scholarly journals Multispecies Transcriptomics Data Set of Brugia malayi, Its Wolbachia Endosymbiont wBm, and Aedes aegypti across the B. malayi Life Cycle

2018 ◽  
Vol 7 (18) ◽  
Author(s):  
Matthew Chung ◽  
Laura Teigen ◽  
Silvia Libro ◽  
Robin E. Bromley ◽  
Nikhil Kumar ◽  
...  
Keyword(s):  
Life Cycle ◽  
Aedes Aegypti ◽  
Brugia Malayi ◽  
Adult Males ◽  
Data Set ◽  
Content Type ◽  
Transcriptomics Data ◽  
Wolbachia Endosymbiont ◽  
Males And Females ◽  
Stage 1

Here, we present a comprehensive transcriptomics data set of Brugia malayi, its Wolbachia endosymbiont wBm, and its vector host. This study samples from 16 stages across the entire B. malayi life cycle, including stage 1 through 4 larvae, adult males and females, embryos, immature microfilariae, and mature microfilariae.

scholarly journals The genital and anal papillae of Compsura heterura (Characidae: Cheirodontinae): morphological structure and possible role in insemination

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Antônio Queiroz Lezama ◽  
Luiz R. Malabarba
Keyword(s):  
Life Cycle ◽  
Morphological Structure ◽  
Genital Papilla ◽  
Adult Males ◽  
Males And Females ◽  
Anal Papillae ◽  
Anal Organ ◽  
Tubular Shape ◽  
Female Genital

ABSTRACT The function of the genital and anal papillae for insemination in Compsura heterura is discussed based on the description of their morphologies at different stages of the life cycle and during copulation and spawning. In males and females both the genital and anal papillae are involved in copulation in C. heterura. A pre-anal organ, anterior to the anus and stretched posteriorly, is present in adult males. The openings of the urinary channel and oviduct are separate in females. During copulation, there is an approximation between the female genital and anal papillae which become temporarily juxtaposed, forming a chamber enclosing the opening of the oviduct, which may also function in sperm capture. During spawning, the lateral edges of the female genital papilla are projected anteriorly, acquiring a tubular shape for oviposition.

Life cycle and mating behavior of Helicotylenchus multicinctus (Nematoda: Hoplolaimidae) on excised Musa cavendishii roots

Biologia ◽  
2007 ◽  
Vol 62 (3) ◽  
Author(s):  
Mehmet Karakaş
Keyword(s):  
Life Cycle ◽  
Mating Behavior ◽  
Juvenile Stage ◽  
Adult Males ◽  
Second Stage ◽  
Stage Juvenile ◽  
Juvenile Stages ◽  
Males And Females ◽  
Final Molt

AbstractThe life cycle and mating behavior of Helicotylenchus multicinctus (Nematoda: Hoplolaimidae) were observed in vitro on excised roots of Musa cavendishii in gnotobiotic culture. Eggs hatched into juveniles whose appearance and structure were similar to those of the adults. Juveniles grew in size and each juvenile stage was terminated by a molt. H. multicinctus had four juvenile stages. The first molt occurred outside the egg shortly after hatching. After the final molt the juveniles differentiated into adult males and females. Mating was required for reproduction. After mating, fertilized females began to lay eggs. The life cycle from second stage juvenile to second stage juvenile was completed in 39 days.

scholarly journals Estimation of life-cycle costs of buildings: regression vs artificial neural network

2016 ◽  
Vol 6 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Ayedh Alqahtani ◽  
Andrew Whyte
Keyword(s):  
Life Cycle ◽  
Cost Estimation ◽  
Coefficient Of Determination ◽  
Percentage Error ◽  
Data Set ◽  
Building Projects ◽  
Content Type ◽  
Testing Stage ◽  
Running Cost ◽  
Artificial Neural

