scholarly journals Clinical and Microbiologic Outcomes in Patients with Monomicrobial Stenotrophomonas maltophilia Infections

2019 ◽  
Vol 63 (11) ◽  
Author(s):  
Cara Nys ◽  
Kartik Cherabuddi ◽  
Veena Venugopalan ◽  
Kenneth P. Klinker
Keyword(s):  
Nosocomial Infections ◽  
Clinical Cure ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Content Type ◽  
High Cure ◽  
Resistance Selection ◽  
Biofilm Production ◽  
Cure Rates

ABSTRACT Stenotrophomonas maltophilia is an opportunistic pathogen observed in nosocomial infections. Due to biofilm production and resistance to numerous antimicrobials, eradication is difficult. This study evaluated outcomes for monomicrobial S. maltophilia infections. Seventy-six patients were included, with 45 patients on trimethoprim-sulfamethoxazole and 31 patients on levofloxacin. Overall clinical cure, microbiological eradication, and 28-day mortality were observed in 79%, 82%, and 14% of patients, respectively. The use of trimethoprim-sulfamethoxazole or levofloxacin resulted in high cure rates; however, a trend toward resistance selection with levofloxacin was identified.

scholarly journals Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam

2017 ◽  
Vol 61 (10) ◽  
Author(s):  
Maria F. Mojica ◽  
Krisztina M. Papp-Wallace ◽  
Magdalena A. Taracila ◽  
Melissa D. Barnes ◽  
Joseph D. Rutter ◽  
...  
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
World Health ◽  
Combination Therapies ◽  
Content Type ◽  
Medical Need ◽  
The World ◽  
Health Organization

ABSTRACT Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.

scholarly journals Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient

2016 ◽  
Vol 60 (9) ◽  
pp. 5130-5134 ◽  
Author(s):  
Maria F. Mojica ◽  
Christopher P. Ouellette ◽  
Amy Leber ◽  
M. Brian Becknell ◽  
Monica I. Ardura ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Stenotrophomonas Maltophilia ◽  
Conventional Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Content Type ◽  
Colistimethate Sodium ◽  
Novel Drug

ABSTRACTStenotrophomonas maltophiliais an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producingS. maltophiliarefractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient'sS. maltophiliaisolate.

scholarly journals Complete Genome Sequence of Klebsiella pneumoniae Siphophage Skenny

2019 ◽  
Vol 8 (39) ◽  
Author(s):  
Jacob Gramer ◽  
Sarah Kenny ◽  
Heather Newkirk ◽  
Mei Liu ◽  
Jason J. Gill ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Nosocomial Infections ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Opportunistic Pathogen ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Content Type

Klebsiella pneumoniae is a Gram-negative opportunistic pathogen and a leading cause of antibiotic-resistant nosocomial infections. The genome sequence of siphophage Skenny, which infects K. pneumoniae, is described here. Skenny encodes 78 genes and is closely related to Klebsiella phages KPN N141 and MezzoGao, which are T1-like phages.

scholarly journals Complete Genome Sequence of Klebsiella pneumoniae Myophage Menlow

2019 ◽  
Vol 8 (17) ◽  
Author(s):  
Heather N. Newkirk ◽  
Lauren Lessor ◽  
Jason J. Gill ◽  
Mei Liu
Keyword(s):  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Nosocomial Infections ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Opportunistic Pathogen ◽  
Content Type

Klebsiella pneumoniae is an opportunistic pathogen that has become an increasing problem in nosocomial infections. Studying phages that infect K. pneumoniae may lead to improvements in phage therapeutics for treating these infections.

Advances in the Microbiology of Stenotrophomonas maltophilia

2021 ◽  
Author(s):  
Joanna S. Brooke
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Bloodstream Infections ◽  
Opportunistic Pathogen ◽  
Content Type ◽  
Susceptible Patient

Stenotrophomonas maltophilia is an opportunistic pathogen of significant concern to susceptible patient populations. This pathogen can cause nosocomial and community-acquired respiratory and bloodstream infections and various other infections in humans.

scholarly journals Complete Genome Sequence of Oxidase-Positive Stenotrophomonas maltophilia Strain SM7059

2019 ◽  
Vol 8 (17) ◽  
Author(s):  
Shuo Gao ◽  
Zhifeng Zhang ◽  
Hui Zhou ◽  
Hong Zhu ◽  
Han Shen ◽  
...  
Keyword(s):  
Female Patient ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Hospitalized Patients ◽  
Content Type ◽  
Positive Strain

