Effect of vibratory stimulation of foot support areas in rats on the functional state of leg muscles and the content of N2A titin isoforms in gravity relief

BIOPHYSICS ◽  
2014 ◽  
Vol 59 (2) ◽  
pp. 316-320 ◽  
Author(s):  
T. V. Baltina ◽  
M. V. Kuznetsov ◽  
A. A. Yeremeev ◽  
M. E. Baltin
Keyword(s):  
Functional State ◽  
Vibratory Stimulation ◽  
Titin Isoforms ◽  
Leg Muscles ◽  
Stimulation Of

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

scholarly journals Vibration Induces BAFF Overexpression and Aberrant O-Glycosylation of IgA1 in Cultured Human Tonsillar Mononuclear Cells in IgA Nephropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Muyao Ye ◽  
Youming Peng ◽  
Chan Liu ◽  
Wenzhe Yan ◽  
Xiaofei Peng ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Cell Activation ◽  
Mononuclear Cells ◽  
Control Group ◽  
B Cell Activation ◽  
Vibratory Stimulation ◽  
Group A ◽  
Stimulation Of ◽  
Group 1

Objective. To investigate the influence ofin vitrovibratory stimulation of human tonsillar mononuclear cells (TMCs).Methods. Fourteen IgA nephropathy (IgAN) patients with chronic tonsillitis (CT) and 12 CT patients with no renal pathology were enrolled. Group A TMCs were collected after 24 hours of culture and used to determine baseline levels. TMCs in groups B, C, D, E, and F were exposed to vibratory stimulation (60 Hz) for 0 (as the control group), 1, 3, 5, and 10 minutes, respectively.Results. Baseline concentrations of B-cell-activation factor (BAFF) and IgA1, BAFF mRNA expression, and aberrant O-glycosylation IgA1 level were higher in the IgAN group as compared to that in the CT group, and all increased after vibratory stimulation. Baseline mRNA expressions of coreβ1,3-galactosyltransferase (C1GALT1) and coreβ1,3GalT-specific molecular chaperone (Cosmc) were lower in the IgAN group; the levels decreased further after vibratory stimulation.Conclusion. In patients with IgAN, vibratory stimulation of TMCs appears to induce IgA1 secretion through activation of BAFF release and to aberrant O-glycosylation IgA1 by suppressing C1GALT1 and Cosmc expression.In vitrovibratory stimulation of human TMCs mimics the vibratory simulation of palatine tonsils produced by vocal cords during phonation.

Alternate rhythmic vibratory stimulation of trunk muscles affects walking cadence and velocity in Parkinson’s disease

2010 ◽  
Vol 121 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Alessandro M. De Nunzio ◽  
Margherita Grasso ◽  
Antonio Nardone ◽  
Marco Godi ◽  
Marco Schieppati
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Trunk Muscles ◽  
Vibratory Stimulation ◽  
Stimulation Of

scholarly journals A Non-Invasive Medical Device for Parkinson’s Patients with Episodes of Freezing of Gait

Sensors ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 737 ◽  
Author(s):  
Catalina Punin ◽  
Boris Barzallo ◽  
Roger Clotet ◽  
Alexander Bermeo ◽  
Marco Bravo ◽  
...  
Keyword(s):  
Wavelet Transform ◽  
Mobile Application ◽  
Low Cost ◽  
Freezing Of Gait ◽  
Discrete Wavelet ◽  
Vibratory Stimulation ◽  
Non Invasive ◽  
Sensitivity Specificity ◽  
Gait Monitoring ◽  
Stimulation Of

A critical symptom of Parkinson’s disease (PD) is the occurrence of Freezing of Gait (FOG), an episodic disorder that causes frequent falls and consequential injuries in PD patients. There are various auditory, visual, tactile, and other types of stimulation interventions that can be used to induce PD patients to escape FOG episodes. In this article, we describe a low cost wearable system for non-invasive gait monitoring and external delivery of superficial vibratory stimulation to the lower extremities triggered by FOG episodes. The intended purpose is to reduce the duration of the FOG episode, thus allowing prompt resumption of gait to prevent major injuries. The system, based on an Android mobile application, uses a tri-axial accelerometer device for gait data acquisition. Gathered data is processed via a discrete wavelet transform-based algorithm that precisely detects FOG episodes in real time. Detection activates external vibratory stimulation of the legs to reduce FOG time. The integration of detection and stimulation in one low cost device is the chief novel contribution of this work. We present analyses of sensitivity, specificity and effectiveness of the proposed system to validate its usefulness.

