scholarly journals Recovery of second trimester pre-eclampsia after fetal reduction of a triplet

2019 ◽  
Vol 12 (9) ◽  
pp. e227667
Author(s):  
Jeske M bij de Weg ◽  
Christianne J de Groot ◽  
Eva Pajkrt ◽  
Marjon A de Boer

Women with a multiple pregnancy are at increased risk of developing hypertensive disorders of pregnancy. We describe a case of a dichorionic triamniotic triplet pregnancy complicated by severe hypertension, proteinuria and maternal symptoms, fitting with the diagnosis of pre-eclampsia, apart from the early gestational age of only 16 weeks. After reduction of the monochorionic pair, the disease resolved and pre-eclampsia was diagnosed again at 30 weeks of gestation, resulting in a delivery on maternal indication at 33 weeks of gestation. In a review of the literature, we found six papers including eight cases on multifetal pregnancy reduction on maternal indication. Multifetal pregnancy reduction resulted in a prolongation of pregnancy of two to 21 weeks and may be considered in extreme early onset pre-eclampsia in dichorionic multiple pregnancies.

Author(s):  
Surabhi Nanda ◽  
James P. Neilson

There has been a consistent rise in multiple pregnancies over recent years. Such pregnancies are at increased risk of miscarriage, fetal abnormalities, preterm birth, complications specific to shared placentation including twin-to-twin transfusion syndrome, selective growth restriction, and twin anaemia–polycythaemia sequence. In addition, a woman with a multiple pregnancy is at a higher risk of maternal complications including pre-eclampsia and other hypertensive disorders of pregnancy, obstetric cholestasis, gestational diabetes, exaggerated maternal pregnancy symptoms, and postpartum haemorrhage. Antenatal care in a multiple pregnancy should ideally be offered in a dedicated setting, with increased contact with the healthcare professionals compared to a singleton pregnancy. Such pregnancies, especially when complicated, need support and appropriate counselling to prepare for an optimal outcome.


2017 ◽  
Vol 34 (14) ◽  
pp. 1417-1423
Author(s):  
Nola Herlihy ◽  
Mariam Naqvi ◽  
Julie Romero ◽  
Simi Gupta ◽  
Ana Monteagudo ◽  
...  

Objective This study aims to determine the efficacy of multifetal pregnancy reduction (MFPR) in improving obstetrical outcomes for trichorionic triplet gestations. Study Design Retrospective cohort study of patients with multiple gestations delivered by a single maternal-fetal medicine practice from 2005 to 2016. We compared patients with trichorionic triamniotic triplet gestations who underwent MFPR to those with an ongoing triplet pregnancy (TT), as well as primary dichorionic diamniotic twin gestations (DD). Logistic regression analysis was used to control for any differences at baseline. Results There were 42 patients in the MFPR group, 43 women in the TT group, and 693 women in the DD group. Comparing MFPR to TT, the likelihood of preterm birth < 34 weeks was similar (31.0 vs. 39.5%, adjusted odds ratio [aOR]: 0.63, 95% confidence interval [CI]: 0.21, 1.87). There were no differences in gestational age at delivery, pregnancy loss < 24 weeks, or the likelihood of all, none, or at least two babies surviving to discharge. Mean birth weights were significantly higher and cesarean delivery rates lower for MFPR (2,128 vs. 1,836 g, p = 0.028 and 69 vs. 86%, aOR: 0.25, 95% CI: 0.06, 0.94) as compared with the TT group. MFPR had significantly worse outcomes than DD. Conclusion In trichorionic triamniotic triplet pregnancies, our study suggests that obstetrical outcomes may not be as dramatically improved with MFPR as seen in older studies.


Twin Research ◽  
2001 ◽  
Vol 4 (3) ◽  
pp. 165-167 ◽  
Author(s):  
Isaac Blickstein

AbstractThe management of multiple pregnancies represents a true challenge for all sub-specialties concerned with perinatal medicine. Many issues were neglected over the years merely because they were rare and therefore considered not sufficiently important to merit clinical trials. This paper discusses a personal selection of controversial issues, such as multifetal pregnancy reduction of triplets and twins, special cases in multifetal preganncy reduction, need for invasive genetic studies, management of twin-twin transfusion, discordant fetal conditions, the definition of “term” in multiples, and the controversy about the mode of delivery.


