The Investigational Agent E1210 Is Effective in Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans
2014 ◽
Vol 59
(1)
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pp. 690-692
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ABSTRACTThein vitroandin vivoactivity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistantCandida albicans. E1210 demonstrated potentin vitroactivity, and in mice with invasive candidiasis caused by echinocandin-resistantC. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistantC. albicansinfections.
2014 ◽
Vol 59
(2)
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pp. 1341-1343
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2012 ◽
Vol 56
(6)
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pp. 3207-3215
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2013 ◽
Vol 58
(3)
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pp. 1789-1792
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2012 ◽
Vol 57
(1)
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pp. 445-451
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2016 ◽
Vol 60
(5)
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pp. 3152-3155
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