Bilateral acute anterior uveitis and iris atrophy caused by moxifloxacin

2020 ◽  
Vol 13 (6) ◽  
pp. e233528 ◽  
Author(s):  
Benjamin Tsun Kiu Hui ◽  
Nicholas Capewell ◽  
Yousuf Ansari ◽  
Xiaoxuan Liu
Keyword(s):  
Anterior Uveitis ◽  
Anterior Segment ◽  
Severe Pneumonia ◽  
The Body ◽  
Supporting Evidence ◽  
Sphincter Muscle ◽  
Acute Anterior Uveitis ◽  
Non Invasive ◽  
Ocular Imaging ◽  
Iris Atrophy

A 56-year-old paramedic was admitted to hospital and treated for severe pneumonia. Shortly after initiating antibiotic treatment (including moxifloxacin), he developed bilaterally painful eyes and was diagnosed with bilateral acute anterior uveitis (AAU). Three years later, he was referred to the ophthalmology clinic with bilateral iris transillumination suggesting iris atrophy and limited pupillary dilation, indicating iris sphincter muscle paralysis. AAU typically presents unilaterally. An onset of bilateral AAU is unusual and warrants investigation for underlying systemic cause. The fluoroquinolone moxifloxacin has been reported in a limited number of cases as a causative agent of bilateral AAU and iris atrophy. This case provides additional supporting evidence that moxifloxacin may cause degradation of collagen and iris muscle in the eye, as well as elsewhere in the body, such as in blood vessels. Additionally, we present novel anterior segment ocular imaging (using optical coherence tomography) demonstrating the ability to detect iris atrophy using non-invasive imaging.

Anterior Segment Fluorophotometry in Acute Anterior Uveitis

1987 ◽  
Vol 105 (11) ◽  
pp. 1550-1555 ◽  
Author(s):  
I. R. Fearnley ◽  
D. J. Spalton ◽  
S. E. Smith
Keyword(s):  
Anterior Uveitis ◽  
Anterior Segment ◽  
Acute Anterior Uveitis

scholarly journals Anterior segment optical coherence tomography in acute anterior uveitis

2014 ◽  
Vol 77 (1) ◽  
Author(s):  
Cristiana Agra ◽  
Lydianne Agra ◽  
Jeanine Dantas ◽  
Tiago Eugênio Faria e Arantes ◽  
João Lins de Andrade Neto
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Uveitis ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Acute Anterior Uveitis

scholarly journals The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Zsuzsanna Szepessy ◽  
Árpád Barsi ◽  
Kinga Kránitz ◽  
Zoltán Zsolt Nagy
Keyword(s):  
Treatment Period ◽  
Anterior Uveitis ◽  
Choroidal Thickness ◽  
Retinal Thickness ◽  
Anterior Segment ◽  
Cell Number ◽  
Acute Anterior Uveitis ◽  
Seronegative Spondyloarthropathy ◽  
Laser Flare

Purpose. To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis). Methods. Thirty eyes of 30 consecutive Caucasian patients with HLA-B27-associated acute anterior uveitis were included in this study. The flare, AC cell number, and central retinal/choroidal thickness were determined at each visit by optical coherence tomography and laser flare photometry. Treatment consisted of topical corticosteroids. Statistical analysis was performed by MathWorks Matlab software. Results. In the follow-up period, central retinal thickness was increased in the first 9-10 days and then decreased until stabilization (after 5-6 weeks). The flare and AC cell number decreased rapidly at the beginning of the treatment, in the first 10 days, and thereafter, slower decrease could be observed until complete resolution of inflammation. Statistically significant, positive correlation was found between initial laser flare value and maximal central retinal thickness (r=0.881, p<0.001). Positive correlation between flare and retinal thickening was observable throughout the treatment period. Central choroidal thickness was decreased also significantly during the follow-up (p<0.001). Conclusions. The retina and choroid may play a biomarker function in the anterior segment inflammation of the eye in the patients with seronegative spondyloarthropathy.

scholarly journals Longitudinal study of anterior segment inflammation by ultrasound biomicroscopy in patients with acute anterior uveitis

2009 ◽  
Vol 87 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Yang Peizeng ◽  
Meng Qianli ◽  
Huang Xiangkun ◽  
Zhou Hongyan ◽  
Wang Li ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Anterior Uveitis ◽  
Anterior Segment ◽  
Ultrasound Biomicroscopy ◽  
Acute Anterior Uveitis

Glucose Calibration Modeling in Blood with Spline Regression Approaching to Non-Invasive Tools

2018 ◽  
pp. 144-149
Author(s):  
Ria Hayatun Nur ◽  
Indahwati A ◽  
Erfiani A
Keyword(s):  
Diabetes Mellitus ◽  
Linear Regression ◽  
Good Health ◽  
Cubic Spline ◽  
The Body ◽  
Spline Regression ◽  
Linear Quadratic ◽  
Important Thing ◽  
Non Invasive

In this globalization era, health is the most important thing to be able to run various activities. Without good health, this will hinder many activities. Diabetes mellitus is one of the diseases caused by unhealty lifestyle.There are many treatments that can be done to prevent the occurrence of diabetes. The treatments are giving the insulin and also checking the glucose rate to the patients.Checking the glucose rate needs the tools which is safety to the body. This research want to develop non invasive tool which is safety and do not injure the patient. The purpose of this research is also finding the best model which derived from Linear, Quadratic, and Cubic Spline Regression. Some respondents were taking to get the glucose measuring by invasive and non invasive tools. It could be seen clearly that Spline Linear Regression was the best model than Quadratic and Cubic Spline Regression. It had 70% and 33.939 for R2 and RMSEP respectively.

