Rectovaginal extragastrointestinal stromal tumour (EGIST): an additional entity to be considered in the differential diagnosis of tumours of the rectovaginal septum

2021 ◽  
Vol 14 (3) ◽  
pp. e237669
Author(s):  
Susan Addley ◽  
Moiad Alazzam ◽  
Catherine Johnson ◽  
Hooman Soleymani majd

Gastrointestinal stromal tumours (GISTs) are rare - and rectovaginal extragastrointestinal stromal tumours (RV-EGISTs) even rarer. We share a case of RV-EGIST, complemented by high-quality radiological and surgical images. A review of current literature pertaining to RV-EGIST is also included. Our case report highlights the diagnostic challenge presented by extragastrointestinal stromal tumours. Differentiated from overlapping pathologies only by targeted application of immunohistopathology and cytogenetics, the inclusion of RV-EGIST in the differential diagnosis of a rectovaginal tumour is essential to making this correct diagnosis. Primary surgery is the treatment of choice for RV-EGIST if complete cytoreduction can be achieved, combined with adjuvant tyrosine kinase inhibitor (TKI) therapy for those with high-risk features to further reduce rates of future recurrence.

PEDIATRICS ◽  
1996 ◽  
Vol 98 (3) ◽  
pp. 461-463
Author(s):  
Gary L. Darmstadt

Genital warts are common relative to other verrucous lesions of the anogenital region. Consideration of the differential diagnosis of verrucous anogenital lesions is necessary, however, to make a correct diagnosis consistently and to avoid futile, painful, and possibly traumatic attempts at treatment. In this report, I describe a child with a history suspicious for sexual abuse who was treated with inappropriate measures because of misdiagnosis of perianal lymphangioma circumscriptum as genital warts. The pathogenesis, differential diagnosis, and treatment of lymphangioma is presented. CASE REPORT A 5-year-old Hispanic boy was referred by his pediatrician to the Dermatology Service with an eruption of red papules on the left buttock and perianal region.


2005 ◽  
Vol 29 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Virginia Karapanou

This report demonstrates a simple endodontic solution to an interdisciplinary case of a patient with multiple gene deficiencies. An adolescent patient presented with an impacted premolar that could not be extracted due to high-risk conditions. A suspicious degree of radiolucency around the crown was clinically diagnosed as dentigerous cyst. The treatment dilemma and implementation are discussed. This case report offers a different treatment option for impacted teeth when significant differential diagnosis of a pericoronal lesion dictates treatment.


Author(s):  
Chandra Dev Sahu ◽  
Nishant Bhargava ◽  
Debabrata Sahana ◽  
Sanjeev Kumar

AbstractRete MCA anomaly is extremely rare and has been seldomly discussed in literature. Embryologically MCA develops by fusion of multiple twigs which form a single channel. If there is failure to fuse a plexiform network of vessels persists known as rete MCA. This web like network of vessels is at high risk of haemorrhagic stroke and therefore for patients presenting incidentally correct diagnosis is paramount. Here we report a case of rete MCA anomaly in a 35-year-old gentle man who presented with a large haemorrhagic stroke in emergency. DSA showed unilateral involvement of proximal MCA, and otherwise normal intra-cranial vasculature. With this report we aim to correctly diagnose this rare condition and avoid misdiagnosis leading to unnecessary treatments.


2012 ◽  
Vol 7 (2) ◽  
pp. 124 ◽  
Author(s):  
Jean-Marc Léger ◽  
Eugen Gavriliuc ◽  
◽  

Multifocal motor neuropathy (MMN) is a rare, clinically well-defined condition within the spectrum of chronic, immune-mediated neuropathies. A typical patient history involves slowly or stepwise progressive, predominantly distal, asymmetrical limb weakness and muscle wasting, most frequently in the arm, that may have developed over a period of years. As a rare condition, MMN may present a diagnostic challenge for non-specialists and some patients may wait years for a correct diagnosis. Timely and accurate diagnosis is essential for patients with MMN. Unlike some motor neuropathies, MMN is treatable with intravenous immunoglobulin and untreated patients are likely to experience progressive muscle weakness that may result in serious functional impairment and impaired quality of life. The aim of this article is therefore to provide a guide for non-specialist neurologists to the clinical recognition and differential diagnosis of MMN.


