Capturing an elusive but critical element: Natural protein enables actinium chemistry

Human beings are deeply related to land. Human beings take birth on land, live on land, die on land and mixes with land ultimately. As stated in the holy Quran: ‘We (Allah) created you (human beings) from the soil, we shall make you return to the soil and We shall call you back again from the soil’ (20:55). Human life is surrounded by soil i.e. land. So, land is a highly completed issue of human life involving economic, social, political, cultural and often religious systems. Land administration is thus a critical element and often a pre-condition for peaceful society and sustainable development. In administrating land, Khatian or record of rights plays a vital role to determine the rights and interests of the respective parties as supportive evidence. In this article, discussion is mainly made on the fact that Khatian or record of rights is not a document of title solely but it may be an evidence of title as well as possession. IIUC Studies Vol.15(0) December 2018: 33-46

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Enzymatic Synthesis of 15N-L-aspartic Acid Using Recombinant Aspartase from Escherichia Coli K12

Revista de Chimie ◽

10.37358/rc.08.11.2004 ◽

2008 ◽

Vol 59 (11) ◽

Cited By ~ 1

Author(s):

Iulia Lupan ◽

Sergiu Chira ◽

Maria Chiriac ◽

Nicolae Palibroda ◽

Octavian Popescu

Keyword(s):

Amino Acids ◽

Aspartic Acid ◽

Enzymatic Synthesis ◽

Large Scale ◽

Recombinant Dna ◽

Industrial Enzymes ◽

Recombinant Dna Technology ◽

Bacterial Fermentation ◽

Natural Protein ◽

Novel Method

Amino acids are obtained by bacterial fermentation, extraction from natural protein or enzymatic synthesis from specific substrates. With the introduction of recombinant DNA technology, it has become possible to apply more rational approaches to enzymatic synthesis of amino acids. Aspartase (L-aspartate ammonia-lyase) catalyzes the reversible deamination of L-aspartic acid to yield fumaric acid and ammonia. It is one of the most important industrial enzymes used to produce L-aspartic acid on a large scale. Here we described a novel method for [15N] L-aspartic synthesis from fumarate and ammonia (15NH4Cl) using a recombinant aspartase.

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SEDIMENT BALANCE OF THE VISTULA LAGOON

Proceedings of International Conference "Managinag risks to coastal regions and communities in a changinag world" (EMECS'11 - SeaCoasts XXVI) ◽

10.21610/conferencearticle_58b43153db8ae ◽

2017 ◽

Author(s):

Vladimir Chechko ◽

Boris Chubarenko ◽

Boris Chubarenko

Keyword(s):

Baltic Sea ◽

Field Measurements ◽

Water Volume ◽

Critical Element ◽

Vistula Lagoon ◽

The Baltic Sea ◽

Direct Measurements ◽

Biogenic Components ◽

The Baltic ◽

The Vistula Lagoon

Vistula Lagoon is the second largest lagoon in the Baltic Sea with maximum depth 5.2 m and average depth 2.7 m. Water volume and area are 2.3 km3 and 838 km2. Lagoon is connected with the Baltic Sea by single inlet 400 m wide and 10-12 m deep. Sediment budget estimation were made using literature sources, results of field measurements (hydrology, suspended sediment content, upper layer sediment structure, direct measurements of sedimentation in summer and winter conditions). The budget for terrigene and biogenic components of sediments were made, considering their contributions from the rivers, inflow from the Baltic Sea, coastal erosion and aerial flux, biological production within the lagoon, totally - ca. 730 thousands ton per year. Nearly half of total gain is washed out (105 and 244 thousands ton per year of terrigene and biogenic components), another half is dissolved and mineralized (biogenic component), and only 10% is deposited on the bottom, resulting in rather low sedimentation rate - 0.4 mm/year during last 100 years. Paper explain the reason of difference with estimation made in (Chubarenko&Chubarenko, 2002) and concludes that the clarification of estimates of the amounts of sediments transported from the lagoon to the Baltic Sea is a critical element for understanding the evolution of the Vistula Lagoon as a sedimentation system.

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Nano-evolution and protein-based enzymatic evolution predicts the novel types of natural product nanozyme of traditional Chinese medicine: cases of herbzymes of Taishan-Huangjing (Rhizoma polygonati) and Goji (Lycium chinense)

Nanoscale Advances ◽

10.1039/d1na00475a ◽

2021 ◽

Author(s):

Guldan Nazarbek ◽

Aidana Kutzhanova ◽

Lazzat Nurtay ◽

Chenglin Mu ◽

Bexultan Kazybay ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Natural Product ◽

Enzyme Function ◽

The Novel ◽

Lycium Chinense ◽

Natural Protein

Nanozyme and natural product-derived herbzyme have been identified in different enzyme types simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozyme when synthesized...

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Severe anemia in patients with Propionic acidemia is associated with branched-chain amino acid imbalance

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-021-01865-7 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Sinziana Stanescu ◽

Amaya Belanger-Quintana ◽

Borja Manuel Fernandez-Felix ◽

Francisco Arrieta ◽

Victor Quintero ◽

...

