SAT0387 ROLE OF HLA-B27 IN THE COMORBIDITIES OBSERVED IN AXIAL SPONDYLOARTHRITIS: DATA FROM COMOSPA

Background:Comorbidities have merged as an important field in Spondyloarthritis, however there is few data about its relationship to genetic factors such as HLA-B27.Objectives:To analyze the potential association between the presence of HLA-B27 and the different comorbidities observed in axSpA patients.Methods:A comparative cross-sectional study including axSpA patients from COMOSPA registry. COMOSPA is a worldwide registry that includes a wide set of anthropometric and clinical variables from 3984 patients with spondyloarthritis. The registry also includes the most frequent comorbidities observed in spondyloarthitis such as obesity, hypertension, diabetes, hyperlipidemia, heart ischemic disease, stroke, renal failure, neoplasms, peptic ulcer, diverticulitis, chronic obstructive pulmonary disease, and the presence of osteoporosis. A descriptive analysis and a multiple logistic regression model was performed including all variables assessed.Results:2370 patients fulfilled ASAS criteria of axSpA patients and were included in the study. 1858 (78.4%) of them were HLA-B27 positive. HLA-B27 positive axSpA patients presented significantly higher percentage of male sex, longer disease duration, higher percentage of definite Ankylosing Spondylitis, higher CRP levels, and were also more frequent tobacco consumers and excessive alcohol intakers compared to the negatives. However, disease activity measured by BASDAI, BASFI and ASDAS-CRP were all significantly higher in the HLA-B27 negative patients compared to the positive ones.The only association observed between any comorbidity and presence of gen HLA-B27 was the presence of osteoporosis. This association was independently significant even after adjusting in the multivariate analysis for all variables assessed.Conclusion:The association observed between the gen HLA-B27 and the presence of osteoporosis in axSpA patients could be of great relevance given the impact of osteoporosis in the phenotypical frame of axSpA patients.Disclosure of Interests:Marta Arévalo: None declared, Clementina López-Medina: None declared, Mireia Moreno: None declared, Anna Moltó Grant/research support from: Pfizer, UCB, Consultant of: Abbvie, BMS, MSD, Novartis, Pfizer, UCB, Font Ugalde Pilar: None declared, Eduardo Collantes-Estévez Grant/research support from: ROCHE and Pfizer., Speakers bureau: ROCHE, Lilly, Bristol and Celgene., Jordi Gratacos-Masmitja Grant/research support from: a grant from Pfizzer to study implementation of multidisciplinary units to manage PSA in SPAIN, Consultant of: Pfizzer, MSD, ABBVIE, Janssen, Amgen, BMS, Novartis, Lilly, Speakers bureau: Pfizzer, MSD, ABBVIE, Janssen, Amgen, BMS, Novartis, Lilly

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Exclusive Breastfeeding Practice And Associated Factors Among Employed And Unemployed Mothers In Ethiopia: Comparative Cross Sectional Study Using EDHS 2016

10.21203/rs.3.rs-989840/v1 ◽

2021 ◽

Author(s):

Desta Markos Minamo

Keyword(s):

