Augmentation of Killing of Escherichia coli O157 by Combinations of Lactate, Ethanol, and Low-pH Conditions
1999 ◽
Vol 65
(3)
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pp. 1308-1311
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Keyword(s):
Low Ph
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ABSTRACT The acid tolerance of Escherichia coli O157:H7 strains can be overcome by addition of lactate, ethanol, or a combination of the two agents. Killing can be increased by as much as 4 log units in the first 5 min of incubation at pH 3 even for the most acid-tolerant isolates. Exponential-phase, habituated, and stationary-phase cells are all sensitive to incubation with lactate and ethanol. Killing correlates with disruption of the capacity for pH homeostasis. Habituated and stationary-phase cells can partially offset the effects of the lowering of cytoplasmic pH.
1999 ◽
Vol 65
(7)
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pp. 3048-3055
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2003 ◽
Vol 95
(3)
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pp. 563-575
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2001 ◽
Vol 67
(4)
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pp. 1983-1985
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Keyword(s):
1995 ◽
Vol 61
(5)
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pp. 2037-2039
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2000 ◽
Vol 66
(9)
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pp. 3911-3916
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Keyword(s):