POS1094 SYNOVITIS IS FACTOR OF OSTEOARTHRITIS KNEE PROGRESSION IN PATIENTS WITH LESS THAN 5 YEARS OF DISEASE DURATION

Background:There are many studies about investigation of risk factors (RF) of knee osteoarthritis (OA) radiologic progression. Especially, in patients with small disease duration. At the moment, there are ambivalent of results of previous studies, lead to uncertain role of synovitis.Objectives:The aim of study is to investigate relationship between knee OA synovitis and progression risk in patients with small disease duration during a follow-up period of 5 years.Methods:Eligible patients had knee OA based on ACR criteria with x-ray confirmation; baseline (BL) disease duration less than 5 years. Patients were evaluated at BL and at 5-year follow-up, using the questionnaires, clinical examination, knee joints pain by visual analog scale (VAS), musculoskeletal ultrasound and X-ray. Unadjusted p-values are presented.Results:Among 52 adults with knee OA (mean age ± standard deviation, 59.11 ± 8.95 years; 100% female) had the proportion of patients at BL 42.3% (n=22), 46.2 % (n=24), 11.5% (n=6) by disease stage 1,2 and 3, respectively. Patients were categorized into 2 groups by progression during 5 years from BL based on changes of radiological stage. After 5-years follow-up period the progression of knee OA was established in 14 patients (1 group) and in 38 patients (2 group) the progression by radiological stage was absent. BL patients’ characteristics were similar across 1st and 2nd groups: mean age 58.29±7.68 vs 56.05±8.74, р>0.05; disease duration 3.43±1.34 vs 3.47±1.33, р>0.05. Individuals with knee OA progression had worse knee joints pain during walking (60.36±18.33 vs 48.71±17.81, р=0.043), higher body mass index (BMI) (34.45±4.60 vs 28.92±4.92 kg/m2, р=0.001), higher frequency of knee synovitis by clinical examination (42.9% vs 10.5%, RR=4.07; 95%Cl (1,3-12,3), р=0.01) and by musculoskeletal ultrasound (57.1% vs 18.4%, RR=3.1; 95%CI (1.38-6.96), р=0.009). At 5-years follow-up knee pain was significantly greater for 1st group (69.64±18,49 vs 55.76±12.76, р = 0.003), higher BMI (35.74±5.83 vs 30.64±4.64, р = 0.002), also higher frequency of knee synovitis by clinical examination (57.1% vs 10.5%, RR = 5.4 (95%Cl 1.9-15.2), р=0.001) and by musculoskeletal ultrasound (50% vs 13.2%, RR=3.8 (95%Cl 1.4-10.0), р=0.009). Spearman correlation coefficients between radiologic stage and OA progression factors were indicated: between radiologic stage and knee pain during walking (r = 0.34, p<0.05), BMI (r = 0.46, p<0.01), knee synovitis by musculoskeletal ultrasound (r = 0.41, p<0.01). Multivariate (discriminant) analysis was determined that synovitis is a significant predictor of radiographic progression (p < 0.05).Conclusion:The proportion of patients with knee synovitis by clinical examination and musculoskeletal ultrasound data increased by 5-year follow-up from BL. Synovitis is a significant predictor of radiographic progression of knee OA in patients with small disease duration.Disclosure of Interests:None declared.Figure 1.

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FAKTORY PROGRESSIROVANIYa OSTEOARTROZA KOLENNYKh SUSTAVOV (5-letnee prospektivnoeNABLYuDENIE)

Osteoporosis and Bone Diseases ◽

10.14341/osteo201329-11 ◽

2013 ◽

Vol 16 (2) ◽

pp. 9-11 ◽

Cited By ~ 1

Author(s):

N G KAShEVAROVA ◽

E M ZAYTsEVA ◽

O V PUShKOVA ◽

A V SMIRNOV ◽

L I ALEKSEEVA

Keyword(s):

