Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice
1998 ◽
Vol 66
(9)
◽
pp. 4503-4506
◽
Keyword(s):
ABSTRACT We studied the immune response induced in mice by recombinantToxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%.
2002 ◽
Vol 70
(2)
◽
pp. 498-503
◽
Keyword(s):
2003 ◽
Vol 71
(1)
◽
pp. 465-473
◽
Keyword(s):
2002 ◽
Vol 70
(12)
◽
pp. 6715-6725
◽
2018 ◽
Vol 36
(2)
◽
2011 ◽
pp. 34-44
◽
Keyword(s):
2016 ◽
Vol 8
(5)
◽
pp. 865-874
◽
Keyword(s):
2001 ◽
Vol 69
(5)
◽
pp. 2808-2814
◽