scholarly journals Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5136
Author(s):  
Shin-ichi Adachi ◽  
Kazunori Sasaki ◽  
Shinji Kondo ◽  
Wataru Komatsu ◽  
Fumiaki Yoshizawa ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Purine Metabolism ◽  
Potential Candidate ◽  
Cultured Hepatocytes ◽  
Microbial Metabolite ◽  
Strong Risk Factor ◽  
Expression Of Genes ◽  
Urolithin A ◽  
High Uric Acid

Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a strong risk factor for gout. Urolithin A (UroA) is a main microbial metabolite derived from ellagic acid (EA), which occurs in strawberries and pomegranates. In this study, we evaluated antihyperuricemic effect of UroA in both cultured hepatocytes and hyperuricemic model mice. In cultured hepatocytes, UroA significantly and dose-dependently reduced UA production. In model mice with purine bodies-induced hyperuricemia, oral administration of UroA significantly inhibited the increase in plasma UA levels and hepatic xanthine oxidase (XO) activity. In addition, DNA microarray results exhibited that UroA, as well as allopurinol, a strong XO inhibitor, induced downregulation of the expression of genes associated with hepatic purine metabolism. Thus, hypouricemic effect of UroA could be, at least partly, attributed to inhibition of purine metabolism and UA production by suppressing XO activity in the liver. These results indicate UroA possesses a potent antihyperuricemic effect and it could be a potential candidate for a molecule capable of preventing and improving hyperuricemia and gout.

High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a

2014 ◽  
Vol 28 (4) ◽  
pp. 451-456 ◽  
Author(s):  
Takahito Moriyama ◽  
Mitsuyo Itabashi ◽  
Takashi Takei ◽  
Hiroshi Kataoka ◽  
Masayo Sato ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Kidney Disease ◽  
Uric Acid Level ◽  
Acid Level ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
High Uric Acid ◽  
High Uric Acid Level

scholarly journals SAT0117 High uric acid as a risk factor for cardiovascular diseases in rheumatoid arthritis patients

2018 ◽  
Author(s):  
A. Al-Herz ◽  
A. Aldei ◽  
K. Saleh ◽  
A. Al-Awadhi ◽  
W. Al-Kandari ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Uric Acid ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
High Uric Acid

Can high uric acid levels be an independent risk factor for acute ischemic stroke due to large-artery atherosclerosis?

2018 ◽  
Vol 71 (7-8) ◽  
pp. 279-283 ◽  
Author(s):  
Türkan Acar ◽  
Yeşim Güzey Aras ◽  
Sıdıka Sinem Gül ◽  
Bilgehan Atılgan Acar
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Independent Risk Factor ◽  
Large Artery ◽  
High Uric Acid

scholarly journals Effects of Sporisorium Reiliana Polysaccharides and Phoenix Dactylifera Monosaccharides on the Gut Microbiota and Serum Metabolism in Mice with Fructose-Induced Hyperuricaemia

2021 ◽  
Author(s):  
Zhixuan Zhang ◽  
Ziyan Wang ◽  
Chenyang Lu ◽  
Jun Zhou ◽  
Jiaojiao Han ◽  
...  
Keyword(s):  
Uric Acid ◽  
Gut Microbiota ◽  
Kidney Injury ◽  
Phoenix Dactylifera ◽  
Purine Metabolism ◽  
Bile Acid Metabolism ◽  
Serum Metabolites ◽  
Expression Of Genes ◽  
High Fructose ◽  
Sporisorium Reiliana