Risk Factors ◽

Severe Pain ◽

Radiographic Progression ◽

Ultrasound Examination ◽

Knee Joints ◽

X Ray ◽

Knee Oa ◽

Group 2 ◽

Radiographic Changes ◽

Group 1

The pain is the main clinical symptom of osteoarthritis (OA) and it has significant influence on the daily activity. It has been shown that joint pain and synovitis are principal risk factors for the disease progression. But the data of some studies are not support this statement. The objective of our study was investigation of association between synovitis, pain intensity and progression of OA. Materials and Methods: a 5-year prospective study included 110 Women (age 42 to 80 years) with knee OA (ACR criteria). We used special questionnaire, visual analog scale for the pain assessment and x-ray and ultrasound examination of the knee joints. Results: At the end of the study 70 patients (group 1) had not radiographic changes and 40 patients (group 2) had radiographic progression. All patients were adjusted for the age and duration of the disease. However the patients from the second group had more often synovitis which was confirmed clinically and instrumentally (accordingly 65,0% and 34,3 %, p=0,004 , 50,0 % and 18,6 %, p=0,001), more severe pain in the knee joints (accordingly 57, 8±16,6 and 48,7±13,3 mm, p=0,002), and higher BMI value (33,2±6,0 and 30,5±5,6 kg/m 2, p=0,021). The patients with radiographic progression had more severe pain at the all visits. At the end of the study increasing of the pain was 56,3±14,7 mm in the nonprogression group and 67,5±21,7 mm in the group with radiographic progression (p=0,002). Conclusion: synovitis, intensity of the pain and higher BMI are risk factors for the progression of OA.

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Exercise and Osteoarthritis: Are We Stopping Too Early? Findings from the Clearwater Exercise Study

Journal of Aging and Physical Activity ◽

10.1123/japa.14.2.169 ◽

2006 ◽

Vol 14 (2) ◽

pp. 169-180 ◽

Cited By ~ 1

Author(s):

Frances V. Wilder ◽

John P. Barrett ◽

Edward J. Farina

Keyword(s):

Clinical Trials ◽

Knee Pain ◽

Exercise Intervention ◽

Pain Reduction ◽

Optimal Length ◽

Knee Oa ◽

Pain Scores ◽

Time Periods

The value of exercise for people with knee osteoarthritis (OA) receives continuing consideration. The optimal length of study follow-up time remains unclear. A group of individuals with knee OA participating in an exercise intervention was followed for 2 years. The authors quantified the change in knee-pain scores during Months 1–12 and during Months 13–24. Eleven individuals with radiographic knee OA and knee-pain scores of 2+ were evaluated. Pain scores were collected weekly from participants who exercised three times a week. Participants demonstrated pain reduction during both time periods. Pain reduction during Months 13–24, –10.7%, was slightly higher than pain reduction during Months 1–12, –7.8%. Among people with knee OA who exercise, these findings suggest that knee-pain amelioration continues beyond 12 months. Clinicians should consider encouraging long-term exercise programs for knee-OA patients. To best characterize the effect of exercise on knee pain, researchers designing clinical trials might want to lengthen the studies’ duration.

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The Effect of a Lower Body Positive Pressure Supported Treadmill Exercise Regime on Systemic Biomarkers of Inflammation and Cartilage Degradation in Individuals with Knee Osteoarthritis: A Pilot Study

International Journal of Kinesiology and Sports Science ◽

10.7575/aiac.ijkss.v.9n.3p18 ◽

2021 ◽

Vol 9 (3) ◽

pp. 18

Author(s):

Stephen Cornish ◽

Jason Peeler

Keyword(s):

