SAT0117 High uric acid as a risk factor for cardiovascular diseases in rheumatoid arthritis patients

Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout. Urolithin A (UroA) is a main microbial metabolite derived from ellagic acid (EA), which occurs in strawberries and pomegranates. In this study, we evaluated antihyperuricemic effect of UroA in both cultured hepatocytes and hyperuricemic model mice. In cultured hepatocytes, UroA significantly and dose-dependently reduced UA production. In model mice with purine bodies-induced hyperuricemia, oral administration of UroA significantly inhibited the increase in plasma UA levels and hepatic xanthine oxidase (XO) activity. In addition, DNA microarray results exhibited that UroA, as well as allopurinol, a strong XO inhibitor, induced downregulation of the expression of genes associated with hepatic purine metabolism. Thus, hypouricemic effect of UroA could be, at least partly, attributed to inhibition of purine metabolism and UA production by suppressing XO activity in the liver. These results indicate UroA possesses a potent antihyperuricemic effect and it could be a potential candidate for a molecule capable of preventing and improving hyperuricemia and gout.

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Hyperuricemia as a Risk Factor for Cardiovascular Diseases

Journal of Biomedicine and Translational Research ◽

10.14710/jbtr.v6i3.9383 ◽

2020 ◽

Vol 6 (3) ◽

pp. 101-109

Author(s):

Ichiro Hisatome ◽

Peili Li ◽

Fikri Taufiq ◽

Nani Maharani ◽

Masanari Kuwabara ◽

...

Keyword(s):

Heart Failure ◽

Uric Acid ◽

Risk Factor ◽

Cardiovascular Diseases ◽

Pharmacological Treatment ◽

Kidney Diseases ◽

Serum Uric Acid Level ◽

Proteolytic Processing ◽

Pyrin Domain ◽

Asymptomatic Patients

Serum uric acid level above 7 mg/dl is defined as hyperuricemia, which gives rise to the monosodium urate (MSU), causing gout and urolithiasis. Hyperuricemia is an independent risk factor as well as a marker for hypertension, heart failure, atherosclerosis, atrial fibrillation, and chronic kidney disease. MSU crystals, soluble uric acid (UA), or oxidative stress derived from xanthine oxidoreductase (XOR) might be plausible explanations for the association of cardio-renovascular diseases with hyperuricemia. In macrophages, MSU activates the Nod-like receptor family, pyrin　domain containing 3(NLRP3) inflammasome, and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1β and IL-18 secretion. Soluble UA accumulates intracellularly through UA transporters (UAT) in vascular and atrial myocytes, causing endothelial dysfunction ad atrial electrical remodeling. XOR generates reactive oxygen species (ROS) that lead to cardiovascular diseases. Since it remains unclear whether asymptomatic hyperuricemia could be a risk factor for cardiovascular and kidney diseases, European and American guidelines do not recommend pharmacological treatment for asymptomatic patients with cardio-renovascular diseases. The Japanese guideline, on the contrary, recommends pharmacological treatment for hyperuricemia with CKD to protect renal function, and it attaches importance of the cardio-renal interaction for the treatment of asymptomatic hyperuricemia patients with hypertension and heart failure.

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Rheumatoid arthritis as cardiovascular risk factor: an update

Romanian Journal of Cardiology ◽

10.47803/rjc.2020.30.4.576 ◽

2021 ◽

Vol 30 (4) ◽

pp. 576-582

Author(s):

Calin D. Popa

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Risk Management ◽

Risk Factor ◽

Cardiovascular Risk ◽

Cardiovascular Diseases ◽

Cardiovascular Risk Factor ◽

Independent Risk Factor ◽

Daily Practice ◽

Cardiovascular Risk Management

Rheumatoid arthritis (RA) patients have a 1.5 – 2.5 higher chance to develop cardiovascular diseases (CVD), which in turn represent the most important cause of mortality and the most frequent comorbidity in these patients. Chronic inflammation crucially contributes to that, either as an independent risk factor or as a modulator of traditional cardiovascular (CV) risk factors, such as dyslipidemia and hypertension. The cardiovascular risk management (CVRM) is therefore essential in these patients. The implementation of it in the daily practice is quite challenging and requires a good networking between different specialists (rheumatologist, cardiologist, internist) and the general practitioners (GPs), and may get various forms of organization depending on region and locations.

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Risk of Systemic Disorders in Patients with Periodontal Infection

10.51626/ijoh.2021.01.00005 ◽

2021 ◽

Vol 1 (1) ◽

Keyword(s):

Rheumatoid Arthritis ◽

Diabetes Mellitus ◽

Risk Factor ◽

Cardiovascular Diseases ◽

Pregnancy Outcomes ◽

Respiratory Infections ◽

Important Risk Factor ◽

Systemic Diseases ◽

Periodontal Infection ◽

Adverse Pregnancy

A number of diverse studies have indicated that there is a link between periodontal infection and systemic diseases, such as cardiovascular diseases, diabetes mellitus, adverse pregnancy outcomes, mouth cancer, rheumatoid arthritis and respiratory infections. This study discusses the correlation between periodontal infections and systemic disorders. Periodontal infections should be considered as an important risk factor for various systemic diseases.

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