Maternal mesalazine-induced neonatal gastrointestinal bleeding

2021 ◽  
Vol 14 (4) ◽  
pp. e238743
Author(s):  
Kohichiroh Nii ◽  
Kaoru Okazaki ◽  
Hitoshi Okada ◽  
Toru Kuboi
Keyword(s):  
Ulcerative Colitis ◽  
Preterm Neonate ◽  
Reproductive Age ◽  
Lymphocyte Stimulation Test ◽  
Food Protein ◽  
Aminosalicylic Acid ◽  
Drug Induced ◽  
Reproductive Age Women ◽  
Allergic Enterocolitis ◽  
Allergic Proctocolitis

Ulcerative colitis often develops in the reproductive age women and can cause exacerbation by pregnancy. Mesalazine (5-aminosalicylic acid) is recommended as a safe anti-inflammatory drug during pregnancy. However, maternal mesalazine is transferred to the fetus through the placenta and may cause allergic events. A pregnant woman with severe ulcerative colitis was treated with a dose of mesalazine 4,000 mg/day from early gestation to delivery. Immediately after birth, the preterm neonate vomited bloody contents and discharged massive gross haematochezia. Serum concentrations of mesalazine and its main metabolite were high in the mother and the umbilical cord. Faecal eosinophils and drug-induced lymphocyte stimulation test suggested possibility that sensitisation with mesalazine in utero caused allergic enterocolitis like food protein-induced allergic proctocolitis. Maternal mesalazine has a potential of fetal sensitisation and cause allergic disease.

scholarly journals Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 226
Author(s):  
Mauro Calvani ◽  
Caterina Anania ◽  
Barbara Cuomo ◽  
Enza D’Auria ◽  
Fabio Decimo ◽  
...  
Keyword(s):  
Clinical Score ◽  
Food Allergies ◽  
Diagnostic Tools ◽  
Lymphocyte Stimulation Test ◽  
Food Protein ◽  
Patch Tests ◽  
Eosinophilic Colitis ◽  
Allergic Proctocolitis ◽  
Clinical Pictures ◽  
Fecal Biomarkers

non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergen-specific lymphocyte stimulation test (ALST) and clinical score (CoMiss).

scholarly journals Pancreatitis: common but forgotten causes

2021 ◽  
Vol 12 (2) ◽  
pp. 96-99
Author(s):  
E. R. Donсova ◽  
O. V. Remizov ◽  
N. V. Novoselya
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Laboratory ◽  
Abdominal Cavity ◽  
Clinical Manifestations ◽  
Blood Analysis ◽  
Aminosalicylic Acid ◽  
Drug Induced ◽  
Ulcer Disease ◽  
Coprological Examination ◽  
High Degree

Objective: to study the causes of pancreatitis. Materials and methods: a clinical case of acute pancreatitis during the treatment of ulcerative colitis with 5-aminosalicylic acid-containing drugs. Methods: clinical, laboratory and instrumental (biochemical blood analysis, standard coprological examination, Ultrasound examination of the abdominal cavity, Esophagogastroduodenoscopy). Results: based on the data of the clinic, laboratory and instrumental studies, a diagnosis was made: drug-induced pancreatitis associated with mesalazine intake. Ulcerative colitis, total form, high degree of activity. Duodenal ulcer disease associated with Helicobacter pylori, unstable remission. Erosive bulbitis. The indicated therapy with polyenzyme drugs, proton pump inhibitors, antispasmodics, and glucocorticosteroids resulted in the resolution of clinical manifestations and the normalization of altered laboratory parameters. Conclusions: the use of 5-aminosalicylic acid preparations for the treatment of ulcerative colitis may be associated with the development of pancreatitis, which must be taken into account in clinical practice.

