Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam
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ABSTRACT Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
2015 ◽
Vol 59
(12)
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pp. 7650-7656
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2020 ◽
Vol 11
(SPL1)
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pp. 1278-1285
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2020 ◽
Vol 25
(10)
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pp. 1108-1122
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1988 ◽
Vol 50
(3)
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pp. 510-513
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2011 ◽
Vol 55
(12)
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pp. 5826-5833
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