Exclusive Breastfeeding ◽

Maternity Leave ◽

Descriptive Analysis ◽

Cross Sectional Study ◽

Feeding Practice ◽

Cross Sectional ◽

Data Set ◽

Factors Associated ◽

The Impact ◽

Breastfeeding Practice

Abstract Introduction Contrary to the recommendation, children under the age of 6 months be exclusively breastfed, many infants are also fed with other liquids such as water, non-milk liquids, and other milks before 6 months. Because of level of education and proportion of employed women in Ethiopia has been increasing gradually. Consequently the practice of exclusive breastfeeding became very lower. The main objective of this study was to assess the magnitude and factors associated with the practice of exclusive breastfeeding among employed and unemployed mothers in Ethiopia, using dataset from EDHS 2016. METHOD Data was extracted from Ethiopia Demographic and Health Survey (EDHS-2016). A total of 1089 mothers with infants aged 0 to 6 months in the data set were included in the analysis. Descriptive analysis, chi-square and binary logistic regression models were used. RESULT This study has demonstrated a 64.7%, 95%CI(58.9-70.5) and 75.4%, 95%CI(72.378.2) prevalence of EBF practices among employed and unemployed mothers respectively in the 24h preceding the survey. Other factors associated with EBF practice included being unemployed mother, larger to normal birth weight; infant aged 0-3 month old, infant being male, have radio in the house, infant being wanted, delivery by non CS mode and presence of ANC follow up during pregnancy were found to be significantly associated with exclusive breastfeeding practice. Conclusion the prevalence of exclusive breast feeding practice among employed mothers was significantly lower than that of unemployed mothers. Thus, Having in consideration the impact of appropriate infant and young children feeding practice on children’s nutritional status and mortality rate, policy makers still need to give more emphasis on promotion of exclusive breastfeeding through creating an enabling environment targeting the extension of postnatal maternity leave up to the first six month.

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Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0248649 ◽

2021 ◽

Vol 16 (3) ◽

pp. e0248649

Author(s):

Marie Gerardin ◽

Morgane Rousselet ◽

Marie-Laure Couec ◽

Agathe Masseau ◽

Marylène Guerlais ◽

...

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Descriptive Analysis ◽

Specific Treatment ◽

Cross Sectional Study ◽

Social Consequences ◽

Cell Disease ◽

Cross Sectional ◽

Link Type ◽

The Impact

Background Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of the PHEDRE study (Pharmacodépendance Et DREpanocytose—drug dependence and sickle-cell disease), which is the largest study of patients with SCD in France. This paper intends to describe characteristics of the French SCD population. We also aimed to assess the impact of the disease on the lives of patients using objective and subjective variables. Methods The PHEDRE study was a national multicentric observational study. Adults, adolescents and children with a confirmed SCD diagnosis were included in the study by their referring doctor. Then, they were interviewed by phone about their socioeconomic status, about the impact of the disease on their lives and about their analgesic and psychoactive drug use. Results The study population consisted of 872 patients (28% were minors). Seventy-two percent of adults were active, and all minors were in school. Many patients presented criteria of severe SCD. Seventy-five percent were homozygous SS, 15% were double heterozygotes SC and 8% were heterozygotes Sβthal, 87% received specific treatment, 58% were hospitalized at least once for vaso-occlusive crisis in the past 12 months, and the number of analgesic drugs taken averaged 3.8. Seventy-five percent of patients reported academic or professional consequences related to their SCD, and 52% reported social consequences. Conclusions The impact of SCD on patients’ lives can be significant, nevertheless their social integration seems to be maintained. We highlighted respect of recommendations regarding analgesic treatments and only a few patients used tobacco, alcohol or cannabis. Trial registration Clinical Trials, NCT02580565; https://clinicaltrials.gov/ Registered 16 October 2015.

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Impacts of Community Pharmacists on Self-medication Management among Rural Dwellers, Kwara State Central, Nigeria

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v12i1.16294 ◽

2013 ◽

Vol 12 (1) ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Shakirat I Bello ◽

Ibrahim K Bello

Keyword(s):

