P08 Does the neonatal continuous intravenous infusion prescription chart reflect the medication the baby is actually receiving?

2018 ◽  
Vol 103 (2) ◽  
pp. e1.11-e1
Author(s):  
Whitticase Louise
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Neonatal Intensive Care ◽  
Daily Basis ◽  
Nurse Training ◽  
Continuous Intravenous Infusion ◽  
Prescribing Practice ◽  
Drug And Therapeutics Committee ◽  
To Come ◽  
Accurate Reflection

AimThe aim of this audit was to examine whether the continuous intravenous infusion prescription chart is an accurate reflection of the infusions the baby is actually receiving. The neonatal continuous infusion prescription charts were redesigned six months ago to reduce the prescribing burden of rewriting all continuous infusions on the Neonatal Intensive Care Unit (NICU) on a daily basis. On the new charts the prescription remains valid until it is crossed off or for a maximum period of 7 days. The impression of the pharmacist however is that prescribers are not always crossing off the prescription when they stop an infusion.MethodData collection commenced in June 2017 by the Lead Neonatal Pharmacist. All babies on NICU on a Monday for a period of 4 weeks were included. The continuous infusion prescription chart was compared to the continuous infusions actually being administered to each baby and the corresponding numbers recorded. Any prescriptions identified that were no longer being administered but had not been crossed off were marked as ‘inactive’ by the pharmacist and the nurse/prescriber made aware. The results were fed back the same day to the nurses/prescribers on shift by the pharmacist and cascaded to the Lead Neonatal Consultant for Medication Safety and Chair of Drug and Therapeutics Committee for dissemination to the wider neonatal team via email.A poster was designed and displayed on the ward to highlight the results.ResultsWeek 1–107 infusions prescribed; 60 being administered (47(44%) inactive prescriptions)Week 2–27 infusions prescribed; 21 being administered (6 (22%) inactive prescriptions)Week 3–26 infusions prescribed, 24 being administered (2 (8%) inactive prescriptions)Week 4–23 infusions prescribed, 20 being administered (3 (13%) inactive prescriptions)ConclusionThe continuous intravenous infusion prescription chart was not an accurate reflection of the medications a baby was actually receiving at the start of the audit; 44% of infusions prescribed were no longer being administered. The number of prescriptions crossed off when the decision was taken to stop the infusion improved throughout the 4 week period. By week 3 the majority of continuous infusion prescription charts matched the medications the baby was actually receiving. Both the infusions identified as inactive in week 3 and 2 out of the 3 infusions in week 4 were inotropes that had been slowly weaned to stop following the decision to stop on the ward round. These prescriptions were unable to be crossed off at the time the decision was made to stop the infusion, as the intention was to wean to stop; however the nurses informed the pharmacist conducting the audit that the prescribers were aware the infusions had now stopped and were due to come back and cross off the prescriptions.This audit demonstrates that a regular pharmacist presence highlighting issues with prescribing practice can drive change quite quickly and promote compliance with good prescribing procedures. Training has been incorporated in to the doctor induction programme and neonatal nurse training. The plan is to repeat the audit monthly to ensure compliance is maintained.

scholarly journals Prolonged Cefoxitin Infusion Using Mobile Elastomeric Infusors In Outpatients With Bone And Joint Infection

2018 ◽  
Vol 3 (4) ◽  
pp. 182-186 ◽  
Author(s):  
Zoé Cavalli ◽  
Agathe Becker ◽  
Alexie Bosch ◽  
Anne Conrad ◽  
Claire Triffault-Filit ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Joint Infection ◽  
Continuous Intravenous Infusion ◽  
Reference Center ◽  
Bone And Joint Infection ◽  
The Stability ◽  
Regional Reference

Abstract. We reviewed all outpatients with bone and joint infection treated with cefoxitin in continuous intravenous infusion using mobile elastomeric infusors in our regional reference center between 2014 and 2017. The stability of cefoxitin provides an interesting and well-tolerated alternative for continuous infusion in outpatients with polymicrobial bone and joint infection.

CONTINUOUS INTRAVENOUS INFUSION IN THE RAT, AND THE EFFECT ON THE ISLETS OF LANGERHANS OF THE CONTINUOUS INFUSION OF GLUCOSE

1954 ◽  
Vol 32 (4) ◽  
pp. 428-433 ◽  
Author(s):  
B. Kinash ◽  
R. E. Haist
Keyword(s):  
Body Weight ◽  
Continuous Infusion ◽  
Islets Of Langerhans ◽  
Intravenous Infusion ◽  
Continuous Intravenous Infusion ◽  
Islet Tissue ◽  
Pancreas Weight

A method is described for the continuous intravenous infusion of fluids in the unanesthetized rat. When rats were infused continuously with glucose solutions for 6–14 days the total amount of islet tissue was greatly increased, as compared to that of saline-infused controls. This increase was evident also when considered in relation to pancreas weight or body weight.

