increase ◽  
Adult Rats ◽  
Ovariectomized Adult Rats

ABSTRACT The weight of the hypophysis and the ratio of the PAS-positive to PAS-negative cells in the anterior lobe of intact and ovariectomized adult rats increased significantly following treatment with serum gonadotrophin (PMS). After the administration of human chorionic gonadotrophin (HCG) a slight decrease of the hypophyseal weight and a moderate increase of the number of PAS-positive cells was observed in both intact and spayed groups of animals. Both gonadotrophic substances failed to inhibit the appearance of castration cells in the hypophysis.

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