Overview of Biological Therapy in Ulcerative Colitis: Current and Future Directions

2015 ◽  
Vol 24 (2) ◽  
pp. 203-213 ◽  
Author(s):  
Federica Furfaro ◽  
Cristina Bezzio ◽  
Sandro Ardizzone ◽  
Alessandro Massari ◽  
Roberto De Franchis ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Immunosuppressive Agents ◽  
Mucosal Healing ◽  
Aminosalicylic Acid ◽  
Proinflammatory Mediators ◽  
Experimental Drugs ◽  
New Treatments ◽  
Aggressive Clinical Course ◽  
Near Future

The treatment of ulcerative colitis (UC) has changed over the last decade. It is extremely important to optimize the therapies which are available nowadays and commonly used in daily clinical practice, as well as to stimulate the search for more powerful drugs for the induction and maintenance of sustained and durable remission, thus preventing further complications. Therefore, it is mandatory to identify the patients' prognostic variables associated with an aggressive clinical course and to test the most potent therapies accordingly.To date, the conventional therapeutic approach based on corticosteroids, salicylates (sulfasalazine, 5-aminosalicylic acid) or immunosuppressive agents is commonly used as a first step to induce and to maintain remission. However, in recent years, knowledge of new pathogenetic mechanisms of ulcerative colitis have allowed us to find new therapeutic targets leading to the development of new treatments that directly target proinflammatory mediators, such as TNF-alpha, cytokines, membrane migration agents, cellular therapies.The aim of this review is to provide the most significant data regarding the therapeutic role of drugs in UC and to give an overview of biological and experimental drugs that will become available in the near future. In particular, we will analyse the role of these drugs in the treatment of acute flare and maintenance of UC, as well as its importance in mucosal healing and in treating patients at a high risk of relapse.

Folate Status and Depressive Symptoms in Reproductive-Age Women

2011 ◽  
Vol 7 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Hiroko Watanabe ◽  
Takashi Sugiyama ◽  
Hiromitsu Chihara ◽  
Hideoki Fukuoka
Keyword(s):  
Depressive Symptoms ◽  
Reproductive Age ◽  
Folate Status ◽  
Reproductive Age Women

scholarly journals Prevalence of Underweight, Overweight, and Obesity Among Reproductive-Age Women and Adolescent Girls in Rural China

2016 ◽  
Vol 106 (12) ◽  
pp. 2103-2110 ◽  
Author(s):  
Yuan He ◽  
An Pan ◽  
Ying Yang ◽  
Yuanyuan Wang ◽  
Jihong Xu ◽  
...  
Keyword(s):  
Adolescent Girls ◽  
Rural China ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Reproductive Age Women

scholarly journals Spatial distribution and determinants of intimate partner violence among reproductive-age women in Ethiopia: Spatial and Multilevel analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dessie Abebaw Angaw ◽  
Alemakef Wagnew Melesse ◽  
Bisrat Misganaw Geremew ◽  
Getayeneh Antehunegn Tesema
Keyword(s):  
Public Health ◽  
Intimate Partner Violence ◽  
Spatial Distribution ◽  
Multilevel Analysis ◽  
Partner Violence ◽  
Intimate Partner ◽  
Reproductive Age ◽  
P Value ◽  
Public Health Programs ◽  
Reproductive Age Women