Blood Pressure ◽

Rural Communities ◽

Descriptive Analysis ◽

Medication Management ◽

Community Pharmacists ◽

Cross Sectional Study ◽

Direct Patient Care ◽

Self Medication ◽

Cross Sectional ◽

The Impact

The role of pharmacist has not only advanced from medication dispensing but also to direct patient care and pharmaceutical interventions aiming at enhancing the populace wellbeing. The objective of this research was to assess the impact of rural community pharmacist interventions on self-medications and disease prevalence among rural settings in the Kwara State Central, Nigeria. A descriptive, cross-sectional study was conducted in eight rural communities with a pre-piloted questionnaire. Data obtained from respondents were computed with Statistical Package for Social Sciences (SPSS) Version 16 using descriptive analysis procedures, and relationships between variables were tested using the chi square. Respondents between the age of 40 and 50 years dominated with 42.3% and majority (88.1%) of the rural residents were illiterates. Farming was the major occupation of the respondents and survived on less than ten thousand naira Nigeria money ($63) per month. Among the combinations of drugs abused by the respondents, the regimen containing combination of prednisolone, diclofenac and paracetamol had the highest users. The least used combination was ibuprofen, diclofenac plus prednisolone. These combinations were taken twice daily by the majority participants. The most common reasons given for self-medications were osteoarthritis (31.1%), poverty (17.4%), general body pain (14.3%), inadequate of health facilities (4.6%), ignorance (4.3%) among others. The intervention offered by the pharmacists had reduced the mean systolic blood pressure significantly (P < 0.05) from 161 mmHg to 129 mmHg and diastolic blood pressure from 104 mmHg at baseline to 86 mmHg. Postintervention evaluation revealed the impact of the pharmacists, as the respondents with dyspepsia at baseline significantly (P < 0.05) reduced from 220 to 53 participants. Dhaka Univ. J. Pharm. Sci. 12(1): 1-9, 2013 (June) DOI: http://dx.doi.org/10.3329/dujps.v12i1.16294

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Built form and depression among the Chinese rural elderly: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-038572 ◽

2020 ◽

Vol 10 (12) ◽

pp. e038572

Author(s):

Qin-wei Qiu ◽

Jing Li ◽

Jia-yu Li ◽

Yong Xu

Keyword(s):

Cross Sectional Study ◽

Rural Elderly ◽

Sectional Study ◽

Cross Sectional ◽

Built Form ◽

Housing Area ◽

Significant Difference ◽

Few Data ◽

The Impact ◽

Rural Elders

ObjectivesFew data on the association between housing structure and depression among rural elders in China are available. We examined the impact of built forms on depression.DesignThis is a cross-sectional study.SettingA representative sample of rural residents aged 60 years or older in China.ParticipantsA total of 5090 older adults in 2019 in rural Suzhou, China.Outcome measuresAssociations of built form with odds of probable and possible depression.ResultsThere was significant difference among elders living in varied sizes of house. Older age (vs 60–64 years: 75–79 years AdjOR, 1.737; 95% CI, 1.309 to 2.305; ≥80 years AdjOR, 2.072; 95% CI, 1.439 to 2.981), male sex (AdjOR, 0.719; 95% CI, 0.593 to 0.871), single (AdjOR, 1.303; 95% CI, 1.032 to 1.646), self-care disability (AdjOR, 4.761; 95% CI, 3.960 to 5.724), three or more chronic diseases (AdjOR, 2.200; 95% CI, 1.657 to 2.920), living alone (AdjOR, 1.443; 95% CI, 1.059 to 1.966), living in cottage (AdjOR, 1.426; 95% CI, 1.033 to 1.967), living space (vs <50 m2: 201–250 m2 AdjOR, 0.566; 95% CI, 0.359 to 0.893; >250 m2 AdjOR, 0.337; 95% CI, 0.223 to 0.511) and space per person (vs <30 m2: 30- m2 AdjOR, 0.502; 95% CI, 0.362 to 0.697; 40- m2 AdjOR, 0.473; 95% CI, 0.347 to 0.646; 50- m2 AdjOR, 0.418; 95% CI, 0.339 to 0.515) were associated with risk of depression among Chinese rural elders.ConclusionThe built form was significantly and meaningfully associated with depression among Chinese rural elders. More attention should be paid to preventing mental illness among the rural elderly living in the small housing area and cottages in China.

