scholarly journals The VR2 Epitope on the PorA P1.7-2,4 Protein Is the Major Target for the Immune Response Elicited by the Strain-Specific Group B Meningococcal Vaccine MeNZB

2006 ◽  
Vol 13 (4) ◽  
pp. 486-491 ◽  
Author(s):  
D. R. Martin ◽  
N. Ruijne ◽  
L. McCallum ◽  
J. O'Hallahan ◽  
P. Oster
Keyword(s):  
Meningococcal Disease ◽  
Young Infant ◽  
Age Groups ◽  
Variable Region ◽  
Age Group ◽  
Public Health Decision ◽  
Antibody Recognition ◽  
Target Strain ◽  
Bactericidal Antibody ◽  
Group B

ABSTRACT A protracted epidemic of group B meningococcal disease in New Zealand led to the testing of a strain-specific tailor-made vaccine, MeNZB. Immunogenicity levels achieved during age group trials enabled New Zealand's regulatory authority to grant licensure to deliver MeNZB to all individuals under age 20. During the trials target strains for serum bactericidal antibody measurements included the vaccine target strain NZ98/254 and two comparator epidemic-type strains (NZ94/167 and NZ02/09). In this study, 12 other strains differing variously from the vaccine strain by their capsular group, PorB type, and PorA variable region specificities, or PorA expression, were used as target strains. The PorA specificity of the serum bactericidal antibody responses to the vaccine was determined for 40 vaccinees. Sets of 10 pre- and postvaccination sera were chosen randomly from the young infant, older infant, toddler, and school-age group trials. Antibody recognition of linearized PorA proteins was also determined using immunoblotting. Across all age groups vaccine-induced serum bactericidal antibodies specifically targeted the VR2 P1.4 epitope of the PorA P1.7-2,4 protein irrespective of the PorB type and/or capsular type of the target strain. Deletion of amino acids within the VR2 epitope or replacement of the epitope through genetic exchange allowed strains variously to resist antibody-directed complement-mediated lysis and negated PorA-specific antibody recognition in immunoblots. The demonstration that the immunodominant antibody response was specifically for the VR2 P1.4 epitope of the PorA protein supports the public health decision to use a strain-specific vaccine for the control of New Zealand's epidemic of meningococcal disease.

scholarly journals Reflections on life-course vaccination: the England experience

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Edelstein
Keyword(s):  
Life Course ◽  
Meningococcal Disease ◽  
Age Groups ◽  
Disease Group ◽  
Life Course Approach ◽  
Group B ◽  
The Uk ◽  
The Right ◽  
The Life Course ◽  
In Pregnancy

Abstract Since the introduction of the expanded programme on immunization in the 1970s, vaccination has evolved from being an intervention of early infancy to being a programme targeting individuals at all stages of life including birth, infancy, childhood, teenage years, pregnancy and adulthood. The UK has been at the forefront of this lifelong approach to vaccination and has introduced vaccines at all stages of life in its national schedule, including vaccination against hepatitis B at birth, Meningococcal disease group B in infancy, influenza in primary school years, Meningococcal disease groups A, C, W and Y in teenage years, pertussis in pregnancy and shingles in older adults. Based on a range of studies conducted by Public Health England, This session will reflect on some of the challenges brought on by the life course approach in the UK including issues of access in different age groups, choosing the right age and settings for vaccinations, age-specific attitudes to vaccination and subsequent communication strategies, and challenges with monitoring a life-course programme.

scholarly journals Sustained reduction in the carriage of Neisseria meningitidis as a result of a community meningococcal disease control programme

1998 ◽  
Vol 121 (3) ◽  
pp. 487-493 ◽  
Author(s):  
K. R. NEAL ◽  
D. J. IRWIN ◽  
S. DAVIES ◽  
E. B. KACZMARSKI ◽  
M. C. J. WALE
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Community Intervention ◽  
Economic Status ◽  
Age Groups ◽  
Control Programme ◽  
Age Group ◽  
Intervention Programme ◽  
Intervention Area ◽  
Sustained Reduction

The effect of a community intervention programme of antibiotics and meningitis vaccine on pharyngeal carriage of Neisseria meningitidis was investigated. Carriage rates were determined in pupils at both secondary schools (ages 11–18 years) included in the community intervention programme and compared with two schools outside the area matched for socio-economic status. A total of 1869 pupils were studied 6 months after the programmes, and 2457 pupils after 11 months.Six months after the programme was completed there was a 72% reduction in pharyngeal carriage of Neisseria meningitidis in pupils attending the schools in the intervention area compared with pupils in the control schools. After 11 months this difference persisted in the 11–14 age group but not in the 15–18 age group. No resistance to the antibiotics used in the programme was found.A community intervention programme of antibiotics and vaccine for the control of meningococcal disease led to a long-term reduction in Neisseria meningitidis carriage in some age groups.

