Central nervous system involvement of anaplasmosis

2021 ◽  
Vol 14 (12) ◽  
pp. e243665
Author(s):  
Jon Brandon Mullholand ◽  
Nathanial Tolman ◽  
Anna De Obaldia ◽  
Eileen Hennrikus
Keyword(s):  
Ixodes Scapularis ◽  
Central Nervous System Involvement ◽  
Peripheral Blood Smear ◽  
Magnetic Resonance Angiogram ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Igm Antibodies ◽  
Word Finding ◽  
Serum Igg ◽  
Normal Glucose

A 64-year-old woman presented with 24 hours of lethargy, confusion, headache, nausea and vomiting. Examination revealed expressive aphasia, conjunctival suffusion and a tick embedded in her popliteal fossa. Labs revealed hyponatraemia, transaminitis, leucopenia, thrombocytopenia and an elevated C reactive protein. Peripheral blood smear was unremarkable. MRI/magnetic resonance angiogram revealed bilateral frontoparietal subarachnoid haemorrhage which was further confirmed by lumbar puncture which revealed six nucleated cells, 92% lymphocytes, 1460 red blood cells, normal glucose and protein and negative cryptococcal antigen, herpes simplex PCR and Lyme PCR. Serum Lyme IgG/IgM antibodies and PCR, Erlichia chaffeensis serum IgG/IgM antibodies and PCR and anaplasma serum IgG/IgM antibodies were negative. Anaplasmosis serum PCR was positive. The tick was identified as Ixodes scapularis. The patient was diagnosed with anaplasmosis and treated with 21 days of doxycycline resulting in improvement of symptoms, but lingering headaches and word finding difficulties.

C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion

Surgery ◽  
2007 ◽  
Vol 142 (5) ◽  
pp. 722-733 ◽  
Author(s):  
Niubel Diaz Padilla ◽  
Arlène K. van Vliet ◽  
Ivo G. Schoots ◽  
Mercedes Valls Seron ◽  
M. Adrie Maas ◽  
...  
Keyword(s):  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia And Reperfusion ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Igm Antibodies ◽  
Natural Igm

scholarly journals Serum High Sensitive C-Reactive Protein in Obese Persons with Normal Glucose Tolerance & Impaired Fasting Glucose

2018 ◽  
Vol 4 (1) ◽  
pp. 21-24
Author(s):  
Soniya Fahmi ◽  
Sunjida Shahriah ◽  
Omma Hafsa Any ◽  
Mahbuba Akter ◽  
Samia Afrin
Keyword(s):  
Fasting Glucose ◽  
Normal Glucose Tolerance ◽  
Control Group ◽  
Case Group ◽  
Obese Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Normal Glucose ◽  
Obese Subjects ◽  
Hs Crp

Background: Obesity, characterized by increased fat mass and is currently regarded as a proinflammatory state and frequently associated with increased risk of cardiovascular diseases including Myocardial Infarction and also future risk for development of metabolic disorders such as T2DM. Highsensitivity C-reactive protein is a well-known inflammatory marker. Objective: In this study we aimed to determine the levels of serum high-sensitive C-reactive protein in obese parsons with normal glucose tolerance (NGT) and obese with impaired fasting glucose (IFG) individuals. Methodology: This was a case-control study which was conducted in the Department of Biochemistry, ZH Sikder Women’s Medical College, Dhaka during the period of July 2014 to June 2015. The age, sex and body mass index (BMI ≥ 30 kg / m²) matched 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. We measured levels of serum high sensitive Creactive protein in all groups. Subjects of both obese groups had significantly higher hs-CRP levels than the normal range. Results: A total number of 50 subjects were recruited for this study of which 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. The level of hs-CRP in obese with NGT and with IFG were found 2.91±1.56 mg/L & 3.42±1.72 mg/L, respectively. There are no significant difference between hs-CRP levels of obese subjects than the subjects with IFG (p>0.1). Conclusion: This study finding has concluded that obesity raises serum hsCRP level. IFG obese individuals are not at much higher cardiovascular and metabolic risk level than normal obese parsons. Bangladesh Journal of Infectious Diseases 2017;4(1):21-24

A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance

Endocrine ◽  
2011 ◽  
Vol 41 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Kyoko Okada ◽  
Norihiro Furusyo ◽  
Masayuki Murata ◽  
Yasunori Sawayama ◽  
Mosaburo Kainuma ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
High Sensitivity ◽  
Normal Glucose Tolerance ◽  
C Reactive Protein ◽  
Japanese Men ◽  
Reactive Protein ◽  
Normal Glucose

scholarly journals Diagnostic Utility of C-Reactive Protein and Permutation Combination of Quantitative and Qualitative Haematological Parameters in Neonatal Sepsis