Abstract In recent decades, the prevalence of hyperuricaemia has increased, and dietary fructose is an important risk factor for the development of this disease. This study investigated and compared the effects of Sphacelotheca reiliana polysaccharides and Phoenix dactylifera monosaccharides on a series of physiological and biochemical indicators and on metagenomes and serum metabolites in mice with hyperuricaemia caused by a high-fructose diet. S. reiliana polysaccharides inhibited uric acid biosynthesis and promoted uric acid excretion, thereby alleviating the hyperuricaemia phenotype. In addition, hyperuricaemia was closely related to the gut microbiota. After treatment with S. reiliana polysaccharides, the abundance of Bacteroidetes and Proteobacteria in the mouse intestines was decreased, the expression of genes involved in glycolysis/gluconeogenesis metabolic pathways and purine metabolism was downregulated, and the dysfunction of the gut microbiota was alleviated. With regard to serum metabolism, the abundance of hippuric acid, uridine, kynurenic acid, propionic acid and arachidonoyl decreased, and the abundance of serum metabolites in inflammatory pathways involved in kidney injury and gout, such as bile acid metabolism, purine metabolism and tryptophan metabolism pathways, decreased. P. dactylifera monosaccharides aggravated hyperuricaemia. This research provides a valuable reference for the development of sugar applications.

Pitfalls in the Evaluation of Uric Acid as a Risk Factor for Vascular Disease~!2009-10-29~!2009-12-23~!2010-04-08~!

2010 ◽  
Vol 3 (2) ◽  
pp. 44-50 ◽  
Author(s):  
Konstantinos Tziomalos ◽  
Vasilios G. Athyros ◽  
Asterios Karagiannis ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Vascular Disease

scholarly journals Impact of an MT-RNR1 Gene Polymorphism on Hepatocellular Carcinoma Progression and Clinical Characteristics

2021 ◽  
Vol 22 (3) ◽  
pp. 1119
Author(s):  
Yang-Hsiang Lin ◽  
Yu-De Chu ◽  
Siew-Na Lim ◽  
Chun-Wei Chen ◽  
Chau-Ting Yeh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Risk Factor ◽  
Distant Metastasis ◽  
Tumor Metastasis ◽  
12S Rrna ◽  
Potential Candidate ◽  
Free Survival ◽  
Mtdna Mutations ◽  
Distant Metastasis Free Survival

Mitochondrial DNA (mtDNA) mutations are highly associated with cancer progression. The poor prognosis of hepatocellular carcinoma (HCC) is largely due to high rates of tumor metastasis. This emphasizes the urgency of identifying these patients in advance and developing new therapeutic targets for successful intervention. However, the issue of whether mtDNA influences tumor metastasis in hepatoma remains unclear. In the current study, multiple mutations in mtDNA were identified by sequencing HCC samples. Among these mutations, mitochondrially encoded 12S rRNA (MT-RNR1) G709A was identified as a novel potential candidate. The MT-RNR1 G709A polymorphism was an independent risk factor for overall survival and distant metastasis-free survival. Subgroup analysis showed that in patients with cirrhosis, HBV-related HCC, α-fetoprotein ≥ 400 ng/mL, aspartate transaminase ≥ 31 IU/L, tumor number > 1, tumor size ≥ 5 cm, and histology grade 3-4, MT-RNR1 G709A was associated with both shorter overall survival and distant metastasis-free survival. Mechanistically, MT-RNR1 G709A was clearly associated with hexokinase 2 (HK2) expression and unfavorable prognosis in HCC patients. Our data collectively highlight that novel associations among MT-RNR1 G709A and HK2 are an important risk factor in HCC patients.

Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis

2021 ◽  
Author(s):  
Xiaofei Zhou ◽  
Bowei Zhang ◽  
Xiuli Zhao ◽  
Yongxi Lin ◽  
Jin Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chlorogenic Acid ◽  
Serum Uric Acid ◽  
Inflammatory Responses ◽  
Elevated Serum ◽  
Purine Metabolism ◽  
Intestinal Homeostasis ◽  
Renal Inflammation ◽  
Acid Supplementation

Hyperuricemia (HUA) is induced by abnormal purine metabolism and elevated serum uric acid (UA) concentrations, and it is often accompanied by inflammatory responses and intestinal disorders. This study aims to...

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