2018 ◽  
Vol 1 (11) ◽  
pp. 334-338
Author(s):  
Shweta Bansal ◽  
Ruchi Juneja ◽  
Gyanendra Mishra ◽  
Akshay Nambiar

Cutaneous draining sinus tracts of odontogenic origin often are a diagnostic challenge. A delay in correctly diagnosing these types of lesions can result in unnecessary antibiotic therapy and surgical treatment. This case report presents the clinical course of two cases with extra-oral sinus tract formation, from diagnosis and treatment to short-term follow-up and evaluation. These facial lesions were initially misdiagnosed as lesions of non-odontogenic origin. Later on an odontogenic cause was identified and endodontic intervention resulted in resolution of the problem, confirming the initial misdiagnosis.


Author(s):  
Kamila Motta Stradiotti ◽  
Felipe Pires de Albuquerque ◽  
Maria Laura Silveira de Castro ◽  
Laiane Milani de Arruda

Introdução: Apendagite epiplóica (AE) é uma causa incomum de dor abdominal causada por alterações inflamatórias e isquêmicas relacionadas à torção ou trombose venosa dos apêndices epiplóicos. Estas estruturas consistem em projeções de tecido adiposo que emergem da superfície serosa do cólon e apêndice cecal, sendo maiores e mais numerosas no cólon descendente e sigmóide. A apendagite epiplóica do apêndice cecal (AEA) é uma forma ainda mais rara de apresentação, tendo poucos casos relatados em literatura. Os sinais e sintomas da AE comumente mimetizam outras causas de abdome agudo, que varia dependendo da sua localização, devendo ser considerada no diagnóstico diferencial de dor abdominal localizada. O diagnóstico correto é fundamental para evitar gastos e procedimentos desnecessários, pois se trata de uma condição benigna e autolimitada, com tratamento conservador sendo suficiente na grande maioria dos casos. Atualmente a tomografia computadorizada é o método de escolha na avaliação de pacientes com abdome agudo. Objetivo: Relatar um caso raro de dor abdominal aguda causada por apendagite epiplóica do apêndice cecal e a importância do seu diagnóstico correto. Relato do caso: Paciente com quadro de dor abdominal aguda no quadrante inferior direito, afebril e sem outras queixas gastrointestinais associadas. Ao exame físico referiu dor à palpação profunda no quadrante inferior direito. Exames laboratoriais sem alterações. Foram solicitados exames de imagem complementares, evidenciando apêndice cecal nos limites superiores da normalidade, inflamação periapendicular e uma imagem com densidade de gordura adjacente ao apêndice. Os diagnósticos diferenciais foram de apendicite inicial e apendagite epiplóica. Foi realizado tratamento operatório e exame anatomopatológico, que confirmou o diagnóstico de apendagite epiplóica do apêndice cecal. As informações foram obtidas por meio de revisão do prontuário, entrevista com o paciente, registro dos métodos diagnósticos, incluindo exames laboratoriais, exames de imagem como tomografia computadorizada e anatomopatológico, aos quais o paciente foi submetido e uma breve revisão da literatura. Conclusão: Relatamos um caso raro de apendagite epiplóica do apêndice cecal, demonstrando um desafio diagnóstico e a importância dos métodos de imagem. Palavras Chave: Dor abdominal, Abdome agudo, Apêndice cecal, Diagnóstico por imagemABSTRACT: Introduction: Epiploic appendagitis (LA) is an uncommon cause of abdominal pain caused by inflammatory and ischemic changes related to venous torsion or thrombosis of the epiploic appendages. These structures consist of projections of adipose tissue that emerge from the serous surface of the colon and cecal appendix, being larger and more numerous in the descending and sigmoid colon. Epiploic appendagitis of the appendix (EAA) is an even rarer form of presentation, with few cases reported in the literature. The signs and symptoms of EAA commonly mimic other causes of acute abdomen, which varies depending on their location, and should be considered in the differential diagnosis of localized abdominal pain. Correct diagnosis is essential to avoid unnecessary expenses and procedures, as it is a benign and self-limited condition, with conservative treatment being sufficient in the vast majority of cases. Currently, computed tomography is the method of choice in the evaluation of patients with acute abdomen. Objectives: To describe a rare cause of abdominal pain due acute epiploic appendagitis of the appendix and reinforce the importance of the CT to diagnosis this condition and rule out other causes of acute abdominal pain. Case report: Patient with acute abdominal pain in the lower right quadrant, afebrile and without other associated gastrointestinal complaints. On physical examination, she reported pain on deep palpation in the lower right quadrant. Laboratory tests without changes. Complementary imaging exams were requested, showing the appendix at the upper limits of normal, periapendicular inflammation and an image with fat density adjacent to the appendix. The differential diagnoses were of initial appendicitis and epiplatic appendagitis. Operative treatment and anatomopathological examination were performed, which confirmed the diagnosis of appendagitis of the appendix. Information was obtained by reviewing medical records, interviewing the patient, recording diagnostic methods, including laboratory tests, imaging tests such as computed tomography, anatomopathology, and a brief review of the literature. Conclusion: We report a case of acute epiploic appendagitis of the appendix, demonstrating a diagnostic challenge and the importance of imaging methods.Keywords: Abdominal pain; Abdomen, acute; Appendix, Diagnostic imaging