Acute Anterior Uveitis

2017 ◽  
Vol 13 (02) ◽  
pp. 99-100 ◽  
Author(s):  
Yupin Leelachaikul
Keyword(s):  
Anterior Uveitis ◽  
Acute Anterior Uveitis

scholarly journals HLA-B27 frequency in Greek patients with acute anterior uveitis.

1977 ◽  
Vol 61 (11) ◽  
pp. 699-701 ◽  
Author(s):  
J Zervas ◽  
G Tsokos ◽  
G Papadakis ◽  
E Kabouklis ◽  
D Papadopoulos
Keyword(s):  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis

scholarly journals The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jon Roger Eidet ◽  
Maja Akopian ◽  
Ole K. Olstad ◽  
Øystein Kalsnes Jørstad ◽  
Morten C. Moe ◽  
...  
Keyword(s):  
Acute Phase ◽  
Anterior Uveitis ◽  
Acute Phase Response ◽  
Phase Response ◽  
Tear Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Bacterial Keratitis ◽  
Acute Anterior Uveitis ◽  
Potential Biomarker

Abstract Background To identify candidate tear fluid biomarkers in patients with unilateral acute anterior uveitis (AAU) that can aid in the differentiation between these patients and patients with bacterial keratitis or healthy controls. Methods Thirteen patients (40.1 ± 16.2 years of age) with unilateral AAU, seven patients with unilateral bacterial keratitis (40.2 ± 15.3 years of age), and 14 healthy subjects (41.1 ± 11.6 years of age) were included. The tear proteome of affected eyes was compared with that of the unaffected eye or healthy controls. Proteins were identified by liquid chromatography tandem mass spectrometry and enzyme-linked immunosorbent assay. Results Relative protein ratios were detected and calculated for 272 unique proteins. Compared with healthy controls and the unaffected eye, the top upregulated proteins in AAU eyes were submaxillary gland androgen regulated protein 3B (SMR3B) and SMR3A. Similarly, the top upregulated proteins in bacterial keratitis were S100 calcium-binding protein A9 and orosomucoid 2. The acute phase response protein Serpin Family A Member 3 (SERPINA3) was increased in the healthy eye of AAU patients (P = 0.019) compared with healthy controls. Laser flare measurements in affected eyes of AAU patients showed positive logarithmic correlation with SERPINA3 in tear samples of the unaffected eye (P = 0.022). The use of SERPINA3 as a tear biomarker yielded a sensitivity of 85% and a specificity of 71% in detecting patients with AAU in the study population. Conclusions The acute phase response protein SERPINA3 was increased in tear samples of unaffected eyes of patients with unilateral AAU compared with healthy controls. This study highlights SERPINA3 as a potential biomarker for AAU. Future research should explore the dynamic properties of SERPINA3 in the tear fluid of active and quiescent uveitis eyes.

scholarly journals Feed Composition Differences Resulting from Organic and Conventional Farming Practices Affect Physiological Parameters in Wistar Rats—Results from a Factorial, Two-Generation Dietary Intervention Trial

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 377
Author(s):  
Marcin Barański ◽  
Dominika Średnicka-Tober ◽  
Leonidas Rempelos ◽  
Gultakin Hasanaliyeva ◽  
Joanna Gromadzka-Ostrowska ◽  
...  
Keyword(s):  
Crop Production ◽  
Wistar Rats ◽  
Dietary Intervention ◽  
Growth Parameters ◽  
Crop Protection ◽  
The Body ◽  
Interactive Effects ◽  
Supporting Evidence ◽  
Feed Composition ◽  
Npk Fertilizer

Recent human cohort studies reported positive associations between organic food consumption and a lower incidence of obesity, cancer, and several other diseases. However, there are very few animal and human dietary intervention studies that provide supporting evidence or a mechanistic understanding of these associations. Here we report results from a two-generation, dietary intervention study with male Wistar rats to identify the effects of feeds made from organic and conventional crops on growth, hormonal, and immune system parameters that are known to affect the risk of a number of chronic, non-communicable diseases in animals and humans. A 2 × 2 factorial design was used to separate the effects of contrasting crop protection methods (use or non-use of synthetic chemical pesticides) and fertilizers (mineral nitrogen, phosphorus and potassium (NPK) fertilizers vs. manure use) applied in conventional and organic crop production. Conventional, pesticide-based crop protection resulted in significantly lower fiber, polyphenol, flavonoid, and lutein, but higher lipid, aldicarb, and diquat concentrations in animal feeds. Conventional, mineral NPK-based fertilization resulted in significantly lower polyphenol, but higher cadmium and protein concentrations in feeds. Feed composition differences resulting from the use of pesticides and/or mineral NPK-fertilizer had a significant effect on feed intake, weight gain, plasma hormone, and immunoglobulin concentrations, and lymphocyte proliferation in both generations of rats and in the second generation also on the body weight at weaning. Results suggest that relatively small changes in dietary intakes of (a) protein, lipids, and fiber, (b) toxic and/or endocrine-disrupting pesticides and metals, and (c) polyphenols and other antioxidants (resulting from pesticide and/or mineral NPK-fertilizer use) had complex and often interactive effects on endocrine, immune systems and growth parameters in rats. However, the physiological responses to contrasting feed composition/intake profiles differed substantially between the first and second generations of rats. This may indicate epigenetic programming and/or the generation of “adaptive” phenotypes and should be investigated further.

scholarly journals Sensors for the detection of ammonia as a potential biomarker for health screening

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Peter P. Ricci ◽  
Otto J. Gregory
Keyword(s):  
Vapor Phase ◽  
Detection System ◽  
Health Screening ◽  
The Body ◽  
Peptic Ulcers ◽  
Non Invasive ◽  
Sensing Platform ◽  
Potential Biomarker ◽  
Screening Protocol ◽  
H Pylori

AbstractThe presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO2) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications.

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