2014 ◽  
Vol 17 (6) ◽  
pp. 589-593 ◽  
Author(s):  
Thérèse H. Griersmith ◽  
Alison M. Fung ◽  
Susan P. Walker

Monochorionic twins as part of a high order multiple pregnancy can be an unintended consequence of the increasingly common practice of blastocyst transfer for couples requiring in vitro fertilisation (IVF) for infertility. Dichorionic triamniotic (DCTA) triplets is the most common presentation, and these pregnancies are particularly high risk because of the additional risks associated with monochorionicity. Surveillance for twin-to-twin transfusion syndrome, including twin anemia polycythemia sequence, may be more difficult, and any intervention to treat the monochorionic pair needs to balance the proposed benefits against the risks posed to the unaffected singleton. Counseling of families with DCTA triplets is therefore complex. Here, we report a case of DCTA triplets, where the pregnancy was complicated by threatened preterm labour, and twin anemia polycythemia sequence (TAPS) was later diagnosed at 28 weeks. The TAPS was managed with a single intraperitoneal transfusion, enabling safe prolongation of the pregnancy for over 2 weeks until recurrence of TAPS and preterm labour supervened. Postnatal TAPS was confirmed, and all three infants were later discharged home at term corrected age, and were normal at follow-up. This case highlights that in utero therapy has an important role in multiple pregnancies of mixed chorionicity, and can achieve safe prolongation of pregnancy at critical gestations.


Author(s):  
Silje Langseth Dahl ◽  
Rebekka Hylland Vaksdal ◽  
Mathias Barra ◽  
Espen Gamlund ◽  
Carl Tollef Solberg

De siste årene har fosterreduksjon i økende grad vært gjenstand for debatt i Norge, og intensiteten nådde et foreløpig maksimum da Lovavdelingen leverte tolknings-uttalelsen § 2 - Tolkning av abortloven i 2016 som svar på at Helse- og omsorgs-departementet (i 2014) ba Lovavdelingen om å vurdere hvorvidt Lov om svangers-kapsavbrudd åpner for fosterreduksjon av friske fostre ved flerlings-vangerskap. Lovavdelingen konkluderte med at abortloven åpner for fosterreduksjon ved flerlingsvangerskap innenfor de rammene som loven ellers oppstiller. Debatten har ikke stilnet, og utover høsten 2018 ble den ytterligere tilspisset i forbindelse med KrFs veivalg og signaler fra Høyre om å vurdere å fjerne § 2.3c, samt å forby fosterreduksjon. Mange av argumentene i fosterreduksjonsdebatten fremstår tilsynelatende like de argumentene som verserer i abortdebatten, og det mangler en analyse av hva som stiller seg annerledes ved fosterreduksjon. Målet med denne artikkelen er følgelig å undersøke hvorvidt det finnes en moralsk relevant forskjell mellom abort og fosterreduksjon av friske fostre. Vi tar for oss typiske argumenter fra den norske debatten, og belyser dem med fagartikler fra forskningslitteraturen. De mest sentrale argumentene mot fosterreduksjon har vi identifisert som skadeargumentet, skråplansargumentet, intensjonsargumentet, sorgargumentet, psykologiske langtids-effekter for kvinnen og sorteringsargumentet. Vi kommer frem til at motargumentene ikke holder mål hva gjelder å påvise en moralsk relevant forskjell mellom abort og fosterreduksjon av friske fostre. Konklusjonen vår er derfor at det – på tross av hva flere debattanter synes å mene - ikke finnes en moralsk relevant forskjell mellom de to. Når vi derfor tillater abort, så bør vi også tillate fosterreduksjon. Nøkkelord: Abort, etikk, fosterreduksjon, medisinsk etikk, selektiv fosterreduksjon   English summary: Abortion and multifetal pregnancy reduction: An ethical comparison  During recent years, multifetal pregnancy reduction has increasingly been subject to debate in Norway, and this debate reached an apex when the Legislation Department delivered the interpretation statement § 2 - Interpretation of the Abortion Act in 2016 in response to the Ministry of Health and Care Services, who had (in 2014) requested the Legislation Department to assess whether the Abortion Act allowed for multifetal pregnancy reductions of healthy fetuses. The Legislation Department concluded that the Abortion Act does regulate and permit multifetal pregnancy reductions within the framework that the law otherwise stipulates. The debate has not subsided, and in the autumn of 2018, it was further intensified in connection with the Norwegian Christian Democratic Party´s (KrF) "crossroads choice" and the signals from the Norwegian Conservative Party that they would consider reverting the Abortion Act’s section 2.3c [regulating second trimester abortions due to fetal anomalies], as well as a ban on multifetal pregnancy reduction. Many of the arguments in the multifetal pregnancy reduction debate appear very similar to the arguments pending in the general abortion debate, and an analysis of what makes multifetal pregnancy reduction significantly different from abortion is wanting. The aim of this article is, accordingly, to investigate to what extent there is a morally relevant distinction between abortion and multifetal pregnancy reduction of healthy fetuses. We take on board typical arguments from the Norwegian debate and consider them in light of the scholarly literature. We have identified the most central arguments against multifetal pregnancy reduction as the harm argument, the slippery slope argument, the intent argument, the grief argument, the regret argument (concerning long-term psychological effects for the woman), and the sorting argument. We argue that these counter-arguments do not succeed in establishing a morally relevant difference between abortion and multifetal pregnancy reduction of healthy fetuses. Our conclusion is, therefore – that despite what is often held – there is no morally significant difference between the two. Therefore, when we allow abortion, we should also allow multifetal pregnancy reductions. Keywords: Abortion, ethics, fetal reduction, medical ethics, multifetal pregnancy reduction


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