2021 ◽  
Author(s):  
Sapna Shreyas Deshpande ◽  
Mohasin Jakirhusain Halgale ◽  
Ravindra Vilas Ramteke
Keyword(s):  
Blood Culture ◽  
Peripheral Blood ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Haematological Parameters ◽  
Diagnostic Utility ◽  
C Reactive Protein ◽  
Reactive Protein

Introduction: Neonatal sepsis at times is subclinical and lacks specific symptoms. The C-Reactive Protein (CRP) which is an acute phase reactant protein is thought to be an alternative biomarker to blood culture. Haematological parameters of sepsis are indirect biomarkers of infection. Authors found it worthwhile to discern efficacy of haematological parameters obtained by such three part haematology analysers in diagnosis of neonatal sepsis, when used in their pure form or with peripheral blood smear or with CRP, in isolation or in their combinations. Aim: To find out the diagnostic utility of combinations of haematological parameters as obtained by three part differential automated haematology analyser and peripheral blood smear along with CRP in neonatal sepsis. Materials and Methods: This observational and analytical study of diagnostic test outcome was carried out over a period of 12 months from January-December 2016 in Rajarshi Chhatrapati Shahu Maharaj Medical College and Chhatrapati Pramilaraje Rugnalaya, Kolhapur, Maharashtra, India, with special reference to clinical profile, blood culture, qualitative and quantitative haematological parameters and CRP. The statistical analysis included calculating diagnostic utility of isolated and combination of parameters and performing Chi-square test to study difference in frequency of occurrence and significance of association. Results: There were 104 cases of neonatal sepsis out of which culture proven sepsis was seen in 73 (70.2%) cases while probable sepsis was seen in 31 (29.8%) cases. There were 32 (30.8%) fatalities. With parallel method with OR values, combination of haemoglobin, platelet parameters and White Blood Cells (WBC) parameters as obtained by analyser and peripheral blood smear exhibited sensitivity of 98.6%, specificity and Positive Predictive Value (PPV) of 100%, Negative Predictive Value (NPV) of 96.9% and Diagnostic Accuracy (DA) of 99%. This was surpassed by combination of CRP and all these parameters to attend values of 100%. Combination of all haematological parameters obtained purely by analyser showed these values to be 89%, 100%, 79.5% and 92.3%. Immature to Total WBC (I:T) ratio and platelet count influenced clinical outcome of fatality. Conclusion: The liberal use of combination of haematological parameters is rewarding in supporting diagnosis of neonatal sepsis. The same was obtained by purely using analyser which showed remarkable diagnostic utility suitable for resource poor settings.

Elevated C-reactive Protein Levels Independently Predict the Development of Prediabetes Markers in Subjects with Normal Glucose Regulation

2019 ◽  
Author(s):  
Katsuhito Kato ◽  
Toshiaki Otsuka ◽  
Yoshiyuki Saiki ◽  
Nobuyuki Kobayashi ◽  
Takayuki Nakamura ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Glucose Regulation ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Glucose Levels ◽  
Reactive Protein ◽  
Increased Risk ◽  
Normal Glucose ◽  
Normal Glucose Regulation ◽  
Hba1c Levels

Abstract Aims Prediabetes is a precursor of diabetes and increases the risk of cardiovascular disease. Individuals with prediabetes reportedly have higher C-reactive protein levels, which is a risk factor for diabetes, relative to individuals with normal glucose regulation. Inflammation may play a role in the very early-phase deterioration of glucose metabolism, although there is insufficient knowledge regarding this relationship. Thus, we examined the association between serum C-reactive protein level and the development of three prediabetes markers. Methods This study included 743 subjects with normal glucose regulation at baseline who completed oral glucose tolerance tests at baseline and after approximately 5 years. Subjects with a history of cardiovascular disease were excluded. Results During the 5-year follow-up, 55 subjects developed isolated impaired glucose tolerance (IGT; 2h-plasma glucose levels of 7.8–11.0 mmol/L), 24 subjects developed isolated impaired fasting glucose (IFG; fasting plasma glucose levels of 6.1–7.0 mmol/L), 3 subjects developed IFG plus IGT, and 53 subjects developed isolated elevated glycated hemoglobin levels (HbA1c; level of 41–47 mmol/mol). The multivariate analysis revealed that, relative to the lowest quartile, the highest serum C-reactive protein quartile was independently associated with an increased risk of developing isolated elevated HbA1c levels (odds ratio: 2.95, 95% confidence interval: 1.16–7.51, P=0.024) and marginally associated with an increased risk of developing impaired glucose tolerance plus diabetes. However, C-reactive protein levels were not associated with an increased risk of developing IFG. Conclusions Elevated serum C-reactive protein levels independently predicted elevated HbA1c levels, but not IFG.

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