scholarly journals Finished Genome Sequence of the Highly Multidrug-Resistant Human Urine Isolate Citrobacter freundii Strain SL151

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Tomasz A. Leski ◽  
Chris R. Taitt ◽  
Umaru Bangura ◽  
Rashid Ansumana ◽  
David A. Stenger ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Genome Sequence ◽  
Human Urine ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Citrobacter Freundii ◽  
Gram Negative ◽  
Resistance Determinants ◽  
Tract Infections ◽  
Hospital Acquired

Citrobacter freundii is a Gram-negative opportunistic pathogen that is increasingly being recognized as a causative agent of hospital-acquired urinary tract infections and an important reservoir of antimicrobial resistance determinants. In this report, we describe the finished genome sequence of C. freundii strain SL151, a highly multidrug-resistant human urine isolate.

scholarly journals Complete Genome Sequence ofCitrobacter freundiiMyophage Mordin

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Jingwen Guan ◽  
Jeffrey D. Snowden ◽  
Jesse L. Cahill ◽  
Eric S. Rasche ◽  
Gabriel F. Kuty Everett
Keyword(s):  
Urinary Tract ◽  
Effective Treatment ◽  
Urinary Tract Infections ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Opportunistic Pathogen ◽  
Citrobacter Freundii ◽  
Gram Negative ◽  
Tract Infections

Citrobacter freundiiis a Gram-negative opportunistic pathogen that is associated with urinary tract infections. Bacteriophages infectingC. freundiican be used as an effective treatment to fight these infections. Here, we announce the complete genome sequence of theC. freundiiFelix O1-like myophage Mordin and describe its features.

scholarly journals Complete Genome Sequence of Multidrug-ResistantCitrobacter freundiiStrain P10159, Isolated from Urine Samples from a Patient with Esophageal Carcinoma

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Xiaodong Liu ◽  
Yong Huang ◽  
Xiaomeng Xu ◽  
Yachao Zhao ◽  
Qiang Sun ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Esophageal Carcinoma ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Opportunistic Pathogen ◽  
Urine Samples ◽  
Citrobacter Freundii ◽  
Coding Sequences ◽  
Tract Infections

Citrobacter freundiiis an opportunistic pathogen that can cause diarrhea, septicemia, meningitis, and urinary tract infections. We report here the complete genome sequence of C. freundii strain P10159, isolated from urine samples from a patient in China with esophageal carcinoma. The genome has 5,080,321 bp and 4,768 coding sequences, with a G+C content of 51.7%.

scholarly journals Cefiderocol, a new antibiotic against multidrug-resistant Gram-negative bacteria

2021 ◽  
Vol 34 (Suppl 1) ◽  
pp. 41-43
Author(s):  
José Tiago Silva ◽  
Francisco López-Medrano
Keyword(s):  
Bacterial Pneumonia ◽  
Treatment Options ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Phase Iii ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Tract Infections ◽  
Transport Channels ◽  
Hospital Acquired

Cefiderocol is a novel catechol-substituted siderophore cephalosporin that binds to the extracellular free iron, and uses the bacterial active iron transport channels to penetrate in the periplasmic space of Gram-negative bacteria (GNB). Cefiderocol overcomes many resistance mechanisms of these bacteria. Cefiderocol is approved for the treatment of complicated urinary tract infections, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in the case of adults with limited treatment options, based on the clinical data from the APEKS-cUTI, APEKS-NP and CREDIBLE-CR trials. In the CREDIBLE-CR trial, a higher all-cause mortality was observed in the group of patients who received cefiderocol, especially those with severe infections due to Acinetobacter spp. Further phase III clinical studies are necessary in order to evaluate cefiderocol´s efficacy in the treatment of serious infections.

scholarly journals Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments

2018 ◽  
Vol 90 (2) ◽  
pp. 85 ◽  
Author(s):  
Gianpaolo Perletti ◽  
Vittorio Magri ◽  
Tommaso Cai ◽  
Konstantinos Stamatiou ◽  
Alberto Trinchieri ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Multidrug Resistant ◽  
Medical Emergency ◽  
Fluoroquinolone Resistance ◽  
Drug Resistant ◽  
Gram Negative ◽  
Resistance Determinants ◽  
Rapid Spread ◽  
The World ◽  
Tract Infections

Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older – but still active – recommended drugs are summarized.

scholarly journals Complete Genome Sequence of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Siphophage Sushi

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Dat T. Nguyen ◽  
Lauren E. Lessor ◽  
Jesse L. Cahill ◽  
Eric S. Rasche ◽  
Gabriel F. Kuty Everett
Keyword(s):  
Urinary Tract ◽  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Negative Bacterium ◽  
Gram Negative ◽  
Klebsiella Pneumoniae Carbapenemase ◽  
The Family ◽  
Tract Infections

Klebsiella pneumoniae is a Gram-negative bacterium in the family Enterobacteriaceae . It is associated with numerous nosocomial infections, including respiratory and urinary tract infections in humans. The following reports the complete genome sequence of K. pneumoniae carbapenemase-producing K. pneumoniae T1-like siphophage Sushi and describes its major features.

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