Therapeutic Efficacy of SQ641-NE against Mycobacterium tuberculosis
2013 ◽
Vol 58
(1)
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pp. 587-589
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Keyword(s):
ABSTRACTA phospholipid-based nanoemulsion formulation of SQ641 (SQ641-NE) was active against intracellularMycobacterium tuberculosisin J774A.1 mouse macrophages, although SQ641 by itself was not. Intravenous (i.v.) SQ641-NE was cleared from circulation and reached peak concentrations in lung and spleen in 1 h. In a murine tuberculosis (TB) model, 8 i.v. doses of SQ641-NE at 100 mg/kg of body weight over 4 weeks caused a 1.73 log10CFU reduction ofM. tuberculosisin spleen and were generally bacteriostatic in lungs.
1999 ◽
Vol 43
(7)
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pp. 1638-1643
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2012 ◽
Vol 56
(8)
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pp. 4331-4340
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Keyword(s):
Keyword(s):
2015 ◽
Vol 59
(11)
◽
pp. 6873-6881
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Keyword(s):
2014 ◽
Vol 59
(2)
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pp. 1341-1343
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Keyword(s):