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Utilisation of and Attitude towards Traditional and Complementary Medicine among Ebola Survivors in Sierra Leone

Medicina ◽

10.3390/medicina55070387 ◽

2019 ◽

Vol 55 (7) ◽

pp. 387 ◽

Cited By ~ 2

Author(s):

Peter Bai James ◽

Jon Wardle ◽

Amie Steel ◽

Jon Adams

Keyword(s):

Immune System ◽

Sierra Leone ◽

Health Care Services ◽

Conventional Medicine ◽

Descriptive Analysis ◽

Healthcare Providers ◽

Cross Sectional Study ◽

Cross Sectional ◽

Healthcare Needs ◽

The Impact

Background and objectives: In addition to conventional healthcare, Ebola survivors are known to seek traditional and complementary healthcare (T&CM) options to meet their healthcare needs. However, little is known about the general beliefs of Ebola survivors regarding T&CM and the impact of these beliefs in influencing their decisions around T&CM use. This study examines Ebola survivors’ attitudes towards T&CM use in Sierra Leone. Materials and Methods: We conducted a nationwide quantitative cross-sectional study of 358 Ebola survivors in Sierra Leone between January and August 2018. We used descriptive analysis, chi-square tests and backward stepwise binary logistic regression for data analysis. Results: Close to half of the survivors (n = 163, 45.5%) had used T&CM since their discharge from an Ebola treatment centre. Survivors who viewed T&CM as boosting their immune system/resistance were 3.89 times (95%CI: 1.57–9.63, p = 0.003) more likely to use T&CM than those who did not view T&CM as boosting their immune system/resistance. Additionally, survivors who viewed T&CM as having fewer side effects than conventional medicine were more likely to use T&CM [OR = 5.03 (95%CI: 1.92–13.19, p = 0.001)]. Ebola survivors were more influenced to use T&CM based on their personal experience of the effectiveness of T&CM than by clinical evidence [OR = 13.72 (95%CI: 6.10–30.84, P < 0.001)]. Ebola survivors who perceived T&CM as providing them with more control than conventional medicine over their health/body were more likely to use T&CM [OR = 4.15 (95%CI: 1.74–9.89, p = 0.001)] as opposed to those who did not perceive T&CM in this way. Conclusions: Considering the widespread use of T&CM, an understanding of Ebola survivors’ attitudes/beliefs towards T&CM is useful to healthcare providers and policymakers with regard to public education and practitioner–survivors communication, T&CM regulation and research in Sierra Leone. Ebola survivors appear to turn to T&CM not only for treatment, but also to fill gaps in conventional health care services.

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Uveitis of spondyloarthritis in Indian subcontinent: a cross sectional study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20174300 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1441

Author(s):

Fini Ninan ◽

John Mathew ◽

Swetha Sara Philip ◽

Deepa John ◽

Debashish Danda ◽

...

Keyword(s):

Anterior Uveitis ◽

Indian Subcontinent ◽

Cross Sectional Study ◽

Musculoskeletal Symptoms ◽

Hla B27 ◽

Sectional Study ◽

Cross Sectional ◽

Asas Criteria ◽

Intimate Association ◽

Seronegative Spondyloarthritis

Background: The seronegative spondyloarthritis (SpA) are known to have intimate association with ocular inflammatory disease. While anterior uveitis accounts for 50-92% of all cases of uveitis in the West, it ranges between 28 and 50% in the Asian countries. The aim of this study was to document the clinical profile of uveitis in patients with spondyloarthritis in the Indian subcontinent.Methods: In our hospital based cross sectional study, 166 patients fulfilling Assessment of SpondyloArthritis international Society’ (ASAS) criteria for spondyloarthritis (SpA) were evaluated for evidence and nature of uveitis, including by a slit lamp bio microscope. The characteristics of Uveitis were defined as per the SUN (Standardization of Uveitis Nomenclature) Working Group criteria. 84.3% (140) of the patients were male.Results: Ankylosing spondylitis was the commonest type of spondyloarthritis accounting for 69.3% patients. Evidence of past or present uveitis was found in 16.3% patients. Of the patients with uveitis 96.3% had anterior uveitis. 88.9% of the patients had redness of the eye, and 85.2% reported pain in the eye during an episode of uveitis. Mean duration of musculoskeletal symptoms prior to the diagnosis of SpA was 4.36 years. Of the 24 patients who could recall the course of uveitis 70.8% (17) had recurrent episodes. As a complication of uveitis 18.5% had cataract, and 14.8% had posterior synechiae. 78.3% patients were HLA-B27 positive. 19.2% of HLA-B27 positive patients had uveitis, whereas only 5.6% out of the 36 HLA-B27 negative patients had uveitis.Conclusions: The proportion of patients with uveitis in our study (16.3%) was considerably less than in other studies. The characteristics and profile of uveitis in our cohort of SpA patients from the Indian subcontinent were similar to those previously reported in literature.