Secular trends in invasive meningococcal disease, Massachusetts, 1988–2011: what happened to invasive disease?

2014 ◽  
Vol 142 (12) ◽  
pp. 2483-2490 ◽  
Author(s):  
A. H. PERUSKI ◽  
P. KLUDT ◽  
R. S. PATEL ◽  
A. DeMARIA
Keyword(s):  
Meningococcal Disease ◽  
Age Groups ◽  
Substantial Reduction ◽  
Invasive Disease ◽  
Secular Trends ◽  
Invasive Meningococcal Disease ◽  
Age Group ◽  
Meningococcal Vaccine ◽  
Average Annual Incidence ◽  
Potential Factors

SUMMARYInvasive meningococcal disease (IMD) reported to the Massachusetts Department of Public Health from 1988 to 2011 was reviewed. The average annual incidence of IMD/100 000 decreased from 1·57 [95% confidence interval (CI) 1·42–1·73] for 1988–1991 to 0·22 (95% CI 0·17–0·29) for 2008–2011. The pattern of decreasing incidence over time differed by age group. There was a decrease in IMD/100 000 in the 0–4 years age group after 1991 from 10·92 (95% CI 8·08–14·70) in 1991 to 5·76 (95% CI 3·78–8·72) in 1992. Incidence in the 0–4 years age group remained below 5/100 000 per year on average thereafter. A substantial reduction in incidence in all age groups was observed between 2000 and 2009, which began before the introduction of conjugate meningococcal vaccine in 2005. Marked reductions in incidence of IMD in Massachusetts, and elsewhere, deserve further investigation with respect to potential factors that go beyond the introduction and deployment of improved meningococcal vaccines.

scholarly journals Morphological study of weight of the ovary at different age group in Bangladeshi people

1970 ◽  
Vol 10 (4) ◽  
pp. 266-268
Author(s):  
MS Ahmed ◽  
H Rahman ◽  
ZG Ara ◽  
SZ Sultana ◽  
M Rahman
Keyword(s):  
Morphological Study ◽  
Minimum Weight ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Age Group ◽  
Cross Sectional ◽  
Weight Variation ◽  
Group A ◽  
Group B ◽  
The Right

Aims: The morphological study was aimed to finedout the ovarian weight in dif ferent age group in Bangladeshi people to increase the knowledge regarding weight variation in our population. Subject & Methods: This cross - sectional study was carried out on Sixty two postmortem tissue contain ovary and fallopian tube along with surrounding structures were collected from 62- female cadaver of different age group by block dissection and fixed in 10% formal saline solution. Gross and fine dissections were carried out to see the morphological parameter of weight of the ovary in different age groups. In the present study, findings were compared with findings of the other researchers. Results: Maximum mean weight of the right ovary is found in this study in group C (46-80) years is 5.78gm and minimum weight is found in group A (2-13 years ) is 3.36gm .But incase left ovary Maximum in group B(14-45)years is 5.01 and minimum group a (2-13)is 2.72gm. statistatical analysis significant different between two groups was calculated by using students "T"Test. In the present study it is observed that the weight of the ovary is not equal on both side of same individual. Key words: ovary,morphology; weight DOI: http://dx.doi.org/10.3329/bjms.v10i4.9498 BJMS 2011; 10 (4): 266-268

scholarly journals Histological study of proportion of cortex and medulla of the ovary in Bangladeshi women

2016 ◽  
Vol 44 (1) ◽  
pp. 8-10
Author(s):  
Hosna Ara Perven ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Dilruba Siddiqua ◽  
Fatema Johora ◽  
Halima Afroz ◽  
...  
Keyword(s):  
Histological Study ◽  
Age Groups ◽  
Age Group ◽  
Cross Sectional ◽  
Medical College ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B ◽  
The Right