Abstract Background Intimate partner violence is a serious global public health problem particularly in low-and middle-income countries such as Ethiopia where women's empowerment is limited. Despite the high prevalence of intimate partner violence in Ethiopia, there is limited evidence on the spatial distribution and determinants of intimate partner violence among reproductive-age women. Exploring the spatial distribution of intimate partner violence is crucial to identify hotspot areas of intimate partner violence to design targeted health care interventions. Therefore, this study aimed to investigate the spatial distribution and determinants of intimate partner violence among reproductive-age women in Ethiopia. Methods A secondary data analysis was done based on the 2016 Ethiopian Demographic and Health Survey (EDHS) data. A total weighted sample of 6090 reproductive-age women were included in the study. The spatial scan statistical analysis was done to identify the significant hotspot areas of intimate partner violence. A multilevel binary logistic regression analysis was fitted to identify significant determinants of intimate partner violence. Deviance, Intra-cluster Correlation Coefficient (ICC), Median Odds Ratio, and Proportional Change in Variance (PCV) were used for model comparison as well as for checking model fitness. Variables with a p-value less than 0.2 were considered in the multivariable analysis. In the multivariable multilevel analysis, the Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) were reported to declare statistical significance and strength of association between intimate partner violence and independent variables. Results The spatial analysis revealed that the spatial distribution of intimate partner violence was significantly varied across the country (Moran’s I = 0.1007, p-value < 0.0001). The SaTScan analysis identified a total of 192 significant clusters, of these 181 were primary clusters located in the Benishangul-Gumuz, Gambella, northwest Amhara, and west Oromia regions. In the multivariable multilevel analysis; women aged 45–49 years (AOR = 2.79, 95% CI 1.52–5.10), women attained secondary education (AOR = 0.61, 95% CI 0.38–0.98), women in the richest household (AOR = 0.58, 95% CI 0.35–0.97), > 10 family size (AOR = 3.85, 95% CI 1.41–10.54), and high community women empowerment (AOR = 0.66, 95% CI 0.49–0.8)) were significantly associated with intimate partner violence. Conclusions Intimate partner violence among reproductive-age women had significant spatial variation across the country. Women's age, education status, family size, community women empowerment, and wealth status were found significant determinants of intimate partner violence. Therefore, public health programs should design targeted interventions in identified hot spot areas to reduce the incidence of intimate partner violence. Besides, health programmers should scale up public health programs designed to enhance women's autonomy to reduce the incidence of intimate partner violence and its consequences.

scholarly journals Contraceptive prevalence rate and associated factors among reproductive age women in four emerging regions of Ethiopia: a mixed method study

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Delayehu Bekele ◽  
Feiruz Surur ◽  
Balkachew Nigatu ◽  
Alula Teklu ◽  
Tewodros Getinet ◽  
...  
Keyword(s):  
Health Care ◽  
Prevalence Rate ◽  
Contraceptive Use ◽  
Reproductive Age ◽  
Sociocultural Factors ◽  
Contraceptive Prevalence Rate ◽  
Individual Health ◽  
Reproductive Age Women ◽  
Contraceptive Prevalence ◽  
Knowledge And Attitude

Abstract Background Ethiopia is the second most populous country in Africa, known for its high fertility and low contraceptive use. The magnitude of contraceptive use in the emerging regions of the country is below the national average. However, there is a paucity of evidence regarding the reasons for low contraceptive use in these regions. Therefore, this study aimed to assess contraceptive use and associated factors in the emerging regions of Ethiopia. Methods For the quantitative part, a community based cross-sectional study was conducted among 2891 reproductive age women who were selected by multistage sampling technique. Data were collected face to face using an open data kit software, and STATA version 14 was used for data analysis. Frequencies, percentages, summary measures and tables were used to summarize and present the data. Bivariable and multivariable logistic regression analyses were performed to identify factors associated with contraceptive use, by computing odds ratio with 95% confidence interval. Level of significance was considered at p-value < 0.05. For the qualitative part, phenomenological study was conducted among 252 health care workers and community members who were selected purposely. The data were collected by focused group discussions, in-depth interviews and key informant interviews. The data were audio-recorded in the local languages, and then translated to English verbatim. NVivo version 11 was used to analyze the data through a thematic analysis method. Results The overall contraceptive prevalence rate was 22.2%; with 11.7, 38.6, 25.5 and 8.8% for Afar, Benshangul Gumuz, Gambela and Somali Regions, respectively. Age, religion, education, marital status, family size, ideal children, knowledge and attitude were significantly associated with contraceptive use. Additionally, the qualitative study identified three themes as barriers to contraceptive use: individual, health care system and sociocultural factors. Conclusions Contraceptive prevalence rate was low in this study compared to the national average. Age, religion, education, marital status, family size, ideal children, knowledge and attitude were significantly associated with contraceptive use. From the qualitative aspect, individual, health care system and sociocultural factors were identified as barriers to contraceptive use. Therefore, the emerging regions of Ethiopia need special focus in increasing contraceptive use through behavioral influence/change.

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