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Work From Home, Mental Health and Employee Needs: A pilot study in selected information technology organizations in India

Asia Pacific Journal of Health Management ◽

10.24083/apjhm.v16i3.977 ◽

2021 ◽

Vol 16 (3) ◽

pp. 103-110

Author(s):

S. Phadnis ◽

S Sengupta ◽

A Chakraborty

Keyword(s):

Mental Health ◽

Occupational Health ◽

Descriptive Analysis ◽

Health And Safety ◽

Health Impact ◽

Cross Sectional Study ◽

Cross Sectional ◽

Work From Home ◽

Inclusive Policy ◽

The Impact

Introduction: The Coronavirus (COVID-19) pandemic has impacted the economy and has resulted in changes to the working arrangements of employees who are based at home and may continue to work from home (WFH). Organizations are expected to develop an inclusive policy for their employees to promote mental health whilst working from home. The aim of this study was to document the impact of WFH on mental health and determine the expectations of employees from their organizations regarding occupational health policy. Methodology: A cross-sectional study was conducted on the impact of work from home on mental health and to document the mental health support needs of employees. Google form was floated through social media platform to receive the responses. A total of 74 responses were received. Descriptive analysis was conducted using Microsoft Excel, while qualitative answers were manually analysed. Results: About 67% employees (n=45) mentioned that their workload has increased significantly during work from home. Thirty five percent (n=26) felt lonely and lost and 47% (n= 34) felt disconnected from the real world, indicating the mental health impact of work from home. Fifty three percent employees (n=40) mentioned that there were no efforts made by their organization to reduce the mental health impact of work from home. Conclusion: The results of this study indicate that there is an urgent need to create a comprehensive occupational health and safety policy inclusive of strategies to improve mental health by the organizations in light of “work from home” as a “new-normal”.

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Study of cross-referrals to the dermatology department in an inpatient setting at a tertiary care centre

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200250 ◽

2020 ◽

Vol 8 (2) ◽

pp. 647

Author(s):

Niyati Bakhtar ◽

Kirit Pandey ◽

Neha Pandey ◽

Nikhil Bakhtar ◽

Vijay Bakhtar

Keyword(s):

Descriptive Analysis ◽

Tertiary Care ◽

General Medicine ◽

Skin Lesions ◽

Cross Sectional Study ◽

Inpatient Setting ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Dermatology Department ◽

The Impact

Background: Till recently, dermatology was primarily being considered to be an outpatient focused discipline. However, several inpatient admissions to other specialties require dermatologic consultation for optimum management. This study was conducted to analyse the incidence and indications for inpatient dermatology referrals and the impact of dermatology consultation on patient management.Methods: A cross-sectional study was undertaken by analyzing the records of 243 patients referred to dermatology department over a 2-year period. Descriptive analysis was conducted in the form of study of presumptive diagnoses by the referring clinicians, causes of referral, distribution of referrals across specialties and the dermatological opinions with respect to diagnosis and management etc.Results: Clinically significant change was documented in the course of skin lesions management of almost two-thirds of referred patients. Maximum referrals were from the department of general medicine with “skin rash” being the most common cause for seeking 2nd opinion. Concordance for diagnosis between the referring clinician and the dermatologist was observed in only 30.2% of the cases.Conclusions: Dermatologic referral does lead to improved patient care. But there is need for better training of non-dermatologists enabling them to recognize and treat common skin lesions.