This cross sectional, descriptive study was done in the Department of Anatomy, Dhaka Medical College, Dhaka from January to December 2009, to determine the proportion of cortex and medulla of the ovary in di_erent age group of Bangladeshi women. This study was based on collection of 140 ovaries of 70 unclaimed female dead bodies from the morgue of Dhaka Medical College, Dhaka. The samples were divided into three age-groups including A (10-13 years), B (14-45 years) & C (46-52 years). Histological slides were prepared by using routine haematoxylin and eosin stain. Ten best prepared histological slides from each age group were examined to determine the thickness of the cortex and medulla & proportion of the thickness of the cortex and the medulla of the ovary were expressed in percentages. The mean proportion of the cortex and the medulla of the right ovary were found 80.83±0.58% and 19.17±0.58% in group A, 86.95±1.14% and 13.05±1.14% in group B, 70.53±1.53% and 29.47±1.53% in group C respectively. The mean proportion of the cortex and the medulla of the left ovary were found 80.63±0.58% and 19.37±0.58% in group A, 86.78±1.14% and 13.22±1.14% in group B, 70.41±1.50% and 29.59±1.50% in group C respectively. The difference in mean proportion of the cortex and the medulla was not signi_cant in between the ovaries. However, the difference in mean proportion of the cortex and the medulla of the ovary between group A & group B, group A & group C and group B & group C were statistically significant.Bangladesh Med J. 2015 Jan; 44 (1): 8-10

scholarly journals Antimeasles antibodies in children submitted to different vaccination schedules

1993 ◽  
Vol 26 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Solange Artimos de Oliveira ◽  
Akira Homma ◽  
Léa Camillo-Coura ◽  
Maria Lucília P. Loureiro ◽  
Maria Teresa G. N. de Almeida
Keyword(s):  
Geometric Mean ◽  
Age Groups ◽  
Age Group ◽  
The Past ◽  
Measles Antibodies ◽  
History Of ◽  
Antibody Titers ◽  
Group A ◽  
Group B ◽  
Group D

ln order to study the measles antibody behavior of three vaccination schedules, 684 children were divided into 4 Groups: Group A (341 vaccinated children under the age of one); Group B (101 children at the age of one); Group C (74 children under the age of one and one at the age of one); Group D (163 unvaccinated children with a history of measles in the past - Group control). Children of Group A presented lower rates and 25.9% of the age group under two did not show any measles antibodies. In Group B, all the children presented antibodies. In Group C onby 4.0% did not. In all age groups, the geometric mean HI antibody titers of Group A were lower than the valuesfound in the other groups. The age at vaccination was the factor of greater influence on the results of this study.

scholarly journals Serotype-specific outbreak of group B meningococcal disease in Iquique, Chile

1990 ◽  
Vol 105 (1) ◽  
pp. 119-126 ◽  
Author(s):  
C. Cruz ◽  
G. Pavez ◽  
E. Aguilar ◽  
L. Grawe ◽  
J. Cam ◽  
...  
Keyword(s):  
Seasonal Variation ◽  
Mortality Rate ◽  
South America ◽  
Meningococcal Disease ◽  
Age Group ◽  
Older Children ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Group 5 ◽  
Group B

SUMMARYFrom 1979 to August 1987, there have been 178 cases of meningococcal disease in Iquique, Chile, a city of about 140000. The attack rate for the last 5 years has been in excess of 20/100000 per year, more than 20 times greater than for the country overall. The mortality rate was 6%. The disease occurred in patients with ages from 4 months to 60 years, but 89% of cases were in patients <21 years. The largest number of cases were in the age group 5–9 years (n= 54), but the highest incidence occurred in children less than 1 year of age (72·8/100000 per year). The male/female ratio was 1·2. Cases occurred all year round with little seasonal variation. Of the 178 cases, 173 were biologically confirmed. Serogroup analysis of strains from 135 patients revealed A = 1, B = 124, C = 10. Forty-four group B strains from 1985–7 were serotyped: 15:P1.3 = 36, 15:NT = 4, 4:P1.3 = 2, NT:NT = 2. Ten of 11 of the outbreak strains tested were sulfadiazine-resistant. This is the first recognized outbreak caused by a Gp B:15 strain in South America. It shares many of the characteristics of outbreaks caused by closely related strains in Europe, such as a predilection for older children and adolescents, sulfadiazine-resistance, and sustained high attack rates. The Iquique strain (B:15:P1.3) belongs to the same genetic clone (ET-5 complex) as the Norway (B:15:P1.16) and the Cuban (B:4:P1.15) strains.

scholarly journals An outbreak of serogroup B:15:P1.16 meningococcal disease, Frederiksborg county, Denmark, 1987–9

1992 ◽  
Vol 108 (1) ◽  
pp. 19-30 ◽  
Author(s):  
S. Samuelsson ◽  
P. Ege ◽  
L. Berthelsen ◽  
I. Lind
Keyword(s):  
Mortality Rate ◽  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Age Group ◽  
Household Contacts ◽  
Epidemiological Features ◽  
Time Space ◽  
Prophylactic Measures ◽  
Group B ◽  
Overall Mortality

