scholarly journals Subacute knee pain and swelling in a healthy male: a case of Brodie’s abscess

2019 ◽  
Vol 12 (3) ◽  
pp. e227926
Author(s):  
Mitesh K Patel ◽  
Steven Barrientos ◽  
Sunny Gupta ◽  
Bradford Tucker
Keyword(s):  
Antibiotic Therapy ◽  
Knee Pain ◽  
Inflammatory Process ◽  
Chronic Osteomyelitis ◽  
Early Recognition ◽  
Healthy Male ◽  
Timely Manner ◽  
Successful Management ◽  
Brodie’S Abscess ◽  
Avascular Necrosis Of Bone

Osteomyelitis is an inflammatory process of the bone caused by an infection. The key to successful management is early recognition and treatment, as complications can arise if interventions are not done in a timely manner. Subacute or chronic osteomyelitis is associated with avascular necrosis of bone requiring surgical debridement and antibiotic therapy. Here, we describe a case illustrating an uncharacteristic presentation of knee pain ending with multiple surgical debridements in a healthy male.

scholarly journals A Case of Brodie's Abscess in Distal Radius of Pediatric following Percutaneous Fixation

2019 ◽  
Vol 12 (03) ◽  
pp. 204-207
Author(s):  
Ali Tabrizi ◽  
Ahmadreza Afshar ◽  
Seyed Amir Mahlisha Kazemi Shishavan
Keyword(s):  
Antibiotic Therapy ◽  
Distal Radius ◽  
Open Reduction ◽  
Chronic Osteomyelitis ◽  
Kirschner Wire ◽  
Conventional Radiography ◽  
Lytic Lesion ◽  
Percutaneous Pinning ◽  
Pediatric Fractures ◽  
Brodie’S Abscess

AbstractDistal radius fractures are among the most common pediatric fractures. In unstable fractures, treatment methods include closed or open reduction and percutaneous pinning with Kirschner wire (K-wire). This report presents a 13-year-old boy with an unstable distal radius and ulnar fractures, following an accident, who was treated with open reduction and K-wire fixation. He had pain and limited wrist range of motion for 6 months. Conventional radiography revealed a lytic lesion with evident sclerotic margin. Chronic osteomyelitis and Brodie's abscess were also indicated. A complete curettage and antibiotic therapy for 3 months was successful. Culturing results showed that Staphylococcus aureus and pathologic findings were in favor of chronic osteomyelitis. Subacute osteomyelitis and Brodie's abscess are rare retarded complications in percutaneous pinning of distal radius pediatric fractures. The curettage of the lesion and antibiotic therapy for at least 3 months would be successful and could result in good prognosis among children.

scholarly journals Going Bone Deep: Osseous Rosai–Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Dominick S. DeFelice ◽  
Megan L. Srinivas ◽  
Sara E. Wobker ◽  
Jonathan B. Parr
Keyword(s):  
Medical Care ◽  
Knee Pain ◽  
Chronic Osteomyelitis ◽  
Rosai Dorfman Disease ◽  
Diagnostic Possibility ◽  
Culture Negative ◽  
Careful Assessment

A patient presented for medical care on three separate occasions over the course of two years with recurrent right knee pain attributed to chronic osteomyelitis. Careful assessment revealed that his symptoms were caused by osseous Rosai–Dorfman disease. This case presents an alternative diagnostic possibility for culture-negative chronic osteomyelitis.

scholarly journals Atypical haemolytic uremic syndrome secondary to acute pancreatitis: a unique presentation

2019 ◽  
Vol 12 (9) ◽  
pp. e230822 ◽  
Author(s):  
Jacob Barish ◽  
Pallavi Kopparthy ◽  
Bradley Fletcher
Keyword(s):  
Renal Failure ◽  
Acute Pancreatitis ◽  
Early Recognition ◽  
Standard Of Care ◽  
Timely Manner ◽  
Haemolytic Uremic Syndrome ◽  
Complement Dysregulation ◽  
Atypical Haemolytic Uraemic Syndrome ◽  
Uremic Syndrome ◽  
To Receive