Articular Cartilage ◽

Knee Pain ◽

Weight Bearing ◽

Cartilage Degradation ◽

Treadmill Walking ◽

Positive Pressure ◽

Control Group ◽

Knee Oa ◽

And Cartilage

Background: Knee osteoarthritis (OA) has been linked to a chronic low-grade inflammatory response and altered metabolic activity of articular cartilage. Objective: The purpose of this investigation was to evaluate the effectiveness of a 12-week (3 times/week) lower body positive pressure (LBPP) treadmill walking regime on knee pain and systemic biomarkers of inflammation and cartilage degradation. Methods: Sixteen overweight (BMI > 25 kg/m2) knee OA patients were randomized to a LBPP treadmill walking exercise group (N = 7) or non-exercise control group (N = 9). Baseline and 12-week follow-up assessments evaluated the following dependent variables: acute knee pain during full weight bearing treadmill walking; inflammatory biomarkers (C-reactive protein, interleukin-1β, interleukin-6, s100A8/A9, and tumor necrosis factor-α), and catabolic metabolism of articular cartilage (sCOMP). Results: Knee pain at baseline and follow-up remained unchanged for the non-exercise control group (P > 0.05). However, knee pain for the LBPP exercise group was significantly decreased at follow-up (P ≤ 0.05). No differences in the biomarkers of inflammation and cartilage degradation were observed for between and within group comparisons (all P > 0.05). Conclusions: Data suggested that the LBPP supported walking regime could be effectively used to promote regular weight bearing exercise without exacerbation of knee joint pain and did not increase levels of systemic inflammation or catabolic activity of articular cartilage in overweight knee OA patients. This pilot investigation offers important insight regarding the potential role that the LBPP technology could play in facilitating investigations examining the disease modifying effect of exercise on knee OA pathogenesis.

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Does MRI Knee in Those over 50 Years with Knee Pain in Osteoarthritis Alter Management? A Retrospective Review

The Journal of Knee Surgery ◽

10.1055/s-0041-1740390 ◽

2021 ◽

Author(s):

Alexandra N. Murphy ◽

Bryan Yelverton ◽

Kevin Clesham ◽

Kathy Hassell ◽

Eoin Kavanagh ◽

...

Keyword(s):

Knee Pain ◽

Retrospective Review ◽

Clinical Information ◽

Management Plan ◽

Knee Oa ◽

Appropriate Treatment ◽

Management Plans ◽

Magnetic Resonance Imaging Mri ◽

Cause Of Pain

AbstractKnee osteoarthritis (OA) is a significant cause of pain and disability worldwide. Imaging provides diagnosis, prognostication, and follow-up. Radiographs are first line, useful, and inexpensive. Magnetic resonance imaging (MRI) can detect additional features not seen on radiograph, but it is of questionable usefulness in the management of knee OA. Our aim was to investigate the usefulness of MRI in the workup of knee OA and whether MRI alters management in knee OA. A retrospective review was performed of consecutive MRI knees performed for knee pain in those over 50 years. Clinical information and documentation of management plan pre- and post-MRI were collected. Assessment was made whether the MRI results influenced the final management plan. Of the 222 MRI knees included for study, the majority (62.2%) had not had a recent radiograph. OA was reported in 86.9% of radiographs and 89.6% of MRI. On MRI, the most prevalent finding was tearing/abnormality of the medial meniscus, seen in 47% of MRIs overall, increasing to all in severe OA. MRI assisted with management in 9.5% of all (21/222) patients, and changed management plans in 23% of those that had documented management plans prior to the MRI (6/26 patients). MRIs can guide tailored management in knee OA and are useful for surgical planning; however, they should only be ordered in certain cases, and a radiograph should always be performed first. MRI should be considered if symptoms are not explained by OA alone or the appropriate treatment option requires MRI.

