THU0419 Association of inflammatory markers c-reactive protein and erythrocyte sedimentation ratewith pulmonary function tests and european scleroderma study group activity index (ESCSG-AI) in systemic sclerosis – associated interstitial lung disease in follow up study

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

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Diagnostic accuracy of serum inflammatory markers in late fracture-related infection

The Bone & Joint Journal ◽

10.1302/0301-620x.100b12.bjj-2018-0586.r1 ◽

2018 ◽

Vol 100-B (12) ◽

pp. 1542-1550 ◽

Cited By ~ 13

Author(s):

J. van den Kieboom ◽

P. Bosch ◽

J. D. J. Plate ◽

F. F. A. IJpma ◽

R. Kuehl ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Sensitivity And Specificity ◽

Inflammatory Markers ◽

Meta Analysis ◽

Diagnostic Value ◽

Mixed Effects Models ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Serum Inflammatory Markers

Aims To assess the diagnostic value of C-reactive protein (CRP), leucocyte count (LC), and erythrocyte sedimentation rate (ESR) in late fracture-related infection (FRI). Materials and Methods PubMed, Embase, and Cochrane databases were searched focusing on the diagnostic value of CRP, LC, and ESR in late FRI. Sensitivity and specificity combinations were extracted for each marker. Average estimates were obtained using bivariate mixed effects models. Results A total of 8284 articles were identified but only six were suitable for inclusion. Sensitivity of CRP ranged from 60.0% to 100.0% and specificity from 34.3% to 85.7% in all publications considered. Five articles were pooled for meta-analysis, showing a sensitivity and specificity of 77.0% and 67.9%, respectively. For LC, this was 22.9% to 72.6%, and 73.5% to 85.7%, respectively, in five articles. Four articles were pooled for meta-analysis, resulting in a 51.7% sensitivity and 67.1% specificity. For ESR, sensitivity and specificity ranged from 37.1% to 100.0% and 59.0% to 85.0%, respectively, in five articles. Three articles were pooled in meta-analysis, showing a 45.1% sensitivity and 79.3% specificity. Four articles analyzed the value of combined inflammatory markers, reporting an increased diagnostic accuracy. These results could not be pooled due to heterogeneity. Conclusion The serum inflammatory markers CRP, LC, and ESR are insufficiently accurate to diagnose late FRI, but they may be used as a suggestive sign in its diagnosis.

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One-Stage Anterolateral Debridement, Bone Grafting, and Internal Fixation for Treating Lumbosacral Tuberculosis

Asian Spine Journal ◽

10.4184/asj.2017.11.2.305 ◽

2017 ◽

Vol 11 (2) ◽

pp. 305-313 ◽

Cited By ~ 1

Author(s):

Tao Zhang ◽

Lihua Ma ◽

Xu Lan ◽

Ping Zhen ◽

Shiyong Wang ◽

...

Keyword(s):

Internal Fixation ◽

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Bone Grafting ◽

Oswestry Disability Index ◽

C Reactive Protein ◽

Reactive Protein ◽

One Stage ◽

Erythrocyte Sedimentation

<sec><title>Study Design</title>Retrospective case series.</sec><sec><title>Purpose</title>To investigate the clinical efficacy and feasibility of one-stage anterolateral debridement, bone grafting, and internal fixation for treating lumbosacral tuberculosis.</sec><sec><title>Overview of Literature</title>There has been no consensus regarding the optimal means of treating lumbosacral tuberculosis. The one-stage anterolateral extraperitoneal approach for radical debridement, bone grafting, and internal fixation for treating lumbosacral tuberculosis is rare in literature.</sec><sec><title>Methods</title>Twenty-one patients with lumbosacral tuberculosis were retrospectively analyzed. All patients underwent the surgery of anterolateral debridement after regularly antituberculous drugs therapy. We evaluated the erythrocyte sedimentation rate, C-reactive protein, radiography, computed tomography, magnetic resonance imaging, visual analogue score, and Oswestry disability index before and after surgery.</sec><sec><title>Results</title>All patients completed a follow-up survey 9–48 months after surgery. All patients' wounds healed well without chronic infection or sinus formation, and all patients with low-back pain reported relief after surgery. All cases had no tuberculosis recurrence. Solid bony fusion was achieved within 6–12 months. At final follow-up, evaluated the erythrocyte sedimentation rate decreased from 38.1±12.5 to 11.3±7.1 mm/hr, C-reactive protein decreased from 6.2±4.2 to 1.6±1.3 mg/dL, the visual analog scale score decreased from 4.6±1.1 to 1.4±1.0, the Oswestry disability index score decreased from 50.2%±11.9% to 13.0%±6.6%, and the lumbosacral angle increased from 20.0°±4.8° to 29.0°±3.9° (<italic>p</italic><0.05).</sec><sec><title>Conclusions</title>One-stage anterolateral debridement, bone grafting, and internal instrument fixation for treating lumbosacral tuberculosis is safe and effective.</sec>

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High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s241774 ◽

2020 ◽

Vol Volume 13 ◽

pp. 581-590 ◽

Cited By ~ 1

Author(s):

Guo-bao Hong ◽

Pei-chun Gao ◽

Yun-ying Chen ◽

Yue Xia ◽

Xiao-su Ke ◽

...