Atypical haemolytic uraemic syndrome (aHUS) is a disease of complement dysregulation and can be fatal if not treated in a timely manner. Although normally associated with triggers such as infection or pregnancy, this case demonstrates acute pancreatitis as the triggering event. The patient’s initial presentation of thrombocytopaenia and acute renal failure was first attributed to a systemic inflammatory response syndrome due to pancreatitis, but with detailed history and further laboratory investigation, we were able to show that patient was having symptoms associated with aHUS. On early recognition of aHUS, this patient was able to receive the proper standard of care with eculizumab and had a full recovery while preventing renal failure. When patients present with thrombocytopaenia and renal failure in acute pancreatitis, we want to ensure physicians keep aHUS on the differential.

scholarly journals Non-infectious causes of chronic pharyngitis

2018 ◽  
pp. 112-115
Author(s):  
S. Ya. Kosyakov ◽  
I. B. Angotoeva ◽  
A. N. Isamov
Keyword(s):  
Antibiotic Therapy ◽  
Sore Throat ◽  
Inflammatory Process ◽  
Common Disease ◽  
Main Symptom ◽  
Systemic Antibiotic ◽  
Pharyngeal Mucosa ◽  
Systemic Antibiotic Therapy

Chronic pharyngitis (CP) is a common disease that is not associated with infections and does not require administration of any systemic antibiotic therapy. Many non-infectious factors cause CP. Despite diversity and variability of factors, the inflammatory process of the pharyngeal mucosa lie at the root of the pathogenesis of CP. A sore throat is the main symptom of this process, which can be successfully relieved with local drugs.

scholarly journals Osteomyelitis: A Literature Review

2019 ◽  
Vol 11 (2) ◽  
pp. 69
Author(s):  
Rangga Rawung ◽  
Chita Moningkey
Keyword(s):  
Literature Review ◽  
Antibiotic Therapy ◽  
Basic Principle ◽  
Treatment Strategy ◽  
Operative Techniques ◽  
Successful Management ◽  
Anatomy And Physiology ◽  
Joint Infections ◽  
Basic Understanding

Abstrak: Infeksi pada tulang dan sendi masih merupakan kasus yang menantang. Kondisi ini memberikan banyak penyulit baik kepada dokter maupun pasien. Meski terapi antibiotika dilaporkan memberikan hasil yang memuaskan pada banyak kasus infeksi, tidak demikian pada kasus infeksi tulang dan sendi. Hal ini berhubungan dengan struktur anatomi dan fisiologi dari tulang. Diperlukan sebuah strategi tata laksana yang baik untuk mencapai hasil yang optimal. Prinsip dasar yang utama dalam mencapai pengobatan yang optimal ialah penegakan diagnosis awal yang tepat, termasuk di dalamnya proses investigasi pemeriksaan mikrobiologi dan patologi. Diperlukan pengertian dasar serta pengenalan kembali anatomi, fisiologi, patofisiologi, dan tata laksana terkini tentang osteomielitis untuk mencapai tatalaksana yang optimal.Kata kunci: diagnosis dan tata laksana osteomielitisAbstract: Infection in bone and joint is still a challenging case. It gives a lot of problems and frustration to the physician and patient. The successful antibiotic therapy in most infectious diseases is abortive to achieve in bone and joint infections because the different characteristic in anatomy and physiology of these structures. Therefore, treatment strategy, including non operative and operative techniques is required to deal with such conditions. The basic principle to achieve a successful management of osteomyelitis in general is correct initial diagnosis including investigation for microbiological and pathological examinations to allow the proper and long term lasting therapy of antibiotic. For that reason, it is required to have the basic understanding in dealing with this issue, obvious and updated. It is commited to review the pathophysiology, the diagnosis, and the management of osteomyelitis in order to presents basic facilities in dealing with osteomyelitis.Keywords: osteomyelitis diagnosis and management

scholarly journals Subacute Thyroiditis from COVID-19 Infection: A Case Report and Review of Literature