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455 PROSPECTIVE EVALUATION OF FRAILTY IN INDIVIDUALS WITH KNEE PAIN IN MALAYSIAN ELDERS LONGITUDINAL RESEARCH (MELOR) STUDY

Age and Ageing ◽

10.1093/ageing/afab119.06 ◽

2021 ◽

Vol 50 (Supplement_2) ◽

pp. ii14-ii18

Author(s):

C L Chiew ◽

S Mat ◽

K S Hui ◽

M P Tan

Keyword(s):

Knee Pain ◽

Longitudinal Research ◽

Computer Assisted ◽

Kuala Lumpur ◽

Frailty Status ◽

Knee Oa ◽

Home Based ◽

Increased Risk ◽

The Relationship

Abstract Introduction Osteoarthritis (OA) is a major cause of physical impairment in older persons. Few studies have determined the relationship between the presence of OA and frailty. We evaluated the prospective relationship between knee pain and frailty in a Malaysian longitudinal cohort. Method Data from Malaysian Elders Longitudinal Research (MELoR) study were utilised. Baseline data were obtained from home-based computer-assisted questionnaires and hospital-based health-checks from 2013–2015. The presence of knee pain was determined with the single question, ‘do you have pain in your knee(s)?’. Frailty status was determined at follow-up in 2019 using SARC-F. Results Data from 1,226 individuals, mean age (SD) = 68.97 (7.48), range = 54–97 years and 56.6% women at baseline, were included. 408 (33.3%) had knee pain. Individuals with knee pain were significantly more likely to be female (66.2% vs 51.8%, p < 0.001). Ethnic differences existed in the presence of knee pain (Malay 43.4% vs Chinese 24.8% vs Indian 31.9%, p < 0.001). Individuals with knee pain was more likely to have diabetes (40.1% vs 29.9%, p < 0.001), hypertension (38.3% vs 27.0%, p < 0.001), dyslipidaemia (38.4% vs 26.5%, p < 0.001) and obesity (52.6% vs 30.2%, p < 0.001). After adjustment for confounders, individuals with knee pain were more significantly to develop frailty at follow-up [odds ratio (95% confidence interval) =2.71(1.61–4.58)]. Conclusion Knee pain was associated with an increased risk of frailty with 5-years follow-up in an urban population in Kuala Lumpur. More detailed evaluation using imaging and clinical diagnosis of osteoarthritis is now indicated. Future studies should also seek to identify modifiable risk factors for the development of frailty in individuals with knee OA and develop strategies to prevent frailty.

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SAT0369 SPINAL RADIOGRAPHIC PROGRESSION IN EARLY SPONDYLOARTHRITIS: SIX-YEAR RESULTS FROM THE ESPERANZA COHORT

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5501 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1132.2-1132

Author(s):

E. De Miguel ◽

J. F. Garcia Llorente ◽

C. Urrego-Laurín ◽

M. L. García-Vivar ◽

C. Fernández-Carballido ◽

...

Keyword(s):