Keyword(s):

Amino Acids ◽

Food Consumption ◽

Protein Intake ◽

Propionic Acidemia ◽

Study Data ◽

Metabolic Decompensation ◽

Severe Anemia ◽

Medical Food ◽

Natural Protein ◽

Branched Chain

Abstract Background Propionic acidemia (PA), an inborn error of metabolism, is caused by a deficiency in propionyl-CoA carboxylase. Patients have to follow a diet restricted in the propiogenic amino acids isoleucine (Ile), valine (Val), methionine (Met) and threonine (Thr); proper adherence can prevent and treat acute decompensation and increase life expectancy. However, chronic complications occur in several organs even though metabolic control may be largely maintained. Bone marrow aplasia and anemia are among the more common. Materials and methods In this retrospective study, data for patients with PA being monitored at the Hospital Ramón y Cajal (Madrid, Spain) (n = 10) in the past 10 years were examined to statistically detect relationships between persistent severe anemia outside of metabolic decompensation episodes and dietary practices such as natural protein intake and medical food consumption (special mixture of precursor-free amino acids) along with plasma levels of branched-chain amino acids (BCAA). High ferritin levels were deemed to indicate that a patient had received repeated transfusions for persistent anemia since data on hemoglobin levels at the moment of transfusion were not always passed on by the attending centers. Results Three patients had severe, persistent anemia that required repeated blood transfusions. Higher medical food consumption and plasma Leu levels were associated with iron overload. Notably, natural protein intake and plasma Val were negatively correlated with ferritin levels. We also observed an inverse relationship between plasma Val/Leu and Ile/Leu ratios and ferritin. Conclusion The present results suggest that severe anemia in patients with PA might be associated with low natural protein intake and BCAA imbalance.

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Assessment of Lithium, Macro- and Microelements in Water, Soil and Plant Samples from Karst Areas in Romania

Materials ◽

10.3390/ma14144002 ◽

2021 ◽

Vol 14 (14) ◽

pp. 4002

Author(s):

Anamaria Iulia Török ◽

Ana Moldovan ◽

Erika Andrea Levei ◽

Oana Cadar ◽

Claudiu Tănăselia ◽

...

Keyword(s):

Modern Society ◽

Critical Element ◽

Unequal Distribution ◽

Industrial Sectors ◽

Plant Samples ◽

Icp Ms ◽

Karst Areas ◽

The Relationship ◽

Li Content

Lithium is a critical element for the modern society due to its uses in various industrial sectors. Despite its unequal distribution in the environment, Li occurrence in Romania was scarcely studied. In this study a versatile measurement method using ICP-MS technique was optimized for the determination of Li from various matrixes. Water, soil, and plant samples were collected from two important karst areas in the Dobrogea and Banat regions, Romania. The Li content was analyzed together with other macro- and microelement contents to find the relationship between the concentration of elements and their effect on the plants’ Li uptake. In Dobrogea region, half of the studied waters had high Li concentration, ranging between 3.00 and 12.2 μg/L in the case of water and between 0.88 and 11.1 mg/kg DW in the case of plants, while the Li content in the soil samples were slightly comparable (from 9.85 to 11.3 mg/kg DW). In the Banat region, the concentration of Li was lower than in Dobrogea (1.40–1.46 μg/L in water, 6.50–9.12 mg/kg DW in soil, and 0.19–0.45 mg/kg DW in plants). Despite the high Li contents in soil, the Li was mostly unavailable for plants uptake and bioaccumulation.

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Regulatory Requirements for the Quality of Allergen Products for Allergen Immunotherapy of Food Allergy

Current Allergy and Asthma Reports ◽

10.1007/s11882-021-01008-9 ◽

2021 ◽

Vol 21 (5) ◽

Author(s):

Lisa Englert ◽

Vera Mahler ◽

Andreas Bonertz

Keyword(s):

Allergen Immunotherapy ◽

Major Allergen ◽

Food Allergies ◽

Manufacturing Processes ◽

Critical Element ◽

Medicinal Products ◽

Regulatory Requirements ◽

Quality Aspects ◽

Allergenic Activity ◽

Recent Developments

Abstract Purpose of Review Medicinal products for allergen immunotherapy (AIT) of food allergies have gained enormous momentum in recent years. With this new class of products entering marketing authorization procedures, compliance to regulatory requirements becomes a critical element. Here, an overview is provided on specific requirements and aspects concerning the quality control and manufacturing of these products. Recent Findings Recent developments in the field of AIT for food allergies are divers, including products for oral, epicutaneous, and subcutaneous application, most notably targeting egg, milk, and peanut allergy. As the source materials for food AIT product are typically produced for food consumption and not for medicinal purposes, unique challenges arise in the manufacturing processes and controls of these medicinal products. Individual approaches are needed to assure acceptable quality, including control of relevant quantitative and qualitative characteristics. Major characteristics for quality verification include determination of protein content, total allergenic activity, and major allergen content. The applied manufacturing processes need to be established such that relevant process parameters are kept within justified limits and consistency of produced batches is assured. Summary Allergen products for food AIT present specific challenges with respect to quality aspects that differentiate them from other commonly available AIT products. While established regulation is available and provides clear guidance for most aspects, other issues require consideration of new and individual settings relevant here. Consequently, as experience grows, respective amendments to currently available guidance may be needed.