2020 ◽  
pp. 1-5
Author(s):  
Akshay Khatri ◽  
Esti Charlap ◽  
Angela Kim
Keyword(s):  
Clinical Features ◽  
Clinical Laboratory ◽  
Early Recognition ◽  
Subacute Thyroiditis ◽  
The Novel ◽  
Review Of Literature ◽  
Successful Management ◽  
Case Presentation ◽  
Radiologic Findings ◽  
History Of

<b><i>Introduction:</i></b> The novel severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) virus has led to the ongoing Coronavirus disease 2019 (COVID-19) disease pandemic. There are increasing reports of extrapulmonary clinical features of COVID-19, either as initial presentations or sequelae of disease. We report a patient diagnosed with subacute thyroiditis precipitated by COVID-19 infection, as well as review the literature of similar cases. <b><i>Case Presentation:</i></b> A 41-year-old female with no significant personal or family history of endocrinologic disorders presented with clinical features of thyroiditis that began after COVID-19 infection. Clinical, laboratory, and radiologic findings were indicative of subacute thyroiditis. Workup for potential triggers other than SARS-CoV-2 was negative. <b><i>Discussion/Conclusion:</i></b> We compared the clinical and diagnostic findings of our patient with other well-documented cases of subacute thyroiditis presumed to be triggered by SARS-CoV-2 viral infection. We also reviewed the literature related to the potential mechanisms leading to thyroiditis. Clinicians must be aware of the possibility of thyroid dysfunction after COVID-19 infection. Early recognition and timely anti-inflammatory therapy help in successful management.

scholarly journals Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients

2019 ◽  
Vol 74 (7) ◽  
pp. 2060-2064 ◽  
Author(s):  
Cécile Pouderoux ◽  
Agathe Becker ◽  
Sylvain Goutelle ◽  
Sébastien Lustig ◽  
Claire Triffault-Fillit ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Prosthetic Joint Infection ◽  
Salvage Therapy ◽  
Chronic Osteomyelitis ◽  
Joint Infection ◽  
Intensive Therapy ◽  
Treatment Modalities ◽  
Surgical Removal ◽  
Prosthetic Joint ◽  
Suppressive Antibiotic Therapy

Abstract Background Optimal treatment of prosthetic joint infection and chronic osteomyelitis consists of surgical removal of biofilm-embedded bacteria, followed by a 6–12 week course of antimicrobial therapy. However, when optimal surgery is not feasible, oral prolonged suppressive antibiotic therapy (PSAT) is recommended to prevent prosthesis loosening and/or relapse of infection. Since 2010, we have used infection salvage therapy using off-label subcutaneous (sc) injection of a β-lactam as PSAT for patients in whom oral PSAT is not possible. Methods A single-centre prospective cohort study (2010–18) reporting treatment modalities, efficacy and safety in all patients receiving sc PSAT. NCT03403608. Results The 10 included patients (median age 79 years) had polymicrobial (n = 5) or MDR bacterial (n = 4) prosthetic joint infection (knee, n = 4; hip, n = 3) or chronic osteomyelitis (n = 3). After initial intensive therapy, seven patients received ertapenem, three patients received ceftriaxone and one patient received ceftazidime by sc injection (one patient received 8 days of ceftriaxone before receiving ertapenem). In one patient, sc PSAT failed with recurrent signs of infection under treatment. In three patients, sc PSAT had to be discontinued due to side effects; in only one of these was the sc route implicated (skin necrosis following direct sc injection and not gravity infusion). Median treatment duration was 433 days. In six patients, sc PSAT was successful with favourable outcome at the time of writing. Interestingly, three patients with MDR bacterial carriage at baseline lost this under PSAT during follow-up. Conclusions As salvage therapy, sc PSAT delivered by gravity infusion is a safe and interesting alternative when an optimal surgical strategy is not feasible and no oral treatment is available.

Successful surgical management of infected modified Blalock-Taussig shunts

2004 ◽  
Vol 14 (2) ◽  
pp. 219-221
Author(s):  
Yoshio Ootaki ◽  
Masahiro Yamaguchi ◽  
Naoki Yoshimura
Keyword(s):  
Antibiotic Therapy ◽  
Surgical Management ◽  
Successful Management

We describe the successful management of two patients with infected modified Blalock-Taussig shunts by replacement of the graft combined with antibiotic therapy.

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