Structural Damage ◽

Radiographic Progression ◽

Intraclass Correlation ◽

Hla B27 ◽

Research Support ◽

Bone Bridge ◽

X Ray ◽

Structural Progression ◽

Absolute Agreement

Background:There are few studies focused on the development of structural damage over time in patients with early SpAObjectives:The aim of this study is to analyze the mSASSS radiographic progression of spine in patients with early spondyloarthritis (SpA) in the Esperanza cohort.Methods:In this longitudinal study, 49 patients of the Spanish early spondyloarthritis (SpA) Esperanza cohort were included. Every patient had a baseline and a six years lateral X-Ray of the cervical and lumbar of spine. The assessment of spine structural damage was done by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Nine readers, blinded for the diagnosis, participated in the reliability exercise, all of them experienced rheumatologists and members of the Spanish spondyloarthritis working group (GRESSER). The mSASSS progression and development of new syndesmophytes was analyzed. The gold standard of every elemental lesion of the mSASSS and the total mSASSS score was the agreement achieved by the independent categorical opinion of at least five of the nine readers. For reliability, intraclass correlation coefficient (ICC) two-way mixed, absolute agreement was used.Results:Forty-nine patients were included, 69 % were males and 49%, HLA B27 positive. Mean ± SD baseline ESR, CRP, BASDAI, BASFI and mSASSS were 10.7±11.7, 5.4±7.1, 3.7±2.5, 2.1±2.0 and 0.326±0.85, respectively. Inter-reader ICC reliability of the 9 readers was 0.812 (CI 95%; 0.764-0.857). The mSASSS score at the six-year visit was 0.67 ± 1.6: thirty-nine patients did not present any changes in this score at the end of the follow-up, two patients had Δ mSASSS of – 1 and eight patients, an increase in this score (four patients, +1; three patients, +2 and one patient, +9 points).At baseline, five patients presented one syndesmophyte; at the six-year visit, seven had one syndesmophyte; one patient, two syndesmophytes and another one, one bone bridge. Only 2/5 patients (40%) with syndesmophytes at baseline showed an increase in Δ mSASSS; the two patients with a Δ mSASSS of -1 did not have syndesmophytes at baseline. Five out of eight patients (62.5%) with an increase of the Δ mSASSS presented this lesion at the six-year visit but only two of them showed syndesmophytes at baseline. On the other hand, two of the three patients who showed an increase of the ΔmSASSS without syndesmophytes at baseline presented an erosion in the anterior vertebral corner and the patient with the bone bridge had a previous syndesmophyte. Our results indicate that in early SpA much of the progression appears in patients without previous syndesmophytes.Conclusion:Spinal radiographic progression was very low in our early SpA cohort, with a mean progression of 0.3 mSASSS units. Only eight patients (16.3%) presented spinal structural progression, most of them not showing syndesmophytes at baseline. It is reasonable to consider that an early diagnosis and monitoring could result in a low radiographic progression.Disclosure of Interests:Eugenio de Miguel Grant/research support from: Yes (Abbvie, Novartis, Pfizer), Consultant of: Yes (Abbvie, Novartis, Pfizer), Paid instructor for: yes (AbbVie, Novartis, Pfizer, MSD, BMS, UCB, Roche, Grunental, Janssen, Sanofi), Speakers bureau: yes (AbbVie, Novartis, Pfizer, MSD, BMS, UCB, Roche, Grunental, Janssen, Sanofi), Jose Francisco Garcia LLorente: None declared, Claudia Urrego-Laurín: None declared, Maria Luz García-Vivar: None declared, Cristina Fernández-Carballido Consultant of: Yes, I have received fees for scientific advice (Abbvie, Celgene, Janssen, Lilly and Novartis), Speakers bureau: Yes, I have received fees as a speaker (Abbvie, Celgene, Janssen, Lilly, MSD, Novartis), María del Carmen Castro Villegas: None declared, Beatriz Joven-Ibáñez Speakers bureau: Abbvie, Celgene, Janssen, Merck Sharp & Dohme, Novartis, Pfizer, Xavier Juanola-Roura: None declared, Carolina Tornero: None declared, E. Galindez: None declared

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Assessment of clinical significance of ultrasonographic detection ofhyperechogenic deposits in hyaline cartilage in patients with knee osteoarthritis

Rheumatology Science and Practice ◽

10.14412/1995-4484-2019-33-37 ◽

2019 ◽

Vol 57 (1) ◽

pp. 33-37

Author(s):

A. V. Petrov ◽

N. V. Matveeva ◽

A. A. Petrov

Keyword(s):