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Modeling Recoveries of US Leading Banks Based on Publicly Disclosed Data

Mathematics ◽

10.3390/math9020188 ◽

2021 ◽

Vol 9 (2) ◽

pp. 188

Author(s):

Pawel Siarka

Keyword(s):

Recovery Rate ◽

Credit Card ◽

Factor Model ◽

Critical Element ◽

Federal Reserve Bank ◽

Rate Analysis ◽

Industry Standards ◽

Risk Management Process ◽

Credit Portfolio ◽

Asset Correlation

The credit risk management process is a critical element that allows financial institutions to withstand economic downturns. Unlike the methods regarding the probability of default, which have been deeply addressed after the financial crisis in 2008, recovery rate models still need further development. As there are no industry standards, leading banks are modeling recovery rates using internal models developed with different assumptions. Therefore, the outcomes are often incomparable and may lead to confusion. The author presents the concept of a unified recovery rate analysis for US banks. He uses data derived from FR Y-9C reports disclosed by the Federal Reserve Bank of Chicago. Based on the historical recoveries and credit portfolio book values, the author examines the distribution function of recoveries. The research refers to a credit card portfolio and covers nine leading US banks. The author leveraged Vasicek’s one-factor model with the asset correlation parameter and implemented it for recovery rate analysis. This experiment revealed that the estimated latent correlation ranges from 0.2% to 1.5% within the examined portfolios. They are large enough to impact the recovery rate volatility and cannot be treated as negligible. It was shown that the presented method could be applied under US Comprehensive Capital Analysis and Review exercise.

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A dyadic perspective of socially responsible mechanisms for retailer-manufacturer relationship in an apparel industry

International Journal of Physical Distribution & Logistics Management ◽

10.1108/ijpdlm-03-2018-0154 ◽

2019 ◽

Vol 49 (3) ◽

pp. 242-266 ◽

Cited By ~ 2

Author(s):

Aswini Yadlapalli ◽

Shams Rahman ◽

Helen Rogers

Keyword(s):

Social Responsibility ◽

Social Factor ◽

Developed Countries ◽

Critical Element ◽

Retail Sector ◽

Socially Responsible ◽

Dyadic Relationship ◽

Case Study Methodology ◽

Content Type ◽

Relational Mechanism

Purpose The purpose of this paper is to identify and prioritise social responsible mechanisms in apparel supply chains to extend social responsibility from large retailers in developed countries to producers in developing nations. Design/methodology/approach A framework that consists of supplier qualification and supplier relational mechanisms as two socially responsible mechanisms, with five factors and 18 dimensions is proposed. To prioritise the dimensions, analytic hierarchy process is employed by using a case study methodology of a major Australian retailer sourcing from Bangladesh manufacturers. Findings Results indicate that at the mechanism level, both retailer and manufacturers perceive qualification of manufacturer as by far the most critical element compared to the relational mechanism. However, substantial differences exist at the factor level; namely, that the social factor is critical for the retailer, whereas the economic factor is critical for the manufacturer. Within the relational mechanism, evaluation helps retailers to enforce social responsibility, while manufacturers believe collaboration helps. Research limitations/implications The major limitation of this study is the generalisation of the findings. The results obtained by focusing on a particular context in the Australian retail sector importing from Bangladesh, may not be applicable to other nations. Practical implications By highlighting the difference of opinion, this study assists managers in developing guidelines to better understand the socially responsible mechanisms in the retailer-manufacturer dyadic relationship and to propose strategies to address the differences. Originality/value This study advances the literature on inter-organisational relationship to retailer-manufacturer dyad for the implementation of social responsibility by including supplier qualification along with supplier relational mechanism.

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Fostering Independence While Teaching Students With or at Risk for Reading Disabilities

Teaching Exceptional Children ◽

10.1177/0040059921994596 ◽

2021 ◽

pp. 004005992199459

Author(s):

Colby Hall ◽

Katlynn Dahl-Leonard ◽

Carolyn A. Denton ◽

Elizabeth A. Stevens ◽

Philip Capin

Keyword(s):

At Risk ◽

Reading Instruction ◽

Special Education Teachers ◽

Instructional Delivery ◽

Primary Grade ◽

Critical Element ◽

Independent Practice ◽

Gradual Release Of Responsibility ◽

High Level ◽

Small Group Reading

The Gradual Release of Responsibility (GRR) model for instructional delivery is well supported by research evidence and is often identified as a critical element of instruction for students with learning difficulties. However, there are challenges associated with effectively releasing responsibility to students. This may be especially true during instruction for primary-grade students with or at risk for learning disabilities. In general, educators want to provide a high level of support to young, struggling students in order to ensure that they feel successful and bolster their confidence. However, too much support means that students are not provided with opportunities for independent practice or independent mastery of content being taught. This article describes the GRR model of instruction and provides specific guidance and resources to support special education teachers in implementing the GRR model during small-group reading instruction in primary-grade classrooms, with a particular emphasis on facilitating group and independent practice.

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