Rough Lipopolysaccharide from Brucella abortus and Escherichia coli Differentially Activates the Same Mitogen-Activated Protein Kinase Signaling Pathways for Tumor Necrosis Factor Alpha in RAW 264.7 Macrophage-Like Cells
2002 ◽
Vol 70
(12)
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pp. 7165-7168
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Keyword(s):
Tnf Α
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ABSTRACT The intracellular, gram-negative pathogen Brucella abortus establishes chronic infections in host macrophages while downregulating cytokines such as tumor necrosis factor alpha (TNF-α). When producing TNF-α, Brucella abortus rough lipopolysaccharide (LPS) activates the same mitogen-activated protein kinase signaling pathways (ERK and JNK) as Escherichia coli LPS, but Brucella LPS is a much less potent agonist.
2004 ◽
Vol 11
(6)
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pp. 1140-1147
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2001 ◽
Vol 69
(3)
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pp. 1273-1279
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2007 ◽
Vol 105
(6)
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pp. 1838-1844
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2005 ◽
Vol 73
(10)
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pp. 6499-6507
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2010 ◽
Vol 198
(2)
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pp. 152-158
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1995 ◽
Vol 92
(5)
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pp. 1614-1618
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