Structural Changes ◽

Hyaline Cartilage ◽

Clinical Manifestations ◽

Joint Space ◽

Calcium Pyrophosphate ◽

Knee Joints ◽

X Ray ◽

Knee Oa ◽

Reactive Protein ◽

History Of

The aimof the study was to assess the relationship between the detection of hyperechogenic deposits (HD) in the hyaline cartilage of the knee joints (KJ) at ultrasonography in patients with osteoarthritis (OA), clinical manifestations and structural changes according to KJ ultrasonography and radiography.Material and methods.A prospective analysis of clinical, radiological and ultrasonographic data of 114 patients with knee OA was conducted. The patients were divided into two groups: 32 patients with HD detected in at least one of the KJ, and 82 patients without HD; 32 patients of the 1st group and 34 patients of the 2nd group were observed for 2 years. A comparative assessment of initial clinical manifestations (WOMAC index), x-ray data and ultrasonographic parameters of the subchondral bone, hyaline cartilage and the degree of synovial inflammation in the groups of patients at the beginning of the study and after 2 years was carried out. The exclusion criteria were other joint diseases; paroxysmal course of the inflammatory process in KJ; trauma and history of operations on KJ; ESR >20 mm/h, uric acid level >360 μmol/l and C-reactive protein >5 mg/l.Results and discussion.HD in hyaline cartilage was found in 28.1% of patients with knee OA. After 2 years HD remained in all patients having them at inclusion, and in 5.6% of the patients they were found for the first time. In 13 patients with HD in hyaline cartilage, synovial fluid was studied and in all cases calcium pyrophosphate crystals were identified by phase-contrast microscopy. The presence of HD in the hyaline cartilage of patients with knee OA was accompanied by more pronounced ultrasonographic signs of synovitis and was associated with a higher rate of osteophytes growth in the absence of the changes of the hyaline cartilage thickness according to the ultrasonography and the width of the joint space according to x-ray.Conclusion.The presence of HD in the hyaline cartilage of patients with knee OA according to ultrasound examination may be associated with the deposition of calcium pyrophosphate crystals and is associated with persistent synovitis and accelerated growth of osteophytes.

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Interrelation of bone mineral density with kneeosteoarthrosis

Osteoporosis and Bone Diseases ◽

10.14341/osteo2011119-20 ◽

2011 ◽

Vol 14 (1) ◽

pp. 19-20

Author(s):

E. M. Zaytseva ◽

A. V. Smirnov ◽

L. I. Alekseeva ◽

E. M. Zaitseva ◽

A. V. Smirnov ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Disease Onset ◽

Axial Skeleton ◽

Knee Joints ◽

Mineral Density ◽

X Ray ◽

Knee Oa ◽

Early Oa

Association of bone mineral density (BMD) of axial skeleton with age of the disease onset as well as with clinical traits and instrumental investigation findings has been studied in osteoarthritic patients. 116 females with primary knee OA, 74 ofwhich exhibited normal or increased BMD at lumbar spine and 42, with osteoporosis were included in the study. Knee joint pain was measured using visual analog scale (VAS). All the patients were subjected to X-ray analysis of their knee joints at two sites (OA stage was determined according to Kellgren-Lawrence scale), densitometry at lumbar spine and proximal femur using QDR-4500W (Hologic), MRT, and ultrasonography of the knee joints. We determined that the increasedBMD at lumbar spine was associated with early OA onset, more pronounced X-ray changes in the knee joints and higher frequency of varus deformation development in tibial bones.

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Relationships between Pain, Function and Radiographic Findings in Osteoarthritis of the Knee: A Cross-Sectional Study

Arthritis ◽

10.1155/2012/984060 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 43

Author(s):

Duygu Cubukcu ◽

Ayse Sarsan ◽

Hakan Alkan

Keyword(s):

Knee Pain ◽

Disease Duration ◽

Osteoarthritis Of The Knee ◽

Womac Pain ◽

Cross Sectional ◽

Radiographic Findings ◽

Knee Oa ◽

Duration Of Disease ◽

Grading Scale ◽

The Mean

Objectives. The aim of this study was to investigate the relationships between pain, disability, and radiographic findings in patients with knee osteoarthritis (OA). Patients and Methods. A total of 114 patients with knee OA who attended the physical medicine and rehabilitation outpatient clinic were included in this study. The diagnosis was based on the American College of Rheumatology (ACR) criteria for knee OA. Age, duration of disease, and body mass index (BMI) of the patients were recorded. Radiographic features on the two-sided knee radiography were assessed with the Kellgren-Lawrence scale. The severity of knee pain, stiffness, and disability were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results. The mean age of the patients was 56.98 (±8.28) years and the mean disease duration was 4.14 (±4.15) years. Kellgren-Lawrence grading scale and age or disease duration were positively and significantly associated, whereas none of the WOMAC subscores were found to be related with Kellgren-Lawrence grading scale (). On the other hand, WOMAC disability scores were significantly associated with WOMAC pain and WOMAC stiffness (). Conclusions. Knee pain, stiffness, and duration of disease may affect the level of disability in the patients with knee OA. Therefore treatment of knee OA could be planned according to the clinical features and functional status instead of radiological findings.