Continuous infusion anaesthesia in baboons with alphaxolone-alphadolone

1983 ◽  
Vol 17 (3) ◽  
pp. 196-197 ◽  
Author(s):  
J. H. Cookson ◽  
F. J. Mills
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Cumulative Effect ◽  
Uneventful Recovery ◽  
Continuous Intravenous Infusion ◽  
Rapid Induction

39 experiments were carried out in baboons using continuous intravenous infusion of alphaxalone-alphadolone as an anaesthetic for periods of up to 6 h. This steroid anaesthetic was found to be safe and reliable, with smooth, rapid induction, uneventful recovery, and no evidence of cumulative effect.

scholarly journals A simple technique for continuous intravenous infusion under neuroleptic tranquillization

1976 ◽  
Vol 10 (1) ◽  
pp. 69-72 ◽  
Author(s):  
H. Saarni ◽  
J. Viikari
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Simple Technique ◽  
Continuous Intravenous Infusion ◽  
Tail Vein

A lateral tail vein of the rat is used as the route for continuous infusion. The animal is kept under neuroleptic tranquilisation during the infusion.

scholarly journals Insulin Affects Glucose Uptake by Muscle and Mammary Tissues of Lactating Ewes

1988 ◽  
Vol 41 (4) ◽  
pp. 453 ◽  
Author(s):  
D Leenanuruksa ◽  
P Niumsup ◽  
GH McDowell
Keyword(s):  
Skeletal Muscle ◽  
Insulin Secretion ◽  
Continuous Infusion ◽  
Plasma Glucose ◽  
Intravenous Infusion ◽  
Mammary Tissue ◽  
Continuous Intravenous Infusion ◽  
Short Term ◽  
Exogenous Glucose ◽  
Frequent Monitoring

Effects of insulin on exchanges of glucose across skeletal muscle and mammary tissue were measured in short-term studies in lactating ewes. Insulin secretion was suppressed by a primed/continuous infusion of somatostatin, then insulin was administered by continuous intravenous infusion of doses that were increased, in a step-wise manner, from 0 to 2 U h -I. Plasma glucose was maintained essentially constant by frequent monitoring and intravenous administration of exogenous glucose.

scholarly journals Gastro-intestinal Tract Function in Sheep Infused with Somatostatin

1985 ◽  
Vol 38 (4) ◽  
pp. 393 ◽  
Author(s):  
TN Barry ◽  
GJ Faichney ◽  
Carolyn Redekopp
Keyword(s):  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Dry Matter ◽  
Intestinal Tract ◽  
Sampling Procedure ◽  
Continuous Intravenous Infusion ◽  
Tract Function ◽  
Pelleted Diet ◽  
Gastro Intestinal Tract

The effect of a 5-day continuous intravenous infusion of somatostatin (4�6 ng min- I kg-I) was studied, using anoestrous ewes given 791 g dry matter per day of a 60: 40 lucerne hay: oat grain pelleted diet from a continuously moving belt. 5ICr-EDTA, I03Ru-phenanthroline and lignin were used as markers to determine digesta mean retention times (MRT) by a continuous infusion-total sampling procedure.

A new system for continuous intravenous infusion of pigs

1996 ◽  
Vol 30 (1) ◽  
pp. 75-78 ◽  
Author(s):  
D. J. van Kleef
Keyword(s):  
Continuous Infusion ◽  
Psychological Stress ◽  
Intravenous Infusion ◽  
Cost Effective ◽  
Continuous Intravenous Infusion ◽  
Restricted Movement ◽  
Physical Discomfort ◽  
Infusion Tube ◽  
New System

The swivel system described has been used by ILOB-TNO for prolonged periods of continuous infusion. It allows for less restricted movement of animals. The swivel prevents the infusion tube from twisting. The swivel system is simple, safe to operate and cost-effective. Animals have greater movement, can stretch and turn around. The physical discomfort and psychological stress of restricted movement are greatly reduced. The potentially complicating/confusing effects on the measurements taken during an experiment are reduced.

scholarly journals Leukocyte Labeling in Rats during and after Continuous Infusion of Tritiated Thymidine: Implications for Lymphocyte Longevity and DNA Reutilization

Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 281-295 ◽  
Author(s):  
STEPHEN H. ROBINSON ◽  
GEORGE BRECHER ◽  
IRA S. LOURIE ◽  
JAMES E. HALEY
Keyword(s):  
Cell Death ◽  
Continuous Infusion ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Intravenous Infusion ◽  
Tritiated Thymidine ◽  
Continuous Intravenous Infusion ◽  
Turnover Rates ◽  
Leukocyte Labeling ◽  
Two Populations