Phase-dependent reflex reversal in human leg muscles during walking

1990 ◽  
Vol 63 (5) ◽  
pp. 1109-1117 ◽  
Author(s):  
J. F. Yang ◽  
R. B. Stein
Keyword(s):  
Stimulus Intensity ◽  
Rectus Femoris ◽  
Leg Muscles ◽  
Middle Latency Response ◽  
Reflex Pathways ◽  
Activation Level ◽  
Reflex Reversal ◽  
Latency Response ◽  
Middle Latency ◽  
Stimulation Of

1. Reflex responses during walking were elicited in humans by stimulation of the tibial nerve at the ankle. The stimulus intensity was controlled by monitoring the M-wave from an intrinsic foot muscle. Responses were observed in the ipsilateral tibialis anterior (TA), soleus (SO), and rectus femoris (RF) muscles. The most reproducible responses were observed at a middle latency between 50 and 90 ms. The responses were most likely of cutaneous origin, because they closely resembled the responses to stimulation of a purely cutaneous nerve, the sural nerve. 2. A reversal in the direction of the middle latency response from excitation to inhibition was observed for the first time within single muscles during walking. Evidence for a reversal was seen in all three muscles examined and in all seven subjects. 3. The reflex reversal could not be elicited in standing. An inhibition whose amplitude varied in a linear fashion with stimulus intensity and background activation level was always observed at middle latency. The responses elicited during standing resembled those during the stance phase of walking. The two tasks shared some common movement goals and appeared to make use of similar reflex pathways.

scholarly journals Metabolic adaptation in phosphorylase kinase deficiency. Changes in metabolite concentrations during tetanic stimulation of mouse leg muscles

1980 ◽  
Vol 186 (1) ◽  
pp. 331-341 ◽  
Author(s):  
Z H Rahim ◽  
D Perrett ◽  
G Lutaya ◽  
J R Griffiths
Keyword(s):  
Initial Rate ◽  
Adenine Nucleotide ◽  
Mass Action ◽  
Metabolic Adaptation ◽  
Phosphorylase Kinase ◽  
Normal Muscle ◽  
Leg Muscles ◽  
Muscle Work ◽  
Muscle Groups ◽  
Stimulation Of

1. Glycogen, nucleotides and glycolytic intermediates and products were measured before and during tetanus in the hamstrings-muscle groups of normal (C3H) and phosphorylase kinase-deficient (ICR/IAn) mice. 2. Phosphorylase kinase-deficient muscles contained 3-4-fold more glycogen and sustained a larger (approx. 2-fold), more rapid (11 +/- 2 ng/s faster) and more prolonged glycogenolysis during 120s tetanus despite their lack of phosphorylase a. 3. No significant change in total adenine nucleotide contents occurred during tetanus in either strain, but there was a 60-100-fold rise in IMP concentration to approx. 2mM in both strains. The initial rate of IMP formation was 6-fold more rapid (112 nmol/s per g) in phosphorylase kinase-deficient muscle. 4. Adenylosuccinate content rose to 36 nmol/g in phosphorylase kinase-deficient muscle and to 9 nmol/g in normal muscle at 45s tetanus, but then fell. 5. In phosphorylase kinase-deficient muscle, glucose 6-phosphate, a powerful phosphorylase inhibitor, was 56% of that in normal muscle. 6. The mass-action ratio of the phosphoglucomutase-catalysed reaction [glucose 6-phosphate]/[glucose 1-phosphate] was markedly lower than Keq. (approx. 17) in relaxed muscle of both strains (approx. 5-7), but rose significantly during tetanus to the value for Keq. 7. The data for IMP satisfy the criteria put forward by Rahim, Perrett & Griffiths [(1976) FEBS Lett. 69, 203-206] for a nucleotide activator of phosphorylase b: it should be present at a higher concentration in phosphorylase kinase-deficient muscle, its concentration should rise during muscle work, and it should attain a concentration comparable with its activation constant for phosphorylase b.

scholarly journals Humans adjust control to initial squat depth in vertical squat jumping

2008 ◽  
Vol 105 (5) ◽  
pp. 1428-1440 ◽  
Author(s):  
Maarten F. Bobbert ◽  
L. J. Richard Casius ◽  
Igor W. T. Sijpkens ◽  
Richard T. Jaspers
Keyword(s):  
Gluteus Maximus ◽  
Maximum Height ◽  
Dynamics Model ◽  
Kinematic Data ◽  
Leg Muscles ◽  
Reaction Forces ◽  
Squat Jumps ◽  
The Brain ◽  
Insight Into ◽  
Stimulation Of

The purpose of this study was to gain insight into the control strategy that humans use in jumping. Eight male gymnasts performed vertical squat jumps from five initial postures that differed in squat depth (P1–P5) while kinematic data, ground reaction forces, and electromyograms (EMGs) of leg muscles were collected; the latter were rectified and smoothed to obtain SREMGs. P3 was the preferred initial posture; in P1, P2, P4, and P5 height of the mass center was +13, +7, −7 and −14 cm, respectively, relative to that in P3. Furthermore, maximum-height jumps from the initial postures observed in the subjects were simulated with a model comprising four body segments and six Hill-type muscles. The only input was the onset of stimulation of each of the muscles (Stim). The subjects were able to perform well-coordinated squat jumps from all postures. Peak SREMG levels did not vary among P1–P5, but SREMG onset of plantarflexors occurred before that of gluteus maximus in P1 and >90 ms after that in P5 ( P < 0.05). In the simulation study, similar systematic shifts occurred in Stim onsets across the optimal control solutions for jumps from P1–P5. Because the adjustments in SREMG onsets to initial posture observed in the subjects were very similar to the adjustments in optimal Stim onsets of the model, it was concluded that the SREMG adjustments were functional, in the sense that they contributed to achieving the greatest jump height possible from each initial posture. For the model, we were able to develop a mapping from initial posture to Stim onsets that generated successful jumps from P1–P5. It appears that to explain how subjects adjust their control to initial posture there is no need to assume that the brain contains an internal dynamics model of the musculoskeletal system.

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