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AB0604 FACTORS ASSOCIATED WITH PAIN IN EARLY KNEE OSTEOARTHRITIS (PRELIMINARY DATA)

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3829 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1338.1-1338

Author(s):

L. Alekseeva ◽

E. Taskina ◽

N. Kashevarova ◽

K. Telyshev ◽

E. Strebkova ◽

...

Keyword(s):

Metabolic Syndrome ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Early Stage ◽

Consent Form ◽

Case Report Form ◽

X Ray ◽

Factors Associated ◽

Knee Oa ◽

Informed Consent Form

Background:Objectives:To identify factors associated with pain in patients with early knee osteoarthritis fulfilling ESKOA criteria [1].Methods:50 patients (46 women (92%); 4 men (8%)) fulfilling ESKOA criteria were enrolled in the trial, every participant signed up the consent form. Median age of patients was 47 ± 8 yrs (36 – 63 yrs), body mass index (BMI) was 28.5 ± 4.9 kg/m2 (40% of patients had obesity). Every patient, after signing the standard informed consent form, was addressed to a physician, who would fill in an individual case report form (CRF), including anthropometric parameters, history of OA, comorbidities and physical examination data. Knee pain was also assessed with the use of visual analog scale (VAS). All participants underwent knee X-ray according to the standardized fixed flexion protocol with the use of positioning frame [2].Results:Most of the patients (70%) were between the ages of 35 and 50 and only 15 of them (30%) were older than 50 years. Median knee pain duration was found to be 16 (12-20) weeks, intensity of VAS – knee pain was 46 mm (42-50). Median number of episodes of knee pain (in the last 6 months) was 3 (2-6); 30 participants (60%) had episodes of knee pain lasting less than a week, 8 of them (6%) had pain lasting for around a week, 12 of them (24%) had episodes of pain lasting more than one week. In most patients (74%) pain relieved with time, without any additional therapy. Most of the patients had episodes of knee pain linked to increased overload (48 (96%)), when squatting (41 (82%)), most of the patients also reported pain when climbing up and down the stairs (80%) and short joint stiffness when starting movement (76%). Knee pain after sitting was reported in 54% of cases and 20 participants (40%) also reported some walking limitations due to knee discomfort.Knee X-ray revealed that most of the patients had I Kellgren&Lawrence (K&L) stage knee OA (picture 1). All the included participants had ESR (7 (5-10 mm/hr)) and CRP (1.24 (0.8-2.2 mg/l)) within normal range.Picture 1 – Radiological knee OA stage (K&L) distribution in the study groupIn the Spearman correlation analysis, we have estimated the factors, which may be associated with more severe pain in patients with early knee OA fulfilling the ESKOA criteria. We found out that higher BMI (r=0.38, р=0.02), presence of metabolic syndrome (r=0.37, р=0.008) and hypertension (r=0.29, р=0.04), as well as walking limitations (r=0.33, р=0.008) are associated with knee pain.Conclusion:The use of ESKOA criteria in patients with short duration of knee pain can facilitate diagnosis of osteoarthritis on an early stage. In addition, the acquired data show that timely diagnosis and correction of certain components of metabolic syndrome may be beneficial for the course of knee pain intensity in patients with early knee OA, further continuation of this trial is necessary.References:[1]Migliore A et al. Rheumatol Int. 2017 Aug;37(8):1227-1236.[2]Mazzuca SA et al. Osteoarthritis Cartilage. 2008 Dec;16(12):1555-9.Disclosure of Interests:None declared.

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