Abstract Leukocyte labeling was studied in rats during and after continuous intravenous infusion of H3-thymidine. The radioisotope was administered for varying periods up to 271 days. The results permit the following conclusions: 1. The median survival of small lymphocytes is about 1 month. Five to 8 per cent of small lymphocytes have a life span of more than 9 months. 2. Following the administration of H3-thymidine, reutilization of the tracer markedly delays the fall-off of labeled cells in the peripheral blood. Reutilization probably involves H3-thymidine released from labeled DNA during cell death, since suppression occurs with massive infusion of non-labeled thymidine. 3. Unlike granulocytes and large lymphocytes, small lymphocytes label nonuniformly, and appear to be comprised of at least two populations with different intensities of labeling and different turnover rates. The more heavily labeled cells have the faster turnover. 4. The complexity of the labeling process indicated by the present observations must be considered in the interpretation of H3-thymidine data. However, the survival of unlabeled cells during continuous H3-thymidine infusion remains a valid means of measuring the life spans of circulating blood cells.

CONTINUOUS INTRAVENOUS INFUSION IN THE RAT, AND THE EFFECT ON THE ISLETS OF LANGERHANS OF THE CONTINUOUS INFUSION OF GLUCOSE

1954 ◽  
Vol 32 (1) ◽  
pp. 428-433 ◽  
Author(s):  
B. Kinash ◽  
R. E. Haist
Keyword(s):  
Body Weight ◽  
Continuous Infusion ◽  
Islets Of Langerhans ◽  
Intravenous Infusion ◽  
Continuous Intravenous Infusion ◽  
Islet Tissue ◽  
Pancreas Weight

A method is described for the continuous intravenous infusion of fluids in the unanesthetized rat. When rats were infused continuously with glucose solutions for 6–14 days the total amount of islet tissue was greatly increased, as compared to that of saline-infused controls. This increase was evident also when considered in relation to pancreas weight or body weight.

METABOLISM OF OESTRIOL-3-SULPHATE AND OESTRIOL-16(17?)-GLUCOSIDURONATE IN PREGNANT WOMEN

1965 ◽  
Vol 50 (2) ◽  
pp. 273-288 ◽  
Author(s):  
U. Goebelsmann ◽  
G. Eriksson ◽  
N. Wiqvist ◽  
E. Diczfalusy
Keyword(s):  
Pregnant Women ◽  
Continuous Infusion ◽  
Intravenous Infusion ◽  
Marked Change ◽  
Urinary Metabolite ◽  
Continuous Intravenous Infusion ◽  
Maternal Circulation ◽  
Specific Activities ◽  
The Relationship ◽  
Infusion Period

ABSTRACT A combination of oestriol-15-3H-3-sulphate (OE3-15-3H-3S) and oestriol-16-14C-16(17?)-glucosiduronate (OE3-16-14C-16(17?)Gl) was administered in the form of a continuous intravenous infusion over 310 and 280 min, respectively, to two women at midpregnancy prior to the interruption of gestation. Eighty and 66 per cent, respectively, of the administered 3H-labelled material and 87 and 83 per cent, respectively, of the 14C-labelled material was recovered within 24 hours from the urine of the two subjects. 3H-labelled OE3-3S and both 3H- and 14C-labelled OE3-16(17?)Gl and oestriol-3-glucosiduronate (OE3-3Gl) were isolated from the urine of both patients in a radiochemically homogeneous form. No 14C-labelled material was found in the OE3-3S isolated. During the continuous infusion period, some 26 per cent of the urinary 3H-labelled material was excreted as OE3-3S, 68 per cent was present as OE3-16(17?)Gl and 6 per cent as OE3-3Gl. Corresponding proportions of the 14C-labelled urinary material were: 97 per cent OE3-16(17?)Gl and 3 per cent OE3-3Gl. During the postinfusion period, the pattern of urinary conjugates showed a marked change: only 2 per cent of the 3H-labelled material was excreted as OE3-3S, 31 per cent was OE3-16(17?)Gl and as much as 67 per cent was OE3-3Gl. Corresponding figures for the 14C-labelled material were: 33 per cent OE3-16(17?)Gl and 67 per cent OE3-3Gl. No radioactive oestrogens other than OE3 were detected. The endogenous urinary oestriol (OE3) excretion during the 24 hours of experiment (expressed in OE3-equivalents) was: 0.086 mg OE3-3S, 1.87 mg OE3-16(17?)Gl and 1.57 mg of OE3-3Gl in the first subject and 0.13 mg OE3-3S, 3.01 mg OE3-16(17?)Gl and 1.53 mg of OE3-3Gl in the second patient. From the relationship between the specific activities of the injected and isolated oestriol conjugates the amount of OE3-3S and OE3-16(17?)Gl reaching the maternal circulation during 24 hours was calculated. On basis of these values it is concluded that in midpregnancy the bulk of oestriol conjugates in the blood consists of glucosiduronates rather than of sulphates and that OE3-3Gl is a quantitatively important urinary metabolite not only of circulating OE3, but also of OE3-3S and OE3-16(17?)Gl.

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