2019 ◽  
Vol 12 ◽  
pp. 117954761982868 ◽  
Author(s):  
Muhammad Ishaq Ghauri ◽  
Syeda Beenish Bareeqa ◽  
Amir Riaz ◽  
Ajeet Kumar

Introduction: Iatrogenic or physician-induced hypervitaminosis D is a rare cause of persistent vomiting. To the best of our knowledge, this is the first case report on iatrogenic hypervitaminosis D presenting with persistent vomiting in Pakistan. Case Report: We report a rare case of continual vomiting for 15 days in a 48-year-old woman of Pakistani descent. She was a known case of diabetes mellitus for 8 years, which was well controlled at the time of presentation. Conclusions: The correct diagnosis of our patient was based on clinical suspicion, appropriate lab tests, and deliberation of the differential diagnosis. It is important to consider hypervitaminosis D as a cause of persistent vomiting if no other obvious is apparent.


2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Anshita Agarwal ◽  
Gaurav P. Agrawal ◽  
Sarwar Alam ◽  
Benazeer Husain

Eosinophilic granuloma of bone is a disease with an incidence of one new case per 350,000 to 2 million per year, which is an uncommon disease of maxillofacial region, and presents in more than 90% in children under the age of ten with predominance for males. As a result, eosinophilic granuloma of the jaw is always unconsidered in the differential diagnosis of similar lesions by many clinicians. It is difficult to make a correct diagnosis on it without proof of a pathological diagnosis, which correlates with the diverse clinical and radiographic presentations of eosinophilic granuloma in the jaws. In the present paper we report a rare case of unifocal eosinophilic granuloma of mandible occurring in an adult female.


Author(s):  
R. John Hurlbert ◽  
Juan M. Bilbao ◽  
William S. Tucker

AbstractBackgroundProgressive deterioration and ensuing death following a neurosurgical procedure often represents a diagnostic challenge to the team responsible for patient care. Many, but not all, causes are treatable if a diagnosis is made early.MethodsA 69-year-old woman who died 6 weeks post-operatively following a meningioma resection is reported. An initial routine post-operative course became complicated by progressive neurological deterioration 3–4 weeks later. Despite extensive investigation she died 6 weeks post-operatively without a diagnosis.ResultsAutopsy demonstrated extensive Candida meningitis. A review of the literature demonstrates this to be a reported complication in high risk patients, difficult to diagnose, but treatable when identified.ConclusionsFungal meningitis should be high in the differential diagnosis in the post-operative patient with delayed, unexplained neurological deterioration, especially when associated with negative CSF cultures.


2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
N. W. Savage ◽  
V. Vucicevic Boras

An interesting case of Kimura's disease was described in the 42-year-old patient manifesting itself as a unilateral parotid swelling, albeit the disease usually affects both parotid glands. Furthermore, first pathohistological finding was not suggestive of the disease, revealing only fatty tissue, but on the repeated biopsy together with CT the correct diagnosis was established. It should be emphasized that Kimura's disease has to be taken into account while making differential diagnosis in parotid gland swellings, especially in people of Oriental origin.


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