Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor
2015 ◽
Vol 59
(4)
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pp. 2439-2442
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ABSTRACTPreliminary enthusiasm over the encouraging spectrum andin vitroactivities of siderophore conjugates, such as MB-1, was recently tempered by unexpected variability inin vivoefficacy. The need for these conjugates to compete for iron with endogenously produced siderophores has exposed a significant liability for this novel antibacterial strategy. Here, we have exploited dependence on efflux for siderophore secretion inPseudomonas aeruginosaand provide evidence that efflux inhibition may circumvent thisin vivo-relevant resistance liability.
2015 ◽
Vol 59
(5)
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pp. 2720-2725
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2014 ◽
Vol 59
(3)
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pp. 1534-1541
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2018 ◽
Vol 63
(2)
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pp. e01718-18
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2012 ◽
Vol 56
(3)
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pp. 1606-1608
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2012 ◽
Vol 56
(9)
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pp. 4771-4778
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Keyword(s):
2012 ◽
Vol 56
(4)
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pp. 2084-2090
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Keyword(s):