Keyword(s):

Metabolic Syndrome ◽

Chinese Population ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Follow Up Study

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Sclerosing osteomyelitis of Garré: A confusing clinical diagnosis

Journal of Orthopaedic Surgery ◽

10.1177/2309499019874704 ◽

2019 ◽

Vol 27 (3) ◽

pp. 230949901987470

Author(s):

Seungcheol Song ◽

Hwa Jae Jeong ◽

Hun-Kyu Shin ◽

Eegene Kim ◽

Se-Jin Park ◽

...

Keyword(s):

Proximal Femur ◽

Chronic Osteomyelitis ◽

Magnetic Resonance Images ◽

Thigh Pain ◽

C Reactive Protein ◽

Reactive Protein ◽

Lower Back ◽

Erythrocyte Sedimentation ◽

The Right

We describe a rare case of sclerosing osteomyelitis of Garré in a 63-year-old woman with uncontrolled right thigh pain. She had suffered from lower back pain and radiating pain on the right lower leg for a year and 4 months and so had spine surgery 8 months ago. But the right thigh pain persisted, and the levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) remained abnormal. Right femur radiographs showed cortical thickening on the proximal femur. Magnetic resonance images showed T2 hypersignal intensity lesions in the proximal femur. Under suspicion of osteoid osteoma or sclerosing osteomyelitis, surgery was performed with biopsy, bone curettage, and drilling. The culture was negative, and the biopsy showed chronic osteomyelitis. Despite surgery, the levels of CRP and ESR still remained abnormal. After using venous antibiotics, the pain subsided and CRP and ESR levels turned to normal. Followed by 6 weeks of oral antibiotics, pain was relieved after 1-year follow-up.

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1249. Images vs. C-Reactive Protein Follow-up of Patients with Organ/space Surgical Site Infections

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1112 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S449-S449

Author(s):

Natalia Garcia Allende ◽

Cristina Freuler ◽

Ana Victoria Sanchez ◽

Cecilia Ezcurra ◽

Micaela Mayer Wolf ◽

...

Keyword(s):

Imaging Study ◽

Surgical Site Infections ◽

Antimicrobial Treatment ◽

Average Score ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

End Of Treatment ◽

Intra Abdominal Infection

Abstract Background End-of-treatment images of infections after intra-abdominal infection could increase costs. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are used to define and predict the evolution of infectious diseases. The aim of this study was to describe clinical outcomes of adult patients with end-of-treatment images or CRP and ESR follow-up, during treatment of organ/space (OS) (intra-abdominal) surgical site infection (SSI). Methods Observational retrospective cohort. Hospitalized patients older than 16 years were included, who developed OS SSI after abdominal surgery, in a general hospital, from June 2014 to June 2018. Population variables: age, gender, comorbidities (cancer, diabetes mellitus, cirrhosis, chronic renal failure, tobacco, immunosuppressants, Charlson score and obesity), ESR, quantitative CRP, imaging study (tomography (CT)/ ultrasound), type of drainage route (surgical, percutaneous). Outcomes variables: antibiotic patient-days, time to infection (TTI), CRP and ESR at the time of diagnosis (TD) and at the end of treatment (TET), rate of relapsing infection. Statistical analysis: Description of variables sort by patients under images follow-up and patients under CRP and ESR follow-up. Fisher test of relapsing infection was calculated between groups. Results Included: 76 patients. Twenty-six were followed with CT or ultrasound and 50 were followed with CRP and ESR. Forty women, with a mean age of 55 years (19–91) and an average score of the Charlson of 3.64 (0–10). Forty patients had cancer before surgery (52.63%). Microbiological diagnosis: 70/76 patients, the majority was polymicrobial. Average of antibiotics patient-days was 24.4 days (14 days of intravenous therapy). TTI: 8.65 days. Average CRP at the TD was 87.5 mg/L and 17.5 mg/L at TET. No differences in ESR values (31.9 mm to 33.5 mm). Percutaneous drainage: 46 patients. Surgical procedure: 27. Relapsing infection: 11,5% in images group vs. 4% in no images group; P = 0.33. Conclusion Quantitative CRP monitoring was useful to guide the duration of antimicrobial treatment. No differences of relapsing infection between groups was found. Disclosures All authors: No reported disclosures.

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