Purpose – The purpose of this paper is to compare the performance of regression and artificial-neural-networks (ANNs) methods to estimate the running cost of building projects towards improved accuracy. Design/methodology/approach – A data set of 20 building projects is used to test the performance of these two (ANNs/regression) models in estimating running cost. The concept of cost-significant-items is identified as important in assisting estimation. In addition, a stepwise technique is used to eliminate insignificant factors in regression modelling. A connection weight method is applied to determine the importance of cost factors in the performance of ANNs. Findings – The results illustrate that the value of the coefficient of determination=99.75 per cent for ANNs model(s), with a value of 98.1 per cent utilising multiple regression (MR) model(s); second, the mean percentage error (MPE) for ANNs at a testing stage is 0.179, which is less than that of the MPE gained through MR modelling of 1.28; and third, the average accuracy is 99 per cent for ANNs model(s) and 97 per cent for MR model(s). On the basis of these results, it is concluded that an ANNs model is superior to a MR model when predicting running cost of building projects. Research limitations/implications – A means for continuous improvement for the performance of the models accuracy has been established; this may be further enhanced by future extended sample. Originality/value – This work extends the knowledge base of life-cycle estimation where ANNs method has been found to reduce preparation time consumed and increasing accuracy improvement of the cost estimation.

scholarly journals Rethinking life cycle cost drivers for sustainable office buildings in Denmark

Facilities ◽  
2019 ◽  
Vol 37 (9/10) ◽  
pp. 624-638 ◽  
Author(s):  
Kim Haugbølle ◽  
Lau M. Raffnsøe
Keyword(s):  
Life Cycle ◽  
Building Design ◽  
Life Cycle Costing ◽  
Office Buildings ◽  
Life Cycle Costs ◽  
Construction Costs ◽  
Data Set ◽  
Sustainable Building ◽  
Content Type ◽  
Cost Drivers

Purpose Sustainable building design suffers from a lack of reliable life cycle data. The purpose of this paper is to compare life cycle costs of sustainable building projects, examine the magnitude of various cost drivers and discuss the implications of an emerging shift in cost drivers. Design/methodology/approach This paper is based on data from 21 office buildings certified in Denmark according to the sustainable certification scheme DGNB. Findings The paper supports previous findings that construction costs and running costs each roughly make up half of the life cycle costs over a 50-year period. More surprising is the finding that the life cycle costs for cleaning are approximately twice as high as the supply costs for energy and water. Research limitations/implications The data set is based on actual construction costs of office buildings constructed in 2013-2017. Although all running costs are calculated rather than measured, they are based on a more detailed, specific and industry-supported set of calculation assumptions than is usual for life cycle costing studies because of extensive collaborative work in a number of concomitant national research and development projects. Practical implications Authorities, clients and building professionals heavily emphasise energy-saving measures in new Danish buildings. The paper suggests redirecting this effort towards other more prominent cost drivers like cleaning and technical installations. Originality/value This paper provides a notable contribution to the academic understanding of the significance of different cost drivers as well as the practical implementation of life cycle costing.

Marketing communication in the digital age: online ads, online WOM and mobile game adoptions

2019 ◽  
Vol 10 (3) ◽  
pp. 382-407
Author(s):  
Shiyang Gong ◽  
Wanqin Wang ◽  
Qian Li
Keyword(s):  
Life Cycle ◽  
Product Life Cycle ◽  
Positive Impact ◽  
Investment Strategy ◽  
Marketing Communication ◽  
Media Effect ◽  
Data Set ◽  
Product Life ◽  
Content Type ◽  
The Impact

Purpose This study aims to explore the interdependent impacts of online word-of-mouth (WOM) and online ads on digital product adoptions, as well as their dynamic changes throughout the product life cycle. Design/methodology/approach This study adopted an empirical approach by using a unique data set of five mobile games launched between 2012 and 2014 provided by Renren Games Ltd. in China. Findings The results indicated that advertising generally has a positive impact on WOM. During the product life cycle, the influence on volume and variance gradually decreases, whereas the impact on valence increases over time. WOM (including WOM volume and WOM valence) and advertising both have positive impacts on game adoptions. They complement each other to shape adoptions throughout the product life cycle: advertising is more effective in encouraging adoptions in the early and later stages of the demand evolution process, whereas WOM has a greater impact on adoptions in the mid-stage. Practical implications This study provided detailed managerial recommendations on how to effectively integrate different types of marketing communication and optimize the investment strategy of online ads and online WOM in different stages of the product life cycle. Originality/value First, the study enriched the theory of digital marketing communication by studying the relationship between mass media (online ads), interpersonal media (online WOM) and product adoptions in the network context. Second, it provided an empirical basis for the inference of the dynamic development of media effect in the new product diffusion theory. Third, the results will be helpful to end the debate in current theoretical literature on whether there is a complementary or alternative relationship between the two effects. Last but not least, it enriched research on the antecedents and dynamic effects of online WOM.