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Alcohol use disorders, beverage preferences and the influence of alcohol marketing: a preliminary study

Substance Abuse Treatment Prevention and Policy ◽

10.1186/s13011-020-00329-8 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Morgane Guillou Landreat ◽

Céline Beauvais ◽

Marie Grall Bronnec ◽

Delphine Le Goff ◽

Jean Yves Le reste ◽

...

Keyword(s):

Alcohol Use ◽

Descriptive Analysis ◽

Alcohol Use Disorders ◽

Premature Mortality ◽

Cross Sectional ◽

Addictive Disorders ◽

Alcohol Marketing ◽

Preliminary Study ◽

Few Data ◽

The Impact

Abstract Background Alcohol Use Disorders (AUD) are among the most prevalent mental disorders in the world. They are the leading risk factor for premature mortality and disability among 15 to 49-year-olds. Links between alcohol marketing and patterns of alcohol consumption are well defined in adolescents but there is few data on the impact of alcohol marketing on a population of drinkers with an AUD and seeking treatment. This study was designed in collaboration among researchers specialising in addictive disorders, in social marketing and primary care. Methods This was a monocentric, cross-sectional, descriptive study. The main objective of this study was to define the type of marketing identified by drinkers with an AUD who were seeking treatment and their beverage preferences. Drinkers aged 18+ with an AUD and seeking treatment were included. A descriptive analysis and a logistic regression were carried out . Results N = 91 patients were included, 73.6% were male, the average age was 46.2 years. 72% said they were not influenced by alcohol marketing, but 76% recalled an alcohol advertisement in the last 6 months. The most frequently reported beverage preferences were wine (39.6%), standard beers (29.6%), spirits (27.5%) and strong beers (16.5%). Conclusions Patients with AUD, defined as vulnerable, reported exposure to alcohol marketing but did not seem to identify it consciously. Marketing influences differed according to beverage preferences. These results need to be confirmed by a larger study.

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The Impact of Haze on Healthcare Utilizations for Acute Respiratory Diseases: Evidence From Malaysia

Frontiers in Ecology and Evolution ◽

10.3389/fevo.2021.764300 ◽

2021 ◽

Vol 9 ◽

Author(s):

Hafiz Jaafar ◽

Amirah Azzeri ◽

Marzuki Isahak ◽

Maznah Dahlui

Keyword(s):

Bronchial Asthma ◽

Disease Burden ◽

Secondary Data ◽

Cross Sectional Study ◽

Chronic Obstructive ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Respiratory Illnesses ◽

Acute Respiratory Diseases ◽

The Impact

Haze imposes a substantial disease burden on the human population especially in the Southeast Asia region due to the high frequency of haze episodes. The reduction of air quality levels by haze has resulted in a substantial disease burden and an increase in healthcare utilization (HU). This study aims to determine the association between haze and HU of haze-related respiratory illnesses with a focus given on the acute exacerbation of bronchial asthma (AEBA) and chronic obstructive pulmonary disease (AECOPD). A cross-sectional study was conducted through secondary data collection of haze/non-haze episodes as the study exposures and HU related to the exacerbation of bronchial asthma and COPD as the study outcomes. Data on haze/non-haze episodes and HU for four consecutive years (2012–2015) were retrieved from the Department of Environment and Ministry of Health Malaysia, respectively. In the four consecutive years, the percentage of haze episodes recorded in all stations was higher (67%) as compared to non-haze (33%) episodes. Means (SD) of patients diagnosed with AEBA and AECOPD were also significantly higher (p < 0.05) for inpatient 74 (62.1) and outpatient 320 (650.1) cases during haze episodes as compared to inpatient 34 (16.5) and outpatient 146 (170.5) cases during non-haze episodes. Findings from this study indicated that haze episodes incurred a significant healthcare burden due to an increase in HU. The evidence from this study will help the policymakers to prepare and allocate resources to control future implications of haze-related illnesses.

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