SUMMARYEpidemiological features of an outbreak of group B:15:P1.16 meningococcal disease (MD) in Frederiksborg country, Denmark, 1987–9, were investigated. The study comprised 149 cases notified during the outbreak and the two preceding years; 115 were confirmed by the isolation of Neisseria meningitidis. In 1989 the incidence had increased to 14·1 per 100 000 population. Among group B strains, B:15:P1.16 accounted for 80% (77/97). The overall mortality rate was 10% (15/149). Regarding cases due to group B:15:P1.16 strains a significant time-space clustering, which exclusively occurred within the 10–19 years age group, was demonstrated. The link between cases within clusters was indirect or unknown, except for ten patients with contact to one particular school. The prophylactic measures used included administration of rifampicin to household contacts. During the outbreak the proportion of secondary cases was high (6–15%). All secondary cases occurred outside the household indicating that the household had been protected.

scholarly journals Immunity to Neisseria meningitidis Group B in Adults despite Lack of Serum Bactericidal Antibody

2007 ◽  
Vol 14 (12) ◽  
pp. 1596-1602 ◽  
Author(s):  
Jo Anne Welsch ◽  
Dan Granoff
Keyword(s):  
Neisseria Meningitidis ◽  
Bactericidal Activity ◽  
Meningococcal Disease ◽  
Whole Blood ◽  
Thrombin Inhibitor ◽  
Blood Samples ◽  
Blood Assay ◽  
Bactericidal Antibody ◽  
Bactericidal Activities ◽  
Group B

ABSTRACT Serum-complement-mediated bactericidal antibody (SBA) remains the serologic hallmark of protection against meningococcal disease, despite experimental and epidemiologic data that SBA may underestimate immunity. We measured bactericidal activity against three strains of Neisseria meningitidis group B in sera from 48 healthy adults and in whole blood from 15 subjects. Blood was anticoagulated with lepirudin, a specific thrombin inhibitor not known to activate complement. Depending on the test strain, protective SBA titers of ≥1:4 were present in only 8 to 15% of the subjects, whereas bactericidal activity was present in 40 to 87% of subjects according to the blood assay. Among SBA-negative subjects, blood from 23 to 42% gave a decrease of ≥2 log10 CFU/ml after 1 h of incubation, and blood from 36 to 83% gave a decrease of ≥1 log10 after 2 h. For most blood samples, bactericidal antibodies primarily were directed against noncapsular antigens, since activity was not inhibited by group B polysaccharide. For some SBA-negative subjects, white cells were not needed, since similar respective bactericidal activities were observed in blood and plasma. Bactericidal activity by whole blood of SBA-negative subjects can be rapid (<1 h) and effective (≥2 log10) and, among all subjects, was four- to sixfold more prevalent than a positive SBA. Thus, while an SBA titer of ≥1:4 predicts protection against meningococcal disease, a titer of <1:4 is poorly predictive of susceptibility. More sensitive assays than SBA are needed to assess protective meningococcal immunity, or we risk underestimating the extent of immunity in the population and the effectiveness of new meningococcal vaccines.

scholarly journals A Postmortem Study on the Weight of the Human Ovary

2014 ◽  
Vol 26 (1) ◽  
pp. 12-14
Author(s):  
Hosna Ara Perven ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Shamim Ara ◽  
Sunjida Shahriah ◽  
Gul Newaz Begum
Keyword(s):  
Age Groups ◽  
Age Group ◽  
Cross Sectional ◽  
Medical College ◽  
Group A ◽  
Human Ovaries ◽  
The Difference ◽  
Medicine Today ◽  
Group B ◽  
The Right

A cross-sectional, descriptive type of study was designed to find out the difference in weight of the ovary of Bangladeshi women in relation to age and to compare with the previous studies. This study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from January to December 2009. The study was performed on 140 post mortem human ovaries collected from 70 unclaimed female dead bodies which were in the morgue under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age-groups including group A (10-13 years), group B (14-45 years) & group C (46-52 years) and the weight of the ovaries were measured and recorded. The difference in mean weight between the right ovary and the left ovary was statistically significant in all age group (P <0.001). The difference in mean weight of the ovary between group A & group B, group A & group C and group B & group C were statistically significant (P <0.001) DOI: http://dx.doi.org/10.3329/medtoday.v26i1.21304 Medicine Today 2014 Vol.26(1): 12-14

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