Infestations of the nematode Skrjabingylus nasicola (Leukart 1842) in Mustela frenata (Lichtenstein) and M. erminea (L.) and some evidence of a paratenic host in the life cycle of this nematode

1982 ◽  
Vol 60 (1) ◽  
pp. 45-52 ◽  
Author(s):  
R. Lloyd Gamble ◽  
R. R. Riewe
Keyword(s):  
Life Cycle ◽  
Definitive Host ◽  
Paratenic Host ◽  
Adult Males ◽  
Parasite Invasion ◽  
Mustela Erminea ◽  
Adult Females ◽  
Condylobasal Length ◽  
Males And Females ◽  
Paratenic Hosts

Examination of 153 Mustela frenata and 16 Mustela erminea from Manitoba revealed 100% parasitism of both hosts by Skrjabingylus nasicola. Cranial damage was significantly less in M. frenata than in M. erminea. In M. frenata, cranial damage was less in adult females than males and greater in adults than in subadults. Adult males and females had a greater degree of damage than subadult males and females. Percentage infestation and damage was related to diet. Data suggest that rodents, particularly the myomorphs, shrew, amphibians, and reptiles are paratenic hosts for S. nasicola. The condylobasal length of the skull of M. frenata apparently is not affected by parasite invasion, though the interorbital breadth is affected and becomes unreliable as a taxonomic measurement. Cranial damage was frequently asymmetrical. Despite repeated invasions, the definitive host is still active and therefore must tolerate the damage.

Impacts of adaptive collaboration on demand forecasting accuracy of different product categories throughout the product life cycle

2015 ◽  
Vol 20 (4) ◽  
pp. 415-433 ◽  
Author(s):  
Masayasu Nagashima ◽  
Frederick T. Wehrle ◽  
Laoucine Kerbache ◽  
Marc Lassagne
Keyword(s):  
Supply Chain ◽  
Life Cycle ◽  
Product Life Cycle ◽  
Forecast Accuracy ◽  
Product Category ◽  
Life Cycle Stage ◽  
Demand Forecast ◽  
Short Life ◽  
Data Set ◽  
Content Type

Purpose – This paper aims to empirically analyze how adaptive collaboration in supply chain management impacts demand forecast accuracy in short life-cycle products, depending on collaboration intensity, product life-cycle stage, retailer type and product category. Design/methodology/approach – The authors assembled a data set of forecasts and sales of 169 still-camera models, made by the same manufacturer and sold by three different retailers in France over five years. Collaboration intensity, coded by collaborative planning forecasting and replenishment level, was used to analyze the main effects and specific interaction effects of all variables using ANOVA and ordered feature evaluation analysis (OFEA). Findings – The findings lend empirical support to the long-standing assumption that supply chain collaboration intensity increases demand forecast accuracy and that product maturation also increases forecast accuracy even in short life-cycle products. Furthermore, the findings show that it is particularly the lack of collaboration that causes negative effects on forecast accuracy, while positive interaction effects are only found for life cycle stage and product category. Practical implications – Investment in adaptive supply chain collaboration is shown to increase demand forecast accuracy. However, the choice of collaboration intensity should account for life cycle stage, retailer type and product category. Originality/value – This paper provides empirical support for the adaptive collaboration concept, exploring not only the actual benefits but also the way it is achieved in the context of innovative products with short life cycles. The authors used a real-world data set and pushed its statistical analysis to a new level of detail using OFEA.

scholarly journals Retirement saving in the UK: a life-cycle analysis

2018 ◽  
Vol 35 (1) ◽  
pp. 109-136 ◽  
Author(s):  
Roberta Adami ◽  
Andrea Carosi ◽  
Anita Sharma
Keyword(s):  
Life Cycle ◽  
Ethnic Minorities ◽  
Empirical Studies ◽  
Control Group ◽  
Cross Sectional ◽  
Data Set ◽  
Content Type ◽  
Population Decrease ◽  
The Uk