Stenotrophomonas maltophilia is an opportunistic pathogen which causes an increasing frequency of infections in hospitalized patients. Here, we present the complete genome sequence of Stenotrophomonas maltophilia SM7059, an oxidase-positive strain isolated from a female patient with hepatolithiasis in China.

scholarly journals Characterization of Maltocin P28, a Novel Phage Tail-Like Bacteriocin from Stenotrophomonas maltophilia

2013 ◽  
Vol 79 (18) ◽  
pp. 5593-5600 ◽  
Author(s):  
Jian Liu ◽  
Peng Chen ◽  
Congyi Zheng ◽  
Yu-Ping Huang
Keyword(s):  
Gene Cluster ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Gene Organization ◽  
Open Reading Frames ◽  
Proteinase K ◽  
Major Protein ◽  
Content Type ◽  
Phage Tail

ABSTRACTStenotrophomonas maltophiliais an important global opportunistic pathogen for which limited therapeutics are available because of the emergence of multidrug-resistant strains. A novel bacteriocin, maltocin P28, which is produced byS. maltophiliastrain P28, may be the first identified phage tail-like bacteriocin fromS. maltophilia. Maltocin P28 resembles a contractile but nonflexible phage tail structure based on electron microscopy, and it is sensitive to trypsin, proteinase K, and heat. SDS-PAGE analysis of maltocin P28 revealed two major protein bands of approximately 43 and 20 kDa. The N-terminal amino acid residues of these two major subunits were sequenced, and the maltocin P28 gene cluster was located on theS. maltophiliaP28 chromosome. Our sequence analysis results indicate that this maltocin gene cluster consists of 23 open reading frames (ORFs), and that its gene organization is similar to that of the P2 phage genome and R2 pyocin gene cluster. ORF17 and ORF18 encode the two major structural proteins, which correspond to gpFI (tail sheath) and gpFII (tail tube) of P2 phage, respectively. We found that maltocin P28 had bactericidal activity against 38 of 81 testedS. maltophiliastrains. Therefore, maltocin P28 is a promising therapeutic substitute for antibiotics forS. maltophiliainfections.

scholarly journals Diffusible Signal Factor signaling regulates multiple functions in the opportunistic pathogen Stenotrophomonas maltophilia

2018 ◽  
Author(s):  
Shi-qi An ◽  
Ji-liang Tang
Keyword(s):  
Nosocomial Infections ◽  
Biofilm Formation ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Negative Bacterium ◽  
Signaling Mechanism ◽  
Gram Negative ◽  
Multiple Functions ◽  
Diffusible Signal Factor ◽  
Dependent Cell

AbstractStenotrophomonas maltophilia is a Gram-negative bacterium commonly isolated from nosocomial infections. Analysis of the genome of the clinical Stenotrophomonas maltophilia isolate K279a indicates that it encodes a diffusible signal factor (DSF)-dependent cell-cell signaling mechanism that is highly similar to the system previously described in phytopathogens from the genera Xanthomonas and Xylella. Here we demonstrate that in S. maltophilia strain K279a, DSF signaling regulates factors contributing to virulence, biofilm formation and motility of this important opportunistic pathogen.

scholarly journals Effectors of the Stenotrophomonas maltophilia Type IV Secretion System Mediate Killing of Clinical Isolates of Pseudomonas aeruginosa

mBio ◽  
2021 ◽  
Author(s):  
Megan Y. Nas ◽  
Jeffrey Gabell ◽  
Nicholas P. Cianciotto
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Lung Infection ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Content Type ◽  
Type Iv

S. maltophilia is an increasingly important opportunistic pathogen. Inherently resistant to many antibiotics, S. maltophilia is often associated with lung infection, being, among other things, a complicating factor in cystic fibrosis patients.

scholarly journals Draft Genome Sequences of Two Cystic Fibrosis Strains of Stenotrophomonas maltophilia, AU30115 and AU32848

2018 ◽  
Vol 7 (11) ◽  
Author(s):  
Korin Eckstrom ◽  
Graham G. Willsey ◽  
John J. LiPuma ◽  
Matthew J. Wargo
Keyword(s):  
Cystic Fibrosis ◽  
Stenotrophomonas Maltophilia ◽  
Draft Genome ◽  
Opportunistic Pathogen ◽  
Genome Sequences ◽  
Content Type ◽  
Airway Infection

Stenotrophomonas maltophilia is an opportunistic pathogen causing airway infection in people with cystic fibrosis (CF). Here, we report the draft genome sequences of two S. maltophilia strains, AU30115 and AU32848, recovered from CF patients.

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