PurposeThis paper aims to study long-term savings accumulation in the UK. The authors use cross-sectional information from the extensive data set of the Family Resources Survey to compare long-term saving amongst different ethnic groups with the control group, the native population. The paper reflects on whether different groups are more likely to suffer poverty in retirement.Design/methodology/approachIn this analysis, the authors apply the life-cycle framework to explain saving profiles. This theoretical model has been used extensively in the field of economics and can be applied to empirical studies to examine changes in income and saving patterns over the life-course. The framework contends that individuals make savings decisions to smooth consumption over different phases of their life-cycle.FindingsThe findings indicate that socio-economic factors are key elements in determining whether individuals plan for retirement if factors are controlled for the differences in saving behaviours between ethnic minorities and the control population decrease considerably. Asian women, with good education and social standing, display greater saving rates than the control group, while the socio-economic disadvantage suffered especially by Pakistani and Bangladeshi women is key to their inability to save long-term. High levels of poverty in retirement are more likely to be caused by the interaction of low levels of education, part-time work and long spells of unemployment than by ethnicity.Originality/valueThe important contribution to the debate on savings by ethnic minorities is the extension of the life-cycle model to specific sections of the population and to proffer new insights into their saving/dis-saving patterns and ultimately their welfare in retirement.

scholarly journals Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics

mSystems ◽  
2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Matthew Chung ◽  
Laura E. Teigen ◽  
Silvia Libro ◽  
Robin E. Bromley ◽  
Dustin Olley ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Lymphatic Filariasis ◽  
Adult Female ◽  
Energy Demand ◽  
Drug Repurposing ◽  
Brugia Malayi ◽  
Life Stages ◽  
Female Embryo ◽  
Content Type

ABSTRACT To better understand the transcriptomic interplay of organisms associated with lymphatic filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial nematode Brugia malayi, its Wolbachia endosymbiont wBm, and its laboratory vector Aedes aegypti across the entire B. malayi life cycle. In wBm, transcription of the noncoding 6S RNA suggests that it may be a regulator of bacterial cell growth, as its transcript levels correlate with bacterial replication rates. For A. aegypti, the transcriptional response reflects the stress that B. malayi infection exerts on the mosquito with indicators of increased energy demand. In B. malayi, expression modules associated with adult female samples consistently contained an overrepresentation of genes involved in chromatin remodeling, such as the bromodomain-containing proteins. All bromodomain-containing proteins encoded by B. malayi were observed to be upregulated in the adult female, embryo, and microfilaria life stages, including 2 members of the bromodomain and extraterminal (BET) protein family. The BET inhibitor JQ1(+), originally developed as a cancer therapeutic, caused lethality of adult worms in vitro, suggesting that it may be a potential therapeutic that can be repurposed for treating lymphatic filariasis. IMPORTANCE The current treatment regimen for lymphatic filariasis is mostly microfilaricidal. In an effort to identify new drug candidates for lymphatic filariasis, we conducted a three-way transcriptomics/systems biology study of one of the causative agents of lymphatic filariasis, Brugia malayi, its Wolbachia endosymbiont wBm, and its vector host Aedes aegypti at 16 distinct B. malayi life stages. B. malayi upregulates the expression of bromodomain-containing proteins in the adult female, embryo, and microfilaria stages. In vitro, we find that the existing cancer therapeutic JQ1(+), which is a bromodomain and extraterminal protein inhibitor, has adulticidal activity in B. malayi.

scholarly journals Life cycle and performance among SMEs: Swedish empirical evidence

2014 ◽  
Vol 15 (5) ◽  
pp. 555-571 ◽  
Author(s):  
Darush Yazdanfar ◽  
Peter Öhman
Keyword(s):  
Life Cycle ◽  
Firm Performance ◽  
Analysis Of Variance ◽  
Set Covering ◽  
Life Cycle Model ◽  
Cycle Model ◽  
Data Set ◽  
Content Type ◽  
Life Cycle Stages ◽  
Performance Pattern

Purpose – This study aims to empirically examine the applicability of the life cycle model of firm performance to growth and profitability among Swedish small- and medium-sized enterprises (SMEs). Design/methodology/approach – Using analysis of variance, multiple analysis of variance and three-stage least square modelling, this study analyses a longitudinal data set covering 26,721 Swedish SMEs in six industries from 2008 to 2011. Findings – The empirical results indicate a clear life cycle performance pattern among the sampled SMEs, and that a six-stage life cycle model is applicable in predicting the performance pattern in terms of growth and profitability. On average, younger SMEs tend to display better performance in terms of growth and profitability than do their older and larger counterparts; moreover, larger SMEs tend to achieve better performance than do smaller ones. Practical implications – The findings help SME managers understand how their decision-making style, strategy and structure can be related to various life cycle stages. Such an understanding may help them improve firm performance over time. Policymakers may find the results useful in coordinating SME support in line with various life cycle stages. Originality/value – To the authors’ knowledge, this study is one of only a few using two performance variables to test the applicability of the life cycle model in a longitudinal and cross-industrial sample.

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